Platelet Survival and Platelet Serotonin Release in vivo in Various Animal Models
Decreased platelet survival is a clinically accepted indicator of increased platelet consumption, and in some cases may reveal “hyperthrombotic” states. Decreased platelet survival has also been demonstrated in the homocystinuric baboon and the hypercholesterolemic rhesus monkey (Ross and Harker). Treatment with antiplatelet drugs does increase platelet survival in patients as well as in experimental animals.We have found platelet survival to be decreased in both uricemic and hypercholesterolemic guinea pigs.However, platelet survival in the atherosclerotic rabbit and the streptozotocin diabetic rat was normal. When atherosclerotic rabbits or diabetic rats were given platelets labelled with 51Cr and 14C-serotonin, they were found, five days after receiving the platelets, to have higher 51Cr/14C ratios than did their corresponding controls. This suggests a higher serotonin release from circulating platelets in these models.The 51Cr/14C ratio in platelets may be a more sensitive measure of platelet activity in vivo than is platelet survival alone.