N-Acetyltransferase-2, Glutathione S-Transferase M1, Alcohol Dehydrogenase, and Cytochrome P450IIE1 Genotypes in Alcoholic Liver Cirrhosis: A Case?Control Study

1999 ◽  
Vol 34 (3) ◽  
pp. 303-307 ◽  
Author(s):  
L. Rodrigo, V. Alvarez, M. Rodrigue
Keyword(s):  
Liver Cirrhosis ◽  
Alcohol Dehydrogenase ◽  
Case Control Study ◽  
Case Control ◽  
Alcoholic Liver Cirrhosis ◽  
Glutathione S Transferase ◽  
Control Study

Analysis of glutathione S-transferase genes polymorphisms and the risk of schizophrenia in a sample of Iranian population

2011 ◽  
Vol 7 (2-4) ◽  
pp. 199-203 ◽  
Author(s):  
Farah Lotfi Kashani ◽  
Dor Mohammad Kordi-Tamandani ◽  
Roya Sahranavard ◽  
Mohammad Hashemi ◽  
Farzaneh Kordi-Tamandani ◽  
...  
Keyword(s):  
Genomic Dna ◽  
Case Control Study ◽  
Gene Interaction ◽  
Case Control ◽  
Glutathione S Transferase ◽  
Chain Reaction ◽  
Healthy Control ◽  
Glutathione S Transferases ◽  
Polymerase Chain ◽  
Control Study

Glutathione S-transferases (GSTs) are major intracellular antioxidants, which, impaired in their function, are involved in the progress of schizophrenia (SCZ). The aim of this case-control study was to investigate the association between the polymorphism of glutathione S-transferases M1 (GSTM1), T1 (GSTT1), the glutathione S-transferase P1 gene (GSTP1) and SCZ. We isolated genomic DNA from peripheral blood of 93 individuals with SCZ and 99 healthy control subjects' genotypes analyzing them for GSTM1, GSTT1 and GSTP1 using polymerase chain reaction. The analysis of the gene–gene interaction between GSTs indicated that the magnitude of the association was greater for the combined AG/GSTT1 & GSTM1 genotypes (OR = 2.51; 95% CI: 1.13–5.63, P = 0.02). The AG and combined AG + GG genotypes of GSTP1 increased the risk of SCZ (OR = 1.83; 95% CI: 0.94–3.75 and OR = 1.71; 95% CI: 0.92–3.19, respectively). The genotypes of GSTT/NULL, NULL/GSTM and NULL/NULL increased the risk of SCZ (OR = 2.05; 95% CI: 0.9–4.74; OR = 2.0; 95% CI: 1.68–2.31; and OR = 1.8; 95% CI: 0.57–2.46, respectively). The present study supports previous data that suggest that impairment in the function of GSTs genes may increase the risk of SCZ.

Polymorphisms of glutathione S-transferase μ and θ, MDR1 and VEGF genes as risk factors of bladder cancer: A case-control study

2012 ◽  
Vol 30 (5) ◽  
pp. 660-665 ◽  
Author(s):  
Luis Alberto Henríquez-Hernández ◽  
Patricio Navarro ◽  
Octavio P. Luzardo ◽  
Eva Elisa Álvarez-León ◽  
Luis D. Boada ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bladder Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Glutathione S Transferase ◽  
Control Study
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