Beneficiary Effect ofTinospora cordifoliaAgainst High-fructose Diet Induced Abnormalities in Carbohydrate and Lipid Metabolism in Wistar Rats

2009 ◽  
Vol 41 (10) ◽  
pp. 741-746 ◽  
Author(s):  
S. Sreenivasa Reddy ◽  
P. Ramatholisamma ◽  
B. Ramesh ◽  
R. Baskar ◽  
D. Saralakumari
Keyword(s):  
Lipid Metabolism ◽  
Wistar Rats ◽  
High Fructose Diet ◽  
Carbohydrate And Lipid Metabolism ◽  
High Fructose

Kombuchas from green and black teas reduce oxidative stress, liver steatosis and inflammation, and improve glucose metabolism in Wistar rats fed a high-fat high-fructose diet

2021 ◽  
Author(s):  
Rodrigo Cardoso ◽  
Luiza Dias Moreira ◽  
Mirian Costa ◽  
Renata Celi Lopes Toledo ◽  
Mariana Grancieri ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Metabolism ◽  
Glucose Metabolism ◽  
Wistar Rats ◽  
Liver Steatosis ◽  
Black Tea ◽  
High Fat ◽  
High Fructose Diet ◽  
High Fructose ◽  
Green And Black Tea

The aim of this study was to evaluate the effect of green and black tea kombuchas consumption on adiposity, lipid metabolism, liver steatosis, oxidative stress, and inflammation in Wistar rats...

scholarly journals High-Fructose Diet-Induced Metabolic Disorders Were Counteracted by the Intake of Fruit and Leaves of Sweet Cherry in Wistar Rats

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2638 ◽  
Author(s):  
Dziadek ◽  
Kopeć ◽  
Piątkowska ◽  
Leszczyńska
Keyword(s):  
Fatty Acid ◽  
Lipid Metabolism ◽  
Fatty Acid Synthesis ◽  
Wistar Rats ◽  
Sweet Cherry ◽  
Acid Synthesis ◽  
High Fructose Diet ◽  
Expression Of Genes ◽  
High Fructose ◽  
Freeze Dried

Numerous studies have indicated that the use of plants rich in bioactive compounds may reduce the risk of non-communicable diseases. The aim of this study was to investigate how the addition of fruit and leaves to high-fructose diet affects lipid metabolism, including the expression of genes involved in fatty acid synthesis and oxidation in the liver and adipose tissue, as well as oxidative stress and inflammation in Wistar rats. The animals were fed with AIN-93G diet, high fructose (HFr) diet, HFr diet with addition of 5% or 10% freeze-dried fruits, and HFr diet with addition of 1% or 3% freeze-dried leaves. The experiment lasted 12 weeks. The results showed that the intake of fruit and leaves of sweet cherry caused the improvement of the liver function, as well as beneficially affected lipid metabolism, among others, by regulating the expression of genes associated with fatty acid synthesis and β-oxidation. Additionally, they exhibited antioxidant and anti-inflammatory properties. In conclusion, the addition of fruit and leaves reduced the adverse changes arising from the consumption of high fructose diet. Therefore, not only commonly consumed fruits, but also leaves can be potentially used as functional foods. These findings may be helpful in prevention and treatment of the obesity-related metabolic diseases, especially cardiovascular diseases.

scholarly journals Effect of extracts from selected Kenyan plants on traits of metabolic syndrom in Wistar rats fed a high-fat high fructose diet

2020 ◽  
Vol 19 (10) ◽  
pp. 2137-2146
Author(s):  
Beatrice N. Kiage-Mokua ◽  
Michael De Vrese ◽  
Ina Kraus-Stojanowic ◽  
Annegret Nielsen ◽  
Patrick Kareru ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Traditional Medicine ◽  
Pancreatic Lipase ◽  
Wistar Rats ◽  
Aqueous Extracts ◽  
High Fat ◽  
High Fructose Diet ◽  
Glucosidase Activity ◽  
High Fructose ◽  
Ethanol Extracts

Purpose: To examine the potential of extracts from selected herbs used in African traditional medicine in diabetes patients, and to determine their effect on traits of metabolic syndrome in rats fed a high-fat and high-fructose diet.Methods: Ethanol and aqueous extracts were prepared from Mangifera indica (MI), Lonchocarpus eriocalyx (LE), Urtica massaica (UM), Schkuhria pinnata (SP) and Launaea cornuta (LC). Ethanol extracts (1:100 dilution) were examined for inhibition of pancreatic lipase and α-glucosidase activity invitro. Furthermore, aqueous extracts were administered for 74 days to male Wistar rats fed a high-fat and high-fructose diet to assess their effect on traits of metabolic syndrome.Results: Ethanol extracts showed at least 30 % inhibition of pancreatic lipase in vitro but no effect on α- glucosidase activity. Administration of the aqueous extracts caused significant reduction in liver triglycerides (except for LE). Muscle triglycerides and fat were also reduced, with the most pronounced effect elicited by LE. Urinary glucose excretion and plasma triglycerides, but not hyperinsulinemia and insulin resistance, were reduced by UM compared to control.Conclusion: This exploratory study indicates that UM may be considered a candidate for the prevention and management of type 2 diabetes. Keywords: Kenyan traditional medicine, High-fat diet, High fructose, Insulin resistance, Triglycerides, Diabetes, Liver steatosis

scholarly journals Analysis of N6-Methyladenosine Methylation Modification in Fructose-Induced Non-Alcoholic Fatty Liver Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Yunchen Luo ◽  
Zhijian Zhang ◽  
Liping Xiang ◽  
Bing Zhou ◽  
Xuejiao Wang ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Leptin Receptor ◽  
Alcoholic Fatty Liver ◽  
High Fructose Diet ◽  
High Fructose ◽  
Deficient Mice ◽  
Alcoholic Fatty Liver Disease

Improvements in living standards have led to non-alcoholic fatty liver disease (NAFLD), one of the most common chronic liver diseases worldwide. Recent studies have shown that N6-methyladenosine (m6A), a type of RNA modification, is strongly associated with many important biological processes. However, the relationship between m6A methylation modifications and NAFLD remains poorly understood. In the present study, through methylated RNA immunoprecipitation sequencing and RNA transcriptome sequencing in high fructose diet-induced NAFLD mice, we found that hypermethylation-encoding genes were mainly enriched in lipid metabolism processes. We identified 266 overlapping and differentially expressed genes (DEGs) that changed at both the mRNA expression level and m6A modification level. Among them, 193 genes displayed increased expression and m6A modification, indicating that m6A RNA modifications tend to be positively correlated with NAFLD. We further compared the high fructose diet-induced NAFLD mouse model with leptin receptor-deficient mice and found that DEGs enriched in the lipid metabolism pathway were up-regulated in both groups. In contrast, DEGs associated with the immune inflammatory response were up-regulated in the high fructose diet group, but down-regulated in leptin receptor-deficient mice. Taken together, our results demonstrate that m6A methylation modifications may play an important role in the development of NAFLD.

scholarly journals Assessing the effect of sugar type and form of its intake on selected parameters of carbohydrate-lipid metabolism and plasma atherogenic indices in rats

2019 ◽  
pp. 59-67
Author(s):  
Joanna Sadowska ◽  
Magda Bruszkowska
Keyword(s):  
Lipid Metabolism ◽  
Water Solution ◽  
Blood Parameters ◽  
Male Rats ◽  
High Fructose Corn Syrup ◽  
Corn Syrup ◽  
Carbohydrate And Lipid Metabolism ◽  
Group I ◽  
High Fructose ◽  
Weight Gains

ABSTRACT Background. Over the past 50 years, the average consumption of sugar worldwide has tripled, also the type of consumed sugar has changed. Due to high price of sucrose and its technological disadvantages, high fructose corn syrup (HFCS) has become one of the most commonly used substitutes. Objective. The aim of the study was to compare, on the animal model, the effect of sugar type (sucrose vs high fructose corn syrup 55% of fructose) and the sugar form (solid vs fluid and solid) on the chosen parameters of carbohydrate-lipid metabolism. Material and methods. The experiment was carried out on 40 Wistar male rats aged 5 months, fed four isocaloric diets, containing: group I (SUC 15%) fodder with 15% sucrose, group II (HFCS 15%) fodder with 15% HFCS-55%, group III (SUC 7.5%+7.5%) – 7.5% sucrose in solid fodder and 7.5% sucrose water solution, group IV (HFCS 7.5%+7.5%) – 7.5% HFCS-55% in solid fodder and 7.5% HFCS water solution. Results. The effect of HFCS-55 on the parameters of carbohydrate and lipid metabolism was not equivalent of the effect of sucrose. Dietary use of HFCS-55 instead of sucrose causes adverse changes in blood parameters of carbohydrate and lipid metabolism, particularly when provided in beverages, as at comparable weight gains to that of sucrose. More intense changes, manifesting in increased blood levels of glucose, triglycerides and uric acid, as well as increased liver fat content, were observed at simultaneous intake of sweeteners in solid foods and fluids, even with less sugar consumption, compared to solid food only. Conclusions. Dietary use of HFCS-55 causes adverse changes in blood parameters of carbohydrate and lipid metabolism, as at comparable weight gains to that of sucrose. But liquid form of sugar intake is more important insulin resistance and cardiovascular disease risk factor than the sugar type.

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