Antidepressant effect of Eucalyptus globulus leaf extracts, neurochemical and pharmacological evaluations, identification of the active ingredients

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
C Fiorini-Puybaret
Keyword(s):  
Eucalyptus Globulus ◽  
Antidepressant Effect ◽  
Active Ingredients ◽  
Leaf Extracts

Conductimetric analysis of the ion binding properties of three leaf extracts of chestnut (Castanea sativa), Eucalyptus (Eucalyptus globulus) and oak (Quercus robur)

Talanta ◽  
1995 ◽  
Vol 42 (12) ◽  
pp. 1919-1923 ◽  
Author(s):  
F. Rey ◽  
M. Pérez-Asenjo ◽  
A.A.S.C. Machado ◽  
P. Facal ◽  
M.A. Ferreira ◽  
...  
Keyword(s):  
Eucalyptus Globulus ◽  
Quercus Robur ◽  
Castanea Sativa ◽  
Ion Binding ◽  
Leaf Extracts ◽  
Binding Properties

scholarly journals Relative Toxicity of Leaf Extracts of Eucalyptus globulus and Centella asiatica against Mosquito Vectors Aedes aegypti and Anopheles stephensi

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Savitha Sekhar Nair ◽  
Vinaya Shetty ◽  
Nadikere Jaya Shetty
Keyword(s):  
Aedes Aegypti ◽  
Diethyl Ether ◽  
Eucalyptus Globulus ◽  
Anopheles Stephensi ◽  
Centella Asiatica ◽  
Hexane Extract ◽  
Ether Extract ◽  
Leaf Extracts ◽  
Diethyl Ether Extract ◽  
Third Instar Larvae

The larvicidal activity of different solvent leaf extracts (hexane, diethyl ether, dichloromethane, and methanol) of Eucalyptus globulus and Centella asiatica against two geographically different strains of Aedes aegypti and Anopheles stephensi was investigated. The extracts were tested against the late third instar larvae of Aedes aegypti and Anopheles stephensi, and larval mortality was observed after 24 hours of treatment. LC50 and LC90 were calculated. The LC50 values of hexane extract of Eucalyptus globulus against the late third instar larvae of the BSN and JPN strains of Aedes aegypti and the DLC and KNG strains of Anopheles stephensi were 225.2, 167.7, 118.8, and 192.8 ppm, while those of the hexane extract of Centella asiatica were 246.5, 268.7, 50.6, and 243.5 ppm, respectively. The LC50 values of diethyl ether extract of Centella asiatica were 339.6, 134.5, 241, and 14.7 ppm. The hexane extracts of both plants and the diethyl ether extract of C. asiatica presented the highest potential for the control of Aedes aegypti and Anopheles stephensi. The present findings also reveal the necessity of assaying multiple strains of a species to fully comprehend the larvicidal efficacy of a compound.

scholarly journals Anti-inflammatory potential of dichloromethane leaf extracts of Eucalyptus globulus (Labill) and Senna didymobotrya (Fresenius) in mice

2021 ◽  
Vol 21 (1) ◽  
pp. 397-409
Author(s):  
Joseph Kiambi Mworia ◽  
Cromwell Mwiti Kibiti ◽  
Joseph JN Ngeranwa ◽  
Mathew Piero Ngugi
Keyword(s):  
Side Effects ◽  
Eucalyptus Globulus ◽  
Gas Chromatography Mass Spectrometry ◽  
Phytochemical Analysis ◽  
Leaf Extracts ◽  
Traditional Use ◽  
Reference Drug ◽  
Similar Dose ◽  
Anti Inflammatory ◽  
Positive Controls

Background: Inflammation is an immune response characterized by swelling, redness, pain and heat. Inflammation is main- ly managed using conventional medicines that are associated with many side effects. Plant-based remedies are considerably better alternative therapies for they have fewer side effects. Objective: This study aimed at determining the anti-inflammatory potential of dichloromethane (DCM) leaf extracts of Eucalyptus globulus and Senna didymobotrya in mice. Methods: Fresh leaves of these plants were harvested from Embu County, Kenya. Quantitative phytochemical analysis was done using Gas Chromatography-Mass Spectrometry (GC-MS). Anti-inflammatory test comprised nine groups of five animals each: normal, negative, positive controls and 6 experimental groups. Inflammation was induced with Carrageenan. One hour post-treatment, the different groups were intraperitoneally administered with the reference drug, diclofenac, 3% DMSO and six DCM leaf extracts at doses of 25, 50, 100, 150, 200 and 250mg/kgbw. Results: GC-MS results revealed α-phellandrene, camphene, terpinolene, and limonene among others. Anti-inflammatory effects showed that extract doses of 100,150,200 and 250mg/kg bw significantly reduced the inflamed paw. Doses of 200 and 250mg/kgbw in both plants were more potent and compared with diclofenac. E. globulus extract dose of 250mg kg bw reduced inflamed paw in the 1st , 2nd, 3rd and 4th hours, by 2.27,6.52,9.09 and 10.90% respectively while S.didymobotrya at similar dose ranges, inflamed paw reduced by 2.41, 5.43, 8.31 and 9.05% respectively. Conclusion: E. globulus and S. didymobotrya have potent anti-inflammatory activities, attributed to their constituent phyto- chemicals. This study confirms the traditional use of these plants in treating inflammation. Keywords: Eucalyptus globulus; Senna didymobtrya; inflammation; phytochemicals.

Eco-friendly synthesis of lanthanum oxide nanoparticles by Eucalyptus globulus leaf extracts for effective biomedical applications

2021 ◽  
Vol 283 ◽  
pp. 128799
Author(s):  
G. Maheshwaran ◽  
R. Selva Muneeswari ◽  
A. Nivedhitha Bharathi ◽  
M. Krishna Kumar ◽  
S. Sudhahar
Keyword(s):  
Eucalyptus Globulus ◽  
Biomedical Applications ◽  
Lanthanum Oxide ◽  
Oxide Nanoparticles ◽  
Leaf Extracts

scholarly journals Screening and Identification of Antidepressant Active Ingredients from Puerariae Radix Extract and Study on Its Mechanism

2021 ◽  
Vol 2021 ◽  
pp. 1-18
Author(s):  
Guoze Wang ◽  
Peng Luo ◽  
Shuai Zhang ◽  
Qun Huang ◽  
Shuling Zhang ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Mental Disease ◽  
Network Pharmacology ◽  
Antidepressant Effect ◽  
Chemical Components ◽  
High Recurrence Rate ◽  
Active Ingredients ◽  
Puerariae Radix ◽  
Tnf Α ◽  
Protein Expressions

Objective. Depression is a common mental disease with long course and high recurrence rate. Previous studies showed that Puerariae Radix and its extracts have powerful antidepressant effects in recent years. The study proposed an integrated strategy, combining network pharmacology and molecular pharmacology experiment to investigate the mechanisms of the antidepressant active ingredients from Puerariae Radix. Methods. TCMSP database, GeneCards database, Venny 2.1, UniProt database, STRING database, Cytoscape 3.7.2, and Metascape database were used to screen the active chemical components, antidepressant-related genes, and core targets, convert the abbreviated gene names in batch, search and predict the interaction between proteins, and construct the PPI network of Puerariae Radix. KEGG pathway and GO biological process enrichment and biological annotation were used to select antidepressant core gene targets. The MTT method was used to detect the effect of puerarin on the damage of PC12 cells induced by corticosterone. The DCFH-DA probe and ROS assay kit were utilized to detect the production of ROS in PC12 cells. PI/Annexin V was used to detect the apoptotic rate of puerarin on PC12 cells. Western blotting was used to verify the regulation of puerarin on the key targets of AKT1, FOS, CASP3, STAT3, and TNF-α in PC12 cells. Results and Conclusion. Eight main active components, 64 potential antidepressant gene targets, and 15 core antidepressant gene targets were obtained. 35 signaling pathways and 52 biological processes related to antidepressant effect of Puerariae Radix were identified. Puerarin was the active ingredient derived from Puerariae Radix which exhibited the antidepression effect by improving the viability of cell, reducing cell apoptosis, regulating ROS production, increasing protein expressions of AKT1 and FOS, and reducing protein expressions of CASP3, STAT3, and TNF-α. The study revealed the pharmacodynamic material basis and possible antidepressant mechanism of Puerariae Radix and provided new theoretical basis and ideas for antidepressant research.

scholarly journals A Strategy Based on GC-MS/MS, UPLC-MS/MS and Virtual Molecular Docking for Analysis and Prediction of Bioactive Compounds in Eucalyptus Globulus Leaves

2019 ◽  
Vol 20 (16) ◽  
pp. 3875 ◽  
Author(s):  
Pan ◽  
Lei ◽  
Zang ◽  
Zhang
Keyword(s):  
Molecular Docking ◽  
Medicinal Plants ◽  
Gallic Acid ◽  
Inhibitory Activity ◽  
Eucalyptus Globulus ◽  
Specific Activity ◽  
Inhibitory Effect ◽  
Scoring Functions ◽  
Active Ingredients ◽  
New Approach

The discovery of medicinal plants is crucial for drug development. Eucalyptus globulus leaves are used as a traditional medicine in many areas of world due to herbicidal and insecticidal activity. While natural products are difficult to be separated and activity assayed, a new approach is needed to predict the active ingredients therein. In this study, a new method for screening active compounds extracted from E. globulus leaves was developed by GC-MS/MS and UPLC-MS/MS combined with molecular docking technology. Predicted compounds with high activity were proposed. Firstly, 35 volatile compounds and 34 aqueous extracted compounds were extracted from E. globulus leaves, and identified by GC-MS/MS and UPLC-MS/MS. The herbicidal receptor (1BX9) was then docked with the identified compounds by docking software, evaluated by docking models and seven scoring functions. The results showed that gallic acid had a strong inhibitory activity of 1BX9, which was speculated to be the main reason for the inhibitory effect of E. globulus leaves. Finally, allelopathic tests of gallic acid, citric acid, and isopulegol were carried out on grass seeds to verify its inhibitory activity against herbicide receptor 1BX9. The results show that the method can screen compounds with specific activity from a complex system of medicinal plants, which is very important for the screening of new active ingredients, confirmation of new medicinal ingredients, and the in-depth development of animal and plant medicines.

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