Dynamic Wrist Radiographs in Patients with and without a Ganglion Cyst

Abstract Objectives The purpose of this study was to find out if carpal instability played a role in the etiology of ganglion cysts. Materials and Methods Dynamic wrist radiographs of 33 patients with and without a ganglion cyst of the wrist were compared. The control group consisted of patients who had dynamic radiographs of both wrists after a traumatic event in one wrist. Measurements were performed on the contralateral uninjured side. Radiological parameters that may indicate carpal instability included: width of the scapholunate gap, scapholunate, radiolunate, and lunocapitate angles, and ulnar translocation. Results No statistically significant difference was found between the two groups except for lunocapitate angle which was higher in wrists with ganglion cysts. However, mean lunocapitate angle was still within the normal range. Conclusions It could be concluded that in this study we did not see a difference between scapholunate gap and radiocarpal angles with the presence or absence of a ganglion cyst.

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Dorsal Wrist Pain in the Extended Wrist-Loading Position: An MRI Study

Journal of Wrist Surgery ◽

10.1055/s-0037-1599829 ◽

2017 ◽

Vol 06 (04) ◽

pp. 276-279 ◽

Cited By ~ 1

Author(s):

Erin Nance ◽

David Byun ◽

Yoshimi Endo ◽

Scott Wolfe ◽

Steve Lee

Keyword(s):

Ganglion Cyst ◽

Weight Bearing ◽

Retrospective Chart Review ◽

Wrist Pain ◽

Control Group ◽

Level Of Evidence ◽

Ganglion Cysts ◽

Magnetic Resonance Imaging Mri ◽

Mri Study ◽

Dorsal Ganglion

Background The etiology of dorsal wrist pain associated with loading of the wrist in extension has not been clearly identified in the literature. Purpose Many exercise disciplines incorporate upper extremity weight-bearing exercises in an extended wrist posture, for example push-ups, plank position, and various yoga and Pilates poses. This study evaluates patients with dorsal wrist pain in the extended wrist-loading position and identifies anatomic abnormalities in the wrist using magnetic resonance imaging (MRI). Methods A retrospective chart review was performed comparing MRI of patients who complained of dorsal wrist pain while performing weight bearing in a wrist extension position with a control group of patients who complained of ulnar-sided wrist pain. The primary MRI outcome was dorsal wrist pathology, including occult dorsal ganglion cyst, scapholunate ligament tear or degeneration, and dorsal capsulitis. Results Dorsal wrist pathology was significantly more prevalent in patients with dorsal wrist pain (84%) than in the patient cohort with ulnar-sided wrist pain (12%). Occult dorsal ganglion cysts were the most common sources of pathology (76%). Conclusion MRI demonstrated an identifiable dorsal abnormality in 84% of patients with dorsal wrist pain associated with weight bearing on the extended wrist. Occult dorsal ganglion cysts are the most common cause of dorsal wrist pain, followed by partial scapholunate tears. When patients complain of dorsal wrist pain during specific extended loading wrist positions such as push-ups, yoga, or Pilates poses, an MRI may be warranted to help identify anatomic abnormalities that may help guide treatment choices. Level of Evidence Diagnostic, Level III.

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The Treatment of Wrist Ganglion Cyst by the Chinese Acupotomy and Crisscross Thread

10.21203/rs.3.rs-94895/v1 ◽

2020 ◽

Author(s):

Shuliang Zhang ◽

Bin Xu ◽

Yangjun Lao ◽

Di Lu

Keyword(s):

Recurrence Rate ◽

Ganglion Cyst ◽

Combined Treatment ◽

Vas Score ◽

Ganglion Cysts ◽

Significant Difference ◽

Group A ◽

Group B ◽

The Cost ◽

Open Excision

Abstract Background: The current treatments of wrist ganglion have considerable recurrence rate, we developed a new treatment for ganglion cysts in our clinical practice, which combined acupotomy with crisscross thread method, so we now to compare the clinical effectiveness of Chinese acupotomy and crisscross thread with aspiration followed by injection of steroid and open excision for ganglion cysts treatment. Methods: Recruited patients with wrist ganglion were divided into three groups according to the treatments. Among them, 27 patients who were treated by a new combined treatment of Chinese acupotomy and crisscross thread method in group A, 30 patients who were treated by aspiration followed by steroid injection in group B, and 28 patients who were treated by open excision in group C. The data of age, gender, weight, size of ganglion cysts, visual analogue scale (VAS) , cost were recorded and compared by One-way analysis of variance, followed by an LSD (Least Significant Difference)test. The recurrence rates were recorded were analysed by chi-square test.Results: At the first day and one week after treatment, VAS score of group A was similar to group B with no statistic difference. VAS score of group C was higher than group A and B with statistic difference. Six months later, there was no statistic difference among the three groups about VAS. The recurrence rate was 3.7% in group A and 36.7% in group B and 10.7% in group C. No patient infected in three groups. The cost of group A was more than group B with no statistic difference. The cost of group A was much less than group C with statistic difference.Conclusions: The combination of Chinese acupotomy and crisscross thread method was a simple, economical and effective procedure for wrist ganglion cysts.

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Ultrasound-Guided Aspiration Does Not Reduce the Recurrence Rate of Ganglion Cysts of the Wrist

Journal of Wrist Surgery ◽

10.1055/s-0038-1668156 ◽

2018 ◽

Vol 08 (02) ◽

pp. 100-103 ◽

Cited By ~ 2

Author(s):

Gregory Kurkis ◽

Albert Anastasio ◽

Marijke DeVos ◽

Michael Gottschalk

Keyword(s):

Recurrence Rate ◽

Ultrasound Guidance ◽

Ganglion Cyst ◽

High Recurrence Rate ◽

P Value ◽

Ultrasound Guided ◽

Recurrence Rates ◽

Level Of Evidence ◽

Ganglion Cysts ◽

Significant Difference

Background Ganglion cysts are the most frequent soft tissue tumor encountered in the upper extremity and are commonly treated by aspiration or by surgical excision. Ultrasound is a promising addition to traditional aspiration, as it allows for visualization of the needle within the ganglion before aspiration. Questions Are ganglion cysts of the wrist less likely to reoccur if they are aspirated under ultrasound guidance versus “blind” aspiration without the use of ultrasound guidance? Does patient functionality change based on whether or not the cyst recurred? Patients and Methods In total, 52 patients were successfully contacted and recurrence rates were compared between those whose cyst was treated with ultrasound-guided (13 patients) with those whose cyst was treated with blind aspiration (39 patients). Mean follow-up time was 2.9 years. Results Recurrence rates were 69% (9 patients) and 74% (29 patients) for the ultrasound-guided and blind aspiration groups, respectively (p-value: 0.73), showing no significant difference in recurrences of wrist ganglion between the two groups. A metric of functionality (Quick–DASH [Disabilities of the Arm, Shoulder, and Hand]) revealed worse outcomes in patients who experienced return of ganglion cyst after aspiration versus those who did not. Conclusion Additional studies with improved sample sizes are needed to demonstrate the superiority of ultrasound-guided aspiration versus blind aspiration. Due to a high recurrence rate following aspiration (both ultrasound-guided and blinded), a lower threshold for surgical intervention is likely reasonable. Level of Evidence This is a Level IIIb study.

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Intraneural ganglion cysts: a systematic review and reinterpretation of the world's literature

Journal of Neurosurgery ◽

10.3171/2015.9.jns141368 ◽

2016 ◽

Vol 125 (3) ◽

pp. 615-630 ◽

Cited By ~ 41

Author(s):

Nicholas M. Desy ◽

Huan Wang ◽

Mohanad Ahmed Ibrahim Elshiekh ◽

Shota Tanaka ◽

Tae Woong Choi ◽

...

Keyword(s):

Systematic Review ◽

Ganglion Cyst ◽

Mr Images ◽

Intraneural Ganglion ◽

Intraneural Ganglion Cyst ◽

Ganglion Cysts ◽

Significant Difference ◽

Joint Connection ◽

Cyst Recurrence ◽

Univariate Analyses

OBJECTIVE The etiology of intraneural ganglion cysts has been controversial. In recent years, substantial evidence has been presented to support the articular (synovial) theory for their pathogenesis. The authors sought to 1) perform a systematic review of the world's literature on intraneural cysts, and 2) reinterpret available published MR images in articles by other authors to identify unrecognized joint connections. METHODS In Part 1, all cases were analyzed for demographic data, duration of symptoms, the presence of a history of trauma, whether electromyography or nerve conduction studies were performed, the type of imaging, surgical treatment, presence of a joint connection, intraneural cyst recurrence, and postoperative imaging. Two univariate analyses were completed: 1) to compare the proportion of intraneural ganglion cyst publications per decade and 2) to assess the number of recurrences from 1914 to 2003 compared with the years 2004–2015. Three multivariate regression models were used to identify risk factors for intraneural cyst recurrence. In Part 2, the authors analyzed all available published MR images and obtained MR images from selected cases in which joint connections were not identified by the original authors, specifically looking for unrecognized joint connections. Two univariate analyses were done: 1) to determine a possible association between the identification of a joint connection and obtaining an MRI and 2) to assess the number of joint connections reported from 1914 to 2003 compared with 2004 to 2015. RESULTS In Part 1, 417 articles (645 patients) were selected for analysis. Joint connections were identified in 313 intraneural cysts (48%). Both intraneural ganglion cyst cases and cyst recurrences were more frequently reported since 2004 (statistically significant difference for both). There was a statistically significant association between cyst recurrence and percutaneous aspiration as well as failure to disconnect the articular branch or address the joint. In Part 2, the authors identified 43 examples of joint connections that initially went unrecognized: 27 based on their retrospective MR image reinterpretation of published cases and 16 of 16 cases from their sampling of original MR images from published cases. Overall, joint connections were more commonly found in patients who received an MRI examination and were more frequently reported during the years 2004 to 2015 (statistically significant difference for both). CONCLUSIONS This comprehensive review of the world's literature and the MR images further supports the articular (synovial) theory and provides baseline data for future investigators.

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Changes in patellar morphology following surgical correction of recurrent patellar dislocation in children

Journal of Orthopaedic Surgery and Research ◽

10.1186/s13018-021-02779-7 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Weifeng Li ◽

Qian Wang ◽

Hui Li ◽

Shunyi Wang

Keyword(s):

Patellar Dislocation ◽

Morphological Characteristics ◽

Surgical Correction ◽

Ct Scans ◽

Control Group ◽

Recurrent Patellar Dislocation ◽

Radiological Parameters ◽

Significant Difference ◽

Patellar Morphology

Abstract Background The aim of this study was to evaluate patellar morphological changes following surgical correction of recurrent patellar dislocation in children. Methods A total of 35 immature children aged 5 to 10 years who suffered from bilateral recurrent patellar dislocation associated with abnormal patella morphology were enrolled in this study. The knees with the most frequent dislocations (treated with medial patellar retinacular plasty) were selected as the study group (SG), and those undergoing conservative treatment for the contralateral knee were selected as the control group (CG). Computed tomography (CT) scans were performed on all children preoperatively and at the last follow-up to evaluate morphological characteristics of the patella. Results All the radiological parameters of the patella showed no significant difference between the two groups preoperatively. At the last follow-up for CT scans, no significant differences were found for the relative patellar width (SG, 54.61%; CG, 52.87%; P = 0.086) and the relative patellar thickness (SG, 26.07%; CG, 25.02%; P = 0.243). The radiological parameters including Wiberg angle (SG, 136.25°; CG, 122.65°; P < 0.001), modified Wiberg index (SG, 1.23; CG, 2.65; P < 0.001), and lateral patellar facet angle (SG, 23.35°; CG, 15.26°; P < 0.001) showed statistical differences between the two groups. Conclusions The patellar morphology can be improved by early surgical correction in children with recurrent patellar dislocation. Therefore, early intervention is of great importance for children diagnosed with recurrent patellar dislocation.

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Changes in Patellar Morphology Following Surgical Correction of Recurrent Patellar Dislocation in Children

10.21203/rs.3.rs-818276/v1 ◽

2021 ◽

Author(s):

Weifeng Li ◽

Qian Wang ◽

Hui Li ◽

shunyi wang

Keyword(s):

Patellar Dislocation ◽

Morphological Changes ◽

Morphological Characteristics ◽

Surgical Correction ◽

Ct Scans ◽

Control Group ◽

Recurrent Patellar Dislocation ◽

Radiological Parameters ◽

Significant Difference

Abstract Background: The aim of this study was to evaluate the morphological changes of patella following surgical correction of recurrent patellar dislocation in children. Methods: 35 immature children aged 5 to 10 years who suffered from bilateral recurrent patellar dislocation associated with abnormal patella morphology. The knee had most frequently patellar dislocation, which was underwent medial patellar retinacular plasty, and defined as in the study group(SG). The contralateral knee was treated conservatively and defined as in the control group (CG). Computed tomography (CT) scans were performed on all children preoperatively and at the last follow-up to evaluate the patellar morphological characteristics. Results: All the radiological parameters of the patella, showed no significant difference between the two groups, Preoperatively. At the last follow-up for CT scans, no signifcant diferences were evaluable for the relative patellar width (SG, 54.61%; CG, 52.87%; p=0.086) and the relative patellar thickness (SG, 26.07% ; CG, 25.02%; p = 0.243). The radiological parameters including Wiberg-angle (SG, 136.25°; CG, 122.65°; p < 0.001), modified Wiberg-index (SG, 1.23; CG, 2.65 ; p < 0.001), and lateral patellar facet angle (SG, 23.35° ; CG, 15.26°; p < 0.001) showed statistical differences between the two groups. Conclusions: The morphology of the patella can be improved by early surgical correction in children with recurrent patellar dislocation. Early intervention for children with recurrent patellar dislocation is important.

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ACUTE TOXICITY EVALUATION OF ETHANOL EXTRACT OF INDONESIAN VELVET BEANS

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2017v9i5.16284 ◽

2017 ◽

Vol 9 (5) ◽

pp. 161

Author(s):

Ratnaningsih Eko Sardjono ◽

Iqbal Musthapa ◽

Sholihin . ◽

Atun Qowiyah ◽

Rahmi Rachmawati

Keyword(s):

Acute Toxicity ◽

Wistar Rats ◽

Ethanol Extract ◽

Mucuna Pruriens ◽

Control Group ◽

Normal Range ◽

Treatment Groups ◽

Significant Difference ◽

The Brain

Objective: This research was conducted to determine the acute toxicity of ethanol extract of velvet beans (Mucuna pruriens) from Indonesia. Extract of Indonesian Mucuna pruriens seeds showed antiparkinson activity due to the presence of L-DOPA inadequate levels. However, research on the toxicity level of Mucuna pruriens seeds from Indonesia is still limited. Acute toxicity data are needed to make Mucuna pruriens as standardized herbal medicine for Parkinson disease.Methods: The dried seed of Mucuna pruriens was extracted by ethanol and suspended with tragacanth to make several dosas of ethanol extract of Mucuna pruriens seeds. Determination of acute toxicity was performed on six groups, each consisting of five Wistar rats. One group was used as a control group; other groups were given ethanol extract of Mucuna pruriens seeds orally at a dose of 5 mg/kg, 50 mg/kg, 300 mg/kg, 2000 mg/kg, and 5000 mg/kg body weight. Symptoms of toxicity, including death, were observed daily for 14 d. At the end of the observation, the surviving Wistar rats were autopsied and the brain, heart, liver, lungs, stomach, spleen, kidneys, and ovaries were weighed to give relative organ weight.Results: There was no mortality observed in all groups. The Wistar rats gained weight within the normal range. The relative organ weights in all groups generally did not show a significant difference. However, the significant differences (P<0.05) were seen in the liver for all treatment groups compared to the control group.Conclusion: The ethanol extract of Mucuna pruriens seeds from Indonesia administered orally has LD50>5000 mg/kg, thus it could be regarded as safe or non-toxic. However, this extract may be potentially toxic to the liver

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Fattening of culled cattle with the use of complex feed additives in the diets in the conditions of Yakutia

IOP Conference Series Earth and Environmental Science ◽

10.1088/1755-1315/845/1/012032 ◽

2021 ◽

Vol 845 (1) ◽

pp. 012032

Author(s):

M F Grigorev ◽

A I Grigoreva ◽

N M Chernogradskaya ◽

Z G Tatarinova

Keyword(s):

Raw Materials ◽

Meat Products ◽

Live Weight ◽

Feed Additives ◽

The Body ◽

Control Group ◽

Normal Range ◽

Organoleptic Evaluation ◽

Experimental Animals ◽

Significant Difference

Abstract The paper presents the results of a study to determine the effectiveness of complex feed additives in the fattening of culled cattle in the conditions of Yakutia. To conduct the experiment, 3 groups of culled cattle were formed. The use of complex feed additives from local natural raw materials in the feeding of culled cattle on fattening allowed increasing the live weight by 1.58% and 0.26%. To determine the safety of experimental feed additives, the clinical parameters of the body of experimental animals were studied. It was found that there was no significant difference between the groups and all the indicators were within the normal range, which in turn proves the harmlessness of complex feed additives. At the end of the experiment, a control slaughter of experimental animals was carried out. When analyzing the data of animal slaughter, it was found that the experimental groups were superior to the control group in terms of parameters: the mass of the steam carcass by 5.53% and 3.61%, the mass of visceral fat by 9.39% and 1.77%, the slaughter mass by 6.07% and 3.87%, the slaughter yield by 2.76% and 2.06%. Next, the organoleptic evaluation of meat products was performed. According to the results of the evaluation of boiled meat, it was found that the experimental groups exceed the control group by 12.92% and 8.33%, and exceed the roasted meat by 11.87% and 8.19%. Thus, complex feed additives showed effectiveness in fattening culled cattle in the conditions of Yakutia.

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Levels of Prothrombin Fragment F1+2 in Patients with Hyperhomocysteinemia and a History of Venous Thromboembolism

Thrombosis and Haemostasis ◽

10.1055/s-0038-1665405 ◽

1997 ◽

Vol 78 (05) ◽

pp. 1327-1331 ◽

Cited By ~ 21

Author(s):

Paul A Kyrle ◽

Andreas Stümpflen ◽

Mirko Hirschl ◽

Christine Bialonczyk ◽

Kurt Herkner ◽

...

Keyword(s):

Venous Thromboembolism ◽

Thrombin Generation ◽

Oral Anticoagulant Therapy ◽

Oral Anticoagulants ◽

Control Group ◽

Prothrombin Fragment ◽

Hemostatic System ◽

Significant Difference ◽

System Activation ◽

One Year

SummaryIncreased thrombin generation occurs in many individuals with inherited defects in the antithrombin or protein C anticoagulant pathways and is also seen in patients with thrombosis without a defined clotting abnormality. Hyperhomocysteinemia (H-HC) is an important risk factor of venous thromboembolism (VTE). We prospectively followed 48 patients with H-HC (median age 62 years, range 26-83; 18 males) and 183 patients (median age 50 years, range 18-85; 83 males) without H-HC for a period of up to one year. Prothrombin fragment Fl+2 (Fl+2) was determined in the patient’s plasma as a measure of thrombin generation during and at several time points after discontinuation of secondary thromboprophylaxis with oral anticoagulants. While on anticoagulants, patients with H-HC had significantly higher Fl+2 levels than patients without H-HC (mean 0.52 ± 0.49 nmol/1, median 0.4, range 0.2-2.8, versus 0.36 ± 0.2 nmol/1, median 0.3, range 0.1-2.1; p = 0.02). Three weeks and 3,6,9 and 12 months after discontinuation of oral anticoagulants, up to 20% of the patients with H-HC and 5 to 6% without H-HC had higher Fl+2 levels than a corresponding age- and sex-matched control group. 16% of the patients with H-HC and 4% of the patients without H-HC had either Fl+2 levels above the upper limit of normal controls at least at 2 occasions or (an) elevated Fl+2 level(s) followed by recurrent VTE. No statistical significant difference in the Fl+2 levels was seen between patients with and without H-HC. We conclude that a permanent hemostatic system activation is detectable in a proportion of patients with H-HC after discontinuation of oral anticoagulant therapy following VTE. Furthermore, secondary thromboprophylaxis with conventional doses of oral anticoagulants may not be sufficient to suppress hemostatic system activation in patients with H-HC.

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Viscosity and Red Cell Deformity in Arterial Disease

10.1055/s-0038-1665789 ◽

1979 ◽

Author(s):

G Cella ◽

H de Haas ◽

M Rampling ◽

V Kakkar

Keyword(s):

Vascular Disease ◽

Blood Viscosity ◽

Whole Blood ◽

Arterial Disease ◽

Plasma Viscosity ◽

Control Group ◽

Fibrinogen Concentration ◽

Red Cell ◽

Whole Blood Viscosity ◽

Significant Difference

Haemorrheological factors have been shown to be affected in many kings of vascular disease. The present study was undertaken to correlate these factors in normal subjects and patients suffering from peripheral arterial disease. Twenty-two patients were investigated; they had moderate or severe intermittent claudication, extent of disease being confirmed by aorto-arteriography and ankle-systolic pressure studies. Twenty-five controls with no symptoms or signs of arterial disease were selected with comparable age and sex distribution. Whole blood viscosity was measured at shear rates of 230 secs-1 and 23 secs-lat 37°c using a Wells Brookfield cone plate microvisco meter. Plasma viscosity was also measured in an identical manner. Erythrocyte flexibility was measured by centrifuge technique and fibrinogen concentration as well as haematocrit by standard techniques. The fibrinogen concentration appeared to be the only significant parameter; the mean concentration in patients with peripheral vascular disease of 463 ± 73mg/l00ml in the control group ( < 0.05). Although whole blood viscosity was high in patients, when corrected to a common haematocrit, there was no significant difference between patients and controls. The same megative correlation was found for plasma viscosity. The red cell flexibility was found to be increased in patients as compared to the control group, but this effect appeared to be simply proportional to the fibrinogen concentration.

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