Syphilis Infection During Pregnancy will Increases the Risk of Hypertensive Disorders of Pregnancy- Results from A Case-Control Study in China
Abstract BackgroundThe incidence of pregnancy syphilis remains at a high level in China. Studies investigating the influencing factors of pregnancy syphilis are mainly concentrated in economically developed areas. Limited studies were conducted in northern China. This study mainly aimed to explore the related factors of pregnancy syphilis and examine the association with the risk of Hypertensive disorders of pregnancy.MethodsThis case-control study compared pregnancy syphilis cases, matched (1:1) to non-syphilitic pregnant women controls by age, which was diagnosed in Changchun between January 2014 and December 2018. Multivariable logistic regression was used to identify potential correlates of HDP in syphilis populations. Then a propensity score-matched method was conducted to match pregnancy syphilis with and without HDP, and further we explore the related factors of HDP in syphilis by multivariable logistic regression.ResultsIn our study, the median age of syphilis in the case group was 28 years (range 16-53 years). A high rate of syphilis-HDP co-infection(49/349, 12.3%)was observed in syphilis patients and further research revealed an association between syphilis and HDP. Multivariate analysis indicated HDP in syphilis was independently associated with Dysmenorrhea [adjusted odds ratio (a OR) 5.413, 95% confidence interval (CI) 2.410-12.158], Maternal anemia (a OR 3.808, 95% CI 1.833-7.911), Total cholesterol (a OR 3.144, 95% CI 1.485-6.655).ConclusionSyphilis infection in pregnancy associate with the increased risk of hypertensive disorders of pregnancy, attention should also be paid to the occurrence of HDP in the lower age group, to further prevent the occurrence of stroke, cardiovascular disease. Besides, Dysmenorrhea, Maternal anemia, Total cholesterol may be risk factors for HDP in syphilis.