Antihyperglycemic Effect of Andrographolide in Streptozotocin-Induced Diabetic Rats

Planta Medica ◽  
2003 ◽  
Vol 69 (12) ◽  
pp. 1075-1079 ◽  
Keyword(s):  
Diabetic Rats ◽  
Antihyperglycemic Effect

Beneficial Effect of Saharan Propolis on Glucose Metabolism in Streptozotocin-induced Diabetic Rats

2021 ◽  
Vol 21 ◽  
Author(s):  
Mourad Akdad ◽  
Azzoui Bouchra ◽  
Mohamed Eddouks
Keyword(s):  
Antioxidant Activity ◽  
Aqueous Extract ◽  
Serum Lipid ◽  
Diabetic Rats ◽  
Histopathological Analysis ◽  
Phytochemical Screening ◽  
Antihyperglycemic Effect ◽  
Desert Region ◽  
Beneficial Action ◽  
Ancient Times

Aims: The aim of the study was to evaluate the antihyperglycemic activity of propolis from Saharan region of Morocco. Background: Propolis is known from ancient times for its beneficial action on health. Objective: The study aimed to evaluate the effect of Moroccan propolis aqueous extract from the desert region on glycemia and lipid metabolism. Methods: The antihyperglycemic and antidyslipidemic activities of Moroccan propolis aqueous extract were evaluated in streptozotocin-induced diabetic rats. Glycemia was monitored during acute (6h) and subchronic treatments. Histopathological analysis of the liver and the serum lipid profile was also evaluated in addition to the glucose tolerance. Results: This work demonstrated that the aqueous extract of Moroccan propolis exhibited a significant antihyperglycemic effect in diabetic rats. Histopathological data demonstrated that propolis acts positively on the liver of diabetic rats. In addition, the preliminary phytochemical screening revealed that Moroccan propolis contains several phytochemicals. Finally, Moroccan propolis had a potent antioxidant activity which may be due to the richness in polyphenols content (90.91 mg EAG/1 g of extract). Conclusion: The present study shows that Moroccan propolis from the hot desert region possesses a potent antihyperglycemic effect.

Antihyperglycemic effect of Codariocalyx motorius modulated carbohydrate metabolic enzyme activities in streptozotocin-induced diabetic rats

2014 ◽  
Vol 11 ◽  
pp. 517-527 ◽  
Author(s):  
C. Uma ◽  
N. Suganya ◽  
P. Vanitha ◽  
E. Bhakkiyalakshmi ◽  
S. Suriyanarayanan ◽  
...  
Keyword(s):  
Enzyme Activities ◽  
Diabetic Rats ◽  
Metabolic Enzyme ◽  
Antihyperglycemic Effect

scholarly journals Antihyperglycemic Effect of Mangiferin in Streptozotocin Induced Diabetic Rats

2009 ◽  
Vol 55 (2) ◽  
pp. 206-214 ◽  
Author(s):  
Periyar Selvam Sellamuthu ◽  
Balu Periamallipatti Muniappan ◽  
Sathiya Moorthi Perumal ◽  
Murugesan Kandasamy
Keyword(s):  
Diabetic Rats ◽  
Antihyperglycemic Effect

Mechanisms of antihyperglycemic effect of p-methoxycinnamic acid in normal and streptozotocin-induced diabetic rats

Life Sciences ◽  
2005 ◽  
Vol 78 (4) ◽  
pp. 406-412 ◽  
Author(s):  
Sirichai Adisakwattana ◽  
Sophon Roengsamran ◽  
Walter H. Hsu ◽  
Sirintorn Yibchok-anun
Keyword(s):  
Diabetic Rats ◽  
Antihyperglycemic Effect ◽  
Methoxycinnamic Acid

The Hypoglycemic Effect of the Crude Drug Prescription Resources from Taiwan on Experimental Diabetic-Mellitus (II) — The Antihyperglycemic Effect of Tang-Niao-Tung No. 2 and No. 3

1989 ◽  
Vol 17 (01n02) ◽  
pp. 9-15 ◽  
Author(s):  
Chun-Ching Lin ◽  
Hui-Fen Chiu ◽  
Seng-I Lu ◽  
Chieh-Fu Chen
Keyword(s):  
Blood Glucose ◽  
Starch Content ◽  
Drug Prescription ◽  
Diabetic Rats ◽  
Pharmacological Effect ◽  
Hypoglycemic Effect ◽  
Diabetic Mellitus ◽  
Antihyperglycemic Effect ◽  
Crude Drugs ◽  
Hypoglycemic Action

The water extracts of crude drugs of Taiwan Tang-Niao-Tung (T.N.T.) No. 2 and No. 3 were administered to normal and diabetic rats for investigating the antihyperglycemic effect of these two prescriptions. It was found that the blood glucose level in normal rats was temporarily increased after T.N.T. No. 2 and No. 3 administration; this may be caused by the starch content of the drugs component. In contrast, the diabetic rats have shown a signficant decrease ( P <0.01) of blood glucose in 2, 4, 6 hours after T.N.T. No. 2 and No. 3 have been given. The blood glucose percentage at 6 hours was 78.1% of T.N.T. No. 2 and 79.2% of T.N.T. No. 3 as compared to the original level. The hypoglycemic effect of T.N.T. No. 2 and No. 3 on alloxan-induced diabetic rats have suggested that action mechanism might not mediate through the release of insulin or positive feedback of glucose to insulin, neither acted on insulin receptor. It might be possible by the indirect promoting of enzyme activity. However, the pharmacological effect of some drugs could elucidate the hypoglycemic action of these prescriptions. Temporary promotion of blood glucose in normal rats will decline to normal level by 12 hours after T.N.T. No. 2 and No. 3 adminstration. The pharmacological effect of these herb prescriptions for diabetic rats is valuable for further study.

HPLC profile and antihyperglycemic effect of ethanol extracts of Andrographis paniculata in normal and streptozotocin-induced diabetic rats

2007 ◽  
Vol 61 (4) ◽  
pp. 422-429 ◽  
Author(s):  
Mariam Ahmad ◽  
Abdul Razak ◽  
Gabriel Akyirem Akowuah ◽  
Zaini Asmawi ◽  
Ismail Zhari
Keyword(s):  
Diabetic Rats ◽  
Andrographis Paniculata ◽  
Antihyperglycemic Effect ◽  
Hplc Profile ◽  
Ethanol Extracts

scholarly journals A comparative study of antihyperglycemic effect of Gymnema sylvestre and metformin in streptozotocin induced diabetic rats

2018 ◽  
Vol 7 (8) ◽  
pp. 1579
Author(s):  
Sarita Mulkalwar ◽  
Aadil S. Shah ◽  
Pallav Kataria ◽  
Tanya Gupta ◽  
A. V. Tilak ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Methanolic Extract ◽  
Statistical Significance ◽  
International Diabetes Federation ◽  
Diabetic Rats ◽  
World Health ◽  
Gymnema Sylvestre ◽  
Sprague Dawley ◽  
Prediabetic State ◽  
Antihyperglycemic Effect

Background: Diabetes mellitus (DM) is a metabolic disorder that has the phenotype of hyperglycemia. According to World Health Organization (WHO) there were 65.1 million diabetics in India in 2013, International Diabetes Federation estimates this to increase to 190 million by 2035. Although a number of drugs are available for treatment of DM, their cost and safety profile are major concern. Medicinal plants are used by clinicians for treatment of diabetes. Gymnema sylvestre (GS) extract has been reported to increase insulin levels in diabetic rats. This study was designed to compare the antihyperglycemic effect of Gymnema sylvestre with metformin.Methods: Diabetes was induced in Sprague-Dawley rats using streptozotocin 45mg/kg. Methanolic extract of Gymnema sylvestre 120mg/kg p.o. prepared using Soxhlet apparatus.Results: GS extract reduced blood glucose levels but not statistically significant. GS extract increased HDL and triglycerides, reduced both serum ALT and AST but no statistical significance seen. Metformin significantly increased serum urea, which was not seen in GS extract group. GS extract showed regenerative changes in pancreas, liver and kidney.Conclusions: The study investigation demonstrates that methanolic extract of GS possesses antihyperglycemic and hypolipidaemic activity and so it can be considered as a promising natural remedy in a prediabetic state and in mild hyperlipidaemia to prevent its progression. Increase in β cell regeneration activity could be a probable mechanism of action. However, further long term clinical studies are recommended to define its possible role in diabetes mellitus and hyperlipidaemia. Role of GS as a potential hepatoprotective agent also needs further evaluation.

Antihyperglycemic Effect of the Moroccan Collard Green (Brassica oleracea var. viridis) in Streptozotocin-Induced Diabetic Rats

2020 ◽  
Vol 20 ◽  
Author(s):  
Ayoub Amssayef ◽  
Mohamed Eddouks
Keyword(s):  
Antioxidant Activity ◽  
Blood Glucose ◽  
Oral Administration ◽  
Brassica Oleracea ◽  
Aqueous Extract ◽  
Diabetic Rats ◽  
Antihyperglycemic Effect ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Collard Green

Aims: The aim of the study was to assess the antihyperglycemic activity of Brassica oleracea. Background: Collard green or Brassica oleracea var. viridis which belongs to Brassicaceae family is ranked at 10th place of “powerhouse” vegetables, and it is commonly used traditionally for the treatment of diabetes in Morocco. Objective: This current investigation aimed to assess the antihyperglycemic capacity of the aqueous extract of Collard green leaves. Methods: The effect of a single (6 hours) and repeated (seven days of treatment) oral administration of Collard green aqueous extract (CGAE) at a dose of 60 mg/kg on glucose and lipid profile was examined in normal and streptozotocin-induced diabetic rats. Additionally, histopathological examination of liver was carried out according to the Hematoxylin-Eosin method. Furthermore, a preliminary phytochemical screening, and the quantification of phenolic, flavonoid and tannins contents as well as the antioxidant activity using DPPH assay were carried out. Results: The results demonstrated that Collard green A.E. (CGAE) exhibited a significant antihyperglycemic effect and positive improvement liver histology in diabetic rats. After a single oral administration of CGAE, blood glucose levels were lowered from 15±2 mM to 4.9±1 mM (p<0.0001) at the sixth hour in diabetic rats but no change was observed in normal rats. Repeated CGAE administration was able to reduce blood glucose levels from 15±2 mM to normal values (5±1 mM at the seventh day, p<0.0001) while the extract had no effect in normal rats. In addition, we revealed that CGAE is rich in several phytochemical compounds and exerts an important antioxidant activity. Conclusion: In conclusion, this study demonstrates that Collard green possesses a beneficial effect against diabetes, and can be used in the program diet of diabetic patients.

Sign in / Sign up

Export Citation Format

Share Document