A Novel Prognostic Marker in Patients Undergoing Spinal Surgery: Prognostic Nutritional Index

2019 ◽  
Vol 80 (06) ◽  
pp. 470-474 ◽  
Author(s):  
Arsal Acarbaş

Abstract Objective The relationship of a preoperative Prognostic Nutritional Index (PNI) with perioperative adverse events (PAEs) other than delirium has never been described in patients undergoing spinal surgery. We aimed to evaluate the impact of admission PNI on the outcome of patients undergoing spinal surgery. Methods Medical records of 408 consecutive patients 50 years or older undergoing spinal surgery were reviewed. Patients' information including demographic data, routine preoperative laboratory tests, and PNI were collected to assess the association between these factors and PAEs. The PNI was calculated from this formula: 10 × serum albumin (g/dL) + 0.005 × total lymphocyte count/mm3. Receiver operating characteristic curve analysis was performed to determine the cutoff value of the PNI. Results PAEs occurred in 61 (14.9%) of the patients. Older patients and those with more comorbid conditions such as atrial fibrillation, chronic renal failure, history of malignancy, and diabetes mellitus tended to have a higher rate of PAEs. Patients with PAEs had higher C-reactive protein (4.4 ± 5.4 vs 2.2 ± 3.0 mg/dL; p < 0.001) but had lower hemoglobin levels (12.2 ± 1.57 vs 13.1 ± 1.84 g/dL; p < 0.001) on admission. Patients who had PAEs had a significantly lower preoperative PNI (46.1 ± 4.4 vs 51.9 ± 5.8; p < 0.001) compared with patients without a PAE. Multivariate analysis showed that age (odds ratio [OR]: 1.23; 95% confidence interval [CI] 0.76–1.35; p < 0.04), PNI < 47.7 (OR: 2.51; 95% CI, 1.188–5.477; p = 0.008) and the presence of diabetes (OR: 3.23; 95% CI, 11.326–7.474; p = 0.004) were significant and independent predictors of PAEs. Conclusion This study is the first to demonstrate that a lower preoperative PNI is associated with PAEs in patients undergoing spinal surgery.

2015 ◽  
Vol 45 (16) ◽  
pp. 3517-3526 ◽  
Author(s):  
L. Gerritsen ◽  
L. van Velzen ◽  
L. Schmaal ◽  
Y. van der Graaf ◽  
N. van der Wee ◽  
...  

Background.Childhood maltreatment (CM) may modify the relationship between major depressive disorder (MDD) and hippocampal volume reduction. To disentangle the impact of MDD and CM on hippocampal volume we investigated the association between MDD and hippocampal volume in persons with and without a history of CM in two independent cohorts.Method.We used data of 262 participants from the Netherlands Study of Depression and Anxiety (NESDA) (mean age 37 years, 32% male) and 636 participants from the SMART-Medea study (mean age 61 years, 81% male). In both studies a 12-month diagnosis of MDD and CM were assessed using a diagnostic interview. Hippocampal volume was measured in NESDA using FreeSurfer software on 3-T magnetic resonance (MR) images and in SMART it was manually outlined on 1.5-T MR images. With analysis of covariance adjusted for intracranial volume, age, gender and lifestyle factors we estimated the effects of MDD and CM on hippocampal volume.Results.In both cohorts CM was not significantly associated with hippocampal volume. After pooling the data MDD was associated with smaller hippocampal volume (B = −138.90 mm3, p = 0.05) and the interaction between MDD and CM reached significance (p = 0.04); in participants with CM, MDD was related to smaller hippocampal volume (NESDA: B = −316.8 mm3, p = 0.02; SMART: B = −407.6, p = 0.046), but not in participants without CM (p > 0.05).Conclusions.Our study shows that in two independent cohorts, particularly in individuals with CM, a diagnosis of MDD is related to smaller hippocampal volume. Prospective studies are needed to further determine through which mechanism CM may amplify the relationship between MDD and hippocampal volume.


1960 ◽  
Vol 20 (4) ◽  
pp. 559-565 ◽  
Author(s):  
W. T. Easterbrook

Present interest in communication research in the social and physical sciences raises some interesting and difficult questions for the economic historian. Arthur Cole, who claims that he is merely trying to carry further the work of Harold Innis and others at Toronto, but who is surely the moving spirit in this session, has suggested that we might begin by pin-pointing a few leading questions for examination. Is this comparatively recent development to be regarded as merely a passing phase in the history of fashions in thought? Is the process of relating communication to economic change mainly a process of sophistication and is there anything to argue about in this relationship? Or, on the other hand, does it in fact amount to a major break-through in scientific and historical analysis, something comparable to the impact made on economics about a century ago by the Austrian School?


1982 ◽  
Vol 10 ◽  
pp. 15-25
Author(s):  
A. Dwight Culler

One of the most dramatic moments in Victorian literature is that in the Apologia pro Vita Sua in which Newman first expresses doubt about the tenablehess of his position in the Anglican Church. It was die summer of 1839 and he was proposing to spend die time quietly, reading in his favorite subject, die history of the early church. As he began to go more deeply into the matter, however, he became uneasy, and by the end of August he was seriously alarmed. “My stronghold,” he says, “was Antiquity; now here, in the middle of die fifth century, I found, as it seemed to me, Christendom of die sixteenth and die nineteenth centuries reflected. I saw my face in that mirror, and I was a monophysite.” It is true, the impact of this passage is somewhat diminished for the modern reader by his uncertainty what a Monophysite is. Even after he has done his researches and learned that a Monophysite is one who believed in the one, not the two, natures of Christ, he is little better off, for Newman was not concerned widi the doctrinal question. He was concerned with the relationship of the parties one to anodier and with the fact that, if an extreme version of a position was heretical, then a moderate version of that position was heretical too. “It was difficult,” he wrote, “to make out how the Eutychians or Monophysites were heretics, unless Protestants and Anglicans were heretics also; … There was an awful similitude, more awful, because so silent and unimpassioned, between die dead records of die past and the feverish chronicle of the present. The shadow of the fifth century was on the sixteenth. It was like a spirit rising from the troubled waters of the old world, with die shape and lineaments of the new.”


2021 ◽  
Vol 2 (2) ◽  
pp. 16-20
Author(s):  
M.V. Slobodyanik ◽  
I.P. Mazur

The article describes the etiologic and pathogenic relationship of periodontopathogenic microbiota in patients with generalized periodontitis and cardiovascular disease development. The article presents the literature data and the results of own investigation regarding the direct impact of periodontal pathogens on cardiovascular disease etiology due to transitory bacteriemia. The article considers the pathogenetic relationship and the impact of infectious and inflammatory diseases in the oral cavity on the development of cardiovascular disease by stimulating the production of proinflammatory cytokines in periodontal tissues and C-reactive protein by the body.


Paleobiology ◽  
1980 ◽  
Vol 6 (02) ◽  
pp. 146-160 ◽  
Author(s):  
William A. Oliver

The Mesozoic-Cenozoic coral Order Scleractinia has been suggested to have originated or evolved (1) by direct descent from the Paleozoic Order Rugosa or (2) by the development of a skeleton in members of one of the anemone groups that probably have existed throughout Phanerozoic time. In spite of much work on the subject, advocates of the direct descent hypothesis have failed to find convincing evidence of this relationship. Critical points are:(1) Rugosan septal insertion is serial; Scleractinian insertion is cyclic; no intermediate stages have been demonstrated. Apparent intermediates are Scleractinia having bilateral cyclic insertion or teratological Rugosa.(2) There is convincing evidence that the skeletons of many Rugosa were calcitic and none are known to be or to have been aragonitic. In contrast, the skeletons of all living Scleractinia are aragonitic and there is evidence that fossil Scleractinia were aragonitic also. The mineralogic difference is almost certainly due to intrinsic biologic factors.(3) No early Triassic corals of either group are known. This fact is not compelling (by itself) but is important in connection with points 1 and 2, because, given direct descent, both changes took place during this only stage in the history of the two groups in which there are no known corals.


2010 ◽  
Vol 20 (1) ◽  
pp. 3-8
Author(s):  
Dee Adams Nikjeh

Abstract Administrators and supervisors face daily challenges over issues such as program funding, service fees, correct coding procedures, and the ever-changing healthcare regulations. Receiving equitable reimbursement for speech-language pathology and audiology services necessitates an understanding of federal coding and reimbursement systems. This tutorial provides information pertaining to two major healthcare coding systems and explains the relationship of these systems to clinical documentation, the Medicare Physician Fee Schedule and equitable reimbursement. An explanation of coding edits and coding modifiers is provided for use in those occasional atypical situations when the standard use of procedural coding may not be appropriate. Also included in this tutorial is a brief discussion of the impact that the Medicare Improvements for Patients and Providers Act of 2008 (HR 6331 Medicare Improvements for Patients and Providers Act [MIPPA], 2008) has had on the valuation of speech-language pathology procedure codes.


Crisis ◽  
2016 ◽  
Vol 37 (4) ◽  
pp. 265-270 ◽  
Author(s):  
Meshan Lehmann ◽  
Matthew R. Hilimire ◽  
Lawrence H. Yang ◽  
Bruce G. Link ◽  
Jordan E. DeVylder

Abstract. Background: Self-esteem is a major contributor to risk for repeated suicide attempts. Prior research has shown that awareness of stigma is associated with reduced self-esteem among people with mental illness. No prior studies have examined the association between self-esteem and stereotype awareness among individuals with past suicide attempts. Aims: To understand the relationship between stereotype awareness and self-esteem among young adults who have and have not attempted suicide. Method: Computerized surveys were administered to college students (N = 637). Linear regression analyses were used to test associations between self-esteem and stereotype awareness, attempt history, and their interaction. Results: There was a significant stereotype awareness by attempt interaction (β = –.74, p = .006) in the regression analysis. The interaction was explained by a stronger negative association between stereotype awareness and self-esteem among individuals with past suicide attempts (β = –.50, p = .013) compared with those without attempts (β = –.09, p = .037). Conclusion: Stigma is associated with lower self-esteem within this high-functioning sample of young adults with histories of suicide attempts. Alleviating the impact of stigma at the individual (clinical) or community (public health) levels may improve self-esteem among this high-risk population, which could potentially influence subsequent suicide risk.


Author(s):  
Ted Geier

Covers the long history of the Smithfield animal market and legal reform in London. Shows the relationship of civic improvement tropes, including animal rights, to animal erasure in the form of new foodstuffs from distant meat production sites. The reduction of lives to commodities also informed public abasement of the butchers.


Author(s):  
Terence Young ◽  
Alan MacEachern ◽  
Lary Dilsaver

This essay explores the evolving international relationship of the two national park agencies that in 1968 began to offer joint training classes for protected-area managers from around the world. Within the British settler societies that dominated nineteenth century park-making, the United States’ National Park Service (NPS) and Canada’s National Parks Branch were the most closely linked and most frequently cooperative. Contrary to campfire myths and nationalist narratives, however, the relationship was not a one-way flow of information and motivation from the US to Canada. Indeed, the latter boasted a park bureaucracy before the NPS was established. The relationship of the two nations’ park leaders in the half century leading up to 1968 demonstrates the complexity of defining the influences on park management and its diffusion from one country to another.


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