scholarly journals Low Bioactive Vitamin D Is Associated with Pregnancy-Induced Hypertension in a Cohort of Pregnant HIV-Infected Women Sampled Over a 23-Year Period

2019 ◽  
Vol 37 (14) ◽  
pp. 1446-1454 ◽  
Author(s):  
Kristi R. Van Winden ◽  
Allison Bearden ◽  
Naoko Kono ◽  
Toni Frederick ◽  
Eva Operskalski ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Group B Streptococcus ◽  
Perinatal Outcomes ◽  
Obstetric Outcomes ◽  
Pregnancy Induced Hypertension ◽  
Vitamin D Metabolism ◽  
Vitamin D Levels ◽  
Induced Hypertension ◽  
The Impact

Objective To examine the association of vitamin D insufficiency and risk of pregnancy-induced hypertension (PIH) among human immunodeficiency virus (HIV)-infected pregnant women. Study Design This is a retrospective cohort study evaluating the impact of low maternal vitamin D levels on PIH and perinatal outcomes among HIV-infected pregnant women receiving care at an urban HIV center from 1991 to 2014. Results A total of 366 pregnant women were included, of which 11% developed PIH. Lower levels of 25-hydroxyvitamin D (25(OH)D) and bioactive 1,25-dihydroxyvitamin D (1,25(OH)2D) were associated with increased HIV disease activity. 25(OH)D levels were not significantly associated with the incidence of PIH. Higher 1,25(OH)2D levels were associated with reduced incidence of PIH in univariate (odds ratio, OR: 0.87 [95% confidence interval, CI: 0.79–0.95], p = 0.004) and multivariate (OR: 0.88 [95% CI: 0.80–0.97], p = 0.010) analyses. No association was found between 25(OH)D levels and other obstetric outcomes. Lower 1,25(OH)2D levels were associated with group B Streptococcus colonization (OR: 0.92 [95% CI: 0.86–0.99]) and low birth weight (LBW) (OR: 0.90 [95% CI: 0.83–0.98]) on multivariate analysis. Mean 1,25(OH)2D levels were significantly lower in women with preterm delivery and LBW infants. Conclusion Lower bioactive vitamin D levels are related to PIH in HIV-infected women. This association may be related to the coexistence of abnormal placental vitamin D metabolism and abnormal placental implantation.

scholarly journals Systemic inflammation and alteration in vitamin D levels in pregnancy induced hypertension

2014 ◽  
Vol 5 (4) ◽  
pp. 11-15 ◽  
Author(s):  
Dilutpal Sharma ◽  
Rahul Saxena ◽  
Raj Saxena ◽  
Mousumi Sharma ◽  
Alok Milton Lal
Keyword(s):  
Vitamin D ◽  
Systemic Inflammation ◽  
Serum Vitamin ◽  
Pregnancy Induced Hypertension ◽  
Serum Vitamin D ◽  
Sodium Calcium ◽  
Group I ◽  
Vitamin D Levels ◽  
Induced Hypertension ◽  
Group Ii

Background: The increasing incidence of Pregnancy induced hypertension (PIH) or Pre-eclampsia in developed and developing countries are alarming. Systemic inflammation and disturbances in vitamin D and minerals (Sodium & Calcium) metabolism are almost invariable consequences of PIH; and variation in their levels can adversely affect the pregnancy leading to the development of PIH. Aim: In this context, a study was carried out to assess the level of serum vitamin D, sodium, calcium and inflammatory marker C-reactive protein (CRP) in non-pregnant (NP), normotensive pregnant (NTP) and PIH women and to determine their role in the etio-pathogenesis of PIH. Material and method: Serum vitamin D, sodium, calcium and CRP levels were estimated in 20 NTP women (Group I) and 20 PIH women (Group II) by using standard methods and statistically compared it with that of age matched 20 healthy non pregnant women (Control group) by using student’s t-test. Result: Serum Ca++ level were found to be significantly low in both Group I (p<0.05) and Group II (p<0.01) as compared to healthy controls. However, plasma vitamin D levels were decreased insignificantly in Group I (p < 0.1) and significantly (p < 0.05) in Group II patients. Similarly, serum sodium and CRP levels were increased significantly only in Group II patients. Conclusion: Thus, regular assessment of serum CRP, vitamin D, sodium and calcium levels and recommendation of diet low in sodium, rich in calcium and appropriate vitamin D should be increased during pregnancy to prevent PIH and its related complications. DOI: http://dx.doi.org/10.3126/ajms.v5i4.9809 Asian Journal of Medical Sciences 2014 Vol.5(4); 11-15

scholarly journals Assessment of the vitamin d levels effect on the course of the first trimester of pregnancy

2022 ◽  
pp. 131-137
Author(s):  
I. V. Kovalevа ◽  
M. O. Bakleicheva ◽  
O. N. Bespalova
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Randomized Study ◽  
Perinatal Outcomes ◽  
First Trimester ◽  
North West ◽  
Vitamin D Levels ◽  
Group 3 ◽  
Group 1

Introduction. The course of physiological pregnancy is provided by many complementary factors. Thus, a deficiency in one of the links of the metabolic network contributes to the development of an imbalance in the work of the whole organism, which ensures the growth and development of the embryo from the first days of gestation. It has been proven that vitamin D can act as an immune regulator during implantation, providing a protective effect in whole period of pregnancy.Aim. The aim of this study is assessed the features of the course of pregnancy in patients with different levels of vitamin D in the blood in the first trimester.Materials and methods. A prospective multicenter randomized study was conducted in the North-West region of the Russian Federation among 88 pregnant women in the first trimester of gestation (up to 13 weeks). All patients were divided into 3 groups depending on the initial level of vitamin D (group 1–14 women with a 25(OH)D < 10 ng/ml, group 2–62 pregnant women from 10 to 30ng/ml, group 3–12 pregnant women with a vitamin D content > 30 ng/ml).Results. In group 1.86% of patients with severe vitamin D deficiency were diagnosed with threatened miscarriage, which is significantly higher than in group 3 (85.7% and 33.3%, χ2 = 7.490, p = 0.007). At the same time, retrochorial hematoma in group 1 occurred 3.5 times more often than in group 3 (57.1% and 16.67%, respectively, χ2 = 4.473, p = 0.035). Subsequently, every 4th woman from the group with vitamin D deficiency gave birth earlier than expected, which was not observed among patients from group 3 (25%, 0%, χ2 = 1.231, p = 0.268).Conclusion. Prescribing cholecalciferol vitamin replacement therapy as part of complex preserving therapy for threatening miscarriage, followed by monitoring its blood level and deviating from normal parameters, contributing to a favorable course of pregnancy and improving perinatal outcomes.

scholarly journals Effect of pregnancy induced hypertension on adverse perinatal outcomes in Tigray regional state, Ethiopia: a prospective cohort study

2019 ◽  
Author(s):  
Abadi Kidanemariam Berhe ◽  
Abiodun O. ILESANMI ◽  
Christopher O. AIMAKHU ◽  
Afework Mulugeta
Keyword(s):  
Cohort Study ◽  
Pregnant Women ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Perinatal Outcomes ◽  
Pregnancy Induced Hypertension ◽  
Care Providers ◽  
Regional State ◽  
Induced Hypertension ◽  
Adverse Perinatal Outcomes

Abstract Background: Pregnancy-induced hypertension is the development of new hypertension with or without proteinuria after 20 weeks of pregnancy. The prevalence of pregnancy-induced hypertension in Ethiopia ranges from 2.2 to 18.3%. Similarly, a study conducted in Tigray regional state indicated a higher prevalence of pregnancy-induced hypertension. However, so far little is known about the adverse perinatal outcomes of pregnancy-induced hypertension in Tigray Regional State, Ethiopia. Therefore the objective of this study was to assess the effect of pregnancy-induced hypertension on adverse perinatal outcomes in Tigray Regional State, Ethiopia. Methods: a prospective cohort study was conducted on a total sample of 782 pregnant women attending antenatal care in hospitals of Tigray regional state, Ethiopia. Data were collected using interviewer-administered questionnaire and review of their medical records from February 1, 2018, to February 30, 2019. Maternal age, wealth status, educational status, residence, gravidity, type of pregnancy, mode of delivery, anemia status and maternal undernutrition variables were controlled in the statistical models. A modified Poisson regression model with robust standard errors was used to analyze Relative risk. Results: In this study, the overall incidence of adverse perinatal outcome was higher among women with pregnancy-induced hypertension than normotensive women (66.4% vs 22.2%). After adjusted for confounders women with pregnancy-induced hypertension were born babies with a higher risk of low birth weight (adjusted RR(95%CI)= 5.1(3.4,7.8)), birth asphyxia (aRR=2.6(1.9,3.8)), small for gestational age (aRR=3.3(2.3,4.6)), preterm delivery (aRR=5.2(3.4,7.9)), stillbirth (aRR=3.46(1.40,8.54)), admission to neonatal intensive care unit (aRR=5.1(3.1,8.4)) and perinatal death (aRR=3.6(1.8,7.4)) compared to normotensive pregnant women. Conclusions: Higher incidences of adverse perinatal outcomes were occurred among women pregnancy-induced hypertension in Tigray regional state, Ethiopia. Hence health care providers should strengthen prevention, early diagnosis and prompt management of pregnancy-induced hypertension to reduce adverse perinatal outcomes of pregnancy-induced hypertension. Keywords: Adverse perinatal outcomes, pregnancy-induced hypertension, Tigray, Ethiopia

scholarly journals Effect of hypovitaminosis D and its related factors in pregnant women and their newborns

2019 ◽  
Vol 8 (3) ◽  
pp. 1115
Author(s):  
Amrita Sandhu ◽  
Ruchira Nautiyal ◽  
Vinit Mehrotra ◽  
Sanober Wasim
Keyword(s):  
Vitamin D ◽  
Cord Blood ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Negative Correlation ◽  
Serum Vitamin ◽  
Related Factors ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
The Impact

Background: Maternal and fetal vitamin D deficiency has nowadays emerged as a frequent morbidity. Adequate vitamin D concentrations during pregnancy are necessary to maintain neonatal calcium homeostasis, bone maturation and mineralization. Objectives of this study were to evaluate serum vitamin D concentration in mothers and its correlation with neonatal cord blood vitamin D at the time of delivery and to study the impact of hypovitaminosis on neonatal anthropometry. Effect of related factors like calcium (Ca), alkaline phosphatase (ALP) and parathyroid hormone (PTH) on maternal vitamin D levels were to be evaluated.Methods: Cross sectional study was done on a total of 220 healthy uncomplicated antenatal females with singleton pregnancy attending labor room at the time of delivery. Maternal and neonatal cord blood samples were drawn in the delivery room and analyzed. Neonatal anthropometry was recorded. Correlations among various maternal and neonatal factors were studied.Results: Widespread vitamin D deficiency was observed in expectant subjects and neonates with 70.91% having deficient levels which were also reflected in newborns (71.82%). Maternal ALP (r= -0.5503, p=0.000) bears a weak negative correlation (p<0.05), maternal serum Ca positive correlation (r = 0.7486, p=0.000) and plasma PTH levels a negative correlation (r = -2.084, p=0.000) with hypovitaminosis. No significant correlation was observed between neonatal anthropometry and vitamin D levels.Conclusions: High prevalence of hypovitaminosis was observed among pregnant women and their neonates in this study. A positive linear relationship was seen between maternal and cord blood vitamin D (r 0.974, p 0.0001).

scholarly journals Impact of Maternal Vitamin D Status on the Formation of Atopic Dermatitis in Young Children

2021 ◽  
Vol 8 ◽  
pp. 2333794X2110229
Author(s):  
Mariam Petriashvili
Keyword(s):  
Vitamin D ◽  
Atopic Dermatitis ◽  
Young Children ◽  
Pregnant Women ◽  
Allergic Diseases ◽  
Maternal Vitamin ◽  
Low Concentrations ◽  
Vitamin D Levels ◽  
Relationship Of ◽  
The Impact

Recent studies have highlighted relationship of allergic diseases with vitamin D deficiency. The aim of the study was to evaluate the impact of maternal vitamin D levels in pregnancy on the formation of atopic dermatitis in early life. A total of 186 pregnant women and their infants who developed atopic dermatitis before the age of 2 years were involved in the prospective study. Most pregnant women (57.5%) were diagnosed with 25(OH)D deficiency (3.6 ± 4.4 ng/ml) ( P = .000). Maternal 25(OH)D deficiency was directly related to atopic family anamnesis and relatively high IgE levels. In these cases, children developed atopic dermatitis before the age of 6 months (70.8%) with prevalence of moderate-severity (55%) and persistent course (68.3%) of the disease. The above mentioned supported the idea that the peculiarities of the formation of atopic dermatitis in young children are associated with low concentrations of vitamin D in mothers during pregnancy.

scholarly journals Prevalence of vitamin D deficiency in patients of pregnancy induced hypertension

2018 ◽  
Vol 7 (8) ◽  
pp. 3358 ◽  
Author(s):  
Guljit Kaur ◽  
Sangeeta Pahwa ◽  
Ibadat Preet
Keyword(s):  
Vitamin D ◽  
Risk Factor ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Pregnancy Induced Hypertension ◽  
Medical Sciences ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Induced Hypertension ◽  
Very High

Background: The objectives of this study were to compare the serum Vitamin D levels in pregnant patients of pregnancy induced hypertension (PIH) and healthy normotensive patients and to study the prevalence of vitamin D deficiency in patients of PIH.Methods: This study was conducted in Shri Guru Ram Das Institute of Medical Sciences and Research, Vallah, Amritsar in year 2015-2017. In total 100 cases were taken for the study and divided into two groups.Results: Serum Vitamin D levels were quite low in women with pregnancy induced hypertension with a mean vitamin D levels of 13.006±6.24 ng/ml as compared to 23.239±10.601 ng/ml in healthy pregnant women. The prevalence of vitamin D deficiency in PIH group was very high i.e. 94% compared to 46% in normotensive group (Mean Vitamin D levels <20 ng/ml).Conclusions: Vitamin D levels are deficient in patients of PIH and there is increased prevalence of vitamin D deficiency with PIH suggesting that vitamin D deficiency can be a risk factor for the development of PIH.

scholarly journals Effect of pregnancy induced hypertension on adverse perinatal outcomes in Tigray Regional State, Ethiopia: a prospective cohort study

2019 ◽  
Author(s):  
Abadi Kidanemariam Berhe ◽  
Abiodun O. ILESANMI ◽  
Christopher O. AIMAKHU ◽  
Afework Mulugeta
Keyword(s):  
Cohort Study ◽  
Pregnant Women ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Perinatal Outcomes ◽  
Pregnancy Induced Hypertension ◽  
Care Providers ◽  
Regional State ◽  
Induced Hypertension ◽  
Adverse Perinatal Outcomes

Abstract Background: Pregnancy induced hypertension is the development of new hypertension with or without proteinuria after 20 weeks of pregnancy. The prevalence of pregnancy induced hypertension in Ethiopia ranges from 2.2 to 18.3%. However, little is known about the adverse perinatal outcomes of pregnancy induced hypertension in Tigray Regional State, Ethiopia.Therefore the objective of this study was to assess effect of pregnancy induced hypertension on adverse perinatal outcomes in Tigray Regional State, Ethiopia. Methods: a prospective cohort study was conducted on a total sample of 782 pregnant women attending antenatal care in hospitals of Tigray regional state, Ethiopia. Data were collected using interviewer-administered questionnaire and review of their medical records from February 1, 2018, to February 30, 2019. Data analysis was performed using Stata version 14.0. Relative risk with 95% CI for the association between pregnancy induced hypertension and perinatal outcomes were assessed using Poisson regression analysis. Results: In this study the overall incidence of adverse perinatal outcome was higher among women with pregnancy induced hypertension than normotensive women ( 66.4% vs 22.2%). After adjusted for confounders women with pregnancy induced hypertension were born babies with a higher risk of low birth weight (adjusted RR(95%CI)= 5.1(3.4,7.8)), birth asphyxia (aRR=2.6(1.9,3.8)), small for gestational age (aRR=3.3(2.3,4.6)), preterm delivery (aRR=5.2(3.4,7.9)), admission to neonatal intensive care unit (aRR=5.1(3.1,8.4)) and with a higher risk of perinatal death (aRR=3.6(1.8,7.4)) compared to normotensive pregnant women Conclusions: Higher incidences of adverse perinatal outcomes were occurred among women pregnancy induced hypertension in Tigray regional state, Ethiopia. Hence health care providers should strengthen prevention, early diagnosis and prompt management of pregnancy induced hypertension to reduce adverse perinatal outcomes of pregnancy induced hypertension. Keywords : Adverse perinatal outcomes, pregnancy induced hypertension, Tigray, Ethiopia

Serum Uric Acid Level as a Predictive Biomarker of Gestational Hypertension Severity; A Prospective Observational Case-Control Study

2020 ◽  
Vol 15 (3) ◽  
pp. 227-239 ◽  
Author(s):  
Hader I. Sakr ◽  
Akef A. Khowailed ◽  
Reham S. Al-Fakharany ◽  
Dina S. Abdel-Fattah ◽  
Ahmed A. Taha
Keyword(s):  
Blood Pressure ◽  
Pregnant Women ◽  
Case Control Study ◽  
Serum Urate ◽  
Interleukin 1Β ◽  
Pregnancy Induced Hypertension ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Induced Hypertension ◽  
Control Study

Background: Pre-eclampsia poses a significant potential risk of hypertensive disorders during pregnancy, a leading cause of maternal deaths. Hyperuricemia is associated with adverse effects on endothelial function, normal cellular metabolism, and platelet aggregation and adhesion. This study was designed to compare serum urate levels in normotensive pregnant women to those with pregnancy-induced hypertension, and to evaluate its value as a potential predictive marker of hypertension severity during pregnancy. Methods: A prospective, observational, case-control study conducted on 100 pregnant women in their third trimester. Pregnant women were classified into two groups (n=50) according to arterial blood pressure measurements: group I had normal blood pressure, and group II had a blood pressure of ≥ 140/90, which was further subdivided according to hypertension severity into IIa (pregnancy- induced hypertension, IIb (mild pre-eclampsia), and IIc (severe pre-eclampsia). Blood samples were obtained on admission. Serum urate, high sensitive C-reactive protein, and interleukin-1β levels, and lipid profile were compared among the groups. Results: A significant increase in the mean values of serum urate, C-reactive protein, and interleukin- 1β levels was detected in gestational hypertensives. In addition, there was a positive correlation between serum urate levels and C-reactive protein and interleukin-1β, as well as between serum urate levels and hypertension severity. Conclusion: Hyperuricemia and increased C-reactive protein and interleukin-1β serum levels correlate with the severity of pregnancy-induced hypertension, and these biomarkers may play a role in the pathogenesis of pre-eclampsia. Serum urate measurement is sensitive, reliable markers that correlate well with the severity of hypertension in pregnant females with pre-eclampsia.

scholarly journals COVID-19: Uncertainties from Conception to Birth

2021 ◽  
Vol 43 (01) ◽  
pp. 054-060
Author(s):  
Bruno Ramalho de Carvalho ◽  
Karina de Sá Adami ◽  
Walusa Assad Gonçalves-Ferri ◽  
Marise Samama ◽  
Rui Alberto Ferriani ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Present Article ◽  
Vertical Transmission ◽  
Scientific Information ◽  
Obstetric Outcomes ◽  
Reproductive Events ◽  
The Impact ◽  
Initial Impressions ◽  
Quality Evidence

AbstractScientific information on the impact of the new coronavirus (SARS-CoV-2) on the health of pregnant women, fetuses and newborns is considered of limited confidence, lacking good-quality evidence, and drawing biased conclusions. As a matter of fact, the initial impressions that the evolution of COVID-19 was no different between pregnant and non-pregnant women, and that SARS-CoV-2 was not vertically transmitted, are confronted by the documentation of worsening of the disease during pregnancy, poor obstetric outcomes, and the possibility of vertical transmission. The present article aims to compile the data available on the association of COVID-19 and reproductive events, from conception to birth.

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