scholarly journals Loss of Androgen Receptor in Aging and Oxidative Stress through Myb Protooncoprotein-regulated Reciprocal Chromatin Dynamics of p53 and Poly(ADP-ribose) Polymerase PARP-1

2008 ◽  
Vol 283 (52) ◽  
pp. 36474-36485 ◽  
Author(s):  
Liheng Shi ◽  
Soyoung Ko ◽  
Soyoung Kim ◽  
Ibtissam Echchgadda ◽  
Tae-Sung Oh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Androgen Receptor ◽  
Chromatin Dynamics ◽  
Parp 1 ◽  
And Oxidative Stress

scholarly journals Palmitoylethanolamide/Baicalein Regulates the Androgen Receptor Signaling and NF-κB/Nrf2 Pathways in Benign Prostatic Hyperplasia

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1014
Author(s):  
Ramona D’Amico ◽  
Tiziana Genovese ◽  
Marika Cordaro ◽  
Rosalba Siracusa ◽  
Enrico Gugliandolo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Androgen Receptor ◽  
Benign Prostatic Hyperplasia ◽  
Fixed Ratio ◽  
Prostatic Hyperplasia ◽  
Prostate Cell ◽  
Common Benign Tumor ◽  
Markers Of Inflammation ◽  
Ultramicronized Palmitoylethanolamide ◽  
And Oxidative Stress

Benign prostatic hyperplasia (BPH) is the most common benign tumor in males. Androgen/androgen receptor (AR) signaling plays a key role in the development of BPH; its alterations cause an imbalance between prostate cell growth and apoptosis. Furthermore, chronic inflammation and oxidative stress, which are common conditions in BPH, contribute to disrupting the homeostasis between cell proliferation and cell death. With this background in mind, we investigated the effect of ultramicronized palmitoylethanolamide (um-PEA), baicalein (Baic) and co-ultramicronized um-PEA/Baic in a fixed ratio of 10:1 in an experimental model of BPH. BPH was induced in rats by daily administration of testosterone propionate (3 mg/kg) for 14 days. Baic (1 mg/kg), um-PEA (9 mg/kg) and um-PEA/Baic (10 mg/kg) were administered orally every day for 14 days. This protocol led to alterations in prostate morphology and increased levels of dihydrotestosterone (DHT) and of androgen receptor and 5α-reductase expression. Moreover, testosterone injections induced a significant increase in markers of inflammation, apoptosis and oxidative stress. Our results show that um-PEA/Baic is capable of decreasing prostate weight and DHT production in BPH-induced rats, as well as being able to modulate apoptotic and inflammatory pathways and oxidative stress. These effects were most likely related to the synergy between the anti-inflammatory properties of um-PEA and the antioxidant effects of Baic. These results support the view that um-PEA/Baic should be further studied as a potent candidate for the management of BPH.

scholarly journals Protective Effects of PARP-1 Knockout on Dyslipidemia-Induced Autonomic and Vascular Dysfunction in ApoE−/− Mice: Effects on eNOS and Oxidative Stress

PLoS ONE ◽  
2009 ◽  
Vol 4 (10) ◽  
pp. e7430 ◽  
Author(s):  
Chetan P. Hans ◽  
Yumei Feng ◽  
Amarjit S. Naura ◽  
Mourad Zerfaoui ◽  
Bashir M. Rezk ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vascular Dysfunction ◽  
Protective Effects ◽  
Parp 1 ◽  
And Oxidative Stress

PARP-1 modulates deferoxamine-induced HIF-1α accumulation through the regulation of nitric oxide and oxidative stress

2008 ◽  
Vol 104 (6) ◽  
pp. 2248-2260 ◽  
Author(s):  
Rubén Martínez-Romero ◽  
Esther Martínez-Lara ◽  
Rocío Aguilar-Quesada ◽  
Andreína Peralta ◽  
F. Javier Oliver ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Parp 1 ◽  
And Oxidative Stress

scholarly journals Antioxidative and Cardioprotective Properties of Anthocyanins from Defatted Dabai Extracts

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Hock Eng Khoo ◽  
Azrina Azlan ◽  
M. Halid Nurulhuda ◽  
Amin Ismail ◽  
Faridah Abas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acid Oxidation ◽  
Linoleic Acid Oxidation ◽  
Hemoglobin Oxidation ◽  
Medicinal Properties ◽  
Parp 1 ◽  
And Oxidative Stress ◽  
Peel Extract ◽  
Oxidation System ◽  
Inhibition Ability

This study aimed to determine anthocyanins and their antioxidative and cardioprotective properties in defatted dabai parts. Anthocyanins in crude extracts and extract fractions of defatted dabai peel and pericarp were quantified using UHPLC, while their antioxidant capacity and oxidative stress inhibition ability were evaluated by using DPPH and CUPRAC assays as well as linoleic acid oxidation system, hemoglobin oxidation, and PARP-1 inhibition ELISA. Cardioprotective effect of the defatted dabai peel extract was evaluated using hypercholesterolemic-induced New Zealand white rabbits. Six anthocyanins were detected in the defatted dabai peel, with the highest antioxidant capacities and oxidative stress inhibition effect compared to the other part. The defatted dabai peel extract has also inhibited lipid peroxidation (plasma MDA) and elevated cellular antioxidant enzymes (SOD and GPx) in the tested animal model. Major anthocyanin (cyanidin-3-glucoside) and other anthocyanins (pelargonidin-3-glucoside, malvidin-3-glucoside, cyanidin-3-galactoside, cyanidin-3-arabinoside, and peonidin-3-glucoside) detected in the defatted dabai peel are potential future nutraceuticals with promising medicinal properties.

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

2020 ◽  
pp. 1-8
Author(s):  
Hasan Haci Yeter ◽  
Berfu Korucu ◽  
Elif Burcu Bali ◽  
Ulver Derici
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Antioxidant Status ◽  
Total Antioxidant Status ◽  
Stress Index ◽  
Total Oxidant Status ◽  
Vitamin D Analog ◽  
Total Antioxidant ◽  
Oxidant Status ◽  
And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

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