Gender-specific differences in the pattern of gene expression during post-MI remodeling

2006 ◽  
Vol 54 (S 1) ◽  
Author(s):  
M Bauer ◽  
G Mitterer ◽  
W Dietl ◽  
K Trescher ◽  
E Wolner ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gender Specific Differences ◽  
Gender Specific

scholarly journals Mechanistic Models of Signaling Pathways Reveal the Drug Action Mechanisms behind Gender-Specific Gene Expression for Cancer Treatments

Cells ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 1579
Author(s):  
Cankut Çubuk ◽  
Fatma E. Can ◽  
María Peña-Chilet ◽  
Joaquín Dopazo
Keyword(s):  
Gene Expression ◽  
Signaling Pathways ◽  
Drug Action ◽  
Specific Gene ◽  
Mechanistic Models ◽  
Modeling Framework ◽  
Specific Gene Expression ◽  
Action Mechanisms ◽  
Gender Specific Differences ◽  
Gender Specific

Despite the existence of differences in gene expression across numerous genes between males and females having been known for a long time, these have been mostly ignored in many studies, including drug development and its therapeutic use. In fact, the consequences of such differences over the disease mechanisms or the drug action mechanisms are completely unknown. Here we applied mechanistic mathematical models of signaling activity to reveal the ultimate functional consequences that gender-specific gene expression activities have over cell functionality and fate. Moreover, we also used the mechanistic modeling framework to simulate the drug interventions and unravel how drug action mechanisms are affected by gender-specific differential gene expression. Interestingly, some cancers have many biological processes significantly affected by these gender-specific differences (e.g., bladder or head and neck carcinomas), while others (e.g., glioblastoma or rectum cancer) are almost insensitive to them. We found that many of these gender-specific differences affect cancer-specific pathways or in physiological signaling pathways, also involved in cancer origin and development. Finally, mechanistic models have the potential to be used for finding alternative therapeutic interventions on the pathways targeted by the drug, which lead to similar results compensating the downstream consequences of gender-specific differences in gene expression.

P3-034: Detection of gender specific differences in the diagnosis of Alzheimer's disease via high-resolution blood-gene expression

2009 ◽  
Vol 5 (4S_Part_12) ◽  
pp. P350-P350
Author(s):  
Richard Einstein ◽  
Pascale Fehlbaum-Beurdeley ◽  
Anne-Charlotte Jarrige-Le Prado ◽  
Weiyin Zhou ◽  
Olivier Sol ◽  
...  
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
High Resolution ◽  
Blood Gene Expression ◽  
Gender Specific Differences ◽  
Gender Specific

scholarly journals Gender and the Sex Hormone Estradiol Affect Multiple Sclerosis Risk Gene Expression in Epstein-Barr Virus-Infected B Cells

2021 ◽  
Vol 12 ◽  
Author(s):  
Jeremy T. Keane ◽  
Ali Afrasiabi ◽  
Stephen D. Schibeci ◽  
Nicole Fewings ◽  
Grant P. Parnell ◽  
...  
Keyword(s):  
Gene Expression ◽  
Multiple Sclerosis ◽  
Gender Differences ◽  
B Cells ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Risk Gene ◽  
Gender Specific Differences ◽  
Epstein Barr ◽  
Gender Specific

Multiple Sclerosis (MS) is a complex immune-mediated disease of the central nervous system. Treatment is based on immunomodulation, including specifically targeting B cells. B cells are the main host for the Epstein-Barr Virus (EBV), which has been described as necessary for MS development. Over 200 genetic loci have been identified as increasing susceptibility to MS. Many MS risk genes have altered expression in EBV infected B cells, dependent on the risk genotype, and are themselves regulated by the EBV transcription factor EBNA2. Females are 2-3 times more likely to develop MS than males. We investigated if MS risk loci might mediate the gender imbalance in MS. From a large public dataset, we identified gender-specific associations with EBV traits, and MS risk SNP/gene pairs with gender differences in their associations with gene expression. Some of these genes also showed gender differences in correlation of gene expression level with Estrogen Receptor 2. To test if estrogens may drive these gender specific differences, we cultured EBV infected B cells (lymphoblastoid cell lines, LCLs), in medium depleted of serum to remove the effects of sex hormones as well as the estrogenic effect of phenol red, and then supplemented with estrogen (100 nM estradiol). Estradiol treatment altered MS risk gene expression, LCL proliferation rate, EBV DNA copy number and EBNA2 expression in a sex-dependent manner. Together, these data indicate that there are estrogen-mediated gender-specific differences in MS risk gene expression and EBV functions. This may in turn contribute to gender differences in host response to EBV and to MS susceptibility.

scholarly journals Gender-specific differences in gene expression profiles in gynogenetic Pengze crucian carp

2016 ◽  
Vol 66 (2) ◽  
pp. 157-171
Author(s):  
Yao Zheng ◽  
Jiazhang Chen ◽  
Xuwen Bing ◽  
Yanping Yang ◽  
Hongwei Liang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Crucian Carp ◽  
Expression Profiles ◽  
Gonadosomatic Index ◽  
Gene Expression Profiles ◽  
High Ratio ◽  
Hepatosomatic Index ◽  
Significant Difference ◽  
Gender Specific Differences ◽  
Gender Specific

Gynogenesis is a form of asexual reproduction that is used to obtain all-female fish stocks. In this study, we were interested in studying gender-specific differences in gene expression profiles in gynogenetic teleosts, using a carp species. The four-month old gynogenetic Pengze crucian carp F1 (Carassius auratus var. pengzensis, Pcc) showed a high ratio of males under laboratory culture condition. The present study aimed to investigate the differences between males and females. The gonadosomatic index of the females was significantly higher than that of the males. Moreover, the hepatosomatic index of the females was significantly lower than that of the males. Vitellogenin B mRNA was abnormally highly expressed in male hepatopancreas and testes compared to females. Similarly, zona pellucida 2 expressed at a significantly high level in the testes. For the sex related genes, dosage-sensitive sex reversal, adrenal hypoplasia congenital critical region on the X-chromosome gene 1, doublesex and mab-3 related transcription factor 1a, nuclear receptor subfamily 5, group A, member 1b and SRY-box containing gene 9a had significantly higher expression levels in the males than in the females, whereas there was no difference in expression of anti-Müllerian hormone, cytochrome P450 family 19 subfamily A member 1A and forkhead box L2 transcripts between the two genders. The females showed higher levels of estrogen but no significant difference in testosterone compared to the males. The data suggest remarkable differences between the two genders of the Pengze crucian carp.

scholarly journals The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences

2009 ◽  
Vol 31 (10) ◽  
pp. 1188-1196 ◽  
Author(s):  
B. Heidecker ◽  
G. Lamirault ◽  
E. K. Kasper ◽  
I. S. Wittstein ◽  
H. C. Champion ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Failure ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Gender Specific Differences ◽  
Gender Specific ◽  
New Onset

Gender-specific differences in the expression of selenoproteins in mammals

2005 ◽  
Vol 113 (S 1) ◽  
Author(s):  
C Riese ◽  
F Streckfuss ◽  
U Schweizer ◽  
J Köhrle ◽  
L Schomburg
Keyword(s):  
Gender Specific Differences ◽  
Gender Specific

scholarly journals Bugs That Can Resist Antibiotics but Not Men: Gender-Specific Differences in Notified Infections and Colonisations in Germany, 2010–2019

2021 ◽  
Vol 9 (5) ◽  
pp. 894
Author(s):  
Michael Brandl ◽  
Alexandra Hoffmann ◽  
Niklas Willrich ◽  
Annicka Reuss ◽  
Felix Reichert ◽  
...  
Keyword(s):  
Methicillin Resistant Staphylococcus Aureus ◽  
Incidence Rates ◽  
Federal State ◽  
German Population ◽  
Hygiene Measures ◽  
Invasive Infections ◽  
Gender Specific Differences ◽  
Acinetobacter Spp ◽  
Notification Data ◽  
Gender Specific

Data from surveillance networks show that men have a higher incidence rate of infections with anti-microbial-resistant (AMR) pathogens than women. We systematically analysed data of infections and colonisations with AMR pathogens under mandatory surveillance in Germany to quantify gender-specific differences. We calculated incidence-rates (IR) per 100,000 person–years for invasive infections with Methicillin-resistant Staphylococcus aureus (MRSA), and for infections or colonisations with carbapenem-non-susceptible Acinetobacter spp. (CRA), and Enterobacterales (CRE), using the entire German population as a denominator. We limited the study periods to years with complete notification data (MRSA: 2010–2019, CRA/CRE: 2017–2019). We used Poisson regression to adjust for gender, age group, federal state, and year of notification. In the study periods, IR for all notifications were 4.2 for MRSA, 0.90 for CRA, and 4.8 for CRE per 100,000 person-–years. The adjusted IR ratio for infections of men compared to women was 2.3 (95% confidence interval [CI]: 2.2–2.3) for MRSA, 2.2 (95%CI: 1.9–2.7) for CRA, and 1.7 (95%CI: 1.6–1.8) for CRE. Men in Germany show about double the risk for infection with AMR pathogens than women. This was also true for colonisations, where data were available. Screening procedures and associated hygiene measures may profit from a gender-stratified approach.

Sign in / Sign up

Export Citation Format

Share Document