scholarly journals Study of a delayed-release system for hard and soft capsules coated with eudragit® s100 acrylic polymers

2020 ◽  
Vol 42 ◽  
pp. e48422
Author(s):  
Luciana Arantes Soares ◽  
Eduardo Crema
Keyword(s):  
Palm Oil ◽  
Coating Process ◽  
Spouted Bed ◽  
Active Ingredients ◽  
Enteric Coating ◽  
Experimental Conditions ◽  
Acrylic Polymers ◽  
Release System ◽  
Delayed Release ◽  
Pharmaceutical Application

The objective of this study was to evaluate a pH-dependent system of ileocolonic release of active ingredients using the polymer Eudragit® S100. A spouted bed was used in the coating process of soft capsules containing palm oil and of hard capsules containing glutamine under standardised experimental conditions. The height and diameter of the palm oil and glutamine capsules were measured using a calliper. The following variables were analysed: Eudragit® S100 dispersion amount used in the capsule coating process, nozzle air pressure, nozzle air flow rate, spray rate and temperature of the spouted bed coating process. The Eudragit® S100 dispersion formulation, trademarked as Quickstart® by Evonik Industries, was used with modifications to prepare the enteric coating. The results showed that the adequate temperature for the spouted bed coating process was 50°C and that 0.2 mL of 6.5% Eudragit® S100 coating per cm2 capsule was resistant for 60 minutes at pH 6.8. The findings demonstrate the pharmaceutical application of Eudragit® S100 in the modification of the coating and the preparation of a delayed-release system of hard and soft capsules, thus enabling ileal release of active ingredients.

Treatment of Cork Wastes in a Conical Spouted Bed Reactor

2006 ◽  
Vol 4 (1) ◽  
Author(s):  
Maria J San Jose ◽  
Sonia Alvarez ◽  
Alvaro Ortiz de Salazar ◽  
Alberto Morales ◽  
Javier Bilbao
Keyword(s):  
Granular Materials ◽  
Particle System ◽  
Previous Knowledge ◽  
Spouted Bed ◽  
Experimental Conditions ◽  
Glass Spheres ◽  
Geometric Factors ◽  
Hydrodynamic Study

The applicability of conical spouted bed reactors for the treatment of cork caps has been studied by means of a hydrodynamic study with homogeneous beds of cork of different size in different experimental conditions. The validity of the ranges of the geometric factors of the contactor and of the contactor-particle system for stable spouting established in previous papers and of the equation for the calculation of the minimum spouting velocity proposed for granular materials and glass spheres has been proven for beds consisting of cork. The suitable design of the conical spouted bed reactor for the combustion of cork wastes requires the previous knowledge of the ranges of the geometric factors of the contactor and of the contactor-particle system for stable spouting.

scholarly journals Pharmaceutical Application of Tablet Film Coating

Pharmaceutics ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 853
Author(s):  
Ki-Soo Seo ◽  
Rajiv Bajracharya ◽  
Sang Hoon Lee ◽  
Hyo-Kyung Han
Keyword(s):  
Computational Modeling ◽  
Analytical Techniques ◽  
Film Coating ◽  
Dosage Forms ◽  
Coating Process ◽  
Coating Materials ◽  
Coating Technology ◽  
Advantages And Disadvantages ◽  
Pharmaceutical Application

Tablet film coating is a common but critical process providing various functionalities to tablets, thereby meeting diverse clinical needs and increasing the value of oral solid dosage forms. Tablet film coating is a technology-driven process and the evolution of coated dosage forms relies on advancements in coating technology, equipment, analytical techniques, and coating materials. Although multiple coating techniques are developed for solvent-based or solvent-free coating processes, each method has advantages and disadvantages that may require continuous technical refinement. In the film coating process, intra- and inter-batch coating uniformity of tablets is critical to ensure the quality of the final product, especially for active film coating containing active pharmaceutical ingredients in the coating layer. In addition to experimental evaluation, computational modeling is also actively pursued to predict the influence of operation parameters on the quality of the final product and optimize process variables of tablet film coating. The concerted efforts of experiments and computational modeling can save time and cost in optimizing the tablet coating process. This review provides a brief overview of tablet film coating technology and modeling approaches with a focus on recent advancements in pharmaceutical applications.

A new multiparticulate delayed release system.

1997 ◽  
Vol 47 (2) ◽  
pp. 181-189 ◽  
Author(s):  
Peter Schultz ◽  
Peter Kleinebudde
Keyword(s):  
Release System ◽  
Delayed Release

scholarly journals Influence of the Degumming Process Parameters on the Formation of Glyceryl Esters and 3-MCPDE in Refined Palm Oil: Optimization and Palm Oil Quality Analyses

Foods ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 124
Author(s):  
Mohammad Saiful Nidzam ◽  
Md. Sohrab Hossain ◽  
Norli Ismail ◽  
Razam Abdul Latip ◽  
Muhammad Khalish Mohammad Ilias ◽  
...  
Keyword(s):  
Reaction Time ◽  
Phosphoric Acid ◽  
Palm Oil ◽  
Oil Quality ◽  
Experimental Conditions ◽  
Rbd Palm Oil ◽  
Degumming Process ◽  
Central Composite ◽  
Phosphoric Acid Concentration

The presence of glyceryl esters (GE) and 3-monochloropropane-1,2-diol esters (3-MCPDE) in refined, bleached, and deodorized (RBD) palm oil is severely concerning to the palm oil consumer. In the present study, the influence of the phosphoric acid degumming process on the formation of GE and 3-MCDE and in the RBD palm oil was determined with varying the acid dose (0.03–0.06 wt%), temperature (70–100 °C), and reaction time (15–45 min). The experimental conditions of the acid degumming process were designed following the central composite design of experiments, and they were optimized using Response Surface Methodology (RSM) based on the minimal formation of GE and 3-MCDE in the RBD palm oil. The optimal experimental conditions of the acid degumming process were a reaction time of 30 min, phosphoric acid concentration of 0.06 wt%, and temperature of 90 °C. Under these experimental conditions, the minimal GE and 3-MCDE formation in RBD palm oil were determined to be 0.61 mg/kg and 0.59 mg/kg; respectively. Several analytical methods were employed to determine RBD palm oil quality, including color, phosphorus, free fatty acids (FFAs), peroxide values, and fatty acid properties. It was found that the phosphoric acid degumming of CPO effectively removed the phosphorus and hydroperoxide content without conceding the quality of palm oil.

scholarly journals FORMULATION AND EVALUATION OF PRESS COATED TABLETS OF LANSOPRAZOLE

2019 ◽  
pp. 49-56
Author(s):  
Prasanthi D ◽  
PRASHANTI. S ◽  
MEGHANA G
Keyword(s):  
Ethyl Cellulose ◽  
Chemical Properties ◽  
Enteric Coating ◽  
Scanning Calorimetry ◽  
Dsc Studies ◽  
Delayed Release ◽  
Ich Guidelines ◽  
Physico Chemical ◽  
Enteric Coated ◽  
Core Tablet

Objective: Lansoprazole an proton pump inhibitor, degrades in acidic environment, hence protection of drug is done by coating the drug with enteric coating polymers. The aim and objective of the present study was to prepare enteric coated delayed release tablets of lansoprazole by using press coating technique. Methods: Core tablets were prepared by direct compression and evaluated for their physico-chemical properties. Press coated tablets were formulated by using different combinations of ethyl cellulose, HPMC E15 and HPMC K4M as a coating layer. Core and coated tablets were optimized by dissolution studies. Fourier transform infra-red spectroscopy (FTIR) and differential scanning calorimetry (DSC) studies were performed to know the compatibility of drug with various excipients. Surface morphology and uniformity of coat was evaluated by Scanning electron microscopy (SEM). Stability of optimized formulation was evaluated according to ICH guidelines. Results: Among the various formulations F5 containing ethyl cellulose: HPMC E15 (10:90) and F9 containing ethyl cellulose: HPMC K4M (25:75) were optimized based on the better drug release within 8 h. DSC studies and FTIR studies revealed compatibility of drug with excipients. Obtained SEM photographs of tablets showed that the surface of core tablet is uniformly coated with coat by press coating. Stability studies showed that the formulations were stable. Conclusion: As a result, delayed release press coated tablets developed in this study delivered lansoprazole in the intestine and protected the drug from degradation.

CFD-DEM simulation of particle coating process coupled with chemical reaction flow model

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Meng Chen ◽  
Zhao Chen ◽  
Yaping Tang ◽  
Malin Liu
Keyword(s):  
Chemical Reaction ◽  
Concentration Distribution ◽  
Coupling Model ◽  
Operating Conditions ◽  
Experimental Result ◽  
Coating Process ◽  
Spouted Bed ◽  
Desorption Process ◽  
Particle Coating ◽  
Coating Efficiency

Abstract Particle coating process, one of the main methods to improve the particle properties, is widely used in industrial production and pharmaceutical industry. For the scale up and optimization of this process, a mechanistic and detailed study is needed or numerical simulation as an alternative way. Decomposition of substances usually involves multiple chemical reactions and produces multiple substances in the actual chemical reaction. In the study, a chemical reaction flow (CRF) model has been established based on kinetic mechanism of elementary reaction, the theory of molecular thermodynamics and the sweep theory. It was established with the comprehensive consideration of the decomposition of substances, deposition process, adhesion process, desorption process, hydrogen inhibition, and clearance effect. Then the CFD-DEM model was coupled with CRF model to simulate particle coating process by FB-CVD method, and the CFD-DEM-CRF coupling model was implemented in the software Fluent-EDEM with their user definition function (UDF) and application programming interface (API). The coating process in the spouted bed was analyzed in detail and the coating behavior under different conditions were compared at the aspects of CVD rate, coating efficiency, particle concentration distribution, particle mixing index and gas concentration distribution. It is found that the average CVD rate is 6.06 × 10−4 mg/s when the inlet gas velocity is 11 m/s and bed temperature is 1273 K, and simulation result agrees with the experimental result well. Average CVD rate and coating efficiency increase with temperature increasing, but decrease acutely with mass fraction of injected hydrogen increasing. The CFD-DEM-CRF coupling model can be developed as a basic model for investigating particle coating process in detail and depth and can provide some guidance for the operating conditions and parameters design of the spouted bed in the real coating process.

scholarly journals Influence of Fresh Palm Fruit Sterilization in the Production of Carotenoid-Rich Virgin Palm Oil

Foods ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2838
Author(s):  
Nik Suhaimi Mat Hassan ◽  
Md. Sohrab Hossain ◽  
Venugopal Balakrishnan ◽  
Mark Harris Zuknik ◽  
Muliadi Mustaner ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Palm Oil ◽  
Oil Palm ◽  
Unsaturated Fatty Acids ◽  
High Heat ◽  
Experimental Conditions ◽  
Palm Fruit ◽  
Nutrient Contents ◽  
Palm Fruits ◽  
Cold Pressed

Palm oil is known to be rich in carotenoids and other phytonutrients. However, the carotenoids and phytonutrients degrade due to high heat sterilization of oil palm fruits. The present study was conducted to produce carotenoid-rich virgin palm oil (VPO) using cold-press extraction. Herein, the influence of sterilization of oil palm fresh fruits in the production of cold-pressed VPO was determined with varying sterilization temperatures, times, and amounts of palm fruits in sterilization. The experimental sterilization conditions were optimized using response surface methodology (RSM) based on the maximum VPO yield and minimum FFAs in cold-pressed VPO. The optimal sterilization experimental conditions of oil palm fruits were determined to be a sterilization temperature of 62 °C, a time of 90 min, and an amount of oil palm fruits of 8 kg. Under these experimental conditions, the maximum cold-pressed VPO yield and the minimal content of free fatty acids (FFAs) obtained were 27.94 wt.% and 1.32 wt.%, respectively. Several analytic methods were employed to determine cold-pressed VPO quality and fatty acids compositions and compared with the crude palm oil. It was found that cold-pressed VPO contains higher carotenoids (708 mg/g) and unsaturated fatty acids compared with the carotenoid (343 mg/g) and fatty acid compositions in CPO. The findings of the present study reveal that the sterilization temperature potentially influences the carotenoid and nutrient contents in VPO; therefore, the optimization of the sterilization conditions is crucial to producing carotenoid- and phytonutrient-rich VPO.

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