Emerging diet-related surrogate end points for colorectal cancer: UK Food Standards Agency diet and colonic health workshop report

2004 ◽  
Vol 91 (2) ◽  
pp. 315-322 ◽  
Author(s):  
Peter Sanderson ◽  
Ian T. Johnson ◽  
John C. Mathers ◽  
Hilary J. Powers ◽  
C. Stephen Downes ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Future Research ◽  
End Points ◽  
Workshop Report ◽  
Food Standards ◽  
Colonic Health ◽  
The Uk ◽  
Review Current

The UK Food Standards Agency convened a group of expert scientists to review current research investigating emerging diet-related surrogate end points for colorectal cancer (CRC). The workshop aimed to overview current research and establish priorities for future research. The workshop considered that the validation of current putative diet-related surrogate end points for CRC and the development of novel ones, particularly in the emerging fields of proteomics, genomics and epigenomics, should be a high priority for future research.

Folate bioavailability: UK Food Standards Agency workshop report

2003 ◽  
Vol 90 (2) ◽  
pp. 473-479 ◽  
Author(s):  
Peter Sanderson ◽  
Helene McNulty ◽  
Pierpaolo Mastroiacovo ◽  
Ian F. W. McDowell ◽  
Alida Melse-Boonstra ◽  
...  
Keyword(s):  
Folic Acid ◽  
Weighted Average ◽  
Relative Bioavailability ◽  
Evidence Base ◽  
Future Research ◽  
Workshop Report ◽  
Food Standards ◽  
Folate Bioavailability ◽  
The Uk ◽  
Review Current

The UK Food Standards Agency convened a group of expert scientists to review current research investigating folate bioavailability. The workshop aimed to overview current research and establish priorities for future research. Discrepancies were observed in the evidence base for folate bioavailability, especially with regard to the relative bioavailability of natural folates compared with folic acid. A substantial body of evidence shows folic acid to have superior bioavailability relative to food folates; however, the exact relative bioavailability still needs to be determined, and in particular with regard to mixed diets. The bioavailability of folate in a mixed diet is probably not a weighted average of that in the various foods consumed; thus the workshop considered that assessment of folate bioavailability of whole diets should be a high priority for future research.

scholarly journals Iron bioavailability: UK Food Standards Agency workshop report

2006 ◽  
Vol 96 (5) ◽  
pp. 985-990 ◽  
Author(s):  
Mamta Singh ◽  
Peter Sanderson ◽  
Richard F. Hurrell ◽  
Susan J. Fairweather-Tait ◽  
Catherine Geissler ◽  
...  
Keyword(s):  
Iron Status ◽  
Premenopausal Women ◽  
Iron Bioavailability ◽  
Dietary Iron ◽  
Menstrual Blood Loss ◽  
Factors Affecting ◽  
Workshop Report ◽  
Food Standards ◽  
The Uk ◽  
Review Current

The UK Food Standards Agency convened a group of expert scientists to review current research investigating factors affecting iron status and the bioavailability of dietary iron. Results presented at the workshop show menstrual blood loss to be the major determinant of body iron stores in premenopausal women. In the presence of abundant and varied food supplies, the health consequences of lower iron bioavailability are unclear and require further investigation.

scholarly journals Folate and colo-rectal cancer risk

2007 ◽  
Vol 98 (6) ◽  
pp. 1299-1304 ◽  
Author(s):  
Peter Sanderson ◽  
Elaine Stone ◽  
Young-In Kim ◽  
John C. Mathers ◽  
Ellen Kampman ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Cancer Risk ◽  
Research Priorities ◽  
Future Research ◽  
Food Standards ◽  
Key Issues ◽  
The Uk ◽  
Review Current

The UK Food Standards Agency convened a group of expert scientists to review current research investigating folate and colo-rectal cancer risk. The workshop aimed to examine current research and establish research priorities. The timing of folate exposure with respect to carcinogenesis, as well as the dose and form of folate, were considered key issues for future research. Also, the need to study further the influence of genetically defined subgroups was highlighted for future research.

scholarly journals UK Food Standards Agency Workshop Report: carbohydrate and cardiovascular risk

2010 ◽  
Vol 103 (11) ◽  
pp. 1688-1694 ◽  
Author(s):  
Emma Peacock ◽  
John Stanley ◽  
Philip C. Calder ◽  
Susan A. Jebb ◽  
Frank Thies ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Health ◽  
Whole Grains ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Workshop Report ◽  
Food Standards ◽  
Intervention Trials ◽  
The Uk

This report summarises a workshop convened by the UK Food Standards Agency (FSA) on 14 October 2008 to discuss current FSA-funded research on carbohydrates and cardiovascular health. The objective of this workshop was to discuss the results of recent research and to identify any areas which could inform future FSA research calls. This workshop highlighted that the FSA is currently funding some of the largest, well-powered intervention trials investigating the type of fat and carbohydrate, whole grains and fruit and vegetables, on various CVD risk factors. Results of these trials will make a substantive contribution to the evidence on diet and cardiovascular risk.

UK Food Standards Agency Workshop Report: Diet and Immune Function

2010 ◽  
Vol 103 (11) ◽  
pp. 1684-1687 ◽  
Author(s):  
Peter Sanderson ◽  
Rachel L. Elsom ◽  
Verity Kirkpatrick ◽  
Philip C. Calder ◽  
Jayne V. Woodside ◽  
...  
Keyword(s):  
Immune Function ◽  
Vegetable Intake ◽  
Pneumococcal Vaccination ◽  
Future Research ◽  
Nutritional Interventions ◽  
Immune Parameters ◽  
Food Standards ◽  
Health Relevance ◽  
The Uk ◽  
Potential Public Health

The UK Food Standards Agency convened a workshop on 13 May 2009 to discuss recently completed research on diet and immune function. The objective of the workshop was to review this research and to establish priorities for future research. Several of the trials presented at the workshop showed some effect of nutritional interventions (e.g. vitamin D, Zn, Se) on immune parameters. One trial found that increased fruit and vegetable intake may improve the antibody response to pneumococcal vaccination in older people. The workshop highlighted the need to further clarify the potential public health relevance of observed nutrition-related changes in immune function, e.g. susceptibility to infections and infectious morbidity.

scholarly journals Review of the FSA’s research programme on food hypersensitivity

2021 ◽  
Author(s):  
Paul Turner ◽  
John O'Brien
Keyword(s):  
Scientific Evidence ◽  
Research Programme ◽  
Global Scale ◽  
Food Hypersensitivity ◽  
Future Research ◽  
Food Standards ◽  
Immune Mediated ◽  
Safe Food ◽  
Food Recalls ◽  
The Uk

The overarching mission of the Food Standards Agency (FSA) is tothe ensure that food is safe, food is what it says it is and that consumers can make informed choices about what to eat. These are of central importance to consumers with food hypersensitivity(FHS).Food hypersensitivity (FHS) encompasses both immune-mediated food hypersensitivity (food allergy and coeliac disease) and non-immune food intolerances. FHS is a complex, multifactorial disease of concern to multiple stakeholders including consumers with FHS, their families, clinicians, regulatory agencies and policy makers, scientists, food manufacturers and food business operators. It affects around 5-8% of children and 2-3% of adults in the UK, and although rare, can be fatal. Public concern over FHS has grown in recent years. In the UK and elsewhere, food recalls due to the presence of undeclared allergens feature predominantly in food alerts; legislation over food labelling has become clearer, and consumers and producers are more aware of FHS. The FSA has been a major funder of research into FHS for over 2 decades, and the outputs of the research programme has had significant impacts at a national and global scale, most notably in the area of the prevention of FHS in children and the presence of declared and undeclared allergens in food products. Strengthening protections for consumers with FHS is a top priority for the FSA. The FSA has established a Food Hypersensitivity Programme Board to oversee and coordinate its work in this area. The working group was tasked with reviewing the research into FHS supported by the Food Standards Agency to date, and prioritising those priority areas where the current scientific evidence is limited and therefore should be a focus for future research investment. The aim –to make the UK the best country in the world for consumers with food hypersensitivity.

scholarly journals Dietary lipids and vascular function: UK Food Standards Agency workshop report

2004 ◽  
Vol 91 (3) ◽  
pp. 491-500 ◽  
Author(s):  
Peter Sanderson ◽  
Margreet Olthof ◽  
Robert F. Grimble ◽  
Philip C. Calder ◽  
Bruce A. Griffin ◽  
...  
Keyword(s):  
Vascular Function ◽  
Detrimental Effect ◽  
Intervention Studies ◽  
Dietary Intervention ◽  
Dietary Lipids ◽  
Food Standards ◽  
Study Population ◽  
The Uk ◽  
Review Current ◽  
Long Chain

The UK Food Standards Agency convened a group of expert scientists to review current research investigating the effect of dietary lipids on vascular function. The workshop highlighted the need for intervention studies to be sufficiently powered for these measures and that they should be corroborated with other, more validated, risk factors for CVD. Work presented at the workshop suggested a beneficial effect of long-chain n-3 PUFA and a detrimental effect of trans fatty acids. The workshop also considered the importance of the choice of study population in dietary intervention studies and that ‘at risk’ subgroups within the general population may be more appropriate than subjects that are unrepresentatively healthy.

scholarly journals Functional markers of selenium status: UK Food Standards Agency workshop report

2006 ◽  
Vol 96 (5) ◽  
pp. 980-984 ◽  
Author(s):  
Rachel Elsom ◽  
Peter Sanderson ◽  
John E. Hesketh ◽  
Malcolm J. Jackson ◽  
Susan J. Fairweather-Tait ◽  
...  
Keyword(s):  
Health Outcomes ◽  
Human Subjects ◽  
Research Priorities ◽  
Future Research ◽  
Functional Markers ◽  
Selenium Status ◽  
Workshop Report ◽  
Food Standards ◽  
The Relationship ◽  
Se Status

The workshop was organised to discuss the validity and limitations of existing functional markers of Se status in human subjects and to identify future research priorities in this area. Studies presented as part of this workshop investigated: the bioavailability of Se from different dietary sources; potential functional markers of Se status; individual variation in response to Se; the effect of marginal Se status on immune function. The workshop highlighted the need to define the relationship between functional markers of Se status and health outcomes.

Using the Change4Life Disney Branded 10-minute Shake Ups During the COVID-19 ‘Lockdown’

2020 ◽  
Author(s):  
Emily Budzynski-Seymour ◽  
James Steele ◽  
Michelle Jones
Keyword(s):  
Perceived Exertion ◽  
Affective Responses ◽  
Online Resources ◽  
Future Research ◽  
Affective States ◽  
Perceived Effort ◽  
Qualitative Feedback ◽  
Bidirectional Relationship ◽  
The Uk

Physical activity (PA) is considered essential to overall health yet it is consistently reported that children are failing to meet the recommended levels. Due to the bidirectional relationship between affective states and PA, affective responses are a potential predictor to long term engagement. Since late March 2020 the UK government enforced ‘lockdown’ measures to help control the spread of Coronavirus (COVID-19); however, this has impacted children’s PA. Using online resources at home to support PA is now common. The primary aim of this research was to investigate the use of the Change4Life 10-minute Shake Ups to support PA by examining the effects of Disney branding upon children’s (n=32) post activity affective responses and perceived exertion. The secondary was to investigate the effect of the lockdown on PA habits. Children had similar positive affective responses and perceived effort to activities; however, branding was considered to be a key contributing factor based upon qualitative feedback from parents. Children’s PA levels dropped slightly since ‘lockdown’ was imposed; though online resources have been utilised to support PA. The use of immersive elements such as characters and narrative in PA sessions, as well as utilising online resources during ‘lockdown’ appear potentially promising for future research.

Transferrin-Conjugated Nanocarriers as Active-Targeted Drug Delivery Platforms for Cancer Therapy

2017 ◽  
Vol 23 (3) ◽  
pp. 454-466 ◽  
Author(s):  
Daniele R. Nogueira-Librelotto ◽  
Cristiane F. Codevilla ◽  
Ammad Farooqi ◽  
Clarice M. B. Rolim
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Therapeutic Benefit ◽  
Active Targeting ◽  
Future Research ◽  
Passive Targeting ◽  
The Right ◽  
Review Current ◽  
Target Effects

A lot of effort has been devoted to achieving active targeting for cancer therapy in order to reach the right cells. Hence, increasingly it is being realized that active-targeted nanocarriers notably reduce off-target effects, mainly because of targeted localization in tumors and active cellular uptake. In this context, by taking advantage of the overexpression of transferrin receptors on the surface of tumor cells, transferrin-conjugated nanodevices have been designed, in hope that the biomarker grafting would help to maximize the therapeutic benefit and to minimize the side effects. Notably, active targeting nanoparticles have shown improved therapeutic performances in different tumor models as compared to their passive targeting counterparts. In this review, current development of nano-based devices conjugated with transferrin for active tumor-targeting drug delivery are highlighted and discussed. The main objective of this review is to provide a summary of the vast types of nanomaterials that have been used to deliver different chemotherapeutics into tumor cells, and to ultimately evaluate the progression on the strategies for cancer therapy in view of the future research.

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