The impact of dexamethasone versus methylprednisolone upon neutrophil/lymphocyte ratio in COVID-19 patients admitted to ICU and its implication upon mortality

Several immune and hematological parameters are associated with survival in patients with oropharyngeal cancer (OPC). The aim of the study was to analyze selected immune and hematological parameters of patients with HPV-related (HPV+) and HPV-unrelated (HPV-) OPC, before and after radiotherapy/chemoradiotherapy (RT/CRT) and to assess the impact of these parameters on survival. One hundred twenty seven patients with HPV+ and HPV− OPC, treated with RT alone or concurrent chemoradiotherapy (CRT), were included. Patients were divided according to HPV status. Confirmation of HPV etiology was obtained from FFPE (Formalin-Fixed, Paraffin-Embedded) tissue samples and/or extracellular circulating HPV DNA was determined. The pre-treatment and post-treatment laboratory blood parameters were compared in both groups. The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), and systemic immune inflammation (SII) index were calculated. The impact of these parameters on overall (OS) and disease-free (DFS) survival was analyzed. In HPV+ patients, a high pre-treatment white blood cells (WBC) count (>8.33 /mm3), NLR (>2.13), SII (>448.60) significantly correlated with reduced OS, whereas high NLR (>2.29), SII (>462.58) significantly correlated with reduced DFS. A higher pre-treatment NLR and SII were significant poor prognostic factors for both OS and DFS in the HPV+ group. These associations were not apparent in HPV− patients. There are different pre-treatment and post-treatment immune and hematological prognostic factors for OS and DFS in HPV+ and HPV− patients. The immune ratios could be considered valuable biomarkers for risk stratification and differentiation for HPV− and HPV+ OPC patients.

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Neutrophil/Lymphocyte ratio in patients with major depression and the impact of electroconvulsive therapy

The Annals of Clinical and Analytical Medicine ◽

10.4328/acam.20130 ◽

2020 ◽

Vol 11 (Suppl 1) ◽

Keyword(s):

Major Depression ◽

Electroconvulsive Therapy ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

The Impact

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The Impact of the Pre-operative Neutrophil-lymphocyte Ratio as the Predictive Marker of Post-operative Weight Loss and Improving Diabetes in Sleeve Gastrectomy.

10.21203/rs.3.rs-131065/v1 ◽

2020 ◽

Author(s):

Hideya Kashihara ◽

Mitsuo Shimada ◽

Kozo Yoshikawa ◽

Jun Higashijima ◽

Takuya Tokunaga ◽

...

Keyword(s):

Weight Loss ◽

Sleeve Gastrectomy ◽

Hemoglobin A1c ◽

Excess Weight Loss ◽

Predictive Marker ◽

Obese Patients ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Remission Of Diabetes ◽

The Impact

Abstract Background: The aim of this study was to investigate the impact of the neutrophil-lymphocyte ratio (NLR) in sleeve gastrectomy (SG).Methods: 15 obese patients were enrolled in this study. They consisted of 5 males and 10 females: mean body weight (BW) 127.5kg; mean body mass index (BMI) 46.7kg/m2. 10 of these were diabetics who underwent a SG. The impact of the pre-operative NLR on the percentage of excess weight loss (%EWL) and remission of diabetes 1 year post-operative were examined.Results: The BMI, %EWL and %TWL at 1 year post-operative were 35.1 kg/m2, 46.3% and 26.2%, respectively. Improvements were also evident in the diabetes at 1 year post-operative: complete remission (CR) (No medication and hemoglobin A1c (HbA1c) HbA1c<6.0%) 40%, PR (HbA1c<6.5) 20%; and (decrease of anti diabetic drug and HbA1c<7.0%) 40%. Comparing pre-operative NLR in %EWL<50% and >50% in one (1) year post-operative, <50% was 2.64 and >50% was 2.03 (p<0.05). The NLR in CR and partial remission (PR) was significantly lower than that in improved (Improve) (2.22 vs 3.27, p<0.05).Conclusions: The pre-operative NLR may be a predictive marker of weight loss and improving diabetes after SG.

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The impact of neutrophil-lymphocyte ratio on risk reclassification of patients with advanced renal cell cancer to guide risk-directed therapy

Acta Oncologica ◽

10.1080/0284186x.2019.1656342 ◽

2019 ◽

Vol 59 (1) ◽

pp. 20-27

Author(s):

Angelina Tjokrowidjaja ◽

David Goldstein ◽

H. Malcolm Hudson ◽

Sarah J. Lord ◽

Val Gebski ◽

...

Keyword(s):

Renal Cell Cancer ◽

Renal Cell ◽

Cell Cancer ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Risk Reclassification ◽

The Impact ◽

Advanced Renal Cell Cancer

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Abstract 306: Impact of Venous Thromboembolism as Independent Predictor of Mortality Among Patients With Gastric Cancer

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvb.37.suppl_1.306 ◽

2017 ◽

Vol 37 (suppl_1) ◽

Author(s):

Harry E Fuentes ◽

Luis H Paz ◽

Diana M Oramas ◽

Xavier A Andrade ◽

Yuchen Wang ◽

...

Keyword(s):

Gastric Cancer ◽

Independent Predictor ◽

Mortality Prediction ◽

Categorical Variables ◽

Continuous Variables ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

One Year ◽

Cancer Associated Thrombosis ◽

The Impact

Background: Cancer-associated thrombosis is a predictor of death. Patients with gastric cancer (GC) are at higher risk for VTE when compared to other solid tumors. There is a paucity of data describing the impact of VTE in GC. Aim: To measure the impact of VTE as independent predictor of gastric cancer mortality. Methods: Single institution chart review of GC treated patients (2010-15). VTE events were objectively confirmed. GC was ascertained if biopsy proven and metastatic, or on active chemotherapy. Along with cancer specific data, we abstracted risk assessments tools, non-GC specific, validated for VTE and mortality prediction in cancer; including, the Khorana Score (KRS), platelet lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR). Continuous variables are expressed by the by the median (interquartile range). Categorical variables are expressed as percentages. We used SPSS 23, specifically Kaplan-Meir curve and Cox proportional hazard were applied for main objectives. Results: We included 112 pts in the analysis, who were predominantly male (66%), 58 (51-64) year-old, with adenocarcinoma (84%) and advanced disease (59%). The median follow-up was 21.3 months (9.5-42.6). We measured high risk of VTE based on the KRS in 59%, 51% had an elevated NLR and 30% had an elevated PLR. VTE occurred in thirteen (12%) patients. The median time from diagnosis to VTE occurrence was 59 days (36-258). After multivariate analysis, the predictors of mortality were: VTE (Hazard Ratio (HR), 2.6; 95% CI, 1.1 to 6.0; p=0.02), Histological type (HR, 3.2; 95% CI, 1.1 to 9.2; p=0.03), Stage (HR, 2.9; 95%CI, 1.4 to 5.8; p<0.01) and PLR (HR, 2.2; 95%CI, 1.3 to 3.9); p<0.01). The one year overall survival of patients with VTE was lower than for those with no VTE (79% vs 41% p<0.05) Conclusion: VTE is associated with worse survival among patients with GC. Moreover, this finding was independent of other cancer-specific variables. NLR and KRS were not associated with survival in our GC database.

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Prognostic value of the postoperative neutrophil-lymphocyte ratio in solid tumors: A meta-analysis

PLoS ONE ◽

10.1371/journal.pone.0250091 ◽

2021 ◽

Vol 16 (4) ◽

pp. e0250091

Author(s):

Meilong Wu ◽

Shizhong Yang ◽

Xiaobin Feng ◽

Chengquan Li ◽

Fei Yu ◽

...

Keyword(s):

Solid Tumors ◽

Relevant Literature ◽

Disease Free Survival ◽

Cochrane Library ◽

Tumor Type ◽

Long Term Outcomes ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

The Impact

Purpose Numerous studies have demonstrated that a variety of systemic inflammatory markers were associated with the survival of different tumors. However, the association between elevated postoperative neutrophil-lymphocyte ratio (postNLR) and long-term outcomes, including overall survival (OS), disease-free survival (DFS), in patients with solid tumors remains controversial. A systematic review was conducted to explore the association between the postNLR and long-term outcomes in solid tumors. Materials and methods Relevant literature was identified using PubMed, Embase, Web of Science, and the Cochrane Library from the initiation of the databases to October 2020. Data were extracted from included studies reporting hazard ratio (HR) and 95% confidence intervals (CI), and were pooled using generic inverse-variance and random-effects modeling. 25 studies reporting on7539 patients were included in the analysis. Results Elevated postNLR was associated with poor OS (HR 1.87, 95% CI = 1.53–2.28; P < 0.00001), and worse DFS (HR 1.69, 95% CI = 1.28–2.22; P = 0.0002). Subgroup analyses showed that the trend of the pooled HR for most of the subgroups was not changed, and the heterogeneity of the same tumor type was not obvious. However, there was no correlation between high postNLR obtained within 7days and poor DFS (n = 3, HR 1.25, 95CI% = 0.54–2.88; P = 0.60). Conclusions Elevated postNLR might be a readily available and inexpensive biomarker for long-term outcomes in solid tumors. Multicenter and prospective studies are needed to explore the impact of the postNLR on the prognosis of solid tumors.

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Impact of Serum Albumin Concentration and Neutrophil-lymphocyte Ratio Score on Gastric Cancer Prognosis

10.21203/rs.3.rs-814875/v1 ◽

2021 ◽

Author(s):

T. Costa ◽

J. Nogueiro ◽

D. Ribeiro ◽

P. Viegas ◽

H. Santos-Sousa

Keyword(s):

Gastric Cancer ◽

Palliative Surgery ◽

Cancer Prognosis ◽

Rank Test ◽

Albumin Concentration ◽

Curative Intent ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Kaplan Meier ◽

The Impact

Abstract Introduction/AimSerum albumin concentration (COA) and neutrophil-lymphocyte ratio (NLR) could reflect immunological and nutritional status. We aim to evaluate the impact of COA-NLR score on the prognosis of gastric cancer (GC). Material and methodsWe perform a retrospective analysis on a database of 637 GC cases, between January 2010 and December 2017. In 396 patients the inclusion criteria for this study were met (non-resectional or palliative surgery were excluded). Analytic data was only available in 203 patients. COA-NLR score was defined as: COA under 35 g/L and NLR value of 2.585 or higher – score 2; one of these conditions – score 1; and neither – score 0. ResultsIn our population (n=203), 87 patients were classified as score 0, 82 as score 1 and 34 as score 2. COA-NLR score was significantly associated with DFS [HR 1,674; CI95% 1,115 – 2,513; p=0,013) and with OS [HR 2,072; CI95% 1,531 – 2,805; p<0,001]. Kaplan-Meier curves analysis (log-rank test) revealed that a higher score of COA-NLR predicted a worse OS (p<0,001) and DFS (p=0,03). COA-NLR was an independent prognostic factor for OS when adjusted to pStage and age [adjusted HR 1,566; CI95% 1,145 – 2,143; p=0,005]. ConclusionsPreoperative COA-NLR score was significantly associated with worse OS and DFS and, in this way, with worse prognosis on GC patients submitted to curative-intent resectional surgery.

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Abstract 1692: The impact of neutrophil/lymphocyte ratio as the predictive marker to anti-PD-1 antibody treatment in NSCLC patients

10.1158/1538-7445.am2018-1692 ◽

2018 ◽

Author(s):

Keiko Tanimura ◽

Tadaaki Yamada ◽

Nobuyo Tamiya ◽

Yoshiko Kaneko ◽

Takayuki Takeda ◽

...

Keyword(s):

Predictive Marker ◽

Antibody Treatment ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Nsclc Patients ◽

The Impact

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Elevated Platelet Count as Predictor of Recurrence in Rectal Cancer Patients Undergoing Preoperative Chemoradiotherapy Followed by Surgery

International Surgery ◽

10.9738/intsurg-d-13-00178.1 ◽

2015 ◽

Vol 100 (2) ◽

pp. 199-207 ◽

Cited By ~ 20

Author(s):

Yuji Toiyama ◽

Yasuhiro Inoue ◽

Mikio Kawamura ◽

Aya Kawamoto ◽

Yoshinaga Okugawa ◽

...

Keyword(s):

Rectal Cancer ◽

Cancer Patients ◽

Locally Advanced ◽

Neoadjuvant Chemoradiotherapy ◽

Disease Free Survival ◽

Advanced Rectal Cancer ◽

Poor Overall Survival ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

The Impact

The impact of systemic inflammatory response (SIR) on prognostic and predictive outcome in rectal cancer after neoadjuvant chemoradiotherapy (CRT) has not been fully investigated. This retrospective study enrolled 89 patients with locally advanced rectal cancer who underwent neoadjuvant CRT and for whom platelet (PLT) counts and SIR status [neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR)] were available. Both clinical values of PLT and SIR status in rectal cancer patients were investigated. Elevated PLT, NLR, PLR, and pathologic TNM stage III [ypN(+)] were associated with significantly poor overall survival (OS). Elevated PLT, NLR, and ypN(+) were shown to independently predict OS. Elevated PLT and ypN(+) significantly predicted poor disease-free survival (DFS). Elevated PLT was identified as the only independent predictor of DFS. PLT counts are a promising pre-CRT biomarker for predicting recurrence and poor prognosis in rectal cancer.

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