Icotinib bei NSCLC-Patienten mit EGFR-Mutationen: Chinesische Eigenentwicklung will auf den Weltmarkt

2012 ◽  
Vol 03 (05) ◽  
pp. 208-208
Author(s):  
Alexander Kretzschmar

Mit Icotinib schickt sich eine weitere, gegen Mutationen des EGF-Rezeptors (EGFRm+) gerichtete Therapie des nicht-kleinzelligen Lungenkarzinoms (NSCLC) an, nach China auch die Zulassung in Europa und USA zu erreichen. Dies berichtete Dr. Sun Yan, Beijing, kürzlich auf der 15. Jahrestagung der Chinese Society of Clinical Oncology (CSCO). Dafür sind allerdings noch einige Verbesserungen am Studiendesign, vor allem bei der molekularen Charakterisierung der Patienten, notwendig, kritisierte Prof. Tony Mok, Honkong.

2020 ◽  
Vol 1 ◽  
pp. 27-27
Author(s):  
Zefei Jiang ◽  
Erwei Song ◽  
Xiaojia Wang ◽  
Haibo Wang ◽  
Xiang Wang ◽  
...  

2021 ◽  
Author(s):  
Feng‐Hua Wang ◽  
Xiao‐Tian Zhang ◽  
Yuan‐Fang Li ◽  
Lei Tang ◽  
Xiu‐Juan Qu ◽  
...  

2021 ◽  
Author(s):  
Ling‐Long Tang ◽  
Yu‐Pei Chen ◽  
Chuan‐Ben Chen ◽  
Ming‐Yuan Chen ◽  
Nian‐Yong Chen ◽  
...  

2021 ◽  
Vol 12 ◽  
Author(s):  
Luping Zhang ◽  
Jun Wang ◽  
Bicheng Zhang ◽  
Qian Chu ◽  
Chunxia Su ◽  
...  

Immune-checkpoint inhibitors (ICIs) are revolutionizing the field of immuno-oncology. Side effects and tumor microenvironment currently represent the most significant obstacles to using ICIs. In this study, we conducted an extensive cross-sectional survey to investigate the concept and practices regarding the use of ICIs in cancer patients in China. The results provide real-world data on the adverse events (AEs) of ICIs and the factors influencing the use of ICIs. This survey was developed by the Expert Committee on Immuno-Oncology of the Chinese Society of Clinical Oncology (CSCO-IO) and the Expert Committee on Patient Education of the Chinese Society of Clinical Oncology (CSCO-PE). The surveys were distributed using a web-based platform between November 29, 2019 and December 21, 2019. A total of 1,575 patients were included. High costs (43.9%), uncertainty about drug efficacy (41.2%), and no reimbursement from medical insurance (32.4%) were the factors that prevented the patients from using ICIs. The patients were most concerned about the onset time or effective duration of ICIs (40.3%), followed by the indications of ICIs and pre-use evaluation (33.4%). Moreover, 9.0, 57.1, 21.0, and 12.9% of the patients reported tumor disappearance, tumor volume reduction, no change in tumor volume, and increased tumor volume. Among the patients who received ICIs, 65.7% reported immune-related AEs (irAEs); 96.1% reported mild-to-moderate irAEs. Cancer patients in China had a preliminary understanding of ICIs. Yet, the number of patients treated with ICIs was small.


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