Auch Mäuse weisen entlang des Intestinaltraktes klonal expandierte gamma delta T-Zellen auf

2005 ◽  
Vol 43 (05) ◽  
Author(s):  
W Holtmeier ◽  
C Sarrazin ◽  
WF Caspary
Keyword(s):  
Gamma Delta

Effects of Increased Dietary Protein and Energy on Composition and Functional Capacities of Blood Mononuclear Cells from Vaccinated, Neonatal Calves

2005 ◽  
Vol 75 (5) ◽  
pp. 357-368 ◽  
Author(s):  
Foote ◽  
Nonnecke† ◽  
Waters ◽  
Palmer ◽  
Beitz ◽  
...  
Keyword(s):  
Weight Gain ◽  
B Cell ◽  
Dietary Protein ◽  
Crude Protein ◽  
Interleukin 2 ◽  
Milk Replacer ◽  
Standard Diet ◽  
Gamma Delta ◽  
Ifn Gamma ◽  
Functional Capacities

Effects of increased protein and energy provided by an intensified milk replacer on the antigen-specific, cell-mediated immune response of the neonatal calf were examined. Calves were fed a standard (0.45 kg/day of a 20% crude protein, 20% fat milk replacer; n = 11) or intensified (1.14 kg/day of a 28% crude protein, 20% fat milk replacer; n = 11) diet from 0 to 6 weeks of age. All calves were vaccinated with Mycobacterium bovis bacillus Calmette-Guerin (BCG) at 1 week of age. The daily weight gain of intensified-diet calves (0.62 kg/day) was greater than the weight gain of standard-diet calves (0.29 kg/day). Liver, kidney, heart, thymus, and subcervical lymph nodes from intensified-diet calves were heavier than the same organs from standard-diet calves. Flow cytometric analysis of peripheral blood mononuclear cell (PBMC) populations indicated that CD4+ cells, gamma delta TCR+ cells, and monocyte percentages, although unaffected by diet during the first 5 weeks of the study, were higher in intensified-diet calves at week 6. The decline in gamma deltad TCR+ cell percentages and increase in B cell percentages with increasing age seen in all calves are characteristic of the maturing immune system of the calf. CD8+ T cell or B cell percentages were not affected by diet. In intensified-diet calves, percentages of CD4+ expressing interleukin-2 receptor increased and percentages of gamma delta TCR+ cells expressing interleukin-2 receptor decreased with time. The same populations in standard-diet calves did not change with time. Percentages of CD4+ and CD8+ T cells, and B cells expressing MHC class II antigen, were unaffected by diet or age. Although mitogen-induced interferon (IFN)-gamma and nitric oxide (NO) secretion increased with age for all calves, PBMC from intensified-diet calves produced less IFN-gamma and more NO than did cells from standard-diet calves at week 6 of the study. Antigen-induced secretion of IFN-gamma and NO also increased with age but was unaffected by diet. Antigen-elicited delayed-type hypersensitivity was unaffected by diet, suggesting increased dietary protein and energy did not alter adaptive immunity in vivo. Overall, these results suggest that feeding calves a commercially available, intensified milk replacer affects minimally the composition and functional capacities of PBMC populations. Additional research is necessary to determine whether these subtle effects influence the calf’s susceptibility to infectious disease.

Anti-Tumor Actions of Trametes Versicolor Extract Polysaccharide K Include Activation of Dendritic Cells and Gamma Delta T Cells

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
CA Wenner ◽  
C Inatsuka ◽  
T Davis Smith ◽  
M Sasagawa ◽  
MR Martzen ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Trametes Versicolor ◽  
Gamma Delta T Cells ◽  
Gamma Delta ◽  
Polysaccharide K

scholarly journals Trigonometric approximation of functions $f(x,y)$ of generalized Lipschitz class by double Hausdorff matrix summability method

2020 ◽  
Vol 2020 (1) ◽  
Author(s):  
Abhishek Mishra ◽  
Vishnu Narayan Mishra ◽  
M. Mursaleen
Keyword(s):  
Double Fourier Series ◽  
Degree Of Approximation ◽  
Trigonometric Approximation ◽  
Lipschitz Class ◽  
Gamma Delta ◽  
Approximation Of Functions ◽  
Matrix Summability ◽  
Alpha Beta ◽  
Generalized Lipschitz Class ◽  
Hausdorff Matrix

AbstractIn this paper, we establish a new estimate for the degree of approximation of functions $f(x,y)$ f ( x , y ) belonging to the generalized Lipschitz class $Lip ((\xi _{1}, \xi _{2} );r )$ L i p ( ( ξ 1 , ξ 2 ) ; r ) , $r \geq 1$ r ≥ 1 , by double Hausdorff matrix summability means of double Fourier series. We also deduce the degree of approximation of functions from $Lip ((\alpha ,\beta );r )$ L i p ( ( α , β ) ; r ) and $Lip(\alpha ,\beta )$ L i p ( α , β ) in the form of corollary. We establish some auxiliary results on trigonometric approximation for almost Euler means and $(C, \gamma , \delta )$ ( C , γ , δ ) means.

Radiation Therapy for Primary Cutaneous Gamma Delta Lymphoma Prior to Stem Cell Transplantation

2021 ◽  
pp. 1-11
Author(s):  
Yufan F Wu ◽  
Lawrie Skinner ◽  
Jonathan Lewis ◽  
Michael S Khodadoust ◽  
Youn H Kim ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Gamma Delta

Functional and morphologic characterization of human T lymphocytes expressing the TCR gamma /delta

Biotherapy ◽  
1992 ◽  
Vol 5 (1) ◽  
pp. 1-9
Author(s):  
Carlo E. Grossi ◽  
Ermanno Ciccone ◽  
Jan Zeromski ◽  
Alessandro Moretta ◽  
Lorenzo Moretta
Keyword(s):  
T Lymphocytes ◽  
Gamma Delta ◽  
Human T Lymphocytes

600 In vitro anticancer and immunomodulatory activities of NBT-167, a dimer of resveratrol

2020 ◽  
Vol 8 (Suppl 3) ◽  
pp. A635-A635
Author(s):  
Jeffrey Zhang ◽  
Everett Henry ◽  
L Harris Zhang ◽  
Wanying Zhang
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Immune Cells ◽  
Cell Killing ◽  
Gamma Delta T Cells ◽  
Gamma Delta ◽  
Raw264.7 Macrophages

BackgroundResveratrol (3,4’,5-trihydroxystilbene), a stilbenoid isolated from many species of plants, is widely known for its antioxidative, anti-inflammatory, immunomodulatory and anticancer activities. Recently, novel resveratrol oligomers have been isolated from various plants; their diverse structures are characterized by the polymerization of two or more resveratrol units. Little is known regarding the anticancer and immunomodulating activities of these oligomers. In this study, we designed in vitro models to compare resveratrol side by side with its natural dimer NBT-167 for their anticancer and immunological activities.MethodsWe isolated resveratrol and its dimer (NBT-167) from plants. The potency of the compounds was compared side by side using cancer cell survival assays and immunological assays with various types of human cells including cancer cell lines, PBMCs and enriched NK, gamma delta T cells, THP-1 monocytic cells, HL-60 promyelocytic leukemia cells as well as mouse RAW264.7 macrophages.ResultsNBT-167 was found to be more potent than resveratrol in inhibiting growth of various cancer cells and modulation of cytokine production from anti-IgM, LPS, PHA or SEB stimulated PBMC. Both compounds similarly enhanced IL-2 stimulated NK and gamma delta T cell killing activity against K562 cells and modulated nitric oxide production from LPS/IFN-g induced RAW264.7 macrophages and phagocytotic activity of HL-60 cells. NBT-167 was slightly more potently than resveratrol in inhibiting chemotaxis of HL-60 cells and blocking cell cycle of THP-1 and HL-60 cells at G1/S transition. In addition, NBT-167, but not resveratrol, could increase IL-2 production and T cell proliferation stimulated with anti-CD3 and anti-CD28 and synergize with anti-PD-1 antibody to increase IL-2 and IFN-gamma production in co-culture of allotypic T cells and dendric cells (MLR).ConclusionsOur data showed that NBT-167, a dimer of resveratrol, had anticancer and immunomodulatory activities such as modulation of expression of cytokines in immune cells and induction of cancer cell-killing activities of NK and gamma delta T cells. Generally, NBT-167 appeared to have higher activities than resveratrol in modulating immune cells and inhibiting cancer cells. NBT-167 could be a promising cancer immunotherapeutic agent targeting both cancer cells and immune cells.

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