Human decidual and placental relaxins

1991 ◽  
Vol 3 (4) ◽  
pp. 385 ◽  
Author(s):  
GD Bryant-Greenwood
Keyword(s):  
Extracellular Matrix ◽  
Corpus Luteum ◽  
Human Placenta ◽  
Northern Analysis ◽  
Fetal Membranes ◽  
Decidual Cell ◽  
Matrix Interaction ◽  
Polypeptide Hormones ◽  
Collagen Remodelling

The human placenta and decidua are intrauterine production sites for a range of polypeptide hormones. Relaxin is one of these hormones, its production having been demonstrated by immunocytochemistry and Northern analysis. There are two relaxin genes in the human genome, termed H1 and H2; only the latter is expressed in cyclic and pregnant corpus luteum. However, it has recently been shown that both genes are expressed in the decidua and placenta. It is not known whether both are translated. These hormone(s) may act in a paracrine fashion and be partly responsible for the control of enzymes and inhibitors involved in collagen remodelling in the fetal membranes in the last weeks of pregnancy. An autocrine role of decidual relaxin and a possible decidual-cell/macrophage/extracellular-matrix interaction is described; this may act as a unit in the elaboration of a range of hormones.

The Role of TIMP3 in Microvascular Endothelial Cell‐Extracellular Matrix Interaction and Regulation of Microvascular Barrier Function

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Nidhi Kulkarni ◽  
Sanjay Mehta ◽  
Lefeng Wang ◽  
Cynthia Pape ◽  
Sean Gill
Keyword(s):  
Extracellular Matrix ◽  
Endothelial Cell ◽  
Barrier Function ◽  
Microvascular Endothelial Cell ◽  
Matrix Interaction ◽  
Microvascular Endothelial

First trimester human placenta prevents breast cancer cell attachment to the matrix: The role of extracellular matrix

2016 ◽  
Vol 56 (1) ◽  
pp. 62-74 ◽  
Author(s):  
Gali Epstein Shochet ◽  
Liat Drucker ◽  
Meir Pomeranz ◽  
Ami Fishman ◽  
Metsada Pasmanik-Chor ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Extracellular Matrix ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Human Placenta ◽  
Cell Attachment ◽  
First Trimester ◽  
The Matrix

Extracellular matrix: the gatekeeper of tumor angiogenesis

2019 ◽  
Vol 47 (5) ◽  
pp. 1543-1555 ◽  
Author(s):  
Maurizio Mongiat ◽  
Simone Buraschi ◽  
Eva Andreuzzi ◽  
Thomas Neill ◽  
Renato V. Iozzo
Keyword(s):  
Extracellular Matrix ◽  
Tumor Angiogenesis ◽  
Signaling Cascades ◽  
Cancer Growth ◽  
Cell Behavior ◽  
Metastatic Progression ◽  
Surface Receptors ◽  
The Matrix ◽  
Multiple Signaling

Abstract The extracellular matrix is a network of secreted macromolecules that provides a harmonious meshwork for the growth and homeostatic development of organisms. It conveys multiple signaling cascades affecting specific surface receptors that impact cell behavior. During cancer growth, this bioactive meshwork is remodeled and enriched in newly formed blood vessels, which provide nutrients and oxygen to the growing tumor cells. Remodeling of the tumor microenvironment leads to the formation of bioactive fragments that may have a distinct function from their parent molecules, and the balance among these factors directly influence cell viability and metastatic progression. Indeed, the matrix acts as a gatekeeper by regulating the access of cancer cells to nutrients. Here, we will critically evaluate the role of selected matrix constituents in regulating tumor angiogenesis and provide up-to-date information concerning their primary mechanisms of action.

Histological Study of Human Placenta in Preeclampsia and the Role of Decidual Natural Killer Cells and Macrophages in its Pathogenesis

2020 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Mira Youssef ◽  
Sahar Abo EL Fadl ◽  
Nada Abd EL Wahab ◽  
Dalia Ismail
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Human Placenta ◽  
Histological Study ◽  
Killer Cells ◽  
Decidual Natural Killer Cells

The Therapeutic Potential and Role of miRNA, lncRNA, and circRNA in Osteoarthritis

2019 ◽  
Vol 19 (4) ◽  
pp. 255-263 ◽  
Author(s):  
Yuangang Wu ◽  
Xiaoxi Lu ◽  
Bin Shen ◽  
Yi Zeng
Keyword(s):  
Gene Expression ◽  
Gene Therapy ◽  
Extracellular Matrix ◽  
Inflammatory Reaction ◽  
Noncoding Rna ◽  
Rna Binding ◽  
Rna Binding Proteins ◽  
Protein Translation ◽  
Cochrane Library

Background: Osteoarthritis (OA) is a disease characterized by progressive degeneration, joint hyperplasia, narrowing of joint spaces, and extracellular matrix metabolism. Recent studies have shown that the pathogenesis of OA may be related to non-coding RNA, and its pathological mechanism may be an effective way to reduce OA. Objective: The purpose of this review was to investigate the recent progress of miRNA, long noncoding RNA (lncRNA) and circular RNA (circRNA) in gene therapy of OA, discussing the effects of this RNA on gene expression, inflammatory reaction, apoptosis and extracellular matrix in OA. Methods: The following electronic databases were searched, including PubMed, EMBASE, Web of Science, and the Cochrane Library, for published studies involving the miRNA, lncRNA, and circRNA in OA. The outcomes included the gene expression, inflammatory reaction, apoptosis, and extracellular matrix. Results and Discussion: With the development of technology, miRNA, lncRNA, and circRNA have been found in many diseases. More importantly, recent studies have found that RNA interacts with RNA-binding proteins to regulate gene transcription and protein translation, and is involved in various pathological processes of OA, thus becoming a potential therapy for OA. Conclusion: In this paper, we briefly introduced the role of miRNA, lncRNA, and circRNA in the occurrence and development of OA and as a new target for gene therapy.

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