Parametrization of particle coating process with chitosan in spouted bed

Abstract Particle coating process, one of the main methods to improve the particle properties, is widely used in industrial production and pharmaceutical industry. For the scale up and optimization of this process, a mechanistic and detailed study is needed or numerical simulation as an alternative way. Decomposition of substances usually involves multiple chemical reactions and produces multiple substances in the actual chemical reaction. In the study, a chemical reaction flow (CRF) model has been established based on kinetic mechanism of elementary reaction, the theory of molecular thermodynamics and the sweep theory. It was established with the comprehensive consideration of the decomposition of substances, deposition process, adhesion process, desorption process, hydrogen inhibition, and clearance effect. Then the CFD-DEM model was coupled with CRF model to simulate particle coating process by FB-CVD method, and the CFD-DEM-CRF coupling model was implemented in the software Fluent-EDEM with their user definition function (UDF) and application programming interface (API). The coating process in the spouted bed was analyzed in detail and the coating behavior under different conditions were compared at the aspects of CVD rate, coating efficiency, particle concentration distribution, particle mixing index and gas concentration distribution. It is found that the average CVD rate is 6.06 × 10−4 mg/s when the inlet gas velocity is 11 m/s and bed temperature is 1273 K, and simulation result agrees with the experimental result well. Average CVD rate and coating efficiency increase with temperature increasing, but decrease acutely with mass fraction of injected hydrogen increasing. The CFD-DEM-CRF coupling model can be developed as a basic model for investigating particle coating process in detail and depth and can provide some guidance for the operating conditions and parameters design of the spouted bed in the real coating process.

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Simulation of Spouted Bed Using a Eulerian Multiphase Model

Materials Science Forum ◽

10.4028/www.scientific.net/msf.498-499.270 ◽

2005 ◽

Vol 498-499 ◽

pp. 270-277 ◽

Cited By ~ 3

Author(s):

Claudio Roberto Duarte ◽

Valéria V. Murata ◽

Marcos A.S. Barrozo

Keyword(s):

Control Volume ◽

Flow Behavior ◽

Cfd Modeling ◽

Gas Flows ◽

Present Calculation ◽

Multiphase Model ◽

Spouted Bed ◽

Particle Coating ◽

Spouted Beds ◽

Good Agreement

Spouted bed systems have emerged as very efficient fluid-particle contactors and find many applications in the chemical and biochemical industry. Some important applications of spouted beds include coal combustion, biochemical reactions, drying of solids, drying of solutions and suspensions, granulation, blending, grinding, and particle coating. An extensive overview can be found in Mathur and Epstein[1]. The pattern of solid and gas flows in a spouted bed was numerically simulated using a CFD modeling technique. The Eulerian-Eulerian multifluid modeling approach was applied to predict gas-solid flow behavior. A commercially available, control-volume-based code FLUENT 6.1 was chosen to carry out the computer simulations. In order to reduce computational times and required system resources, the 2D axisymmetric segregated solver was chosen. The typical flow pattern of the spouted bed was obtained in the present calculation. The simulated velocity and voidage profiles presented a good agreement qualitative and quantitative with the experimental results obtained by He et al. [4].

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Analysis of particle coating by spouted bed process

International Journal of Pharmaceutics ◽

10.1016/s0378-5173(97)00181-6 ◽

1997 ◽

Vol 158 (1) ◽

pp. 1-9 ◽

Cited By ~ 22

Author(s):

W.P. de Oliveira ◽

J.T. Freire ◽

J.R. Coury

Keyword(s):

Spouted Bed ◽

Particle Coating

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Effect of Surface Properties on Particle Growth Kinetics for Polymer Coating in Spouted Bed

Materials Science Forum ◽

10.4028/www.scientific.net/msf.727-728.1616 ◽

2012 ◽

Vol 727-728 ◽

pp. 1616-1621 ◽

Cited By ~ 1

Author(s):

Boeira Braga Matheus ◽

Cristina dos Santos Rocha Sandra

Keyword(s):

Surface Energy ◽

Surface Properties ◽

Growth Kinetics ◽

Particle Growth ◽

Operating Conditions ◽

Polymeric Film ◽

Spouted Bed ◽

Particle Coating ◽

Solids Concentration ◽

Before And After

In this research, glass beads with size range between 1.68 and 2mm were coated with 5 polymeric suspensions. The suspensions formulations differ in relation to their employment and physical properties (solids concentration, surface tension and rheology), generating different characteristics of wettability and adhesion with the nucleus. The aim of this study was to evaluate particle coating in a spouted bed through analysis of particle growth in terms of solid surface energy, wettability, and adhesion before and after the formation of the first layer of polymeric film on the particle. The solid-suspension and film-suspension systems were characterized by contact angle and surface energy. The operating conditions were fixed for all suspensions: 1.5 kg of beads, air velocity of 0.369 m/s, air temperature of 60 °C, suspension flow rate of 4 ml and atomizing pressure of 10 psig. Analyzing particle growth kinetics, different behaviors were observed and related not only to glass-suspension wettability, but also to polymeric film-suspension surface properties.

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Increasing flowability and bulk density of PE-HD powders by a dry particle coating process and impact on LBM processes

Rapid Prototyping Journal ◽

10.1108/rpj-07-2013-0074 ◽

2015 ◽

Vol 21 (6) ◽

pp. 697-704 ◽

Cited By ~ 20

Author(s):

Christina Blümel ◽

Marius Sachs ◽

Tobias Laumer ◽

Bettina Winzer ◽

Jochen Schmidt ◽

...

Keyword(s):

Product Quality ◽

Bulk Density ◽

Design Methodology ◽

Coating Process ◽

Content Type ◽

Particle Coating ◽

Laser Beam Melting ◽

Powder Deposition ◽

Dry Particle Coating

Purpose – The purpose of this paper is to demonstrate the processability of cohesive PE-HD particles in laser beam melting processes (LBM) of polymers. Furthermore, we present a characterization method for polymer particles, which can predict the quality of the powder deposition via LBM processes. Design/methodology/approach – This study focuses on the application of dry particle coating processes to increase flowability and bulk density of PE-HD particles. Both has been measured and afterwards validated via powder deposition of PE-HD particles in a LBM machine. Findings – For efficient coating in a dry particle coating process, the PE-HD particles and the attached nanoparticles need to show similar surface chemistry, i.e. both need to behave either hydrophobic or hydrophilic. It is demonstrated that dry particle coating is appropriate to enhance flowability and bulk density of PE-HD particles and hence considerably improves LBM processes and the resulting product quality. Originality/value – At present, in LBM processes mainly polyamide (PA), 12 particles are used, which are so far quite expensive in comparison to, for example, PE-HD particles. This work provides a unique and versatile method for nanoparticulate surface modification which may be applied to a wide variety of materials. After the coating, the particles are applicable for the LBM process. Our results provide a correlation between flowability and bulk density and the resulting product quality.

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Optimization of the UO2 kernel coating process by 2D simulation of spouted bed dynamics in the coater

Nuclear Engineering and Design ◽

10.1016/j.nucengdes.2011.10.062 ◽

2012 ◽

Vol 251 ◽

pp. 124-130 ◽

Cited By ~ 12

Author(s):

Malin Liu ◽

Bing Liu ◽

Youlin Shao

Keyword(s):

Coating Process ◽

Spouted Bed ◽

2D Simulation

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Influence of Polymeric Suspension Characteristics on the Particle Coating in a Spouted Bed

Drying Technology ◽

10.1080/07373930500209905 ◽

2005 ◽

Vol 23 (9-11) ◽

pp. 1811-1823 ◽

Cited By ~ 10

Author(s):

Marta Wilk Donida ◽

Sandra C. S. Rocha ◽

Flávia Bartholomeu

Keyword(s):

Spouted Bed ◽

Particle Coating

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Study of a delayed-release system for hard and soft capsules coated with eudragit® s100 acrylic polymers

Acta Scientiarum Health Sciences ◽

10.4025/actascihealthsci.v42i1.48422 ◽

2020 ◽

Vol 42 ◽

pp. e48422

Author(s):

Luciana Arantes Soares ◽

Eduardo Crema

Keyword(s):

Palm Oil ◽

Coating Process ◽

Spouted Bed ◽

Active Ingredients ◽

Enteric Coating ◽

Experimental Conditions ◽

Acrylic Polymers ◽

Release System ◽

Delayed Release ◽

Pharmaceutical Application

The objective of this study was to evaluate a pH-dependent system of ileocolonic release of active ingredients using the polymer Eudragit® S100. A spouted bed was used in the coating process of soft capsules containing palm oil and of hard capsules containing glutamine under standardised experimental conditions. The height and diameter of the palm oil and glutamine capsules were measured using a calliper. The following variables were analysed: Eudragit® S100 dispersion amount used in the capsule coating process, nozzle air pressure, nozzle air flow rate, spray rate and temperature of the spouted bed coating process. The Eudragit® S100 dispersion formulation, trademarked as Quickstart® by Evonik Industries, was used with modifications to prepare the enteric coating. The results showed that the adequate temperature for the spouted bed coating process was 50°C and that 0.2 mL of 6.5% Eudragit® S100 coating per cm2 capsule was resistant for 60 minutes at pH 6.8. The findings demonstrate the pharmaceutical application of Eudragit® S100 in the modification of the coating and the preparation of a delayed-release system of hard and soft capsules, thus enabling ileal release of active ingredients.

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