Relation between Maternal and Neonatal Serum Lipid Profile and Their Impact on Birth Weight

2020 ◽  
Author(s):  
Tamer A. Abdel-Hamid ◽  
Dalia AbdelLatif ◽  
Eman Ahmed ◽  
Mazen Abdel-Rasheed ◽  
Ahmed A-Mageed
Keyword(s):  
Birth Weight ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Gestational Age ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Maternal Serum ◽  
Serum Lipid Profile ◽  
Maternal Malnutrition

Objective Maternal malnutrition with disturbed lipid metabolism during pregnancy may affect the fetal lipid profile. We aimed to detect the relation between maternal and neonatal serum lipid profile, as well as to detect the serum lipid profile difference between small for gestational age (SGA) infants and appropriate for gestational age (AGA) infants to disclose the impact of maternal malnutrition on birth weight. Study Design A cross-sectional study was conducted on 150 pregnant women coming to the labor room. Before delivery, maternal serum levels of high-density lipoprotein (HDL), low density lipoprotein (LDL), triglycerides (TGs), and total cholesterol were assessed, then after delivery, cord blood samples were taken for assessment of the neonatal lipid profile. Birth weights were measured, then the neonates were divided into SGA and AGA groups. Results Serum levels of LDL, TGs, and total cholesterol in the SGA infants were lower than that in the AGA infants. A positive correlation between maternal and neonatal serum TGs levels was found. Besides, there was a positive correlation between birth weight and maternal serum levels of LDL, TGs, and total cholesterol. Conclusion Maternal serum lipid profile could be an indicator of the neonatal serum lipid profile and birth weight. Key Points

scholarly journals A Study of Serum Lipid Profile Changes in Children with Dengue Haemorrhagic Fever and its Correlation with Severity in a Tertiary Care Hospital

2020 ◽  
Author(s):  
A Prabhuraj ◽  
KS Kumaravel ◽  
V Anu Rekha ◽  
A Nithiyapriya ◽  
P Sampathkumar ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Pearson Correlation ◽  
Statistical Significance ◽  
Density Lipoprotein ◽  
Serum Levels ◽  
Denv Infection ◽  
Lipid Levels ◽  
Serum Lipid Levels

Introduction: Dengue Virus (DENV) infection now remains as the most rapidly spreading viral disease worldwide. Lower lipid level occurs in critically ill patients with DENV infection and is postulated as an independent predictor of the clinical outcome. Aim: To find the correlation between serum lipid levels and severity in children admitted with various grades of Dengue Haemorrhagic Fever (DHF) and secondarily to correlate serum lipid levels with factors like platelet count and duration of hospital stay. Materials and Methods: This was a prospective descriptive study done in the Paediatric ward from October 2019 to December 2019. Febrile Children with a platelet count of less than 1 lakh/cu.mm and positive for DENV IgM antibodies by Enzyme Linked Immuno Sorbent Assay (ELISA) formed the study group. Demographic details, number of days of fever on admission, duration of stay in hospital and severity grading of DENV infection as per the National guidelines were collected. These children were evaluated with Complete Blood Counts (CBC), fasting lipid profile, X-ray chest and ultrasound abdomen. Mean and standard deviation was used for categorical variables. Chi-square test was used to assess the strength of association between lipids and severity of DENV infections. Pearson correlation coefficient was used to assess R value between length of stay and serum lipid levels. Results: The Total Cholesterol, Low Density Lipoprotein (LDL), Triglyceride and Very Low Density Lipoprotein (VLDL) showed a simple linear decline as the severity grade advanced from grade I to grade IV. However, statistical significance was found only for total cholesterol and LDL with p-values of 0.046 and 0.041 respectively. The distribution of High Density Lipoprotein (HDL) across the grades of severity did not follow any pattern and was randomly distributed. On analysis of Pearson correlation between number of days of hospital stay and lipid profile, statistical significance was observed for LDL alone (p=0.023). Conclusion: The serum levels of total cholesterol and LDL were significantly reduced in severe grades of DHF. Serum levels of total cholesterol and LDL can be used as an economical surrogate marker to predict the severity of DHF at the time of admission.

scholarly journals EFFECT OF TAMOXIFEN ON FASTING SERUM LIPID PROFILE IN BREAST CANCER PATIENTS

2021 ◽  
Vol 9 (01) ◽  
pp. 1013-1018
Author(s):  
Anum Khan ◽  
Fauzia Abdus Samad ◽  
Abdus Samad Syed ◽  
Asif Riaz ◽  
Sharmin Arif ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Mammary Epithelium ◽  
Serum Lipid Profile ◽  
P Value ◽  
Breast Cancer Patients ◽  
Fasting Serum

Background:Tamoxifen acts as a selective estrogen receptor modulator by binding to the estrogenreceptors on mammary epithelium andblockingtheproliferative action of estrogen on mammaryepithelium. In contrast to that it has a weak estrogen agonistic effect on bone, liver and endometrium.Tamoxifen therapy has favorable effects on serum lipid profile by decreasing serum levels of Total cholesterol and low density lipoprotein (LDL), while its effect on high density lipoprotein (HDL) and triglyceride (TG)is still controversial. So this study is to evaluate the effects of tamoxifenTherapy on fasting serum lipid profile in patients with breast cancer. Results: Mean age was 43.56±3.53yrs , most common BMI was 30-34.9. Patient serum TG levels were raised from baseline after 3 months of tamoxifen with p values of (0.000) which was statistically significant while HDL levels were raised but with p value of (0.008 ) which was statistically insignificant. Serum LDL and total cholesterol were reduced from baseline after 3 month with p value of (0.000) and (0.000) respectively. Conclusion: This study concludes that tamoxifen has effects on serum lipid profile by increasing TG levels and lowering TC and LDL levels so this should be in consideration while prescribing tamoxifen to the patients having other risk factors for cardiovascular abnormalities.

scholarly journals Serum Lipid Profile of Hypertensive Patients in the Northern Region of Bangladesh

1970 ◽  
Vol 14 ◽  
pp. 93-98 ◽  
Author(s):  
MS Saha ◽  
NK Sana ◽  
Ranajit Kumar Shaha
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Northern Region ◽  
Serum Lipid Profile ◽  
Hypertensive Patients ◽  
Control Subjects

A prospective study was conducted in the Northern region of Bangladesh, to investigate the serum lipid profile viz the level of total cholesterol (TC), Triglyceride (TG), HDL-cholesterol and LDL-cholesterol of hypertensive patients and compares them with levels of control subjects. The results revealed that serum total cholesterol, triglyceride and LDL-cholesterol were significantly markedly raised (p>0.001) whereas the level of HDL-cholesterol was significantly lower (p>0.001) in hypertensive patients as compared to control subjects. No significant changes of serum lipid profile were found between male and female hypertensive patients, but in control subjects, markedly higher levels of serum lipid profile was observed in male compared to that of female. It was concluded that hypercholesterolaemia, hypertrigyceridaemia and low density lipoprotein are the main lipid abnormalities on the incidence of hypertension in the study area. Key words: Hypertension, Total cholesterol (TC), triglyceride (TG), HDL- cholesterol and LDL-cholesterol. J. bio-sci. 14: 93-98, 2006

scholarly journals Effect of Tree Nuts Consumption on Serum Lipid Profile in Hyperlipidemic Individuals: A Systematic Review

2020 ◽  
Vol 13 ◽  
pp. 117863882092652
Author(s):  
Mohammad Altamimi ◽  
Souzan Zidan ◽  
Manal Badrasawi
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Serum Lipid Profile ◽  
Controlled Clinical Trials ◽  
Tree Nuts

Many epidemiological studies have regularly connected nuts intake with decreased risk for coronary heart disease. The primary mechanism by which nuts protect against cardiovascular disease is through the improvement of lipid and apolipoprotein profile. Therefore, numerous dietary intervention studies investigated the impact of nut consumption on blood lipid levels. Many studies have shown that nut intake can enhance the lipid profile in a dose-response way among individuals with increased serum lipids. This systematic review examines the effectiveness of nuts on the lipid profile among patients with dyslipidemia from different age groups. A total of 29 interventional studies from 5 databases met the inclusion criteria. In all, 20 studies were randomized controlled clinical trials, whereas 9 were crossover-controlled clinical trials. Participants included in the studies were different in terms of age, sex and, serum lipid profile. The studies were inconsistent in the type of tree nuts, duration, dose, and the nut forms. All studies indicated changes in the lipid profile after the intervention particularly on the total cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides, total cholesterol/high-density lipoprotein. Interventional periods ranged from 3 weeks up to 12 months with doses ranged from 15 to 126 gm. In conclusion, this review provides an evidence of favorable effect of nuts consumption of serum lipid profile.

scholarly journals Serum lipid profile of broilers fed diets with inclusion of mango waste meal

2016 ◽  
Vol 37 (5) ◽  
pp. 3327 ◽  
Author(s):  
Patrícia Aparecida Fontes Vieira ◽  
Christiane Silva Souza ◽  
Anderson De Almeida Barbosa ◽  
Heder José D’Ávila Lima ◽  
Edimar Aparecida Filomeno Fontes ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Serum Lipid Profile ◽  
Albumin Concentration ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

We evaluated the effect of including 2.5, 5.0, 7.5 and 10.0% mango waste meal (MWM) variety UBA in corn and soybean meal-based diet son the serum lipid profile of broilers. The experimental design was completely randomized, with five treatments and six replicates with 20 birds per experimental unit. Concentrations of creatinine, albumin, total protein, total cholesterol, triacylglycerols (TAG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and very-low-density lipoprotein cholesterol (VLDL-C), were evaluated at the ages of 14, 28 and 42 days, with 30 birds evaluated per age. At 14 days, there was no difference serum creatinine, total cholesterol, HDL, triacylglycerols, total proteins or VLDL-C concentrations as compared with control. Albumin concentration was the highest at the MWM inclusion levels of 5.0, 7.5 and 10.0%. At 28 days, triacylglycerols, VLDL-C and LDL-C were the lowestat 7.5% inclusion whereas at 42 days, these same variables were the lowest with addition of 10.0% meal. At 14, 28 and 42 days of age, the VLDL-C, LDL-C and total TAG contents were found to decrease at mango waste meal inclusion levels of 5.0 and 7.5% in the diets, which maybe considered an indicator of improvements in the metabolic conditions of broilers.

scholarly journals Evaluation of Predictor like Maternal Serum Lipid Profile in 2nd Trimester in Pregnancy Related Hypertensive Disorders

2021 ◽  
pp. 195-201
Author(s):  
Arpita Jaiswal ◽  
Dhruva Halani
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Clinical Symptoms ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Maternal Serum ◽  
Lipoprotein Cholesterol ◽  
Serum Lipid Profile ◽  
Hypertensive Disorders ◽  
In Pregnancy

Background: The most leading cause of perinatal and maternal deaths and morbidity in developed and developing countries like India is pregnancy related hypertensive disorders especially pre-eclampsia. PIH is defined as; in previously normotensive and normoproteinuric women, hypertension of >_ 140/90 mmHg with or without proteinuria measured on two occasions 6 hours apart after gestational age (20 weeks).Women with pregnancy related hypertensive disorders experience varied and altered lipid changes.    Increased TG, low-density lipoprotein cholesterol (LDL-C), cholesterol and decreased high-density lipoprotein cholesterol (HDL-C) concentrations leading to dyslipidemia was found in majority of the studies. Aim: The study aims to evaluate predictor like maternal sr. lipid profile in 2nd trimester in pregnancy related hypertensive disorders. Objective: To evaluate the occurrence of normal maternal and altered maternal serum lipid profile serum lipid profile in 2nd trimester of pregnancy in pregnancy related hypertensive disorders and compare them . Materials and Methods: The design of the study will be prospective as well as observational conducted from September 2020 to august 2022 with an estimated sample size of 1000. Patients included were nnormotensive and non-proteinuric in second trimester (13-20 weeks of gestation). Subjects will be evaluated on the basis of preformed and pretested proforma consisting of history, clinical symptoms and presentation and investigations. Blood samples for serum lipid profile will be collected in plain bulb with aseptic conditions and analyzed at the biochemistry laboratory by enzymatic method. Expected Results: We expect that from our results, altered maternal serum lipid profile in 2nd trimester will be positively associated with pregnancy related hypertensive disorders.

scholarly journals Study of maternal serum lipid profile and apolipoprotein a levels and its correlation with fetal growth restriction

2019 ◽  
Vol 9 (1) ◽  
pp. 270
Author(s):  
Akoijam Tamphasana Devi ◽  
Reena Yadav ◽  
Amita Yadav ◽  
Yanglem Ajitkumar Singh
Keyword(s):  
Pregnant Women ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Ldl Cholesterol ◽  
Maternal Serum ◽  
Serum Lipid Profile ◽  
Total Serum ◽  
Apolipoprotein A ◽  
Vldl Cholesterol

Background: This study was aimed to estimate maternal serum lipid profile and apolipoprotein A levels in pregnancies complicated with FGR and to compare the levels with the levels in normal pregnancies.Methods: A prospective observational study was conducted in Lady Hardinge Medical College, New Delhi, in a study group consisting of 30 pregnant women at gestation 32-34 weeks with ultrasound diagnosed FGR and control group consisting of 30 age and gestation matched uncomplicated pregnant women. Maternal serum lipid profile and apolipoprotein A levels were measured and compared between the two groups.Results: Total serum cholesterol, triglyceride, LDL-cholesterol, VLDL-cholesterol and Apolipoprotein A were significantly lower in FGR group compared to normal controls. Mean±SD of total cholesterol was found to be 199.17±49.06 mg/dl in cases and 244.10±53.17 mg/dl in controls. Mean±SD of triglyceride was 200.53±60.25 mg/dl in cases compared to 304.13±69.12 mg/dl in controls. Mean±SD of LDL-Cholesterol was 98.19±37.91 mg/dl in cases and 127.07±47.84 mg/dl in controls. Mean±SD of VLDL-cholesterol was 40.11±12.05 mg/dl in cases and 60.83±13.82 mg/dl in controls. Mean±SD of Apolipoprotein A was 147.71±16.40 mg/dl in cases compared to 163.30±16.07 mg/dl in controls. HDL-cholesterol did not change significantly as its mean±SD was 60.87±15.18 mg/dl in FGR group and 56.20±16.07 mg/dl in control group.Conclusions: The decreased levels of total cholesterol, triglyceride, LDL-cholesterol, VLDL-cholesterol and apolipoprotein A levels may be used as biochemical marker for detection of FGR.

scholarly journals The Influence of Chronic Helicobacter Pylori Infection on some Serum Lipid Profile Parameters, Apolipoproteins A-I and B and Lp(a) Lipoprotein

2009 ◽  
Vol 28 (1) ◽  
pp. 22-29
Author(s):  
Sunčica Kojić-Damjanov ◽  
Mirjana Đerić ◽  
Nevena Eremić ◽  
Velibor Čabarkapa
Keyword(s):  
Helicobacter Pylori ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Serum Levels ◽  
Serum Lipid Profile ◽  
Apo B ◽  
Lipid Parameters

The Influence of Chronic Helicobacter Pylori Infection on some Serum Lipid Profile Parameters, Apolipoproteins A-I and B and Lp(a) Lipoprotein Data on proatherogenic lipid profile alterations due to chronic Helicobacter pylori (HP) infection are contradictory. Aim of this study was to examine the differences in some lipid parameters between 55 subjects of both gender with a chronic HP infection (IgG>50 U/mL and IgA <20 U/mL) and 55 gender matched HP seronegative subjects (IgG and IgA <20 U/mL). Total cholesterol (TC) (p<0.001), triglycerides (TG) (p<0.05), LDL-cholesterol (LDL-C) (p<0.02), non-HDL-cholesterol (non-HDL-C), apolipoprotein (apo) B (p<0.001), Lp(a) and HDL-cholesterol (HDL-C) serum levels were higher in HP seropositive than in seronegative subjects, while there were almost no differences in apo A-I. In HP seropositive subjects, the frequency of pathological TC (p<0.001), TG (p<0.05), LDL-C (p<0.01), non-HDL-C (p<0.01), apo B (p<0.02) and Lp(a) serum levels was higher compared to seronegative. Serum HP IgG titers correlated negatively with TC, LDL-C (p<0.05), non-HDL-C, apo B and Lp(a) levels, and positively with TG, HDL-C and apo A-I levels. Results are similar for both genders. Our results confirm the hypothesis that a chronic HP infection could modify the lipid profile in a proatherogenic way.

scholarly journals Association between Serum Lipid Profile and Glycated Hemoglobin in Middle Aged Pre-Diabetic Individuals: The Bangladesh Study

2017 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Glycated Hemoglobin ◽  
Density Lipoprotein ◽  
Serum Lipid Profile ◽  
Middle Aged ◽  
Significant Difference

Diabetes Mellitus is one of the leading non-communicable diseases all over the world including Bangladesh. Diabetes is often preceded by a prodromal condition termed pre-diabetes. Pre-diabetes is a condition in which the blood glucose level is above normal but below the diagnostic threshold for diabetes mellitus. Impaired lipid profile is commonly present in type 2 diabetes and can also occur in pre-diabetes. The present study was undertaken to evaluate the association between serum lipid profile and glycated hemoglobin in pre-diabetic individuals in middle-aged Bangladeshi subjects. This observational cross sectional study was carried out in the department of Biochemistry, Bangladesh Institute of Research & Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) hospital, from July 2013 - June 2014. A total 131 subjects of age within the range of 30-45 years were selected for the purpose and classified into apparently healthy control (n=62), pre-diabetes (n= 69) groups based on the values of OGTT. Blood glucose – both fasting and 2hr after glucose, HbA1C, total cholesterol, triglyceride, high density lipoprotein (HDL) cholesterol and low density lipoprotein (LDL) cholesterol level were measured in all study subjects. Among the middle aged Bangladeshi subjects attending BIRDEM hospital, mean±SD of HbA1c values were 5.3±1.1% in control group and 5.9±1.2% in pre-diabetes. There was no significant difference in total cholesterol, triglyceride, HDL-c and LDL-c in patients with normal and Pre-diabetic individuals. According to this study, HbA1c value does not correlate well with total cholesterol, triglyceride and LDL-c (p=0.47, 0.93, 0.49) in patients with pre-diabetic individuals. Studies on larger population are required to determine the prognostic

scholarly journals A case control study: to evaluate the lipid profile in ischemic and hemorrhagic stroke

2021 ◽  
Vol 7 (4) ◽  
pp. 235
Author(s):  
Chandan Sharma ◽  
Ashima Badyal
Keyword(s):  
Ischemic Stroke ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Lipid ◽  
Hemorrhagic Stroke ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Serum Lipid Profile ◽  
Stroke Patients ◽  
Mean Values

<p class="abstract"><strong>Background:</strong> Stroke, be it ischemia or hemorrhage, is the most common clinical manifestation of cerebrovascular disease of which more than 99% are due to arterial involvement and less than 1% due to venous involvement. The aim of the present study was to assess the lipid profile of patients with ischemic and hemorrhagic stroke and to compare it with control group.</p><p class="abstract"><strong>Methods:</strong> This study was conducted in the Department of Medicine in collaboration with Department of Biochemistry between February 2018 to August 2018 on 50 patients of infarct and 50 patients of hemorrhagic stroke admitted in GMC Jammu and 50 healthy controls. Serum was analyzed for estimation of serum lipid profile including total cholesterol, triglyceride, high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), by using fully automatic analyzer.   </p><p class="abstract"><strong>Results:</strong> More than 54% of patients and controls belonged aged more than 60 years, with a total of 81 males and 69 females. Mean values of total cholesterol (233.53±27.09 mg) and LDL (165.89±30.54 mg) showed up higher in hemorrhagic stroke patients however higher mean values of triglycerides (177.80±40.44 mg) showed up in ischemic stroke patients. Serum cholesterol was abnormal among 50% ischemic and 54% hemorrhagic patients. A significant association is found between raised cholesterol, LDL, abnormal HDL and ischemic stroke.</p><p class="abstract"><strong>Conclusions:</strong> A significant rise in total cholesterol level was found in case of both the groups, therefore high risk patients with stroke should be regularly screened for serum lipid profile.</p>

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