Modulation of Cancer-Related Signaling by Secondary Metabolites From Salvia Officinalis and Zingiber Officinale

Planta Medica ◽  
2016 ◽  
Vol 82 (05) ◽  
Author(s):  
MA Ibrahim ◽  
P Balachandran ◽  
I Muhammad ◽  
D Pasco
2005 ◽  
Vol 68 (3) ◽  
pp. 607-609 ◽  
Author(s):  
D. P. OVERY ◽  
J. C. FRISVAD

Twenty naturally infected ginger (Zingiber officinale) rhizomes displaying visible mold growth were examined to identify the fungi and to evaluate the presence of fungal secondary metabolites. Penicillium brevicompactum was the predominant species isolated from 85% of the samples. Mycophenolic acid was identified from corresponding tissue extracts. Because mycophenolic acid is a potent immunosuppressant and synergistic mycotoxicosis studies involving human consumption have not been carried out on this metabolite, spoilage of commercially marketed produce caused by P. brevicompactum is a concern. This is the first reported occurrence of mycophenolic acid in commercially sold plant food products.


2009 ◽  
Vol 61 (7) ◽  
pp. 961-967 ◽  
Author(s):  
Fábio Ricardo Carrasco ◽  
Gustavo Schmidt ◽  
Adriano Lopez Romero ◽  
Juliano Luiz Sartoretto ◽  
Silvana Martins Caparroz-Assef ◽  
...  

2009 ◽  
Vol 89 (6) ◽  
pp. 1090-1096 ◽  
Author(s):  
Monika Nell ◽  
Marlies Vötsch ◽  
Horst Vierheilig ◽  
Siegrid Steinkellner ◽  
Karin Zitterl-Eglseer ◽  
...  

2011 ◽  
Vol 41 (6) ◽  
pp. 1051-1056 ◽  
Author(s):  
Deise Flores Santurio ◽  
Mateus Matiuzzi da Costa ◽  
Grazieli Maboni ◽  
Carlos Pasqualin Cavalheiro ◽  
Mariangela Facco de Sá ◽  
...  

A discutida questão da substituição do uso de antibacterianos em rações (promotores de crescimento) requer urgentes alternativas. Face às necessidades de inibidores microbianos nesses alimentos, os óleos essenciais (OES) se constituem em alternativa, sob avaliação. Neste estudo, avaliou-se a atividade antimicrobiana dos OES de Origanum vulgare (orégano), Thymus vulgaris (tomilho), Cinnamomum zeylanicum (canela), Lippia graveolens (orégano mexicano), Zingiber officinale (gengibre), Salvia officinalis (sálvia), Rosmarinus officinalis (alecrim) e Ocimum basilicum (manjericão) frente a amostras de Escherichia coli isoladas de fezes de aves (n=43) e de bovinos (n=36). A concentração inibitória mínima (CIM) e a concentração bactericida mínima (CBM) foram determinadas para cada isolado através da técnica de microdiluição em caldo, a partir da máxima concentração de 6400µg mL-1 de cada OE testado. Observou-se atividade antimicrobiana para os OES de orégano, orégano mexicano, tomilho, canela. Para todas as amostras testadas, independente de sua origem, os OES mais e menos efetivos quanto à atividade antimicrobiana foram o orégano e a canela, respectivamente. Esses resultados confirmaram o potencial antibacteriano de alguns OES, os quais merecem novas investigações abordando sua adição na alimentação de aves e bovinos.


2021 ◽  
Vol 170 ◽  
pp. 113730
Author(s):  
Alessandra Marchica ◽  
Roberta Ascrizzi ◽  
Guido Flamini ◽  
Lorenzo Cotrozzi ◽  
Mariagrazia Tonelli ◽  
...  

2020 ◽  
Vol 26 ◽  
pp. 144-148
Author(s):  
S. A. Pchelovska ◽  
S. V. Litvinov ◽  
Yu. V. Shylina ◽  
V. V. Zhuk ◽  
K. V. Lystvan ◽  
...  

Aim. Long-term studies of the effect of sublethal doses of pre-sowing low-LET ionizing radiation on seeds have demonstrated the effectiveness of radiation biotechnology to stimulate the accumulation of pharmaceutically valuable secondary metabolites in medicinal raw materials of a number of common medicinal plants in Ukraine. The aim of this research was to evaluate the effectiveness of radiation technology in the case of seeds of Salvia officinalis L. and Silybum marianum L. Methods. X-ray irradiation of seeds at doses up to 50 Gy, spectrophotometric analysis of water-ethanol extracts, fluorescence microscopy of leaf epidermis were used. Results. Doses of pre-sowing X-ray irradiation were selected which maximally stimulate both the increase of biomass of medicinal raw materials and the accumulation of secondary metabolites. In particular for Salvia officinalis L. doses are 5 Gy and 20 Gy, for Silybum marianum L. are 10 Gy and 20 Gy. Conclusions. It is recommended to use two stimulating doses at the same time, as the result of exposure depends essentially on the physiological status of the seeds, growing conditions, varietal characteristics. Increasing the content of flavonoids and phenols in medicinal raw materials has been shown to be a reliable and reproducible marker of stimulating of rosemary acid accumulation in Salvia officinalis leaves. Keywords: radiation-induced stimulation, Salvia officinalis, Silybum marianum, rosemary acid, silibinin.


AGROFOR ◽  
2018 ◽  
Vol 3 (1) ◽  
Author(s):  
Mohd YASEER SUHAIMI ◽  
Mat Arshad ADZEMI ◽  
Wan Sembok WAN ZALIHA

Ginger (Zingiber officinale Rosc.) belongs to a tropical and sub-tropicalZingiberaceae family, which originated from Southeast Asia. Ginger is one of themost widely used herbs contains several interesting bioactive constituentsincluding [6]-gingerol that has potent antioxidant activity and health promotingproperties. Substrates plays an important role for plants to growth in the soillessculture system. Given the nature of the substrate may play a crucial role indetermining water and nutrient availability for the plant and hence may affect themetabolic pathways involved in the synthesis of specific biochemical compounds,this study was conducted to determine the effects of organic soilless substrates suchas coir dust and burnt paddy husks on ginger growth, yield and [6]-gingerol contentusing soilless culture system. The treatments were arranged in a randomizedcomplete block design (RCBD) with five levels of treatment with three replicates.The treatments include, T1 = 100% coir dust; T2 = 100% burnt paddy husks; T3 =70% coir dust and 30% burnt paddy husks; T4 = 30% coir dust and 70% burntpaddy husks; and T5 = 50% coir dust and 50% burnt paddy husks. Results showedthat plant in T1 gave rise to highest rhizomes yield (5480  325 gm) compare toother treatments. Media containing high amount of coir dust (70 – 100%) showedgood growth and increased the rhizome yield up to 36% compared to thosecontaining high amount of burnt paddy husks. There was no significant differencebetween all treatments in term of [6]-gingerol content in the fresh and dry gingerrhizomes. The studies suggested that the secondary metabolites like [6]-gingerolcontent and accumulation were not affected by the substrates. It can be concludedthat 100% coir dust are the best substrates for growing ginger in soilless culturesystem.


2011 ◽  
Vol 41 (4) ◽  
pp. 667-672 ◽  
Author(s):  
Marcelo Dal Pozzo ◽  
Julio Viégas ◽  
Deise Flores Santurio ◽  
Luana Rossatto ◽  
Isaura Helena Soares ◽  
...  

Avaliou-se a atividade antimicrobiana dos óleos essenciais (OEs) de Origanum vulgare (orégano), Thymus vulgaris (tomilho), Lippia graveolens (lípia), Zingiber officinale (gengibre), Salvia officinalis (sálvia), Rosmarinus officinalis (alecrim) e Ocimum basilicum (manjericão), bem como de frações majoritárias carvacrol, timol, cinamaldeído e cineol frente a 33 isolados de Staphylococcus spp oriundos de rebanhos leiteiros caprinos. A concentração inibitória mínima (CIM) e a concentração bactericida mínima (CBM) foram determinadas por meio da técnica de microdiluição em caldo. Observou-se atividade antimicrobiana para os OEs de orégano, lípia e tomilho, bem como para as frações majoritárias de carvacrol, timol e cinamaldeído. A ordem decrescente de atividade foi orégano = tomilho > lípia. As frações majoritárias carvacrol, timol e cinamaldeído evidenciaram melhor atividade do que os óleos essenciais e, dentre elas, carvacrol e cinamaldeído foram mais ativas que o timol.


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