Haplotype-based, case–control study of myosin phosphatase target subunit 1 (PPP1R12A) gene and hypertensive disorders of pregnancy

2021 ◽  
Vol 40 (1) ◽  
pp. 88-96
Author(s):  
Ai Kono ◽  
Kaori Shinya ◽  
Tomohiro Nakayama ◽  
Elisa Shikata ◽  
Tatsuo Yamamoto ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Hypertensive Disorders Of Pregnancy ◽  
Myosin Phosphatase ◽  
Hypertensive Disorders ◽  
Control Study

Basal Plate Myometrial Fibers and Hypertensive Disorders of Pregnancy: A Case–Control Study

2017 ◽  
Vol 21 (3) ◽  
pp. 296-299 ◽  
Author(s):  
Ann A Wang ◽  
Linda M Ernst ◽  
Emily S Miller
Keyword(s):  
Case Control Study ◽  
Gestational Hypertension ◽  
Case Control ◽  
Basal Plate ◽  
Common Finding ◽  
Pathological Examination ◽  
Chronic Hypertension ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Control Study

Introduction Basal plate myometrium (BPMYO), the pathological presence of myometrial fibers in the basal plate, is a common finding on pathological examination of the placenta, yet its clinical correlates are not well studied. As myometrial fibers are frequently located in proximity to poorly converted maternal spiral arteries, our objective was to determine whether BPMYO is associated with hypertensive disorders of pregnancy (HDP), a well-known clinical sequela of abnormal maternal artery remodeling. Methods This case–control study included women who delivered a live-born singleton gestation whose placentas were sent for pathological examination. Cases were women with HDP (gestational hypertension, preeclampsia, or HELLP syndrome) as defined by American College of Obstetricians and Gynecologists. Controls were women without HDP. Women with chronic hypertension were excluded. The primary outcome was the presence of BPMYO. Secondary outcomes included the pathologic stage of BPMYO and the incidence of pathologically defined accreta. Each outcome was compared between cases and controls in bivariable and multivariable analyses. Results Of the 306 women who met inclusion criteria, 230 (75%) had HDP. BPMYO was present in 99 (32%) of placentas. Compared to controls, cases were younger, had higher body mass index, and were more likely to have diabetes, be nulliparous, deliver preterm, and have had a prior cesarean. There were no differences in the incidence of BPMYO, stage of BPMYO, or incidence of pathologically defined accreta between cases and controls. These findings persisted after controlling for potential confounders. Conclusions Although BPMYO may be more common in the setting of abnormal placental vasculature, there is no significant association between BPMYO and HDP.

scholarly journals Can serum homocysteine predict hypertensive disorders of pregnancy?: an evidence from a case control study in a North Indian tertiary health care institution

2019 ◽  
Vol 8 (8) ◽  
pp. 3117
Author(s):  
Kushla Pathania ◽  
S. K. Verma ◽  
Shaina Chamotra ◽  
Ankit Chaudhary
Keyword(s):  
Case Control Study ◽  
Homocysteine Level ◽  
Perinatal Outcomes ◽  
Case Control ◽  
Unknown Etiology ◽  
Intrauterine Death ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Increased Risk ◽  
Control Study

Background: Hypertensive disorders of pregnancy are a major cause of both maternal and foetal morbidity and mortality. Although pregnancy induced hypertension (PIH) is still regarded as a disease of theories and unknown etiology, elevated homocysteine level has been hypothesized as a key risk factor. Abnormally raised homocysteine has been significantly associated with increased risk of PIH, abruption, intrauterine growth restriction, recurrent pregnancy loss, intrauterine death and prematurity.Methods: The present case control study was conducted among 180 pregnant women (90 cases and 90 controls) in Kamla Nehru State Hospital for Mother and Child, IGMC Shimla, Himachal Pradesh with an objective of ascertaining the role of homocysteine in pregnancy related hypertensive disorders. Socio-demographic, clinical, biochemical including homocysteine level, laboratory and ultrasonographic parameters of all the participants were documented.Results: The mean homocysteine level of cases (18.30±10.81) was significantly higher than the controls (8.70±2.64).  About 62.2% cases had abnormally raised homocysteine level (>15 µmol/L), while only 1.1% controls had such level. The odds of a case having abnormally elevated homocysteine level were 146.6 (CI: 19.52-1101) times to that of controls. Eclamptics had the highest homocysteine level followed by preeclamptics and controls.Conclusions: The present study significantly associates the abnormally elevated homocysteine levels with pregnancy related hypertensive ailments and demands much needed robustly designed studies to further explore the phenomenon. A simple intervention like estimating the much neglected homocysteine levels prior to pregnancy can definitely aid in predicting and preventing perinatal outcomes.

A case–control study between the STIM1 gene and hypertensive disorders of pregnancy

2017 ◽  
Vol 41 (1) ◽  
pp. 39-44 ◽  
Author(s):  
Kaori Shinya ◽  
Tomohiro Nakayama ◽  
Takuo Nakayama ◽  
Tatsuo Yamamoto
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Control Study

scholarly journals Risk factors for hypertensive disorders of pregnancy in Abuja, Nigeria: A prospective case-control study

2020 ◽  
Vol 37 (1) ◽  
pp. 46
Author(s):  
MalachyEmeka Ayogu ◽  
GodwinOtuodichinma Akaba ◽  
RichardA Offiong ◽  
NathanielD Adewole ◽  
BissalahAhmed Ekele
Keyword(s):  
Risk Factors ◽  
Case Control Study ◽  
Case Control ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Control Study ◽  
Prospective Case Control Study

scholarly journals Risk factors associated with hypertensive disorders in pregnancy in Nekemte referral hospital, from July 2015 to June 2017, Ethiopia: case-control study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Leta Hinkosa ◽  
Almaz Tamene ◽  
Negeso Gebeyehu
Keyword(s):  
Risk Factors ◽  
Case Control Study ◽  
Case Control ◽  
Hypertensive Disorders Of Pregnancy ◽  
Positive History ◽  
Factors Associated ◽  
Hypertensive Disorders ◽  
History Of ◽  
Control Study ◽  
In Pregnancy

Abstract Background Hypertension is the most common medical problem encountered in pregnancy and is a leading cause of perinatal and maternal morbidity and mortality. However, its magnitude and risk factors yet not adequately assessed at the study area. Methods Facility-based retrospective unmatched case-control study was conducted to identify risk factors associated with Hypertensive disorders of pregnancy in Nekemte Referral Hospital just two years back from study period July 1, 2015, to June 30, 2017. Bivariate logistic regression was considered for inclusion in to the multivariate logistic regression. Finally, multi varaite analysis were done to identify risk factors of hypertensive disorders of pregnancy. Results Among 6826 total delivery records from July 2015 –June 2017, 199 women developed hypertension during pregnancy. Among 199 women 153(76.9%) were pre-eclampsia/eclampsia,28(14.1%) were gestational hypertension, 14(0.7%) were superimposed hypertension and 4 (2.9%) were chronic hypertension. Age ≥ 35 (AOR: 2.51, 95% CI: 1.08, 5.83), rural residential area (AOR: 1.79, 95% CI: 1.150, 2.799), prim gravida (AOR: 3.39, 95% CI: 2.16, 5.33), null parity (AOR: 4.35, 95% CI: 2.36, 8.03), positive history of abortion (AOR: 4.39, 95% CI: 1.64, 11.76), twin pregnancy (AOR: 3.78, 95% CI: 1.52, 9.39), lack of ANC follow up (AOR: 3.05, 95% CI: 1.56, 5.96) as well as positive pre-existing hypertension (AOR: 3.81, 95% CI: 1.69, 8.58), positive family history of hypertension (AOR: 5.04, 95% CI: 2.66, 9.56) and positive history of diabetes mellitus (AOR: 5.03, 95% CI: 1.59, 15.89) were risk factors for hypertensive disorders during pregnancy. Conclusion This study found that Women with hypertension during pregnancy have a greater risk of developing adverse pregnancy outcome as compared to normotensive pregnant women. so, identification of these risk factors would be useful for early diagnosis of hypertension disorders during pregnancy to give appropriate clinical monitoring and treatments and timely managing maternal and perinatal complications.

scholarly journals Syphilis Infection During Pregnancy will Increases the Risk of Hypertensive Disorders of Pregnancy- Results from A Case-Control Study in China

2021 ◽  
Author(s):  
Xiangyi Zhang ◽  
Huixin Yang ◽  
Lixin Sun ◽  
Jing Hu ◽  
Mujinyan Li ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Total Cholesterol ◽  
Case Control Study ◽  
Case Control ◽  
Hypertensive Disorders Of Pregnancy ◽  
Related Factors ◽  
Syphilis Infection ◽  
Maternal Anemia ◽  
Hypertensive Disorders ◽  
Control Study

Abstract BackgroundThe incidence of pregnancy syphilis remains at a high level in China. Studies investigating the influencing factors of pregnancy syphilis are mainly concentrated in economically developed areas. Limited studies were conducted in northern China. This study mainly aimed to explore the related factors of pregnancy syphilis and examine the association with the risk of Hypertensive disorders of pregnancy.MethodsThis case-control study compared pregnancy syphilis cases, matched (1:1) to non-syphilitic pregnant women controls by age, which was diagnosed in Changchun between January 2014 and December 2018. Multivariable logistic regression was used to identify potential correlates of HDP in syphilis populations. Then a propensity score-matched method was conducted to match pregnancy syphilis with and without HDP, and further we explore the related factors of HDP in syphilis by multivariable logistic regression.ResultsIn our study, the median age of syphilis in the case group was 28 years (range 16-53 years). A high rate of syphilis-HDP co-infection（49/349, 12.3%）was observed in syphilis patients and further research revealed an association between syphilis and HDP. Multivariate analysis indicated HDP in syphilis was independently associated with Dysmenorrhea [adjusted odds ratio (a OR) 5.413, 95% confidence interval (CI) 2.410-12.158], Maternal anemia (a OR 3.808, 95% CI 1.833-7.911), Total cholesterol (a OR 3.144, 95% CI 1.485-6.655).ConclusionSyphilis infection in pregnancy associate with the increased risk of hypertensive disorders of pregnancy, attention should also be paid to the occurrence of HDP in the lower age group, to further prevent the occurrence of stroke, cardiovascular disease. Besides, Dysmenorrhea, Maternal anemia, Total cholesterol may be risk factors for HDP in syphilis.

scholarly journals The burden of severe hypertensive disorders of pregnancy on perinatal outcomes: a nationwide case-control study in Suriname

2021 ◽  
pp. 100027
Author(s):  
Zita D. PRÜST ◽  
Lachmi R. KODAN ◽  
Thomas VAN DEN AKKER ◽  
Kitty W.M. BLOEMENKAMP ◽  
Marcus J. RIJKEN ◽  
...  
Keyword(s):  
Case Control Study ◽  
Perinatal Outcomes ◽  
Case Control ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
Control Study

scholarly journals Determinants of Preterm Birth among Mothers Who Gave Birth in Dilla University Referral Hospital, Southern Ethiopia: A Case-Control Study

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Dagmawit Wakeyo ◽  
Yohannes Addisu ◽  
Moges Mareg
Keyword(s):  
Urinary Tract Infection ◽  
Preterm Birth ◽  
Urinary Tract ◽  
Tract Infection ◽  
Case Control Study ◽  
Case Control ◽  
Hypertensive Disorders Of Pregnancy ◽  
Hypertensive Disorders ◽  
History Of ◽  
Control Study

Globally, every year, 1.1 million newborns die due to prematurity. In Ethiopia, 320,000 preterm births occur each year; out of these, 24,400 deaths were due to preterm complications. However, there is little evidence about preterm birth in the study area. Therefore, this study provides an important direction for health professionals, health programmers, and researchers. A facility-based unmatched case-control study design was employed among 244 women (61 cases and 183 controls) who gave birth in Dilla University Referral Hospital and were selected with purposive sampling. The bivariate and multivariable logistic regression model was used to select independent predictors of preterm birth. The multivariate analysis was used, and the results were interpreted using an adjusted odds ratio at 95% confidence interval and statistically significant level at a P value less than 0.05. A total of 240 mothers (60 cases and 180 controls) were included in the study with a 98.3% response rate. Factors like attending secondary educational and above [adjusted odd ratio aOR = 0.07 (0.08-0.65)] and attending antenatal care [ aOR = 0.41 (0.18-0.93)] were protective whereas having urinary tract infection [ aOR = 3.6 (1.1-11)], having human immune virus diseases [ aOR = 4.2 (0.9-18)], having a history of abortion [ aOR = 2.3 (1.1-5)], having a history of preterm delivery [ aOR = 5 (1.6-15)], and having hypertensive disorders of pregnancy [ aOR = 5 (1.9-13)] were significantly associated risk factors for preterm birth. The main determinant factors for preterm birth are having antenatal care follow-up, attending secondary education and above, hypertensive disorders of pregnancy, having HIV/AIDS, and history of abortion. This shows a need to strengthen female education; screen mothers for HIV/AIDS, urinary tract infection, and hypertension; and strengthen nutritional counseling, during ANC visits.

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