Folate bioavailability: UK Food Standards Agency workshop report

2003 ◽  
Vol 90 (2) ◽  
pp. 473-479 ◽  
Author(s):  
Peter Sanderson ◽  
Helene McNulty ◽  
Pierpaolo Mastroiacovo ◽  
Ian F. W. McDowell ◽  
Alida Melse-Boonstra ◽  
...  
Keyword(s):  
Folic Acid ◽  
Weighted Average ◽  
Relative Bioavailability ◽  
Evidence Base ◽  
Future Research ◽  
Workshop Report ◽  
Food Standards ◽  
Folate Bioavailability ◽  
The Uk ◽  
Review Current

The UK Food Standards Agency convened a group of expert scientists to review current research investigating folate bioavailability. The workshop aimed to overview current research and establish priorities for future research. Discrepancies were observed in the evidence base for folate bioavailability, especially with regard to the relative bioavailability of natural folates compared with folic acid. A substantial body of evidence shows folic acid to have superior bioavailability relative to food folates; however, the exact relative bioavailability still needs to be determined, and in particular with regard to mixed diets. The bioavailability of folate in a mixed diet is probably not a weighted average of that in the various foods consumed; thus the workshop considered that assessment of folate bioavailability of whole diets should be a high priority for future research.

Emerging diet-related surrogate end points for colorectal cancer: UK Food Standards Agency diet and colonic health workshop report

2004 ◽  
Vol 91 (2) ◽  
pp. 315-322 ◽  
Author(s):  
Peter Sanderson ◽  
Ian T. Johnson ◽  
John C. Mathers ◽  
Hilary J. Powers ◽  
C. Stephen Downes ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Future Research ◽  
End Points ◽  
Workshop Report ◽  
Food Standards ◽  
Colonic Health ◽  
The Uk ◽  
Review Current

The UK Food Standards Agency convened a group of expert scientists to review current research investigating emerging diet-related surrogate end points for colorectal cancer (CRC). The workshop aimed to overview current research and establish priorities for future research. The workshop considered that the validation of current putative diet-related surrogate end points for CRC and the development of novel ones, particularly in the emerging fields of proteomics, genomics and epigenomics, should be a high priority for future research.

scholarly journals Iron bioavailability: UK Food Standards Agency workshop report

2006 ◽  
Vol 96 (5) ◽  
pp. 985-990 ◽  
Author(s):  
Mamta Singh ◽  
Peter Sanderson ◽  
Richard F. Hurrell ◽  
Susan J. Fairweather-Tait ◽  
Catherine Geissler ◽  
...  
Keyword(s):  
Iron Status ◽  
Premenopausal Women ◽  
Iron Bioavailability ◽  
Dietary Iron ◽  
Menstrual Blood Loss ◽  
Factors Affecting ◽  
Workshop Report ◽  
Food Standards ◽  
The Uk ◽  
Review Current

The UK Food Standards Agency convened a group of expert scientists to review current research investigating factors affecting iron status and the bioavailability of dietary iron. Results presented at the workshop show menstrual blood loss to be the major determinant of body iron stores in premenopausal women. In the presence of abundant and varied food supplies, the health consequences of lower iron bioavailability are unclear and require further investigation.

scholarly journals Folate and colo-rectal cancer risk

2007 ◽  
Vol 98 (6) ◽  
pp. 1299-1304 ◽  
Author(s):  
Peter Sanderson ◽  
Elaine Stone ◽  
Young-In Kim ◽  
John C. Mathers ◽  
Ellen Kampman ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Cancer Risk ◽  
Research Priorities ◽  
Future Research ◽  
Food Standards ◽  
Key Issues ◽  
The Uk ◽  
Review Current

The UK Food Standards Agency convened a group of expert scientists to review current research investigating folate and colo-rectal cancer risk. The workshop aimed to examine current research and establish research priorities. The timing of folate exposure with respect to carcinogenesis, as well as the dose and form of folate, were considered key issues for future research. Also, the need to study further the influence of genetically defined subgroups was highlighted for future research.

scholarly journals Folate bioavailability

2004 ◽  
Vol 63 (4) ◽  
pp. 529-536 ◽  
Author(s):  
Helene McNulty ◽  
Kristina Pentieva
Keyword(s):  
Folic Acid ◽  
Methodological Approach ◽  
Relative Bioavailability ◽  
Food Sources ◽  
Future Research ◽  
Natural Food ◽  
Limiting Factor ◽  
Folic Acid Fortification ◽  
Folate Status ◽  
Folate Bioavailability

The achievement of optimal folate status to prevent neural-tube defects, and possibly other diseases, is hindered by the well-recognised incomplete bioavailability of the natural folates found in foods compared with the synthetic vitamin, folic acid. Folate bioavailability from different foods is considered to be dependent on a number of factors, including the food matrix, the intestinal deconjugation of polyglutamyl folates, the instability of certain labile folates during digestion and the presence of certain dietary constituents that may enhance folate stability during digestion. There is conflicting evidence as to whether the extent of conjugation of polyglutamyl folate (in the absence of specific inhibitors of deconjugation in certain foods) is a limiting factor in folate bioavailability. Estimates of the extent of lower bioavailability of food folates compared with folic acid (relative bioavailability) show great variation, ranging anywhere between 10 and 98%, depending on the methodological approach used. The lack of accurate data on folate bioavailability from natural food sources is of particular concern in those countries in which there is no mandatory folic acid fortification, and therefore a greater reliance on natural food folates as a means to optimise status. Apart from the incomplete bioavailability of food folates, the poor stability of folates in foods (particularly green vegetables) under typical conditions of cooking can substantially reduce the amount of vitamin ingested and thereby be an additional factor limiting the ability of food folates to enhance folate status. A recent workshop convened by the Food Standards Agency concluded that gaining a better understanding of folate bioavailability in representative human diets is a high priority for future research.

scholarly journals Areas of agreement in the management of childhood non-infectious chronic anterior uveitis in the UK

2019 ◽  
Vol 104 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Ameenat Lola Solebo ◽  
Jugnoo S Rahi ◽  
Andrew D Dick ◽  
Athimalaipet V Ramanan ◽  
Jane Ashworth ◽  
...  
Keyword(s):  
Anterior Uveitis ◽  
Severe Disease ◽  
Evidence Base ◽  
Future Research ◽  
Multiple Sources ◽  
Delphi Consensus ◽  
Modified Delphi ◽  
The Uk ◽  
High Level

Background/aimsThere is a paucity of high-level evidence to support the management of childhood uveitis, particularly for those children without juvenile idiopathic arthritis uveitis (JIA). We undertook a modified Delphi consensus exercise to identify agreement in the management of chronic anterior uveitis (CAU), the most common manifestation of childhood disease.MethodsA four-round, two-panel process was undertaken between June and December 2017. Paediatric uveitis specialists identified through multiple sources, including a multicentre network (the Paediatric Ocular Inflammation Group), were invited to participate. They were asked whether they agreed with items derived from existing guidelines on the management of JIA-U when extrapolated to the population of all children with CAU. Consensus was defined as agreement greater than or equal to 75% of respondents.Results26 of the 38 (68%) invited specialists participated with the exercise, and response rates were 100% for rounds one to three, and 92% for round four. Consensus was reached on 23 of the 44 items. Items for which consensus was not reached included management at presentation, use of systemic and periocular steroids for children with severe disease and the role of conventional steroid sparing immunosuppressants beyond methotrexate.ConclusionThe areas of management uncertainty at the level of the group, as indicated by absence of consensus, reflect the areas where the evidence base is particularly poor. Our findings identify the key areas for the future research needed to ensure better outcomes for this blinding childhood ocular inflammatory disorders.

“Take home” naloxone: what does the evidence base tell us?

2015 ◽  
Vol 15 (2) ◽  
pp. 67-75 ◽  
Author(s):  
Josefien J. F. Breedvelt ◽  
Derek K. Tracy ◽  
Emily C. Dickenson ◽  
Lucy V. Dean
Keyword(s):  
Evidence Base ◽  
Future Research ◽  
Opioid Overdose ◽  
Pilot Studies ◽  
Content Type ◽  
Practical Concern ◽  
Drug Overdoses ◽  
Associated Risk Factors ◽  
The Uk

Purpose – Opiod users are at high risk of suffering from drug overdoses. Naloxone has been used for decades in emergency treatment settings to reverse the symptoms of opioid overdose. Pilot studies and regional programmes have been rolled out to make naloxone more widely available. This review of user/carer administration of naloxone – so-called “take home naloxone” – aims to provide health professionals and interested readers with an up-to-date evidence base, clinical implications and practical concern considerations for such community management. The paper aims to discuss these issues. Design/methodology/approach – A review and analysis of the recent literature on naloxone. Findings – The evidence base suggests training and education is effective in preparing users for wider naloxone distribution. Furthermore, studies of varying quality indicate that naloxone may prove useful in reducing overdose-related deaths. However, even after implementation ineffective response techniques continued to be used at times and there remained a heistance to call medical services post overdose. Intranasal naloxone may reduce some of the risks associated with intramuscular naloxone. Ethical considerations, including provision of a needle and syringe kit to the community, should be considered. Studies suffered from a lack of follow-up data and methodological difficulties are associated with establishing opioid-related deaths post implementation. Two running trials in the UK might mitigate these concerns. Research limitations/implications – Future research is needed to address wider context of an overdose and targeting associated risk factors. Originality/value – Clinicians and other professionals will be informed on the most up-to-date evidence base and which areas are improtant to consider when take-home naloxone is introduced in their services.

scholarly journals UK Food Standards Agency Workshop Report: carbohydrate and cardiovascular risk

2010 ◽  
Vol 103 (11) ◽  
pp. 1688-1694 ◽  
Author(s):  
Emma Peacock ◽  
John Stanley ◽  
Philip C. Calder ◽  
Susan A. Jebb ◽  
Frank Thies ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Health ◽  
Whole Grains ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Workshop Report ◽  
Food Standards ◽  
Intervention Trials ◽  
The Uk

This report summarises a workshop convened by the UK Food Standards Agency (FSA) on 14 October 2008 to discuss current FSA-funded research on carbohydrates and cardiovascular health. The objective of this workshop was to discuss the results of recent research and to identify any areas which could inform future FSA research calls. This workshop highlighted that the FSA is currently funding some of the largest, well-powered intervention trials investigating the type of fat and carbohydrate, whole grains and fruit and vegetables, on various CVD risk factors. Results of these trials will make a substantive contribution to the evidence on diet and cardiovascular risk.

scholarly journals Identifying research priorities for occupational therapy in the UK: A James Lind Alliance Priority Setting Partnership

2021 ◽  
pp. 030802262110265
Author(s):  
Jo Watson ◽  
Katherine Cowan ◽  
Hannah Spring ◽  
Jenny Mac Donnell ◽  
Ruth Unstead-Joss
Keyword(s):  
Lived Experience ◽  
Nominal Group Technique ◽  
Research Priorities ◽  
Occupational Therapists ◽  
Evidence Base ◽  
Nominal Group ◽  
Future Research ◽  
Health And Social Care ◽  
James Lind Alliance ◽  
The Uk

Introduction As the scope and nature of practice evolves in an ever-changing health and social care landscape, it is imperative the profession continues to expand the evidence base underpinning interventions. The Royal College of Occupational Therapists partnered with the James Lind Alliance to bring together people with lived experience, occupational therapists and other people working in the health and care sector to identify contemporary research priorities for the profession in the United Kingdom. Method The JLA’s well-established methodology was adopted. An opening consultation survey gathered unanswered questions. Analysis of responses and evidence checking preceded an initial prioritisation survey. The final prioritisation workshop drew on nominal group technique. Findings 927 respondents submitted 2193 questions. Those within the project’s scope were captured in 66 overarching summary questions using thematic analysis. These were initially ranked by 1140 respondents. 18 questions comprising the 10 most highly ranked by people with lived experience and by those with professional experience were considered by 19 participants in the final workshop. Together, they reached consensus on the Top 10 priorities. Conclusion These research priorities provide a contemporary framework influencing and guiding future research, ensuring it addresses the issues of greatest importance to people accessing and delivering services.

scholarly journals Evidence-Based Healthcare: The Importance of Effective Interprofessional Working for High Quality Veterinary Services, a UK Example

2016 ◽  
Vol 1 (4) ◽  
Author(s):  
Tierney Kinnison ◽  
Stephen A May
Keyword(s):  
Service Delivery ◽  
Evidence Base ◽  
Patient Treatment ◽  
Future Research ◽  
Evidence Based ◽  
Veterinary Services ◽  
Interprofessional Working ◽  
Evidence Based Healthcare ◽  
The Uk

<p class="AbstractSummary"><strong>Objective: </strong></p><p class="AbstractSummary">To highlight the importance of evidence-based research, not only for the consideration of clinical diseases and individual patient treatment, but also for investigating complex healthcare systems, as demonstrated through a focus on veterinary interprofessional working.</p><p class="AbstractSummary"><strong>Background:</strong></p><p class="AbstractSummary">Evidence-Based Veterinary Medicine (EBVM) was developed due to concerns over inconsistent approaches to therapy being delivered by individuals. However, a focus purely on diagnosis and treatment will miss other potential causes of substandard care including the holistic system. Veterinary services are provided by interprofessional teams; research on these teams is growing.</p><p class="AbstractSummary"><strong>Evidentiary value:</strong></p><p class="AbstractSummary">This paper outlines results from four articles, written by the current authors, which are unique in their focus on interprofessional practice teams in the UK. Through mixed methods, the articles demonstrate an evidence base of the effects of interprofessional working on the quality of service delivery.</p><p class="AbstractSummary"><strong>Results:</strong></p><p class="AbstractSummary">The articles explored demonstrate facilitators and challenges of the practice system on interprofessional working and the outcomes, including errors. The results encourage consideration of interprofessional relationships and activities in veterinary organisations. Interprofessional working is an example of one area which can affect the quality of veterinary services.</p><p class="AbstractSummary"><strong>Conclusion: </strong></p><p class="AbstractSummary">The papers presented on veterinary interprofessional working are an example of the opportunities for future research on various topics within evidence-based healthcare.</p><p class="AbstractSummary"><strong>Application:</strong></p><p class="AbstractSummary">The results are pertinent to members of veterinary teams seeking to improve their service delivery, to educators looking to enhance their students’ understanding of interprofessional working, and to researchers, who will hopefully be encouraged to consider evidence-based healthcare more holistically. </p><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />

UK Food Standards Agency Workshop Report: Diet and Immune Function

2010 ◽  
Vol 103 (11) ◽  
pp. 1684-1687 ◽  
Author(s):  
Peter Sanderson ◽  
Rachel L. Elsom ◽  
Verity Kirkpatrick ◽  
Philip C. Calder ◽  
Jayne V. Woodside ◽  
...  
Keyword(s):  
Immune Function ◽  
Vegetable Intake ◽  
Pneumococcal Vaccination ◽  
Future Research ◽  
Nutritional Interventions ◽  
Immune Parameters ◽  
Food Standards ◽  
Health Relevance ◽  
The Uk ◽  
Potential Public Health

The UK Food Standards Agency convened a workshop on 13 May 2009 to discuss recently completed research on diet and immune function. The objective of the workshop was to review this research and to establish priorities for future research. Several of the trials presented at the workshop showed some effect of nutritional interventions (e.g. vitamin D, Zn, Se) on immune parameters. One trial found that increased fruit and vegetable intake may improve the antibody response to pneumococcal vaccination in older people. The workshop highlighted the need to further clarify the potential public health relevance of observed nutrition-related changes in immune function, e.g. susceptibility to infections and infectious morbidity.

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