A Modified Franz Diffusion Cell for Simultaneous Assessment of Drug Release and Washability of Mucoadhesive Gels

Antifungal drug, Ketoconazole was encapsulated in liposomes for topical application. Ketoconazole liposomes were prepared by thin film hydration technique using soya lecithin, cholesterol and drug in different weight ratios. The prepared liposomes were characterized for size, shape, entrapment efficiency, in-vitro drug release (by franz diffusion cell) and physical stability. The studies demonstrated successful preparation of Ketoconazole liposomes and effect of soya lecithin: cholesterol weight ratio on entrapment efficiency and on drug release.

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Diffusion of lidocaine hydrochloride from lipid microparticles

Chemical Industry and Chemical Engineering Quarterly ◽

10.2298/ciceq0901033p ◽

2009 ◽

Vol 15 (1) ◽

pp. 33-35 ◽

Cited By ~ 4

Author(s):

Rada Pjanovic ◽

Radoslava Stojanovic ◽

Milana Sajber ◽

Jelena Veljkovic ◽

Nevenka Boskovic-Vragolovic ◽

...

Keyword(s):

Drug Release ◽

Diffusion Rate ◽

Drug Carriers ◽

Lidocaine Hydrochloride ◽

Diffusion Cell ◽

Sustained Drug Release ◽

Franz Diffusion Cell ◽

Diffusion Rates ◽

Hydrochloride Solution ◽

Prolonged Drug Release

Lipid particles, as drug carriers, are of increasing research interest, because a sustained drug release and avoidance of side effects could be achieved by using them. Lidocaine hydrochloride is a very efficient local anesthetic, but it has a short effect. The objective was to prolong the effect of the drug by encapsulating lidocaine hydrochloride in phospholipids microparticles. Two different procedures were used for the preparation of phospholipids microparticles. In both cases, phosphatidylcholine and lysophosphatidylcholine were used for the preparation of microparticles in which 5 % w/w lidocaine hydrochloride solution was encapsulated. The standard Franz diffusion cell was used for the experimental diffusion rate determination. The obtained results show that diffusion rate from microparticles is significantly lower than from the lidocaine hydrochloride solution, which means that this kind of microparticles could be used for the prolonged drug release. There was no much difference in diffusion rates from microparticles obtained by different procedures. That indicates that only the composition of the particles membrane has an influence on the lidocaine hydrochloride release rate.

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Ion mobility spectrometry as a high-throughput technique for in vitro transdermal Franz diffusion cell experiments of ibuprofen

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2011.02.027 ◽

2011 ◽

Vol 55 (3) ◽

pp. 472-478 ◽

Cited By ~ 13

Author(s):

B. Baert ◽

S. Vansteelandt ◽

B. De Spiegeleer

Keyword(s):

High Throughput ◽

Ion Mobility Spectrometry ◽

Ion Mobility ◽

Diffusion Cell ◽

Franz Diffusion Cell ◽

Diffusion Cell Experiments

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ASSESSMENT OF PERMEABILITY BEHAVIOR OF BERBERINE CHLORIDE ACROSS GOAT INTESTINAL MEMBRANE IN PRESENCE OF NATURAL BIOPOTENTIATOR CURCUMIN

INDIAN DRUGS ◽

10.53879/id.58.04.12162 ◽

2021 ◽

Vol 58 (4) ◽

pp. 23-27

Author(s):

Sarika Narade ◽

Yogesh Pore ◽

◽

Keyword(s):

Efflux Pump ◽

Diffusion Cell ◽

Apparent Permeability ◽

Franz Diffusion Cell ◽

Permeability Characteristics ◽

Berberine Chloride ◽

Intestinal Membrane ◽

Permeability Studies ◽

Cell Data ◽

Intestinal Efflux

The present study investigates the influence of co-administration of different concentrations (2, 6, and 10 mg) of curcumin on goat intestinal permeability of berberine chloride (BBC) using Franz diffusion cell. Data obtained in triplicate from permeability studies were used to calculate percentage cumulative drug release (% CDR), apparent permeability (Papp), flux (J) and enhancement ratio (ER). Co-administration of 6 mg concentration of curcumin with BBC was found to be optimum to enhance the permeability of BBC up to 23.92 ± 0.78 % CDR, over control (8.49 ± 1.45 % CDR). At the optimized concentration of curcumin, permeability characteristics were improved significantly compared to control. The present study reveals the beneficial effect of co-administration of curcumin (6 mg) to promote membrane permeability of BBC which would be expected to improve its bioavailability, thereby therapeutic efficacy. The effect could be attributed to curcumin-mediated inhibition of intestinal efflux pump P-gp, acting as an absorption barrier for BBC.

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EVALUATION OF NONBIOLOGIC MEMBRANES FOR USE WITH FRANZ DIFFUSION CELL STUDIES OF TWO ENZYMATIC DEBRIDEMENT FORMULATIONS

Journal of Wound Ostomy and Continence Nursing ◽

10.1097/00152192-200505002-00096 ◽

2005 ◽

Vol 32 ◽

pp. S29

Author(s):

David W. Brett ◽

Sharon Brett

Keyword(s):

Diffusion Cell ◽

Franz Diffusion Cell ◽

Enzymatic Debridement

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Comparative Effects of Span 20 and Span 40 on Liposomes Release Properties

International Journal of Food Engineering ◽

10.1515/ijfe-2017-0339 ◽

2017 ◽

Vol 13 (12) ◽

Cited By ~ 1

Author(s):

Radoslava N. Pravilović ◽

Bojana D. Balanč ◽

Kata T. Trifković ◽

Verica B. Đorđević ◽

Nevenka M. Bošković-Vragolović ◽

...

Keyword(s):

Mass Transfer ◽

Natural Antioxidants ◽

Polyphenolic Compounds ◽

Diffusion Cell ◽

Transfer Resistance ◽

Franz Diffusion Cell ◽

Model Substance ◽

Different Types ◽

Liposome Size ◽

The Common

AbstractLiposomes are known as convenient carriers for a broad range of actives. The release rate of actives can be adjusted/controlled by the addition of different surfactants. The aim of this study was to compare the effects of two surfactants, Span 20 and Span 40, on liposomes release properties. In particular, the study shows how the membrane modification affects the mass transfer resistances and liposome size compared with the common liposomes. The aqueous extract of thyme was used as a model substance. It is a valuable source of natural antioxidants – polyphenols. The diffusion of polyphenols from native thyme extract (un-encapsulated) and from different types of liposomes was conducted using Franz diffusion cell. The results were approximated with Fick’s second law and they implied that liposomes modified with Span 20 provided the slowest release of polyphenolic compounds due to the highest value of mass transfer resistance (2.523 × 106s/m).

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