Platelet-rich plasma reduces the oxidative damage determined by a skeletal muscle contusion in rats

Abstract Ginger (Zingiber Officinale Roscoe) has been known reduce muscle pain after exercise, and 6-shogaol {(E)-1-(4-Hydroxy-3-methoxyphenyl)dec-4-en-3-one)} is the major essential oil contained in ginger. In this study, the protective effect of 6-shogaol on L6 muscle cells against oxidative damage was measured. 6-shagol inhibited the damage of L6 cell induced by H2O2, and allowed the increase in mRNA and protein expression levels of intracellular HO-1 and NRF2. 6-shogaol also reduced the production of intracellular ROS. These results suggested that 6-shagol effectively inhibits oxidative damage of skeletal muscle cell.

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Platelet-Rich Plasma and Skeletal Muscle Healing: A Molecular Analysis of the Early Phases of the Regeneration Process in an Experimental Animal Model

PLoS ONE ◽

10.1371/journal.pone.0102993 ◽

2014 ◽

Vol 9 (7) ◽

pp. e102993 ◽

Cited By ~ 44

Author(s):

Ivan Dimauro ◽

Loredana Grasso ◽

Simona Fittipaldi ◽

Cristina Fantini ◽

Neri Mercatelli ◽

...

Keyword(s):

Skeletal Muscle ◽

Animal Model ◽

Molecular Analysis ◽

Experimental Animal ◽

Platelet Rich Plasma ◽

Experimental Animal Model ◽

Regeneration Process ◽

Early Phases

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Structural characterization of corn silk polysaccharides and its effect in H2O2 induced oxidative damage in L6 skeletal muscle cells

Carbohydrate Polymers ◽

10.1016/j.carbpol.2018.12.049 ◽

2019 ◽

Vol 208 ◽

pp. 161-167 ◽

Cited By ~ 13

Author(s):

Qingwen Guo ◽

Leilei Xu ◽

Yue Chen ◽

Qiqi Ma ◽

Ramesh Kumar Santhanam ◽

...

Keyword(s):

Skeletal Muscle ◽

Oxidative Damage ◽

Structural Characterization ◽

Muscle Cells ◽

Skeletal Muscle Cells ◽

Corn Silk ◽

L6 Skeletal Muscle Cells

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Mitochondrial Oxidative Damage in Chicken Skeletal Muscle Induced by Acute Heat Stress

The Journal of Poultry Science ◽

10.2141/jpsa.44.439 ◽

2007 ◽

Vol 44 (4) ◽

pp. 439-445 ◽

Cited By ~ 99

Author(s):

Ahmad Mujahid ◽

Neil R. Pumford ◽

Walter Bottje ◽

Kiyotaka Nakagawa ◽

Teruo Miyazawa ◽

...

Keyword(s):

Skeletal Muscle ◽

Heat Stress ◽

Oxidative Damage ◽

Acute Heat Stress ◽

Mitochondrial Oxidative Damage ◽

Chicken Skeletal Muscle

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EFFECT OF SKELETAL MUSCLE CONTUSION ON POLYMORPHONUCLEAR NEUTROPHIL (PMN) ROLLING

Southern Medical Journal ◽

10.1097/00007611-199610001-00178 ◽

1996 ◽

Vol 89 (Supplement) ◽

pp. S90

Author(s):

Al Marr ◽

Thomas Smith ◽

Walton Curl ◽

Eileen Rosencrance

Keyword(s):

Skeletal Muscle ◽

Polymorphonuclear Neutrophil ◽

Skeletal Muscle Contusion

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PO-052 Study on the Expression of Inflammatory Factor, chemotactic factor in the Repair of Skeletal Muscle Contusion in Mic

Exercise Biochemistry Review ◽

10.14428/ebr.v1i3.10703 ◽

2018 ◽

Vol 1 (3) ◽

Author(s):

Linlin Zhao ◽

Weihua Xiao ◽

Xin Xu

Keyword(s):

Skeletal Muscle ◽

Muscle Injury ◽

Inflammatory Factors ◽

Control Group ◽

Inflammatory Factor ◽

Post Injury ◽

Skeletal Muscle Contusion ◽

Chemotactic Factors ◽

Polymerase Chain ◽

Gastrocnemius Muscles

Objective To investigate the regulation of muscle inflammatory factors and chemotactic factors during the repair of skeletal muscle contusion in mice. Methods Forty C57 male mice were needed. Eight for control group (C, n=8) and thirty-tow for muscle contusion group (S, n=32). Subsequently, their gastrocnemius muscles were harvested at 0d, 1d, 3d, 7d, 14d after injury. Hematoxylinand eosin (HE) stain were used to assess the changes of muscle morphology. In addition, the gene expression of inflammatory factors and chemotactic factors was analyzed by real-time polymerase chain reaction. Results 1、Morphology of skeletal muscles showed signs of regeneration at 3d post injury. The maximumamount of regeneration muscle fibers appeared during one week post contusion. Two weeks post-injury morphology of myofibers nearly recovered to normal. 2、After skeletal muscle injury, macrophage markers (CD68, CD163, CD206), a variety of inflammatory factors (IL-1, IL-6, IL-10) were up-regulated. 3、chemotactic factors (CCL2, CCL3, CCL5, CCL8, CXCL9, CXCL10, CXCL12, mRNA) were up-regulated。 Conclusions After skeletal muscle contusion, the expression of a variety of chemotactic factors is up-regulated, which promotes macrophage infiltration and produces a variety of inflammatory factors. They may be involved in the inflammatory response and regeneration process after skeletal muscle contusion.

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Exercise protects against doxorubicin-induced oxidative stress and proteolysis in skeletal muscle

Journal of Applied Physiology ◽

10.1152/japplphysiol.00677.2010 ◽

2011 ◽

Vol 110 (4) ◽

pp. 935-942 ◽

Cited By ~ 69

Author(s):

Ashley J. Smuder ◽

Andreas N. Kavazis ◽

Kisuk Min ◽

Scott K. Powers

Keyword(s):

Oxidative Stress ◽

Skeletal Muscle ◽

Antioxidant Enzymes ◽

Heat Shock ◽

Heat Shock Protein ◽

Oxidative Damage ◽

Muscle Fibers ◽

Muscular Exercise ◽

Protease Activation ◽

Exercise Induced

Doxorubicin (Dox) is a potent antitumor agent used in cancer treatment. Unfortunately, Dox is myotoxic and results in significant reductions in skeletal muscle mass and function. Complete knowledge of the mechanism(s) by which Dox induces toxicity in skeletal muscle is incomplete, but it is established that Dox-induced toxicity is associated with increased generation of reactive oxygen species and oxidative damage within muscle fibers. Since muscular exercise promotes the expression of numerous cytoprotective proteins (e.g., antioxidant enzymes, heat shock protein 72), we hypothesized that muscular exercise will attenuate Dox-induced damage in exercise-trained muscle fibers. To test this postulate, Sprague-Dawley rats were randomly assigned to the following groups: sedentary, exercise, sedentary with Dox, or exercise with Dox. Our results show increased oxidative stress and activation of cellular proteases (calpain and caspase-3) in skeletal muscle of animals treated with Dox. Importantly, our findings reveal that exercise can prevent the Dox-induced oxidative damage and protease activation in the trained muscle. This exercise-induced protection against Dox-induced toxicity may be due, at least in part, to an exercise-induced increase in muscle levels of antioxidant enzymes and heat shock protein 72. Together, these novel results demonstrate that muscular exercise is a useful countermeasure that can protect skeletal muscle against Dox treatment-induced oxidative stress and protease activation in skeletal muscles.

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