The LYMFASIM Simulation Program for Modeling Lymphatic Filariasis and its Control

1998 ◽  
Vol 37 (01) ◽  
pp. 97-108 ◽  
Author(s):  
S. Subramanian ◽  
P. K. Das ◽  
W. Souza ◽  
T. Lapa ◽  
A. F. Furtado ◽  
...  
Keyword(s):  
Lymphatic Filariasis ◽  
Mosquito Control ◽  
Control Strategies ◽  
Wuchereria Bancrofti ◽  
Control Measures ◽  
Modeling Framework ◽  
Eastern Brazil ◽  
North Eastern ◽  
History Of ◽  
And Control

Abstract:The LYMFASIM modeling framework for the transmission and control of the tropical parasitic disease lymphatic filariasis is described and its use in the context of an endemic community in north-eastern Brazil is illustrated. Lymphatic filariasis is a disease with a complex natural history with many unknowns. This complicates decision making with respect to control strategies. With LYMFASIM, a variety of hypotheses can be tested about the life history of the parasite Wuchereria bancrofti, its transmission from man to man through mosquitoes, the role of the immune system in regulating parasite numbers, the development of disease symptoms, and the effects of control measures (drug treatment or mosquito control). The implications of alternative assumptions and uncertainty about the quantification of parameters for the effectiveness of control strategies can be investigated. Thanks to the use of stochastic microsimulation, LYMFASIM is highly flexible and can be adapted and extended as new knowledge emerges.

scholarly journals SELF-REPORTED MALARIA AND MOSQUITO AVOIDANCE IN RELATION TO HOUSEHOLD RISK FACTORS IN A KENYAN COASTAL CITY

2005 ◽  
Vol 37 (6) ◽  
pp. 761-771 ◽  
Author(s):  
JOSEPH KEATING ◽  
KATE MACINTYRE ◽  
CHARLES M. MBOGO ◽  
JOHN I. GITHURE ◽  
JOHN C. BEIER
Keyword(s):  
Rural Areas ◽  
Mosquito Control ◽  
Control Measure ◽  
Control Measures ◽  
Level Control ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Household Level ◽  
Household Factors ◽  
History Of

A geographically stratified cross-sectional survey was conducted in 2002 to investigate household-level factors associated with use of mosquito control measures and self-reported malaria in Malindi, Kenya. A total of 629 households were surveyed. Logistic regressions were used to analyse the data. Half of all households (51%) reported all occupants using an insecticide-treated bed net and at least one additional mosquito control measure such as insecticides or removal of standing water. Forty-nine per cent reported a history of malaria in the household. Of the thirteen household factors analysed, low (OR=0·23, CI 0·11, 0·48) and medium (OR=0·50, CI 0·29, 0·86) education, mud–wood–coral (OR=0·0·39, CI 0·24, 0·66) and mud block–plaster (OR=0·47, CI 0·25, 0·87) wall types, farming (OR=1·38, CI 1·01, 1·90) and travel to rural areas (OR=0·48, CI 0·26, 0·91) were significantly associated with the use of mosquito control, while controlling for other covariates in the model. History of reported malaria was not associated with the use of mosquito control (OR=1·22, CI 0·79, 1·88). Of the thirteen covariates analysed in the second model, only two household factors were associated with history of malaria: being located in the well-drained stratum (OR=0·49, CI 0·26, 0·96) and being bitten while in the house (OR=1·22, CI 0·19, 0·49). These results suggest that high socioeconomic status is associated with increased household-level mosquito control use, although household-level control may not be enough, as many people are exposed to biting mosquitoes while away from the house and in areas that are more likely to harbour mosquitoes.

scholarly journals Times to Key Events in the Course of Zika Infection and their Implications for Surveillance: A Systematic Review and Pooled Analysis

2016 ◽  
Author(s):  
Justin Lessler ◽  
Cassandra T. Ott ◽  
Andrea C. Carcelen ◽  
Jacob M. Konikoff ◽  
Joe Williamson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Supply ◽  
Zika Virus ◽  
Blood Donation ◽  
Case Reports ◽  
Fold Increase ◽  
Pooled Analysis ◽  
Control Measures ◽  
History Of ◽  
And Control

Background Evidence suggests that Zika virus has driven a 10-fold increase in babies born with microcephaly in Brazil, prompting the WHO to declare a Public Health Emergency of International Concern. However, little is known about the natural history of infection. These data are critical for implementation of surveillance and control measures such as protecting the blood supply. Methods We conducted a systematic review and pooled analysis to estimate the distribution of times from Zika infection to symptom onset, seroconversion, and viral clearance, and analyzed their implications for surveillance and blood supply safety. Results Based on 25 case reports, we estimate the median incubation period of Zika virus infection is 5.9 days (95% CI: 4.4-7.6), and that 95% of cases will develop symptoms by 11.1 days post-infection (95% CI: 7.6-18.0). On average seroconversion occurs 9.0 days (95% CI, 7.0-11.6) after infection, and virus is detectable in blood for 9.9 days (95% CI: 6.8-21.4). In 5% of cases detectable virus persists for over 18.9 days (95% CI: 12.6-79.5). The baseline (no screening) risk of a blood donation being infected with Zika increases by approximately 1 in 10,000 for every 1 per 100,000 person-days increase in Zika incidence. Symptom based screening reduces this by 7% (RR 0.93, 93% CI 0.86-0.99), and antibody screening by 29% (RR 0.71, 95% CI: 0.28-0.88). Conclusions Symptom or antibody-based surveillance can do little to reduce the risk of Zika contaminated blood donations. High incidence areas may consider PCR testing to identify lots safe for use in pregnant women.

scholarly journals Serological Investigations of Brucellosis in Cattle, Farmers and Veterinarians in the Kars District of Turkey

2008 ◽  
Vol 77 (1) ◽  
pp. 117-121 ◽  
Author(s):  
S. Otlu ◽  
M. Sahin ◽  
H. I. Atabay ◽  
A. Unver
Keyword(s):  
Control Measures ◽  
Serum Samples ◽  
Serological Tests ◽  
Significant Difference ◽  
High Prevalence ◽  
History Of ◽  
And Control

The prevalence of brucellosis was investigated in cattle, farmers and veterinarians in the Kars district of Turkey between 2004 - 2006. In order to achieve this, a total of 407 serum samples of cattle from 27 herds having history of abortions were examined for Brucella antibodies by RBPT and SAT. In addition, the sera collected from 246 farmers (130 males and 116 females) and 28 veterinarians in the same district were analysed serologically by RBPT, SAT and ELISA. Of the cattle sera analysed, 134 (32.92%) and 141 (34.64%) were determined as positive by RBPT and SAT, respectively. Thirty-two (13%), 35 (14.22%) and 44 (17.88%) of the farmers' sera were found positive for brucellosis by RBPT, SAT and ELISA, respectively. There was no significant difference between sexes for Brucella seropositivity. Of the 28 sera from veterinarians, 13 (46.42%) were positive by the three serological tests. The high prevalence of brucellosis both in cattle and humans suggests that brucellosis is common in this area. Preventive and control measures should be implemented and pursued more strictly to reduce and/or eradicate brucellosis from the area.

The Study of the Beijing Traffic Noise Pollution Control Countermeasures

2014 ◽  
Vol 641-642 ◽  
pp. 853-859
Author(s):  
Wei Wang ◽  
Hui Zhao ◽  
Guan Xing Wang ◽  
Hua Zhen Zhou
Keyword(s):  
Road Traffic ◽  
Control Strategies ◽  
Traffic Noise ◽  
Noise Pollution ◽  
Environmental Issues ◽  
Control Measures ◽  
Road Traffic Noise ◽  
Typical Time ◽  
The Status ◽  
And Control

Traffic noise is a major source of noise pollution in the urban environment, including road traffic noise and rail traffic noise, which has become one of the domestic large and medium cities in environmental issues to be solved. This paper analyzes the status of the Beijing traffic noise pollution and control strategies, and a typical apartment block selected as a case, analyzes its noise pollution elements, severity, time distribution, and draws a noise map of the plane area and a dormitory building in the noise conditions typical time. Last we discussed and gave the method based on noise control measures.

scholarly journals LYMPHATIC FILARIASIS: AN OVERVIEW

2019 ◽  
pp. 1-5
Author(s):  
KANAAN AL-TAMEEMI ◽  
RAIAAN KABAKLI
Keyword(s):  
Chronic Disease ◽  
Early Diagnosis ◽  
Infection Control ◽  
Lymphatic Filariasis ◽  
Lymphatic System ◽  
Wuchereria Bancrofti ◽  
Health Organizations ◽  
The World ◽  
And Control ◽  
Sexual Disability

Lymphatic filariasis (LF) is a tropical disease caused by infection with the parasitic filarial worms: Wuchereria bancrofti, Brugia malayi, and Brugia timori. The symptoms of this chronic disease appear in adults (in men more than in women) and include damage to the lymphatic system, arms, legs, and genitals, which cause significant pain, reducing productivity, and social problems. LF is a cause of continued disability, pain, disfigurement, and sexual disability in the world, so the knowledge of the disease and the infection control is very important. In addition to the importance of prevention, that includes giving medicine and using controlling ways of mosquitoes. Moreover, the prevention of disease is important, that includes giving medicine and using controlling ways of mosquitoes. However, although the efforts of health organizations to reduce the LF infections, there are still many challenges including the early diagnosis and control of infection among people.

scholarly journals Detection of the Emerging Picornavirus Senecavirus A in Pigs, Mice, and Houseflies

2016 ◽  
Vol 54 (6) ◽  
pp. 1536-1545 ◽  
Author(s):  
Lok R. Joshi ◽  
Kristin A. Mohr ◽  
Travis Clement ◽  
Kyle S. Hain ◽  
Bryan Myers ◽  
...  
Keyword(s):  
Small Intestine ◽  
Neonatal Mortality ◽  
Environmental Samples ◽  
Control Strategies ◽  
Diagnostic Investigation ◽  
Mouse Small Intestine ◽  
History Of ◽  
Swine Herds ◽  
And Control ◽  
Vesicular Disease

Senecavirus A (SVA) is an emerging picornavirus that has been recently associated with an increased number of outbreaks of vesicular disease and neonatal mortality in swine. Many aspects of SVA infection biology and epidemiology remain unknown. Here, we present a diagnostic investigation conducted in swine herds affected by vesicular disease and increased neonatal mortality. Clinical and environmental samples were collected from affected and unaffected herds and were screened for the presence of SVA by real-time reverse transcriptase PCR and virus isolation. Notably, SVA was detected and isolated from vesicular lesions and tissues of affected pigs, environmental samples, mouse feces, and mouse small intestine. SVA nucleic acid was also detected in houseflies collected from affected farms and from a farm with no history of vesicular disease. Detection of SVA in mice and housefly samples and recovery of viable virus from mouse feces and small intestine suggest that these pests may play a role on the epidemiology of SVA. These results provide important information that may allow the development of improved prevention and control strategies for SVA.

scholarly journals An International Observational Prospective Survey Assessing the Control of Atrial Fibrillation in Asia-Pacific: Results of the Record-AFAP Registry

2015 ◽  
Vol 9 ◽  
pp. CMC.S22022 ◽  
Author(s):  
John Amerena ◽  
Shih-Ann Chen ◽  
Charn Sriratanasathavorn ◽  
Jeong-Gwan Cho ◽  
Huang Dejia ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Rate Control ◽  
Treatment Strategy ◽  
Control Strategies ◽  
Asia Pacific ◽  
Therapeutic Success ◽  
Cardiovascular Comorbidities ◽  
Choice Of Treatment ◽  
History Of ◽  
And Control

A prospective 1-year observational survey was designed to assess the management and control of atrial fibrillation (AF) in eight countries within the Asia-Pacific region. Patients ( N = 2,604) with recently diagnosed AF or a history of AF ≤1 year were included. Clinicians chose the treatment strategy (rhythm or rate control) according to their standard practice and medical discretion. The primary endpoint was therapeutic success. At baseline, rhythm- and rate-control strategies were applied to 35.7% and 64.3% of patients, respectively. At 12 months, therapeutic success was 43.2% overall. Being assigned to rhythm-control strategy at baseline was associated with a higher therapeutic success (46.5% vs 41.4%; P = 0.0214) and a lower incidence of clinical outcomes (10.4% vs 17.1% P < 0.0001). Patients assigned to rate-control strategies at baseline had higher cardiovascular morbidities (history of heart failure or valvular heart disease). Cardiovascular outcomes may be less dependent on the choice of treatment strategy than cardiovascular comorbidities.

scholarly journals Lymphatic filariasis in India: Epidemiology and control measures

2010 ◽  
Vol 56 (3) ◽  
pp. 232 ◽  
Author(s):  
S Sabesan ◽  
P Vanamail ◽  
KH.K Raju ◽  
P Raju
Keyword(s):  
Lymphatic Filariasis ◽  
Control Measures ◽  
And Control

scholarly journals Epidemiology of Bovine Mastitis and its Diagnosis, Prevention, and Control

2021 ◽  
Author(s):  
S.D. Audarya ◽  
D. Chhabra ◽  
R. Sharda ◽  
R. Gangil ◽  
R. Sikrodia ◽  
...  
Keyword(s):  
Prevention And Control ◽  
Control Strategies ◽  
Significant Proportion ◽  
Bovine Mastitis ◽  
The State ◽  
Madhya Pradesh ◽  
Control Measures ◽  
Prevention And Control Measures ◽  
Etiological Agents ◽  
And Control

Mastitis is an inflammation of mammary glands that is prevalent in dairy bovines. It causes a significant proportion of economic losses to the dairy farmers in India. Cattle and buffalo farming contribute significantly to the economy of the state. Various infectious agents such as bacteria, fungi, and algae may cause mastitis. Hence, it is essential to understand the etiological agents and predisposing factors that lead to mastitis in susceptible bovine populations in Madhya Pradesh state so that appropriate prevention and control strategies can be implemented. In this chapter, epidemiology, diagnosis, prevention, and control measures of mastitis in general and in India, the state of Madhya Pradesh, in particular, will be presented.

scholarly journals A Survey of Program Capacity and Skills of Florida Mosquito Control Districts to Conduct Arbovirus Surveillance and Control

2020 ◽  
Vol 36 (2) ◽  
pp. 99-106
Author(s):  
Imelda K. Moise ◽  
Rui-De Xue ◽  
Leo C. Zulu ◽  
John C. Beier
Keyword(s):  
Vector Control ◽  
Mosquito Control ◽  
Control Measures ◽  
Fiscal Year ◽  
Surveillance Systems ◽  
Mosquito Surveillance ◽  
Staffing Levels ◽  
Routine Surveillance ◽  
Timely Access ◽  
And Control

ABSTRACT Effective and efficient surveillance systems are key for preventing arthropod-borne diseases. We examined the capacity of Florida mosquito control districts (both state-approved and open programs, n = 90; 48.9% response rate). Questions centered on budgets, staffing levels, equipment, vector control measures, and staff perceptions of own agency's capacity to implement routine surveillance and vector control activities. Bivariate analyses indicate that districts with relatively large budgets have advanced capacities regarding staffing levels, employee specialties, mosquito control equipment, conduct routine surveillance and vector control yet they serve only a small proportion of the population. Independent tax districts' average annual budgets were 9 times higher than Board of County Commissioners programs in fiscal year 2017–18. Most respondents indicated that staff is appropriately trained, and has timely access to information and needed equipment for mosquito surveillance and control. Slightly more than half of respondents feel they are understaffed. Perceived understaffing may compromise mosquito surveillance and control efforts in some districts.

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