Solute dispersion of drug carrier during magnetic drug targeting for a blood flow through a microvessel

Magnetic drug targeting can be used for locoregional cancer therapy, although the limitation is minuteness of the induced force. A new and simple procedure to enhance the magnetic force is changing the shape of carrier particles. It has been mathematically proved that exerting much stronger magnetic dipoles to nanowires are more possible than to spheres with the same volume. The magnetic dipole of wires having aspect quotient (ratio of length to diameter) of 3 is higher than the spheres of the same volume. Nanowires with α = 5 have magnetic dipoles 1.95 times greater than the spheres with the same volume. At a fixed radius, the magnetic dipole increases with the volume of the drug carrier. Magnetic targeting depth is an important parameter depending on the aspect quotient α of particles. Calculations show that the depth of targeting can exceed 8.5 cm if a nanowire with 15 nm radius and length larger than 150 nm is used as the drug carrier. This depth is 1.7 times more than that reported by previous authors for spherical particles with the same-volume.

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Two-Phase Fluid Modeling of Magnetic Drug Targeting in a Permeable Microvessel Implanted With a Toroidal Permanent Magnetic Stent

Journal of Fluids Engineering ◽

10.1115/1.4042557 ◽

2019 ◽

Vol 141 (8) ◽

Cited By ~ 1

Author(s):

Chibin Zhang ◽

Kangli Xia ◽

Keya Xu ◽

Xiaohui Lin ◽

Shuyun Jiang ◽

...

Keyword(s):

Stokes Equation ◽

Drug Targeting ◽

Drug Carrier ◽

Navier Stokes ◽

Magnetic Drug Targeting ◽

Tissue Fluid ◽

Momentum Exchange ◽

Two Phase ◽

Navier Stokes Equation ◽

Phase Fluid

The key to effective magnetic drug targeting (MDT) is to improve the aggregation of magnetic drug carrier particles (MDCPs) at the target site. Compared to related theoretical models, the novelty of this investigation is mainly reflected in that the microvascular blood is considered as a two-phase fluid composed of a continuous phase (plasma) and a discrete phase (red blood cells (RBCs)). And plasma flow state is quantitatively described based on the Navier–Stokes equation of two-phase flow theory, the effect of momentum exchange between the two-phase interface is considered in the Navier–Stokes equation. Besides, the coupling effect between plasma pressure and tissue fluid pressure is considered. The random motion effects and the collision effects of MDCPs transported in the blood are quantitatively described using the Boltzmann equation. The results show that the capture efficiency (CE) presents a nonlinear increase with the increase of magnetic induction intensity and a nonlinear decrease with the increase of plasma velocity, but an approximately linear increase with the increase of the particle radius. Furthermore, greater permeability of the microvessel wall promotes the aggregation of MDCPs. The CE predicted by the model agrees well with the experimental results.

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Nanowires on Magnetic Drug Targeting

10.20944/preprints201711.0054.v2 ◽

2018 ◽

Author(s):

Zafar Ali Moghimi ◽

Fazel Baniasadi ◽

Gholamreza Naghieh

Keyword(s):

Magnetic Dipole ◽

Drug Targeting ◽

Magnetic Force ◽

Simple Procedure ◽

Drug Carrier ◽

Spherical Particles ◽

Magnetic Drug Targeting ◽

Magnetic Targeting ◽

Magnetic Dipoles ◽

Fixed Radius

Magnetic drug targeting can be used for locoregional cancer therapy, although the limitation is minuteness of the induced force. A new and simple procedure to enhance the magnetic force is changing the shape of carrier particles. It has been mathematically proved that exerting much stronger magnetic dipoles to nanowires are more possible than to spheres with the same volume. The magnetic dipole of wires having aspect quotient (ratio of length to diameter) of 3 is higher than the spheres of the same volume. Nanowires with α = 5 have magnetic dipoles 1.95 times greater than the spheres with the same volume. At a fixed radius, the magnetic dipole increases with the volume of the drug carrier. Magnetic targeting depth is an important parameter depending on the aspect quotient α of particles. Calculations show that the depth of targeting can exceed 8.5 cm if a nanowire with 15 nm radius and length larger than 150 nm is used as the drug carrier. This depth is 1.7 times more than that reported by previous authors for spherical particles with the same-volume.

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SIMULATION OF MAGNETIC NANOPARTICLES IN BLOOD FLOW FOR MAGNETIC DRUG TARGETING APPLICATIONS

nano Online ◽

10.1515/nano.0007.00017 ◽

2016 ◽

Author(s):

I Slabu ◽

A Röth ◽

G Güntherodt ◽

T Schmitz-Rode ◽

M Baumann

Keyword(s):

Blood Flow ◽

Magnetic Nanoparticles ◽

Drug Targeting ◽

Magnetic Drug Targeting

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Modelling the Effect of SPION Size in a Stent Assisted Magnetic Drug Targeting System with Interparticle Interactions

The Scientific World JOURNAL ◽

10.1155/2015/618658 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Adil Mardinoglu ◽

P. J. Cregg

Keyword(s):

Magnetic Field ◽

Drug Targeting ◽

Computational Analysis ◽

Drug Carrier ◽

Superparamagnetic Iron Oxide ◽

Clinical Applications ◽

Magnetic Drug Targeting ◽

Oxide Nanoparticles ◽

Interparticle Interactions ◽

Different Diameters

Cancer is a leading cause of death worldwide and it is caused by the interaction of genomic, environmental, and lifestyle factors. Although chemotherapy is one way of treating cancers, it also damages healthy cells and may cause severe side effects. Therefore, it is beneficial in drug delivery in the human body to increase the proportion of the drugs at the target site while limiting its exposure at the rest of body through Magnetic Drug Targeting (MDT). Superparamagnetic iron oxide nanoparticles (SPIONs) are derived from polyol methods and coated with oleic acid and can be used as magnetic drug carrier particles (MDCPs) in an MDT system. Here, we develop a mathematical model for studying the interactions between the MDCPs enriched with three different diameters of SPIONs (6.6, 11.6, and 17.8 nm) in the MDT system with an implanted magnetizable stent using different magnetic field strengths and blood velocities. Our computational analysis allows for the optimal design of the SPIONs enriched MDCPs to be used in clinical applications.

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Statistical Mechanics Transport Model of Magnetic Drug Targeting in Permeable Microvessel

Journal of Nanotechnology in Engineering and Medicine ◽

10.1115/1.4030787 ◽

2015 ◽

Vol 6 (1) ◽

Cited By ~ 1

Author(s):

Xiaohui Lin ◽

Chibin Zhang ◽

Kai Li

Keyword(s):

Blood Flow ◽

Statistical Mechanics ◽

Flow Velocity ◽

Blood Flow Velocity ◽

Interstitial Fluid ◽

Transport Model ◽

Coupling Effect ◽

Drug Carrier ◽

Fluid Pressure ◽

Magnetic Drug Targeting

A transport model of magnetic drug carrier particles (MDCPs) in permeable microvessel based on statistical mechanics has been developed to investigate capture efficiency (CE) of MDCPs at the tumor position. Casson-Newton two-fluid model is used to describe the flow of blood in permeable microvessel and the Darcy model is used to characterize the permeable nature of the microvessel. Coupling effect between the interstitial fluid flow and blood flow is considered by using the Starling assumptions in the model. The Boltzmann equation is used to depict the transport of MDCPs in microvessel. The elastic collision effect between MDCPs and red blood cell is incorporated. The distribution of blood flow velocity, blood pressure, interstitial fluid pressure, and MDCPs has been obtained through the coupling solutions of the model. Based on these, the CE of the MDCPs is obtained. Present results show that the CE of the MDCPs will increase with the enhancement of the size of the MDCPs and the external magnetic field intensity. In addition, when the permeability of the inner wall is better and the inlet blood flow velocity is slow, the CE of the MDCPs will increase as well. Close agreements between the predictions and experimental results demonstrate the capability of the model in modeling transport of MDCPs in permeable microvessel.

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Quantification of Magnetic Nanoparticles by Magnetorelaxometry and Comparison to Histology After Magnetic Drug Targeting

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2006.477 ◽

2006 ◽

Vol 6 (9) ◽

pp. 3222-3225 ◽

Cited By ~ 58

Author(s):

F. Wiekhorst ◽

C. Seliger ◽

R. Jurgons ◽

U. Steinhoff ◽

D. Eberbeck ◽

...

Keyword(s):

Magnetic Nanoparticles ◽

Cross Sections ◽

Drug Targeting ◽

Magnetic Particles ◽

Particle Distribution ◽

Drug Carrier ◽

Magnetic Drug Targeting ◽

Tissue Samples ◽

Drug Carrier System

Magnetic nanoparticles can be used in medicine in vivo as contrast agents and as a drug carrier system for chemotherapeutics. Thus local cancer therapy is performed with Magnetic Drug Targeting (MDT) and allows a specific delivery of therapeutic agents to desired targets, i.e., tumors, by using a chemotherapeutic substance bound to magnetic nanoparticles and focused with an external magnetic field to the tumor after intraarterial application. Important for this therapeutic principle is the distribution of the particles in the whole organism and especially in the tumor. Therefore we used magnetorelaxometry to quantify ferrofluids delivered after MDT. Tissue samples of some mm3 volume of a VX2 squamous cell carcinoma were measured by magnetic relaxation and the amount of iron was determined using the original ferrofluid suspension as a reference. From this the distribution of the magnetic particles within the slice of tumor was reconstructed. Histological cross-sections of the respective tumor offer the opportunity to map quantitatively the particle distribution and the vascularisation in the targeted tumor on a microscopic scale. Our data show that the integral method magnetorelaxometry and microscopic histological methods can complete each other efficiently.

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