Sulforaphane-decorated gold nanoparticle for anti-cancer activity: in vitro and in vivo studies

Polyphenols are naturally occurring compounds found in abundance in fruits and vegetables. Their health-promoting properties and their use in the prevention and treatment of many human diseases, including cancer, have been known for years. Many anti-cancer drugs are derived from these natural compounds. Etoposide, which is a semi-synthetic derivative of podophyllotoxin, a non-alkaloid lignan isolated from the dried roots and rhizomes of Podophyllum peltatum or Podophyllum emodi (Berberidaceae), is an example of such a compound. In this review, we present data on the effects of polyphenols on the anti-cancer activity of etoposide in in vitro and in vivo studies.

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Novel daidzein molecules exhibited anti-prostate cancer activity through nuclear receptor ERβ modulation, in vitro and in vivo studies

Journal of Chemotherapy ◽

10.1080/1120009x.2021.1924935 ◽

2021 ◽

pp. 1-13

Author(s):

R. Ranjithkumar ◽

K. Saravanan ◽

B. Balaji ◽

S. Hima ◽

S. Sreeja ◽

...

Keyword(s):

Prostate Cancer ◽

Nuclear Receptor ◽

In Vivo Studies ◽

Cancer Activity

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The Occurrence and Biological Activity of Tormentic Acid—A Review

Molecules ◽

10.3390/molecules26133797 ◽

2021 ◽

Vol 26 (13) ◽

pp. 3797

Author(s):

Marta Olech ◽

Wojciech Ziemichód ◽

Natalia Nowacka-Jechalke

Keyword(s):

Biological Activity ◽

Plant Species ◽

Current Knowledge ◽

In Vivo Studies ◽

Natural Sources ◽

Anti Cancer ◽

Biochemical Mechanisms ◽

Tormentic Acid

This review focuses on the natural sources and pharmacological activity of tormentic acid (TA; 2α,3β,19α-trihydroxyurs-2-en-28-oic acid). The current knowledge of its occurrence in various plant species and families is summarized. Biological activity (e.g., anti-inflammatory, antidiabetic, antihyperlipidemic, hepatoprotective, cardioprotective, neuroprotective, anti-cancer, anti-osteoarthritic, antinociceptive, antioxidative, anti-melanogenic, cytotoxic, antimicrobial, and antiparasitic) confirmed in in vitro and in vivo studies is compiled and described. Biochemical mechanisms affected by TA are indicated. Moreover, issues related to the biotechnological methods of production, effective eluents, and TA derivatives are presented.

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Evaluation of the anti-cancer activity of the triterpenoidal saponin fraction isolated from the traditional Chinese medicine Conyza blinii H. Lév.

RSC Advances ◽

10.1039/c6ra26361e ◽

2017 ◽

Vol 7 (6) ◽

pp. 3408-3412 ◽

Cited By ~ 11

Author(s):

Long Ma ◽

Haiyan Liu ◽

Lingpei Meng ◽

Ping Qin ◽

Botao Zhang ◽

...

Keyword(s):

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Anti Cancer ◽

Saponin Fraction ◽

Cancer Activity

Triterpenoidal saponins fraction isolated from a traditional Chinese medicine Conyza blinii H. Lév. demonstrates anti-cancer activity both in vitro and in vivo.

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Viscum album (L) extracts in cancer treatment: a systematic review of in vitro and in vivo studies

International Journal of High Dilution Research - ISSN 1982-6206 ◽

10.51910/ijhdr.v14i2.787 ◽

2021 ◽

Vol 14 (2) ◽

pp. 52-52

Author(s):

Aloisio Cunha de Carvalho ◽

Leoni Villano Bonamin

Keyword(s):

Systematic Review ◽

Experimental Studies ◽

Pharmaceutical Preparations ◽

Viscum Album ◽

In Vitro Models ◽

In Vivo Studies ◽

Pubmed Database ◽

Anti Cancer

Background: Several reviews about phytotherapy and homeopathy have been published in the last years, including Viscum album (VA.L). VA is a parasite plant whose extract has anti-cancer proprieties and is used alone or in combination with conventional chemotherapy. Methods: We performed a systematic review about the in vivo and in vitro models described in the literature, including veterinary clinical trials. The literature was consulted from Pubmed database. Results: There are several kinds of pharmaceutical preparations about VA and their active principles used in experimental studies, lectin being frequently studied (alone or as an extract compound). More than 50% of available literature about VA is related to the lectin effects. On the other hand, the effects of viscotoxins are less studied. Among the in vivo experimental studies about VA and its compounds, the B16 murine melanoma is the most used model, followed by Ehrlich, Walker and Dalton tumors. The results point to the apoptotic effects, metastasis control and tumor regression. Some veterinary clinical studies about the use of VA in the treatment of sarcoid, fibrosarcoma and neuroblastoma are quoted in literature too, with interesting results. Considering the in vitro models, our review revealed that NALM6 leukemia cells, B16 melanoma and NC1-H460 lung carcinoma were the most studied tumor models, apoptosis signals being the most important findings. Only one study verified immunoglobulin and interleukin production. All consulted papers were related to phytotherapy preparations only. Conclusions: Although the literature about the anti-cancer activity of VA extract and its lectins is enough, there is a marked lack of information about viscotoxin activities and about the effects of homeopathic preparations of this plant on animal tumors and on in vitro cultivated tumor cells.

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