Intergenerational effects of omega-6 fatty acids. 1. The reproductive rate of Border Leicester × Merino ewes is influenced by the diet fed to their dams around conception

2017 ◽  
Vol 57 (1) ◽  
pp. 51 ◽  
Author(s):  
E. H. Clayton ◽  
M. A. Friend ◽  
J. F. Wilkins
Keyword(s):  
Fatty Acids ◽  
Cottonseed Meal ◽  
Maternal Diet ◽  
Female Offspring ◽  
Reproductive Rate ◽  
Reproduction Rate ◽  
Intergenerational Effects ◽  
Omega 6 ◽  
Ewe Lamb ◽  
Fat Score

The proportion of female lambs was previously higher when Merino dams were fed a diet high in omega-6 (n-6) based on oats and cottonseed meal compared with low in n-6 based on silage around mating. The effect of maternal diet on the reproductive success of the female offspring from these dams has not previously been examined. The aim of the present study was to determine whether the reproductive rate of Border Leicester × Merino ewes was higher when their Merino dams were previously fed a diet high in n-6 compared with low in n-6 around conception. Merino dams were fed diets based on either silage low in n-6 or oats and cottonseed meal high in n-6 fatty acids for ~40 days pre-mating only or 40 days pre-mating and 17 days post-mating in each of 2 years. The reproductive performance (proportion pregnant and fetuses conceived) of their Border Leicester × Merino ewe offspring born in each year was examined at their first mating. Ewe lamb birthweight and fat score at the time of mating was not significantly affected by the diet fed to their dams around mating. The proportion of Border Leicester × Merino ewes pregnant was not different, however the number of fetuses per ewe was significantly (P = 0.002) higher when their dams were fed a High n-6 compared with a Low n-6 diet around mating (1.64 ± 0.05 vs 1.42 ± 0.05 fetuses/ewe pregnant, respectively). The reproduction rate of ewes may be affected by diet fed to their dams in the peri-conceptional period and could be associated with fetal programming.

A higher proportion of female lambs when ewes were fed oats and cottonseed meal prior to and following conception

2013 ◽  
Vol 53 (5) ◽  
pp. 464 ◽  
Author(s):  
C. E. Gulliver ◽  
M. A. Friend ◽  
B. J. King ◽  
J. F. Wilkins ◽  
E. H. Clayton
Keyword(s):  
Fatty Acids ◽  
Sex Ratio ◽  
Cottonseed Meal ◽  
Body Condition Score ◽  
Control Diet ◽  
Saturated Fat ◽  
Female Offspring ◽  
Dietary Fatty Acids ◽  
Condition Score ◽  
Omega 6

Diets high in omega-6 (n-6) fatty acids in mice have been associated with a higher proportion of female offspring, however, the specific effects of dietary fatty acids on the sex ratio of sheep has not previously been reported. The aim of the present study was to determine whether feeding ewes a diet differing in n-6 for 6 weeks before and 3 weeks following conception would increase the proportion of female lambs born. Merino × Border Leicester ewes (n = 296) were allocated to receive either a diet high in n-6 (70% oat grain, 8% cottonseed meal, High n-6 diet) or, a control diet low in n-6 (88% legume silage, Low n-6 diet), for 42 or 53 days before and 17 days after conception, using a stratified block randomisation procedure based on body condition score and liveweight. Following synchronisation, oestrus was detected daily during natural mating with rams. After mating, all ewes grazed improved pastures as one group until lambing. Plasma n-6 concentrations were greater (P < 0.001), the time to parturition was shorter (P < 0.001) and the proportion of female offspring was higher (58.2 vs 43.5%, P = 0.010) when ewes were fed the High n-6 diet compared with the Low n-6 diet. Further research is required to determine whether the observed differences in sex ratio were due to specific alterations in n-6 fatty acids, or other differences in the diets not specifically related to n-6 such as saturated fat or energy density.

Intergenerational effects of omega-6 fatty acids. 2. Preliminary evidence for the influence of diet fed to dams at conception on the sex ratio of lambs born to their daughters

2017 ◽  
Vol 57 (2) ◽  
pp. 237
Author(s):  
E. H. Clayton ◽  
J. F. Wilkins ◽  
M. A. Friend
Keyword(s):  
Fatty Acids ◽  
Sex Ratio ◽  
Previous Experiment ◽  
Preliminary Evidence ◽  
Plasma Fatty Acid ◽  
Fatty Acid Status ◽  
Intergenerational Effects ◽  
Omega 6 ◽  
Acid Status ◽  
Fat Score

In a previous experiment, the proportion of female lambs was higher when Merino ewes were offered a diet high in omega-6 (n-6) compared with low in n-6 around joining. The effect of these diets on the sex ratio of lambs born to the offspring of these ewes has not previously been investigated. The aim of the current study was to determine whether the proportion of female lambs when Border Leicester × Merino ewes were fed a diet high compared with low in n-6 around mating was affected by diet previously fed to their dams at conception. Ewes were stratified to treatment group based on the diet previously fed to their dams around mating and fed a Low n-6 (lucerne hay) or High n-6 (oats and cottonseed meal) diet for ~40 days pre-mating and 17 days post-mating. Liveweight, fat score, plasma fatty acid status and lamb sex was determined. The ratio of n-6 : n-3 fatty acids in plasma was higher (P < 0.001) and the time to oestrus shorter (P < 0.001) when ewes received the High n-6 compared with the Low n-6 diet. The proportion of female lambs was not significantly (P = 0.229) higher when ewes were fed the High n-6 compared with the Low n-6 diet (59.8 vs 42.7%), but was significantly (r2 = 0.78, P = 0.008) positively correlated with the ratio of arachidonic acid to eicosapentaenoic acid in ewe plasma. The effect of the High n-6 diet on the sex ratio of lambs born to Border Leicester × Merino ewes was not affected by diet previously fed to dams around conception; however, results need to be confirmed with larger numbers of ewes. The effect of dam nutrition on the sex ratio of lambs and overall productivity should be monitored over several years.

Increased proportion of female lambs by feeding Border Leicester × Merino ewes a diet high in omega-6 fatty acids around mating

2016 ◽  
Vol 56 (5) ◽  
pp. 824 ◽  
Author(s):  
E. H. Clayton ◽  
J. F. Wilkins ◽  
M. A. Friend
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Sex Ratio ◽  
Cottonseed Meal ◽  
Plasma Fatty Acid ◽  
Fatty Acid Status ◽  
Omega 6 ◽  
Acid Status ◽  
Fat Score ◽  
Time Of Feeding

The proportion of female lambs was previously higher when ewes were offered a diet high in omega-6 fatty acids (n-6) based on oats and cottonseed meal (oats/CSM) around joining. The effect of the length of time of feeding the high n-6 diet on the sex ratio of lambs has not previously been reported. The aim of the present study was to determine whether the proportion of female lambs was higher when Border Leicester × Merino ewes were fed a diet high in n-6 either pre-conception only or both pre- and post-conception. Ewes were fed a low n-6 diet based on silage or a high n-6 diet based on oats/CSM for 40 days pre-mating until the end of mating (pre-mating) or 40 days pre-mating and 17 days post-mating. Liveweight, fat score, plasma fatty acid status and lamb sex was determined. Plasma n-6 concentration was higher (P < 0.001) and the time to oestrus shorter (P < 0.001) when ewes received oats/CSM compared with silage. The proportion of female lambs was higher when ewes were fed a high n-6 compared with low n-6 diet pre-mating only (54.1% vs 44.4%, P = 0.049) and both pre- and post-mating (57.2% vs 43.4%, P = 0.018). The interaction between diet and length of time of feeding was not significant (P = 0.537). The mechanism resulting in the diet high in omega-6 influencing the sex ratio of lambs appears to operate before or around conception but is yet to be determined.

Increasing the proportion of female lambs by feeding Merino ewes a diet high in omega-6 fatty acids around mating

2016 ◽  
Vol 56 (7) ◽  
pp. 1174 ◽  
Author(s):  
E. H. Clayton ◽  
M. A. Friend ◽  
J. F. Wilkins
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Sex Ratio ◽  
Cottonseed Meal ◽  
Plasma Fatty Acid ◽  
Fatty Acid Status ◽  
Omega 6 ◽  
Acid Status ◽  
Fat Score ◽  
Time Of Feeding

In previous experiments, the proportion of female lambs was higher when BL × Merino ewes were offered a diet high in omega-6 (n-6) than when offered one low in n-6 around joining. The aim of the current study was to determine whether the proportion of female lambs increases when Merino ewes are fed a diet high in n-6 and to further test the effect of time of feeding relative to mating. Ewes were fed a low n-6 (ryegrass silage) or high n-6 (oats and cottonseed meal) diet for ~40 days pre-mating or 40 days pre- and 17 days post-mating. Liveweight, fat score, plasma fatty acid status and lamb sex were determined. The concentration of plasma n-6 was higher (P < 0.001) and the time to oestrus shorter (P < 0.001) when ewes received the high n-6 compared with the low n-6 diet. The proportion of female lambs was higher when ewes were fed the high n-6 compared with the low n-6 diet either pre-mating only (71.3% vs 48.7%, P = 0.017) or both pre- and post-mating (69.6% vs 37.3%, P < 0.001). The sex ratio differed from an expected 50 : 50 when ewes were fed the high n-6 diet (P < 0.001), but not the low n-6 diet (P = 0.223). The effect of the high n-6 diet on the sex ratio of lambs in Merino ewes may act pre-conception, as the effect of the diet was not greater when ewes were fed both pre- and post-mating. Altering diet to increase female lamb proportions may be economically viable to producers of first-cross ewes.

Maternal diet rich in omega-6 polyunsaturated fatty acids during gestation and lactation produces autistic-like sociability deficits in adult offspring

2013 ◽  
Vol 238 ◽  
pp. 193-199 ◽  
Author(s):  
Karen L. Jones ◽  
Matt J. Will ◽  
Patrick M. Hecht ◽  
Cassandra L. Parker ◽  
David Q. Beversdorf
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Maternal Diet ◽  
Adult Offspring ◽  
Omega 6

Effect of maternal diet rich in omega-6 and omega-9 fatty acids on the liver of LDL receptor-deficient mouse offspring

2010 ◽  
Vol 89 (2) ◽  
pp. 164-170 ◽  
Author(s):  
Dilênia De Oliveira Cipriano Torres ◽  
Ana Célia Oliveira Dos Santos ◽  
Amanda Karolina Soares E. Silva ◽  
Jacqueline Isaura Alvarez Leite ◽  
José Roberto Botelho De Souza ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Maternal Diet ◽  
Ldl Receptor ◽  
Deficient Mouse ◽  
Omega 6

scholarly journals Maternal diet high in linoleic acid alters offspring fatty acids and cardiovascular function in a rat model

2021 ◽  
pp. 1-37
Author(s):  
Nirajan Shrestha ◽  
Simone L Sleep ◽  
Tessa J Helman ◽  
Olivia J Holland ◽  
James SM Cuffe ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Linoleic Acid ◽  
Cardiac Function ◽  
Maternal Diet ◽  
Cardiovascular Function ◽  
Hdl Cholesterol ◽  
Female Offspring ◽  
Total Plasma ◽  
Alpha Linolenic Acid ◽  
Wistar Kyoto

Abstract Linoleic acid (LA), an essential n-6 fatty acid (FA), is critical for fetal growth and development. We investigated the effects of maternal high LA (HLA) diet on offspring cardiac development and how it relates to circulating FAs and cardiovascular function in adolescent offspring, and the ability of the postnatal diet to reverse any adverse effects. Female Wistar Kyoto rats were fed low LA (LLA; 1.44% energy from LA) or HLA (6.21% energy from LA) diets for 10 weeks before pregnancy, and during gestation/lactation. Offspring, weaned at postnatal day 25 (PN25), were fed LLA or HLA diets and euthanised at PN40 (n = 6-8). Maternal HLA diet decreased circulating total cholesterol and HDL-cholesterol in females and decreased total plasma n-3 FA in males, while maternal and postnatal HLA diets decreased total plasma n-3 FA in females. Alpha- linolenic acid (ALA) and eicosapentaenoic acid (EPA) were decreased by postnatal but not maternal HLA diets in both sexes. Maternal and postnatal HLA diets increased total plasma n-6 and LA, and a maternal HLA diet increased circulating leptin, in both male and female offspring. Maternal HLA decreased slopes of systolic and diastolic PVRs, and increased cardiac Col1a1, Col3a1, Atp2a1 and Notch1 in males. Maternal and postnatal HLA diets left-shifted the diastolic PVR in female offspring. Coronary reactivity was altered in females, with differential effects on flow repayment after 10–20 sec occlusions. In conclusion, maternal HLA diets impact lipids, fatty acids and cardiac function in offspring, with postnatal diet modifying fatty acids and cardiac function in the female offspring.

EFFECT OF GINGER, LEMURU FISH OIL SAPONIFICATION AND OLIVE OIL ON COMPOSITION FATTY ACID OF BEEF

2014 ◽  
Vol 4 (1) ◽  
pp. 31-39
Author(s):  
Siwitri Kadarsih
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Fish Oil ◽  
Olive Oil ◽  
Rice Bran ◽  
Dry Matter ◽  
Unsaturated Fatty Acids ◽  
Saturated Fatty Acids ◽  
Omega 3 ◽  
Omega 6

The objective was to get beef that contain unsaturated fatty acids (especially omega 3 and 6), so as to improve intelligence, physical health for those who consume. The study design using CRD with 3 treatments, each treatment used 4 Bali cattle aged approximately 1.5 years. Observations were made 8 weeks. Pasta mixed with ginger provided konsentrat. P1 (control); P2 (6% saponification lemuru fish oil, olive oil 1%; rice bran: 37.30%; corn: 62.70%; KLK: 7%, ginger paste: 100 g); P3 (lemuru fish oil saponification 8%, 2% olive oil; rice bran; 37.30; corn: 62.70%; KLK: 7%, ginger paste: 200 g). Konsentrat given in the morning as much as 1% of the weight of the cattle based on dry matter, while the grass given a minimum of 10% of the weight of livestock observation variables include: fatty acid composition of meat. Data the analyzies qualitative. The results of the study showed that the composition of saturated fatty acids in meat decreased and an increase in unsaturated fatty acids, namely linoleic acid (omega 6) and linolenic acid (omega 3), and deikosapenta deikosaheksa acid.Keywords : 

Increased Prostaglandin Response to Oxytocin in Ewes Fed a Diet High in Omega-6 Polyunsaturated Fatty Acids

Lipids ◽  
2012 ◽  
Vol 48 (2) ◽  
pp. 177-183 ◽  
Author(s):  
Catherine E. Gulliver ◽  
Michael A. Friend ◽  
Belinda J. King ◽  
Susan M. Robertson ◽  
John F. Wilkins ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Omega 6
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