scholarly journals A Meta-Analysis in Assessing Oxidative Stress Using Malondialdehyde in Oral Submucous Fibrosis

2021 ◽  
Author(s):  
Khadijah Mohideen ◽  
Chandrasekaran Krithika ◽  
Nadeem Jeddy ◽  
Sameena Parveen ◽  
T. Radhika ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Animal Studies ◽  
Meta Analysis ◽  
Research Question ◽  
Oral Submucous Fibrosis ◽  
Google Scholar ◽  
Oxidative Stress Marker ◽  
Qualitative Synthesis ◽  
Standard Difference ◽  
Submucous Fibrosis

Abstract Objective This study aims to evaluate the oxidative stress marker Malondialdehyde (MDA) in oral submucous fibrosis with available literature. Materials and Methods We conducted a literature search electronically in PubMed (MeSH), Science Direct, Scopus, and Google Scholar using specific keywords. Results A systematic search in PubMed, Science Direct, and Google Scholar identified 334 articles. Of these, four were duplicate reports, and three were animal studies. After reading the abstracts of the collected articles, 288 articles were excluded for the following reasons: low quality, not relevant to the research question, or did not meet the inclusion criteria. The remaining 46 articles were chosen for full-text assessment. Finally, the present qualitative synthesis included 23 articles for evaluation. The selected studies in MDA analysis in a random-effects model showed higher heterogeneity (Q = 477.636, p < 0.001, I2 = 95.394%). The standard difference in mean MDA concentration between oral submucous fibrosis (OSMF) and healthy subjects was estimated as 2.73 nmol/mL (95% confidence interval: 2.08–3.38). Conclusion The selected studies showed significantly higher MDA levels in various biological samples of patients with OSMF. Therefore, further studies are needed to estimate oxidative stress levels by using different biomarkers in OSMF to direct future therapy.

scholarly journals Meta-Analysis of the Use of 8-OHdG in Saliva as a Marker of Periodontal Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Esther Paredes-Sánchez ◽  
José María Montiel-Company ◽  
José Enrique Iranzo-Cortés ◽  
Teresa Almerich-Torres ◽  
Carlos Bellot-Arcís ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Meta Analysis ◽  
Research Question ◽  
Oxidative Stress Marker ◽  
Cochrane Library ◽  
Qualitative Synthesis ◽  
Disease Marker ◽  
Saliva Collection ◽  
The Difference ◽  
Meta Analyses

The objective was to collect the available evidence on oxidative stress marker measurements in periodontal patients, focusing specifically on 8-hydroxy-2′-deoxyguanosine (8-OHdG) as a salivary marker of periodontal disease, and to perform meta-analyses to calculate differences in concentration compared to healthy persons. A systematic search in PubMed, Cochrane Library, Embase, and Scopus identified 81 articles. Of these, 38 were duplicates. After reading the abstracts of the remaining 43, 42 were selected for full-text assessment. Finally, 17 articles were included in the qualitative synthesis. Those excluded were of low quality, did not answer the research question, or did not meet the inclusion and exclusion criteria. Of the 17 in the qualitative synthesis, 9 were included in the meta-analysis. The 9 studies in the meta-analysis were combined in a random effects model. Their heterogeneity was high (Q=3982.02, p<0.001, I2=99.8%). The difference in mean 8-OHdG concentration in saliva between periodontal and healthy subjects was estimated at 2.11 ng/ml (95% CI 1.23–2.98). The different saliva collection methods (stimulated/unstimulated) did not explain the heterogeneity. The 8-OHdG levels in saliva of periodontal patients were almost double to those of healthy patients: 8-OHdG is clearly a powerful periodontal disease marker.

scholarly journals Aberrations in Oxidative Stress Markers in Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Zihao Wang ◽  
Zhile Bai ◽  
Xiaoyan Qin ◽  
Yong Cheng
Keyword(s):  
Oxidative Stress ◽  
Meta Analysis ◽  
Density Lipoprotein ◽  
Protein Product ◽  
Oxidative Stress Marker ◽  
Oxidative Stress Markers ◽  
Stress Marker ◽  
Stress Markers ◽  
Als Patients ◽  
Lateral Sclerosis

Oxidative stress has been reported to be involved in the onset and development of amyotrophic lateral sclerosis (ALS). Data from clinical studies have highlighted increased peripheral blood oxidative stress markers in patients with ALS, but results are inconsistent. Therefore, we quantitatively pooled data on levels of blood oxidative stress markers in ALS patients from the literature using a meta-analytic technique. A systematic search was performed on PubMed and Web of Science, and we included studies analyzing blood oxidative stress marker levels in patients with ALS and normal controls. We included 41 studies with 4,588 ALS patients and 6,344 control subjects, and 15 oxidative stress marker levels were subjected to random-effects meta-analysis. The results demonstrated that malondialdehyde (Hedges’ g, 1.168; 95% CI, 0.812 to 1.523; P<0.001), 8-hydroxyguanosine (Hedges’ g, 2.194; 95% CI, 0.554 to 3.835; P=0.009), and Advanced Oxidation Protein Product (Hedges’ g, 0.555; 95% CI, 0.317 to 0.792; P<0.001) levels were significantly increased in patients with ALS when compared with control subjects. Uric acid (Hedges’ g, -0.798; 95% CI, -1.117 to -0.479; P<0.001) and glutathione (Hedges’ g, -1.636; 95% CI, -3.020 to -0.252; P=0.02) levels were significantly reduced in ALS patients. In contrast, blood Cu, superoxide dismutase, glutathione peroxidase, ceruloplasmin, triglycerides, total cholesterol, low-density lipoprotein, high-density lipoprotein, coenzyme-Q10, and transferrin levels were not significantly different between cases and controls. Taken together, our results showed significantly increased blood levels of 8-hydroxyguanosine, malondialdehyde, and Advanced Oxidation Protein Product and decreased glutathione and uric acid levels in the peripheral blood of ALS patients. This meta-analysis helps to clarify the oxidative stress marker profile in ALS patients, supporting the hypothesis that oxidative stress is a central component underpinning ALS pathogenesis.

scholarly journals Turmeric in the management of oral submucous fibrosis: A systematic review and meta-analysis

2021 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Arpita Rai ◽  
Neeta Kumar ◽  
Shashi Sharma ◽  
Saba Parveen ◽  
Abdur Rasheed
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Oral Submucous Fibrosis ◽  
Submucous Fibrosis

Impact of anthocyanin-rich whole fruit consumption on exercise-induced oxidative stress and inflammation: a systematic review and meta-analysis

2019 ◽  
Vol 77 (9) ◽  
pp. 630-645 ◽  
Author(s):  
Taylor K Bloedon ◽  
Rock E Braithwaite ◽  
Imogene A Carson ◽  
Dorothy Klimis-Zacas ◽  
Robert A Lehnhard
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Inflammatory Marker ◽  
Data Extraction ◽  
Meta Analysis ◽  
Cochrane Collaboration ◽  
Oxidative Stress Marker ◽  
Exercise Induced ◽  
The Impact ◽  
And Oxidative Stress

Abstract Context Supplementing with fruits high in anthocyanins to reduce exercise-induced oxidative stress and inflammation has produced mixed results. Objective This systematic review and meta-analysis aims to discuss the impact of whole fruits high in anthocyanins, including processing methods and the type and amount of fruit, on inflammation and oxidative stress. Data Sources PICOS reporting guidelines and a customized coding scheme were used to search 5 databases (SPORTDiscus, Science Direct, Web of Science [BIOSIS], Medline [Pubmed], and the Cochrane Collaboration) with additional cross-referencing selection. Data Extraction A random-effects meta-analysis was used to measure effects of the fruit supplements with 3 statistics; the QTotal value based on a χ2 distribution, τ2 value, and I2 value were used to determine homogeneity of variances on 22 studies (out of 807). Outliers were identified using a relative residual value. Results A small significant negative summary effect across the sum of all inflammatory marker outcomes (P < 0.001) and a moderate negative effect for the sum of all oxidative stress marker outcomes (P = 0.036) were found. Moderator analyses did not reveal significant (P > 0.05) differences between subgrouping variables. Conclusions Results indicate that consumption of whole fruit high in anthocyanins can be beneficial for reducing inflammation and oxidative stress.

scholarly journals Oxidative Stress Marker Aberrations in Multiple Sclerosis: A Meta-Analysis Study

2020 ◽  
Vol 14 ◽  
Author(s):  
Shu-Yao Zhang ◽  
Lue-Ning Gui ◽  
Yi-Ying Liu ◽  
Sha Shi ◽  
Yong Cheng
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Meta Analysis ◽  
Oxidative Stress Marker ◽  
Analysis Study ◽  
Stress Marker

The Effects of Resveratrol on Oxidative Stress Markers: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

2020 ◽  
Vol 20 (5) ◽  
pp. 718-727 ◽  
Author(s):  
Mahsa Omidian ◽  
Mina Abdolahi ◽  
Elnaz Daneshzad ◽  
Mohsen Sedighiyan ◽  
Mohadeseh Aghasi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Serum Levels ◽  
Oxidative Stress Marker ◽  
Cochrane Library ◽  
Oxidative Stress Markers ◽  
Stress Markers

Objective: Recent trial studies have found that resveratrol supplementation beneficially reduces oxidative stress marker, but, there is no definitive consensus on this context. The present systematic review and meta-analysis aimed to investigate the effect of resveratrol supplementation on oxidative stress parameters. Methods: We searched databases of Pubmed, Scopus and Cochrane Library up to December 2018 with no language restriction. Studies were reviewed according to preferred reporting items for systematic reviews and meta-analyses (PRISMA) and Cochrane handbook. To compare the effects of resveratrol with placebo, weighted mean difference (WMD) with 95% confidence intervals (CI) were pooled based on the random-effects model. Results: Among sixteen clinical trials, we found that resveratrol supplementation increased GPx serum levels significantly (WMD: 18.61; 95% CI: 8.70 to 28.52; P<0.001) but had no significant effect on SOD concentrations (WMD: 1.01; 95% CI: -0.72 to 2.74; P= 0.25), MDA serum levels (WMD: -1.43; 95% CI: -3.46 to 0.61; P = 0.17) and TAC (WMD: -0.09; 95% CI: -0.29 to 0.11; P = 0.36) compared to placebo. Finally, we observed that resveratrol supplementation may not have a clinically significant effect on oxidative stress. Conclusion: However, the number of human trials is limited in this context, and further large prospective clinical trials are needed to confirm the effect of resveratrol supplement on oxidative stress markers.

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