scholarly journals Collaboration in the time of COVID: a scientometric analysis of multidisciplinary SARS-CoV-2 research

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Eoghan Cunningham ◽  
Barry Smyth ◽  
Derek Greene
Keyword(s):  
Scientometric Analysis ◽  
The Novel ◽  
Multidisciplinary Research ◽  
Scientific Impact ◽  
Multidisciplinary Collaboration ◽  
Research Teams ◽  
Fields Of Study ◽  
Public Health Challenge ◽  
Novel Coronavirus ◽  
Scientific Fields

AbstractThe novel coronavirus SARS-CoV-2 and the COVID-19 illness it causes have inspired unprecedented levels of multidisciplinary research in an effort to address a generational public health challenge. In this work we conduct a scientometric analysis of COVID-19 research, paying particular attention to the nature of collaboration that this pandemic has fostered among different disciplines. Increased multidisciplinary collaboration has been shown to produce greater scientific impact, albeit with higher co-ordination costs. As such, we consider a collection of over 166,000 COVID-19-related articles to assess the scale and diversity of collaboration in COVID-19 research, which we compare to non-COVID-19 controls before and during the pandemic. We show that COVID-19 research teams are not only significantly smaller than their non-COVID-19 counterparts, but they are also more diverse. Furthermore, we find that COVID-19 research has increased the multidisciplinarity of authors across most scientific fields of study, indicating that COVID-19 has helped to remove some of the barriers that usually exist between disparate disciplines. Finally, we highlight a number of interesting areas of multidisciplinary research during COVID-19, and propose methodologies for visualising the nature of multidisciplinary collaboration, which may have application beyond this pandemic.

scholarly journals A blueprint for academic laboratories to produce SARS-CoV-2 quantitative RT-PCR test kits

2020 ◽  
Vol 295 (46) ◽  
pp. 15438-15453 ◽  
Author(s):  
Samantha J. Mascuch ◽  
Sara Fakhretaha-Aval ◽  
Jessica C. Bowman ◽  
Minh Thu H. Ma ◽  
Gwendell Thomas ◽  
...  
Keyword(s):  
Support Group ◽  
Diagnostic Testing ◽  
The Novel ◽  
Rt Pcr ◽  
Research Teams ◽  
Environmental Testing ◽  
Resource Limited ◽  
Test Kit ◽  
Institute Of Technology ◽  
Novel Coronavirus

Widespread testing for the presence of the novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in individuals remains vital for controlling the COVID-19 pandemic prior to the advent of an effective treatment. Challenges in testing can be traced to an initial shortage of supplies, expertise, and/or instrumentation necessary to detect the virus by quantitative RT-PCR (RT-qPCR), the most robust, sensitive, and specific assay currently available. Here we show that academic biochemistry and molecular biology laboratories equipped with appropriate expertise and infrastructure can replicate commercially available SARS-CoV-2 RT-qPCR test kits and backfill pipeline shortages. The Georgia Tech COVID-19 Test Kit Support Group, composed of faculty, staff, and trainees across the biotechnology quad at Georgia Institute of Technology, synthesized multiplexed primers and probes and formulated a master mix composed of enzymes and proteins produced in-house. Our in-house kit compares favorably with a commercial product used for diagnostic testing. We also developed an environmental testing protocol to readily monitor surfaces for the presence of SARS-CoV-2. Our blueprint should be readily reproducible by research teams at other institutions, and our protocols may be modified and adapted to enable SARS-CoV-2 detection in more resource-limited settings.

scholarly journals Arterial Hypertension as a Risk Comorbidity Associated with COVID-19 Pathology

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Alexander Kamyshnyi ◽  
Inna Krynytska ◽  
Victoriya Matskevych ◽  
Mariya Marushchak ◽  
Oleh Lushchak
Keyword(s):  
Arterial Hypertension ◽  
Pressure Control ◽  
The Novel ◽  
Global Public Health ◽  
Angiotensin Converting Enzyme 2 ◽  
Cardiovascular Comorbidities ◽  
Public Health Challenge ◽  
Novel Coronavirus ◽  
Ace2 Gene

Coronavirus disease 2019 (COVID-19), caused by the novel coronavirus severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), is an ongoing global public health challenge. Current clinical data suggest that, in COVID-19 patients, arterial hypertension (AH) is one of the most common cardiovascular comorbidities; it can worsen outcomes and increase the risk of admission to intensive care unit (ICU). The exact mechanisms through which AH contributes to the poor prognosis in COVID-19 are not yet clear. The putative relationship between AH and COVID-19 may be linked to the role of angiotensin-converting enzyme 2 (ACE2), a key element of the AH pathophysiology. Another mechanism connecting AH and COVID-19 is the dysregulation of the immune system resulting in a cytokine storm, mediated by an imbalanced response of T helper cells subtypes. Therefore, it is essential to optimize blood pressure control in hypertensive patients and monitor them carefully for cardiovascular and other complications for the duration of COVID-19 infection. The question whether AH-linked ACE2 gene polymorphisms increase the risk and/or worsen the course of SARS-CoV-2 infection should also receive further consideration.

scholarly journals A Review on COVID-19 Forecasting Models

2020 ◽  
Author(s):  
Iman Rahimi ◽  
Fang Chen ◽  
Amir H. Gandomi
Keyword(s):  
Web Of Science ◽  
Scientometric Analysis ◽  
The Novel ◽  
Forecasting Models ◽  
Subject Areas ◽  
Novel Coronavirus

Abstract The Novel coronavirus (COVID-19) has distributed to more than 200 territory worldwide leading to about 24 million confirmed cases as of August 25, 2020. Several models have been released that forecast the outbreak globally. This work presents a review of the most important forecasting models against COVID-19 and shows a short analysis of each one. The work presented in this study possesses two parts. A detailed scientometric analysis was done in the first section that provides an influential tool for describing bibliometric analyses. The analysis was performed on data corresponding to COVID-19 using the Scopus and Web of Science databases. For analysis, keywords and subject areas were addressed while classification of forecasting models, criteria evaluation and comparison of solution approaches were done in the second section of the work. Conclusion and discussion are provided as the final sections of this study.

scholarly journals A blueprint for academic labs to produce SARS-CoV-2 RT-qPCR test kits

2020 ◽  
Author(s):  
Samantha J. Mascuch ◽  
Sara Fakhretaha-Aval ◽  
Jessica C. Bowman ◽  
Minh Thu H. Ma ◽  
Gwendell Thomas ◽  
...  
Keyword(s):  
Support Group ◽  
Diagnostic Testing ◽  
The Novel ◽  
Research Teams ◽  
Environmental Testing ◽  
Resource Limited ◽  
Test Kit ◽  
Polymerase Chain ◽  
Institute Of Technology ◽  
Novel Coronavirus

Widespread testing for the presence of the novel coronavirus SARS-CoV-2 in individuals remains vital for controlling the COVID-19 pandemic prior to the advent of an effective treatment. Challenges in testing can be traced to an initial shortage of supplies, expertise and/or instrumentation necessary to detect the virus by quantitative reverse transcription polymerase chain reaction (RT-qPCR), the most robust, sensitive, and specific assay currently available. Here we show that academic biochemistry and molecular biology laboratories equipped with appropriate expertise and infrastructure can replicate commercially available SARS-CoV-2 RT-qPCR test kits and backfill pipeline shortages. The Georgia Tech COVID-19 Test Kit Support Group, composed of faculty, staff, and trainees across the biotechnology quad at Georgia Institute of Technology, synthesized multiplexed primers and probes and formulated a master mix composed of enzymes and proteins produced in-house. Our in-house kit compares favorably to a commercial product used for diagnostic testing. We also developed an environmental testing protocol to readily monitor surfaces across various campus laboratories for the presence of SARS-CoV-2. Our blueprint should be readily reproducible by research teams at other institutions, and our protocols may be modified and adapted to enable SARS-CoV-2 detection in more resource-limited settings.

scholarly journals Acute Hemorrhagic Encephalitis Related to COVID-19

2020 ◽  
pp. 10.1212/CPJ.0000000000000900
Author(s):  
Alan Chalil ◽  
Carmen S. Baker ◽  
Robert B. Johnston ◽  
Caroline Just ◽  
Derek B. Debicki ◽  
...  
Keyword(s):  
External Ventricular Drain ◽  
Underlying Mechanism ◽  
Neurological Status ◽  
The Novel ◽  
Altered Level ◽  
Level Of Consciousness ◽  
Public Health Challenge ◽  
Novel Coronavirus ◽  
Acute Changes ◽  
Critical Public Health

AbstractPurposeof Review: The novel coronavirus, SARS-CoV-2 is the most critical public health challenge in recent history. In this report, we present a case of suspected acute hemorrhagic encephalitis with bilateral intracranial hemorrhages associated with COVID-19 infectionRecent Findings:A 48-year-old female COVID-19 positive patient developed acute changes in her neurological status. A head CT with CT angiography demonstrated extensive bilateral parietal and occipital intraparenchymal hemorrhage with intraventricular extension and acute hydrocephalus. The patient was treated with an external ventricular drain (EVD) and a CSF sample was tested for SARS-CoV-2 but was found to be negative.Summary:The underlying mechanism for developing acute hemorrhagic encephalitis in viral illnesses may be autoimmune in nature and warrants further investigation. The initial neurologic presentation of COVID-19-related hemorrhagic encephalitis is altered level of consciousness which may prompt further neurologic examination and imaging to exclude this feature.

scholarly journals Repositioning Chloroquine as Ideal Antiviral Prophylactic against COVID-19 - Time is Now

2020 ◽  
Author(s):  
Raymond Chang ◽  
Wei-Zen Sun
Keyword(s):  
Public Health ◽  
Host Cells ◽  
Post Exposure Prophylaxis ◽  
The Novel ◽  
Viral Attachment ◽  
Therapeutic Trials ◽  
Agency Support ◽  
Public Health Challenge ◽  
Novel Coronavirus ◽  
Exposure Prophylaxis

The novel coronavirus 2019 (COVID-19) pandemic is rapidly advancing despite public health measures. Pharmaceutical prophylaxis is an established approach to potentially control infectious diseases and is one solution to the urgent public health challenge posed by COVID-19. Screening and development of new vaccines and antivirals is expensive and time consuming while the repositioning of available drugs should receive priority attention as well as international government and agency support. Here we propose an old drug chloroquine (CQ) to be urgently repositioned as an ideal antiviral prophylactic against COVID-19. CQ has ability to block viral attachment and entry to host cells. Its proven clinical efficacy against a variety of viruses including COVID-19 and its current deployment in COVID-19 therapeutic trials strengthens its potential candidacy as a prophylactic. Furthermore, CQ has a long safety record, is inexpensive and widely available. Here we reviewed CQ's antiviral mechanisms, its laboratory efficacy activity against COVID-19, as well as CQ's pharmacokinetics in its established use against malaria and autoimmune diseases to recommend safe and potentially efficacious dose regimens for protection against COVID-19: a pre-exposure prophylaxis of 250-500mg daily and post-exposure prophylaxis at 8mg/kg/day for 3 days. We recommend further urgent research on CQ for COVID-19 prevention and urge that the above regimens be investigated in parallel with mass deployment by relevant agencies in attempts to contain the pandemic without unnecessary regulatory delays as benefits far outweigh risks or costs.

Comparative docking of SARS-CoV-2 receptors antagonists from repurposing drugs

2020 ◽  
Author(s):  
Micael Davi Lima de Oliveira ◽  
Kelson Mota Teixeira de Oliveira
Keyword(s):  
World Health Organisation ◽  
World Health ◽  
Lung Cells ◽  
The Novel ◽  
High Modulation ◽  
Main Protease ◽  
The World ◽  
Novel Coronavirus ◽  
Viral Receptors ◽  
Theoretical Results

According to the World Health Organisation, until 16 June, 2020, the number of confirmed and notified cases of COVID-19 has already exceeded 7.9 million with approximately 434 thousand deaths worldwide. This research aimed to find repurposing antagonists, that may inhibit the activity of the main protease (Mpro) of the SARS-CoV-2 virus, as well as partially modulate the ACE2 receptors largely found in lung cells, and reduce viral replication by inhibiting Nsp12 RNA polymerase. Docking molecular simulations were performed among a total of 60 structures, most of all, published in the literature against the novel coronavirus. The theoretical results indicated that, in comparative terms, paritaprevir, ivermectin, ledipasvir, and simeprevir, are among the most theoretical promising drugs in remission of symptoms from the disease. Furthermore, also corroborate indinavir to the high modulation in viral receptors. The second group of promising drugs includes remdesivir and azithromycin. The repurposing drugs HCQ and chloroquine were not effective in comparative terms to other drugs, as monotherapies, against SARS-CoV-2 infection.

SARS-COV2 virus and Coronavirus disease (COVID-19)

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 977-982
Author(s):  
Mohamed J. Saadh ◽  
Bashar Haj Rashid M ◽  
Roa’a Matar ◽  
Sajeda Riyad Aldibs ◽  
Hala Sbaih ◽  
...  
Keyword(s):  
Close Contact ◽  
Antiviral Agents ◽  
Health Concern ◽  
The Novel ◽  
Global Public Health ◽  
Fatal Disease ◽  
Mild Disease ◽  
Life Threatening ◽  
Novel Coronavirus

SARS-COV2 virus causes Coronavirus disease (COVID-19) and represents the causative agent of a potentially fatal disease that is of great global public health concern. The novel coronavirus (2019) was discovered in 2019 in Wuhan, the market of the wet animal, China with viral pneumonia cases and is life-threatening. Today, WHO announces COVID-19 outbreak as a pandemic. COVID-19 is likely to be zoonotic. It is transmitted from bats as intermediary animals to human. Also, the virus is transmitted from human to human who is in close contact with others. The computerized tomographic chest scan is usually abnormal even in those with no symptoms or mild disease. Treatment is nearly supportive; the role of antiviral agents is yet to be established. The SARS-COV2 virus spreads faster than its two ancestors, the SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), but has lower fatality. In this article, we aimed to summarize the transmission, symptoms, pathogenesis, diagnosis, treatment, and vaccine to control the spread of this fatal disease.

Coronavirus: Towards controlling of the pandemic - Indian scenario

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 462-468
Author(s):  
Latika kothari ◽  
Sanskruti Wadatkar ◽  
Roshni Taori ◽  
Pavan Bajaj ◽  
Diksha Agrawal
Keyword(s):  
Control Measures ◽  
The Novel ◽  
Medical Treatments ◽  
Health Crisis ◽  
The Public ◽  
Infection Control Measures ◽  
The Social ◽  
Asking Questions ◽  
The Government ◽  
Novel Coronavirus

Coronavirus disease 2019 (COVID-19) is a communicable infection caused by the novel coronavirus resulting in severe acute respiratory syndrome coronavirus 2 (SARS-CoV). It was recognized to be a health crisis for the general population of international concern on 30th January 2020 and conceded as a pandemic on 11th March 2020. India is taking various measures to fight this invisible enemy by adopting different strategies and policies. To stop the COVID-19 from spreading, the Home Affairs Ministry and the health ministry, of India, has issued the nCoV 19 guidelines on travel. Screening for COVID-19 by asking questions about any symptoms, recent travel history, and exposure. India has been trying to get testing kits available. The government of India has enforced various laws like the social distancing, Janata curfew, strict lockdowns, screening door to door to control the spread of novel coronavirus. In this pandemic, innovative medical treatments are being explored, and a proper vaccine is being hunted to deal with the situation. Infection control measures are necessary to prevent the virus from further spreading and to help control the current situation. Thus, this review illustrates and explains the criteria provided by the government of India to the awareness of the public to prevent the spread of COVID-19.

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