Effects of Metformin or an Oral Contraceptive Containing Cyproterone Acetate on Serum C-reactive Protein, Interleukin-6 and Soluble Vascular Cell Adhesion Molecule-1 Concentrations in Women with Polycystic Ovary Syndrome

2014 ◽  
Vol 122 (02) ◽  
pp. 118-125 ◽  
Author(s):  
J. Dardzińska ◽  
D. Rachoń ◽  
M. Kuligowska-Jakubowska ◽  
E. Aleksandrowicz-Wrona ◽  
A. Płoszyński ◽  
...  
Keyword(s):  
Oral Contraceptive ◽  
Cyproterone Acetate ◽  
Cell Adhesion Molecule ◽  
Polycystic Ovary ◽  
Vascular Cell Adhesion ◽  
C Reactive Protein ◽  
Ovary Syndrome ◽  
Vascular Cell ◽  
Reactive Protein ◽  
Cell Adhesion Molecule 1

scholarly journals Conjugated linoleic acid increased C-reactive protein in human subjects

2005 ◽  
Vol 94 (5) ◽  
pp. 791-795 ◽  
Author(s):  
Annika Smedman ◽  
Samar Basu ◽  
Stefan Jovinge ◽  
Gunilla Nordin Fredrikson ◽  
Bengt Vessby
Keyword(s):  
Cell Adhesion ◽  
Linoleic Acid ◽  
Cell Adhesion Molecule ◽  
Human Subjects ◽  
Vascular Cell Adhesion ◽  
C Reactive Protein ◽  
Vascular Cell ◽  
Reactive Protein ◽  
Tnf Α ◽  
Cell Adhesion Molecule 1

We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F2α, a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-α, TNF-α receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study, fifty-three human subjects were supplemented with a mixture (4·2g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P=0·003) compared with the control group. However, no changes in TNF-α, TNF-α receptors 1 and 2, and vascular cell adhesion molecule-1 were detected.

scholarly journals Perubahan Konsentrasi Interleukin-6, C-Reactive Protein dan Soluble Vascular Cell Adhesion Molecule-1 Pada Pasien Hemodialisis dengan Dialiser Proses Ulang

2017 ◽  
Vol 3 (3) ◽  
pp. 131
Author(s):  
Pringgodigdo Nugroho ◽  
Aida Lydia ◽  
Endang Susalit
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Interleukin 6 ◽  
Cell Adhesion Molecule ◽  
Vascular Cell Adhesion ◽  
C Reactive Protein ◽  
Vascular Cell ◽  
Vascular Cell Adhesion Molecule ◽  
Reactive Protein ◽  
Cell Adhesion Molecule 1

Pendahuluan. Penyakit kardiovaskular merupakan penyebab utama morbiditas dan mortalitas pada pasien hemodialisis (HD). Faktor risiko kardiovaskular non-tradisional yang berperan salah satunya adalah inflamasi. Penggunaan dialiser proses ulang (DPU) dilaporkan menimbulkan reaksi inflamasi yang lebih ringan dibandingkan dengan dialiser baru, tetapi belum ada data pada membran selulosa diasetat.Metode. Dua puluh pasien HD diikutsertakan pada penelitian dengan desain pre and post untuk mengetahui perubahan konsentrasi interleukin 6 (IL-6), C-reactive protein (CRP) dan soluble vascular cell adhesion molecule-1 (sVCAM-1) pasca-HD pada penggunaan DPU ke-0, ke-5, dan ke-10. Subjek penelitian adalah pasien HD kronik >3 bulan dengan membran dialiser selulosa diasetat yang diproses ulang menggunakan mesin, cairan campuran asam perasetat dan hidrogen peroksida. Urea Reduction Ratio (URR) dan delivered Kt/V dinilai pada DPU ke 0, 5 dan 10.Hasil. Konsentrasi CRP selama penelitian menurun. Median konsentrasi CRP saat DPU ke-0 adalah 3,55 mg/L, saat DPU ke-5 adalah 2,97 mg/L dan saat DPU ke-10 adalah 2,92 mg/L, dengan p=0,074. Median konsentrasi IL-6 pada DPU ke-0 adalah 9,05 pg/ml, pada DPU ke-5 adalah 10,64 pg/ml dan pada DPU ke-10 adalah 8,51 pg/ml, dengan p=0,316. Rerata konsentrasi sVCAM-1 saat DPU ke-0 adalah 3078±786 ng/ml, saat DPU ke-5 adalah 3260±836 ng/ml, saat DPU ke-10 adalah 3154±631, dengan p=0,746. Selama penggunaan DPU hingga 10 kali tidak didapatkan perubahan adekuasi HD yang dinilai dengan URR dan Kt/V.Simpulan. Pada penggunaan DPU hingga proses ulang ke-10 tidak didapatkan peningkatan respons inflamasi yang bermakna, bahkan didapatkan penurunan konsentrasi CRP walaupun secara statistik tidak bermakna.Kata Kunci: CRP, DPU, hemodialisis, IL-6, inflamasi, sVCAM-1Change of Interleukin-6, C-Reactive Protein and Soluble Vascular Cell Adhesion Molecule-1 Concentrations in Hemodialysis Patients with Reprocessed DialyzerIntroduction. Cardiovascular disease is a major cause of morbidity and mortality in hemodialysis patients. In addition to traditional cardiovascular risk factors, non-traditional cardiovascular risk factors such as inflammation were also involved. Reprocessed dialyzer has been showed to induce less inflammation than new dialyzer, but data in diacetate cellulose membrane have not been presented. Methods. Twenty hemodialysis (HD) patients were enrolled. Pre and post study design was conducted to know post dialysis concentration changes of interleukin 6 (IL-6), C-reactive protein (CRP) and soluble vascular cell adhesion molecule-1 (sVCAM-1) at reuse 0, 5 and 10. Patients were recruited if medically stable, on maintenance HD >3 months, using reprocessed diacetate cellulose membrane by automated machine with mixture of periacetic acid and hydrogen peroxide solution. Urea reduction ratio (URR) and delivered dialysis dose were used to evaluate dialysis adequacy at reuse 0, 5, and 10.Results. CRP concentration was decreased. Median concentration of CRP at reuse 0, 5 and 10 were 3.55 mg/L, 2.97 mg/L and 2.92 mg/L, p=0.074. There were no significant changes of IL-6 concentration. Median concentration of IL-6 at reuse 0, 5, and 10 were 9.05 pg/ml, 10.64 pg/ml and 8.51 pg/ml, p=0.316. Concentration of sVCAM-1 was not changed significantly, with mean sVCAM-1 concentration 3078±786 ng/ml, 3260±836 ng/ml and 3154±631 ng/ml at reuse 0, 5 and 10,p=0.746. During use of reprocessed dialyzer through 10 times, there were no significant changes of hemodialysis adequacy using URR and Kt/V.Conclusions. The use of reprocessed dialyzer through 10 times showed no significant increase in inflammatory responses. CRP concentration was decreased, although statistically not significant. Keywords: CRP, hemodialysis, IL-6, inflammation, reprocessed dialyzer, sVCAM-1  

Expression Of Nitric Oxide Synthase, Vascular Cell Adhesion Molecule and C- Reactive Protein Receptor In Sickle Cell Leucocytes: Relationship With Chronic Inflammation

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 2243-2243
Author(s):  
Wendell Vilas Boas ◽  
Bruno A. V. Cerqueira ◽  
Thassila Nogueira Pitanga ◽  
Sanzio Silva Santana ◽  
Joao Oliveira Reis ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Alkaline Phosphatase ◽  
Cell Adhesion Molecule ◽  
Biochemical Profile ◽  
Vascular Cell Adhesion ◽  
C Reactive Protein ◽  
Vascular Cell ◽  
Reactive Protein ◽  
Protein Receptor ◽  
Oxide Synthase

Abstract Introduction Chronic and acute inflammatory phenomenon’s can contribute to activate several cells types and may play important role in the steady- and crisis-states of sickle cell anemia (HbSS) patients. Under normal circumstances, the nitric oxide synthase (NOS) constitutively produces low levels of nitric oxide (NO) that are important in the maintenance of vascular homeostasis, but in HbSS this balance is disrupted, mainly because the lack of arginine and the depletion of NO. This molecule also has an anti-inflammatory role in the vascular system and the state of resistance of NO can lead to deregulation of several other factors and interaction with many molecules. The aim of this study was correlate the expression of NOS, vascular cell adhesion molecule (VCAM), c-reactive protein receptor (rCRP) genes and biochemical profile of HbSS patients. Patients and Methods We studied 21 HbSS patients from Northeast Brazil, at steady state and were transfusion free. Blood samples were obtained during regular clinical visits. The expression of NOS, VCAM and rCRP genes were performed by real time PCR with Taqman assays from leucocytes RNA in trizol reagent. Serum biochemical analysis was determined using commercially available biochemical kits. The study was approved by the FIOCRUZ ethical committee and informed consents were signed by patients or official responsible. Results Our results showed a positive correlation among the expression of NOS and VCAM (p= 0.031, r=0.525), NOS and rCRP (p< 0.001, r=0.816) and VCAM and rCRP (p=0.003, r=0.659). Analyses of biochemical profile of HbSS individuals showed a correlation of NOS and serum calcium (p=0.044, r=0.456) as well as NOS and alkaline phosphatase (p=0.036, r=0.472). Discussion and Conclusion In this study, the correlation among genetic expression of NOS, VCAM and rCRP molecules suggests how factors involved to inflammation in HbSS are linked. In response to inflammation, the liver releases a variety of acute phase proteins. One such product, CRP, serves as a dominating diagnostic marker of inflammation. Chronic inflammatory reflects in the up-regulation of VCAM and VOC susceptibility, can increase the release of alkaline phosphatase, as well as deregulation of NOS expression due to impaired constitutive NOS activity with loss of endothelial NOS dimerization, increased NO scavenging by plasma hemoglobin and superoxide, increased arginase activity, and depleted intravascular nitrite reserves. Also, NOS couples electron flux for NO production by binding calmodulin, which is calcium-dependent, which explain the positive correlation between NOS and serum calcium. Furthermore, additional studies will elucidate the mechanism involved with the interaction of this complex network of molecule and the endothelial activation and dysfunction described in the pathophysiology of HbSS chronic and acute inflammatory. Disclosures: No relevant conflicts of interest to declare.

Sign in / Sign up

Export Citation Format

Share Document