scholarly journals Resistance of Tumor Cells to Cytolytic T Lymphocytes Involves Rho-GTPases and Focal Adhesion Kinase Activation

2008 ◽  
Vol 283 (46) ◽  
pp. 31665-31672 ◽  
Author(s):  
Soraya Abouzahr-Rifai ◽  
Meriem Hasmim ◽  
Habib Boukerche ◽  
Jocelyne Hamelin ◽  
Bassam Janji ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Focal Adhesion Kinase ◽  
Tumor Cells ◽  
Focal Adhesion ◽  
Rho Gtpases ◽  
Cytolytic T Lymphocytes ◽  
Kinase Activation

scholarly journals Apigenin Inhibits NNK-Induced Focal Adhesion Kinase Activation in Pancreatic Cancer Cells

Pancreas ◽  
2012 ◽  
Vol 41 (8) ◽  
pp. 1306-1315 ◽  
Author(s):  
Hung Pham ◽  
Monica Chen ◽  
Hiroki Takahashi ◽  
Jonathan King ◽  
Howard A. Reber ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Focal Adhesion Kinase ◽  
Cancer Cells ◽  
Focal Adhesion ◽  
Kinase Activation ◽  
Pancreatic Cancer Cells

scholarly journals A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation

2013 ◽  
Vol 126 (21) ◽  
pp. 5074-5085 ◽  
Author(s):  
N. L. G. Miller ◽  
C. Lawson ◽  
E. G. Kleinschmidt ◽  
I. Tancioni ◽  
S. Uryu ◽  
...  
Keyword(s):  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Kinase Activation

scholarly journals Focal Adhesion Kinase Suppresses Apoptosis by Binding to the Death Domain of Receptor-Interacting Protein

2004 ◽  
Vol 24 (10) ◽  
pp. 4361-4371 ◽  
Author(s):  
Elena Kurenova ◽  
Li-Hui Xu ◽  
Xihui Yang ◽  
Albert S. Baldwin ◽  
Rolf J. Craven ◽  
...  
Keyword(s):  
Focal Adhesion Kinase ◽  
Tumor Cells ◽  
Focal Adhesion ◽  
Death Receptor ◽  
Human Tumors ◽  
Receptor Complex ◽  
Death Domain ◽  
Functional Link ◽  
Interacting Protein ◽  
Survival Signals

ABSTRACT Tumor cells resist the apoptotic stimuli associated with invasion and metastasis by activating survival signals that suppress apoptosis. Focal adhesion kinase (FAK), a tyrosine kinase that is overexpressed in a variety of human tumors, mediates one of these survival signals. Attenuation of FAK expression in tumor cells results in apoptosis that is mediated by caspase 8- and FADD-dependent pathways, suggesting that death receptor pathways are involved in the process. Here, we report a functional link between FAK and death receptors. We have demonstrated that FAK binds to the death domain kinase receptor-interacting protein (RIP). RIP is a major component of the death receptor complex and has been shown to interact with Fas and tumor necrosis factor receptor 1 through its binding to adapter proteins. We have shown that RIP provides proapoptotic signals that are suppressed by its binding to FAK. We thus propose that FAK overexpression in human tumors provides a survival signal function by binding to RIP and inhibiting its interaction with the death receptor complex.

scholarly journals The Netrin-1-Neogenin-1 signaling axis controls neuroblastoma cell migration via integrin-β1 and focal adhesion kinase activation

2021 ◽  
Vol 15 (1) ◽  
pp. 58-73
Author(s):  
Andrea A. Villanueva ◽  
Pilar Sanchez-Gomez ◽  
Ernesto Muñoz-Palma ◽  
Sofía Puvogel ◽  
Bárbara S. Casas ◽  
...  
Keyword(s):  
Cell Migration ◽  
Focal Adhesion Kinase ◽  
Focal Adhesion ◽  
Neuroblastoma Cell ◽  
Integrin Β1 ◽  
Kinase Activation ◽  
Signaling Axis
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