scholarly journals Implementation of Evidence-Based Cervical Ripening Protocol: Outcomes and Next Steps

2020 ◽  
Vol 10 (04) ◽  
pp. e408-e412
Author(s):  
Arthurine Zakama ◽  
Nasim C. Sobhani ◽  
Robyn Lamar ◽  
Melissa G. Rosenstein
Keyword(s):  
Cesarean Delivery ◽  
Vaginal Delivery ◽  
San Francisco ◽  
Management Practices ◽  
Low Dose ◽  
Cervical Ripening ◽  
Evidence Based ◽  
Nulliparous Women ◽  
Before And After ◽  
Time To Delivery

Abstract Objective A prominent randomized controlled trial demonstrated that low-dose misoprostol with the concurrent cervical Foley shortened the median time to delivery when compared with either method alone. Our study aims to address implementation of this protocol and evaluate its impact on time to delivery. Study Design This was a retrospective before-and-after study of nulliparous women who delivered nonanomalous, term, singletons at the University of California San Francisco (UCSF) in two separate 2-year periods before and after changes in UCSF's cervical ripening protocol. The primary outcome was time from first misoprostol dose to delivery. Results A total of 1,496 women met inclusion criteria, with 698 in the preimplementation group and 798 in the postimplementation group. There were no statistically significant differences in time to delivery (29 vs. 30 hours, p = 0.69), rate of cesarean delivery (30 vs. 26%, p = 0.09), or cesarean delivery for fetal indications (11 vs. 8%, p = 0.15) between the groups. Conclusion Implementing evidence-based low-dose misoprostol with the concurrent cervical Foley did not change the time to delivery, time to vaginal-delivery, or likelihood of vaginal delivery in our population. This may be due to differences in labor management practices and incomplete fidelity to the protocol. Real-world effectiveness of these interventions will vary and should be considered when choosing an induction method.

scholarly journals Clinical predictive factors for vaginal delivery following induction of labour among pregnant women in Jordan

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Rawan A. Obeidat ◽  
Mahmoud Almaaitah ◽  
Abeer Ben-Sadon ◽  
Dina Istaiti ◽  
Hasan Rawashdeh ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Pregnant Women ◽  
Cesarean Delivery ◽  
Vaginal Delivery ◽  
Induction Of Labour ◽  
Labour Induction ◽  
Bishop Score ◽  
Nulliparous Women ◽  
Multiparous Women ◽  
The Mean

Abstract Background Induction of labour (IOL) is an important and common clinical procedure in obstetrics. In the current study, we evaluate predictors of vaginal delivery in both nulliparous and multiparous women in north Jordan who were induced with vaginal prostaglandins. Method A prospective study was conducted on 530 pregnant women at King Abdullah University Hospital (KAUH) in north Jordan. All pregnant mothers with singleton live fetuses, who had induction of labour (IOL) between July 2017 and June 2019, were included in the study. Mode of delivery, whether vaginal or caesarean, was the primary outcome. Several maternal and fetal variables were investigated. The safety and benefit of repeated dosage of vaginal prostaglandin E2 (PGE2) tablets, neonatal outcomes and factors that affect duration of labour were also evaluated. Pearson χ2 test was used to investigate the significance of association between categorical variables, while student’s t-test and ANOVA were applied to examine the mean differences between categorical and numerical variables. Linear regression analysis was utilized to study the relation between two continuous variables. A multivariate regression analysis was then performed. Significance level was considered at alpha less than 0.05. Results Nulliparous women (N = 254) had significantly higher cesarean delivery rate (58.7% vs. 17.8%, p < 0.001) and longer duration of labour (16.1 ± 0.74 h vs. 11.0 ± 0.43 h, p < 0.001) than multiparous women (N = 276). In nulliparous women, the rate of vaginal delivery was significantly higher in women with higher Bishop score; the mean Bishop score was 3.47 ± 0.12 in nulliparous women who had vaginal delivery vs. 3.06 ± 0.10 in women who had cesarean delivery (Adjusted odds ratio (AOR) = 1.2, 95% CI: 1.03–1.28, p = 0.03). In multiparous women, the rate of vaginal delivery was significantly higher in women with higher Bishop scores and lower in women with higher body mass index (BMI). The mean Bishop score was 3.97 ± 0.07 in multiparous women who had vaginal delivery vs. 3.56 ± 0.16 in women who had cesarean delivery (AOR = 1.5, 95% CI: 1.1–2.1, p = 0.01). The mean BMI was 30.24 ± 0.28 kg/m2 in multiparous women who had vaginal delivery vs. 32.36 ± 0.73 kg/m2 in women who had cesarean delivery (AOR = 0.89, 95% CI: 0.84–0.96, p = 0.005). 27% of nulliparous women who received more than two PGE2 tablets and 50% of multiparous women who received more than two PGE2 tablets had vaginal delivery with no significant increase in neonatal morbidity. Conclusion Parity and cervical status are the main predictors of successful labour induction. Further studies are required to investigate the benefit of the use of additional doses of vaginal PGE2 above the recommended dose for IOL.

Effectiveness of Sequential Low Dose Oral Misoprostol Solution for Induction of Labor: An Experience in a Thai Quaternary Hospital

2021 ◽  
Vol 104 (4) ◽  
pp. 645-653
Keyword(s):  
Birth Weight ◽  
Cesarean Section ◽  
Vaginal Delivery ◽  
Pregnancy Outcomes ◽  
Associated Factors ◽  
Low Dose ◽  
Labor Induction ◽  
Cervical Ripening ◽  
Bishop Score ◽  
Oral Misoprostol

Background: Siriraj Hospital has seen remarkably high cesarean section rates during the last decade. A labor induction protocol has been established to reduce cesarean section rate from “failed induction”. Objective: To determine effectiveness of a sequential low dose misoprostol solution protocol for labor induction. Cervical ripening and vaginal delivery rates, pregnancy outcomes, and associated factors of successful vaginal delivery were determined. Materials and Methods: The present study was a retrospective observational study. Medical records of women with a term singleton pregnancy and with Bishop score of 6 or less who underwent labor induction were reviewed. The induction protocol started with series 1 which was 25 mL oral misoprostol solution (1 mcg/mL) every two hours for a maximum of 24 hours. If Bishop score was 6 or less by the end of series 1, then series 2 would follow, comprising 50 mL oral misoprostol solution (1 mcg/mL) every four hours for a maximum of 24 hours. Data of Bishop scores, delivery route by the end of each series, pregnancy outcomes, and possible associated factors were collected. Results: One hundred twenty-eight women were analyzed. The overall rate of cervical ripening, with a Bishop score of more than 6, was 92.2%, and at 88.3% with series 1 only. Successful vaginal delivery was achieved in 70 cases (54.7%), 53 of whom were delivered within 24 hours. Significantly associated factors with successful vaginal delivery were multiparity, and birth weight of 3,200 grams or less; adjusted OR 4.0 (95% CI 1.31 to 12.16, p=0.015) and 3.4 (95% CI 1.48 to 7.63, p=0.004), respectively. No serious adverse pregnancy outcomes were observed. Conclusion: With Siriraj induction protocol, success rates of cervical ripening and vaginal delivery were 92.2% and 54.7%, respectively, without serious adverse outcomes. Significant associated factors of successful vaginal delivery were multiparity and birth weight of 3,200 grams or less. Keywords: Oral misoprostol, Misoprostol solution, Low dose, Labor induction, Cervical ripenting, Vaginal delivery

Cesarean delivery among women with prolonged labor induction

2016 ◽  
Vol 44 (7) ◽  
Author(s):  
Louise L. Highley ◽  
Rebecca A. Previs ◽  
Sarah K. Dotters-Katz ◽  
Leo R. Brancazio ◽  
Chad A. Grotegut
Keyword(s):  
Cesarean Delivery ◽  
Vaginal Delivery ◽  
Mode Of Delivery ◽  
Labor Induction ◽  
University Hospital ◽  
Delivery Rate ◽  
Multivariate Logistic Regression Model ◽  
Nulliparous Women ◽  
Prolonged Labor ◽  
Cesarean Delivery Rate

AbstractObjective:The objective of this study was to determine characteristics associated with cesarean delivery among women with labor induction lasting over 24 h.Study design:Women with live singleton pregnancies without prior cesarean delivery undergoing a labor induction lasting >24 h between September 2006 and March 2009 at Duke University Hospital were identified. Collected variables were compared between subjects by mode of delivery. A multivariate logistic regression model for the outcome cesarean delivery was constructed separately for nulliparous and parous women.Results:There were 303 women who met inclusion criteria. The overall cesarean delivery rate was 57% (n=172) and remained constant with time (P=0.15, test-for-trend). Nulliparous women having a cesarean delivery were more likely to be obese [adjusted OR (aOR) 2.00; 95% CI 1.05, 3.80] and have a larger fetus [aOR 1.11 (aOR for every 100 g increase in birthweight), 95% CI 1.03, 1.20] compared to those having a vaginal delivery.Conclusion:Increasing BMI and birthweight were independent predictors of cesarean delivery among nulliparous women with prolonged labor induction. Despite this, after 24 h of labor induction, the overall mean cesarean delivery rate remained constant at 57%, and did not change with time. Among women having a vaginal delivery following a prolonged labor induction, we saw high rates of shoulder dystocia, operative vaginal delivery and severe perineal laceration.

scholarly journals Recovery after Nulliparous Birth

2017 ◽  
Vol 127 (4) ◽  
pp. 684-694 ◽  
Author(s):  
Ryu Komatsu ◽  
Brendan Carvalho ◽  
Pamela D. Flood
Keyword(s):  
Cesarean Delivery ◽  
Vaginal Delivery ◽  
Functional Recovery ◽  
Rating Scale ◽  
Area Under The Curve ◽  
The United States ◽  
Opioid Use ◽  
Pain Experience ◽  
Nulliparous Women ◽  
Time Required

Abstract Background The majority of parturients in the United States first return for evaluation by their obstetric practitioner 6 weeks after delivery. As such, there is little granular data on the pain experience, analgesic requirements, and functional recovery during the postpartum period. This prospective observational study was performed to evaluate these factors to provide expectations for patients. Methods A total of 213 nulliparous women were enrolled and assessed daily until they completed 3 outcomes: (1) pain resolution; (2) opioid cessation; and (3) self-assessed functional recovery from delivery. The primary endpoint, pain- and opioid-free functional recovery, was the time required to reach all three of the endpoints. Pain burden was assessed as the area under the curve created by plotting the daily numerical pain rating scale against the days required to attain pain resolution. Times to attain study endpoints after cesarean delivery and vaginal delivery were compared using survival analysis. Results After vaginal delivery, days required for pain and opioid-free functional recovery (median [interquartile range (IQR)]) were 19 [11 to 26], for opioid cessation 0 [0 to 2], termination of all analgesic (including nonsteroidal antiinflammatories and acetaminophen) 11 [5 to 17], and pain resolution 14 [7 to 24]. Achievement of these endpoints after cesarean delivery required 27 [19 to 40], 9 [5 to 12], 16 [11 to 24], and 21 [14 to 27] days, respectively. Conclusions There is clinically significant variability between healthy nulliparous parturients in the pain experience, opioid use, and functional recovery after childbirth following vaginal and cesarean delivery. Recovery to predelivery function is similar after vaginal and cesarean delivery, and approximately half of the variance was explained by pain burden.

Association between Maternal Serum Hormones along the Maternal–Fetal Hypothalamic–Pituitary–Adrenal Axis and Successful Vaginal Delivery Measured Prior to Labor Induction

2020 ◽  
Vol 37 (12) ◽  
pp. 1195-1200
Author(s):  
Chase R. Cawyer ◽  
Elena Lobashevksy ◽  
Glenda Corley-Topham ◽  
Sarah Anderson ◽  
John Owen ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Cesarean Delivery ◽  
Vaginal Delivery ◽  
Hpa Axis ◽  
Maternal Serum ◽  
Labor Induction ◽  
Vaginal Birth ◽  
Serum Hormones ◽  
Hypothalamic Pituitary Adrenal ◽  
Nulliparous Women

Abstract Objective This study aimed to evaluate if maternal serum hormones along the maternal–fetal hypothalamic–pituitary–adrenal (HPA) axis, when drawn prior to labor induction, differed between women who delivered vaginally and those who underwent cesarean. Study Design This was a prospective observational study at a single perinatal center performed from August 2017 to May 2018. Nulliparous women with uncomplicated singleton pregnancies ≥39 weeks had maternal serum collected prior to induction. Corticotrophin-releasing hormone (CRH) was measured by ELISA; dehydroepiandrosterone sulfate (DHEA-S), cortisol, estriol (E3) estradiol (E2), and progesterone (P4) were measured by chemiluminescent reaction. Mean analyte concentrations as well as three ratios (E2/P4, E3/P4, and E2/E3) were compared between women who had a vaginal versus cesarean delivery. Logistic regression was used to model the relationship between CRH and the odds of vaginal birth. We estimated that a sample size of 66 would have 90% power to detect a 25% difference in mean CRH levels assuming a vaginal:cesarean ratio of 2:1 with a baseline CRH concentration of 140 (standard deviation = 36) pg/mL. Results Of the 88 women who had their serum analyzed, 27 (31%) underwent cesarean. Mean maternal serum CRH levels were similar between the vaginal delivery and cesarean groups (122.6 ± 95.2 vs. 112.3 ± 142.4, p = 0.73). Similarly, there were no significant differences in any other maternal serum analytes or ratios. Logistic regression showed a nonsignificant odds ratio for successful vaginal birth (p = 0.69) even when evaluating only the 16 women who had a cesarean for an arrest disorder (p = 0.08). Conclusion In low-risk nulliparous women undergoing full-term labor induction, there were no differences noted in a broad array of other maternal-fetal HPA-axis hormones between women who had a vaginal or cesarean delivery.

Controlled Release Dinoprostone Insert and Foley Compared to Foley Alone: A Randomized Pilot Trial

2020 ◽  
Author(s):  
Rodney K. Edwards ◽  
Michelle L. Norris ◽  
Mitchell D. West ◽  
Christina Zornes ◽  
Katherine A. Loeffler ◽  
...  
Keyword(s):  
Vaginal Delivery ◽  
Controlled Trial ◽  
Foley Catheter ◽  
Pilot Trial ◽  
Cervical Ripening ◽  
Open Label ◽  
Cumulative Incidence Functions ◽  
Uterine Incision ◽  
Nulliparous Women ◽  
Incidence Functions

Abstract Objective The aim of study is to compare, in a pilot study, combined dinoprostone vaginal insert and Foley catheter (DVI + Foley) with Foley alone (Foley) for cervical ripening and labor induction at term. Study Design In this open-label pilot randomized controlled trial, women not in labor, with intact membranes, no prior uterine incision, an unfavorable cervix, gestational age ≥37 weeks, and a live, nonanomalous singleton fetus in cephalic presentation were randomly assigned, stratified by parity, to DVI + Foley or Foley. Oxytocin was used in both groups after cervical ripening. Primary outcome was time to vaginal delivery. Results From April 2017 to January 2018, 100 women were randomized. Median (25–75th percentile) time to vaginal delivery for nulliparous women was 21.2 (16.6–38.0) hours with DVI + Foley (n = 26) compared with 31.3 (23.3–46.9) hours with Foley (n = 24) (Wilcoxon p = 0.05). Median time to vaginal delivery for parous women was 17.1 (13.6–21.9) hours with DVI + Foley (n = 25) compared with 14.8 (12.7–19.5) hours with Foley (n = 25) (Wilcoxon p = 0.21). Results were also analyzed to consider the competing risk of cesarean using cumulative incidence functions. Conclusion Compared with Foley alone, combined use of the dinoprostone vaginal insert and Foley for cervical ripening may shorten time to vaginal delivery for nulliparous but not parous women.

The Association between Cervical Exam after Ripening with Foley Balloon Catheter and Outcomes of Nulliparous Labor Induction

2018 ◽  
Vol 35 (10) ◽  
pp. 1001-1005 ◽  
Author(s):  
Anna Palatnik ◽  
Danielle Peress ◽  
William Grobman ◽  
Ashley Battarbee
Keyword(s):  
Confidence Interval ◽  
Vaginal Delivery ◽  
Foley Catheter ◽  
Multivariable Analysis ◽  
Balloon Catheter ◽  
Labor Induction ◽  
Cervical Ripening ◽  
Bishop Score ◽  
Labor Duration ◽  
Nulliparous Women

Objective Evaluate the association between cervical examination after ripening with Foley catheter and labor induction outcomes. Materials and Methods In this retrospective cohort, nulliparous women with singleton, viable gestation undergoing cervical ripening with Foley catheter were compared based on cervical status after catheter removal or expulsion: favorable (modified Bishop score ≥ 5) or unfavorable (score < 5). Bivariable and multivariable analyses were performed to determine whether cervical examination postripening was associated with time to delivery and chance of vaginal delivery. Results A total of 774 women were eligible. Women with favorable examination postripening had lower body mass index (BMI) and more favorable admission cervical examination. The frequency of vaginal delivery was higher in women with favorable cervical examination postripening (57.9% versus 46.8%, p < 0.01). Median durations from Foley removal or expulsion to complete dilation (8.6 h versus 11.5 h) and vaginal delivery (10.4 h versus 13.2 h) were shorter for women with favorable cervical examination postripening (p < 0.001). In multivariable analysis, favorable examination postripening remained associated with vaginal delivery (adjusted odds ratio 1.39, 95% confidence interval 1.04–1.87), and time to vaginal delivery (adjusted hazard ratio 1.39, 95% confidence interval 1.13–1.70). Conclusion A favorable modified Bishop score after cervical ripening with Foley balloon catheter is associated with higher chance of vaginal delivery and shorter labor duration.

Use of translabial three-dimensional power Doppler ultrasound for cervical assessment before labor induction

2017 ◽  
Vol 45 (5) ◽  
Author(s):  
Sertac Esin ◽  
Bulent Yirci ◽  
Serdar Yalvac ◽  
Omer Kandemir
Keyword(s):  
Cesarean Delivery ◽  
Vaginal Delivery ◽  
Power Doppler ◽  
Three Dimensional ◽  
Cervical Length ◽  
Cervical Ripening ◽  
Flow Index ◽  
Bishop Score ◽  
Power Doppler Ultrasound ◽  
Failure To Progress

AbstractObjective:To compare translabial three-dimensional (3D) power Doppler ultrasound with Bishop score and transvaginal ultrasound measurements for cervical assessment before induction of labor with dinoprostone or cervical ripening balloon.Materials and methods:Translabial cervical volume and length, vascularization indices and transvaginal cervical length were measured. Results were compared among women who had vaginal delivery at 24 h or less and more than 24 h after the insertion of the dinoprostone vaginal insert or cervical ripening balloon and among women who had vaginal delivery and cesarean delivery for failure to go into labor or failure to progress.Results:There was no correlation between the time to delivery after a ripening agent was applied and translabial cervical volume, translabial cervical length, vascularization index (VI), flow index (FI), vascularization flow index (VFI), transvaginal cervical length and Bishop scores. The ultrasonographic measurements were no different among women who had vaginal delivery at 24 h or less and more than 24 h and among women who had vaginal delivery and cesarean delivery for failure to go into labor or failure to progress.Conclusion:In this study, we failed to demonstrate the superiority of translabial 3D ultrasonography over Bishop score and transvaginal ultrasonography for predicting the success of induction of labor.

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