scholarly journals High-intensity interval training (HIIT) increases insulin-like growth factor-I (IGF-I) in sedentary aging men but not masters’ athletes: an observational study

2016 ◽  
Vol 20 (1) ◽  
pp. 54-59 ◽  
Author(s):  
Peter Herbert ◽  
Lawrence D. Hayes ◽  
Nicholas Sculthorpe ◽  
Fergal M. Grace
Keyword(s):  
Growth Factor ◽  
Observational Study ◽  
High Intensity ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
Factor I ◽  
Aging Men ◽  
Masters Athletes ◽  
Igf I ◽  
High Intensity Interval

scholarly journals High-intensity interval training-induced hypertrophy in gastrocnemius muscle via improved IGF-I/Akt/FoxO and myostatin/Smad signaling pathways in rats

2020 ◽  
Vol 107 (2) ◽  
pp. 220-230 ◽  
Author(s):  
Soheil Biglari ◽  
Alireza Ghardashi Afousi ◽  
Farnoosh Mafi ◽  
Fatemeh Shabkhiz
Keyword(s):  
Signal Transduction ◽  
High Intensity ◽  
Muscle Hypertrophy ◽  
Gastrocnemius Muscle ◽  
Interval Training ◽  
Male Rats ◽  
Signal Transduction Pathways ◽  
High Intensity Interval Training ◽  
Igf I ◽  
High Intensity Interval

AbstractObjectiveIt has been shown that high-intensity interval training (HIIT) leads to skeletal muscle hypertrophy; however, its mechanisms of cellular and molecular regulation are still unclear. The purpose of this study was to investigate the effect of HIIT on muscle hypertrophy and major signal transduction pathways.Design12 male rats were randomly divided into two groups: control and HIIT. The exercise group performed 30-min HIIT in each session (5 × 4-min intervals running at 85–95% VO2max separated by 2-min active rest at 55–60% VO2max), 3 days/week for 8 weeks. Muscle fiber cross-sectional area (CSA) and the expression of signal transduction pathway proteins were determined in the gastrocnemius muscle.ResultsIn the HIIT group, the expression of IGF-I, IGF-IR Akt, p-Akt, AMPKα, p-AMPKα and follistatin increased significantly, whereas a significant decrease was observed in the expression of FoxO1, p-FoxO1, myostatin, ActRIIB, Smad2/3 and p-Smad2/3 (P < 0.05). However, there were no significant differences between the HIIT and control groups in the expression of mTOR, p-mTOR, P70S6K, and p-P70S6K (P > 0.05). In addition, CSA and gastrocnemius muscle weight increased significantly in the HIIT group (P < 0.05).ConclusionsHIIT induced muscle hypertrophy by improving IGF-I/Akt/FoxO and myostatin/Smad signal transduction pathways.

scholarly journals Effect of High Intensity Interval Training on the Level of Atrial Fibrillation, Fibroblast Growth Factor 23 and Klotho Protein in Male Rats with Renal Failure

2020 ◽  
Author(s):  
Sina Rokhsati ◽  
Rahman Souri ◽  
Fatemeh Shabkhiz ◽  
Shahram Rabbani ◽  
Zahra Shahsavari
Keyword(s):  
Atrial Fibrillation ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
High Intensity ◽  
Fibroblast Growth Factor 23 ◽  
Interval Training ◽  
Male Rats ◽  
Fibroblast Growth ◽  
High Intensity Interval Training ◽  
High Intensity Interval

Introduction: Cardiovascular problems and atrial fibrillation is one of the most prevalent secondary consequences in hemodialysis patients. This study aimed to examine the effect of high intensity interval training on the level of atrial fibrillation, fibroblast growth factor 23 and Klotho in male rats with chronic kidney disease. Methods: In this study, 30 male rats Wistar (7-8 weeks) were randomly assigned into three groups of exercise, control and sham. Rats in the exercise and control groups were entered to the study by using nephrectomy 5/6Nx, which made renal failure. Exercise protocol included training protocol as high intensity interval training (85% Maximum oxygen consumption) on treadmill for 8 weeks and three sessions in each week. Atrial fibrillation, fibroblast growth factor 23, Klotho, and other parameters were examined at the post intervention in all three groups. Data analysis was performed by one-way ANOVA and to examine the difference between groups, followed post-hoc Bonferroni analysis test at P <0.05. Results: Interval training was able to make a significant difference between the exercise and control groups in the level of atrial fibrillation (P<0/05). Klotho protein also had a considerable increase in the exercise group compared to the control group. However, the fibroblast growth factor 23 did not differ significantly between the exercise and control groups (P>0/05). Conclusion: High intensity interval training can cause a significant decrease in the level of atrial fibrillation in chronic kidney patients; however, in the process of this improvement, the changes in fibroblast growth factor 23 and related factors are less and the role of Klotho protein has an important effect.

scholarly journals Preconditioning Effect of High-Intensity Interval Training (HIIT) and Berberine Supplementation on the Gene Expression of Angiogenesis Regulators and Caspase-3 Protein in the Rats with Myocardial Ischemia-Reperfusion (IR) Injury

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Parisa Banaei ◽  
Farzad Nazem ◽  
Afshin Nazari ◽  
Arash Arjomand
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
High Intensity ◽  
Caspase 3 ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
Related Factors ◽  
Significant Difference ◽  
High Intensity Interval ◽  
The Impact

Objective. It has been shown that angiogenesis is a desirable treatment for patients with ischemic heart disease. We set out to investigate the impact of high-intensity interval training (HIIT) and berberine supplementation on the gene expression of angiogenesis-related factors and caspase-3 protein in rats suffering from myocardial ischemic-reperfusion injury. Methods. Fifty rats were divided into the following groups: (1) trained, (2) berberine supplemented, (3) combined, and (4) IR. Each cohort underwent five sessions of HIIT per week for a duration of 8 weeks followed by induction of ischemia. Seven days after completion of reperfusion, changes in the gene expression of angiogenesis-related factors and caspase-3 protein were evaluated in the heart tissue. Results. We observed a significant difference between four groups in the transcript levels of vascular endothelial cell growth factor (VEGF), fibroblast growth factor-2 (FGF2), and thrombospondin-1(TSP-1) (p≤0.05). However, the difference in endostatin (ENDO) levels was not significant among the groups despite a discernible reduction (p≥0.05). Moreover, caspase-3 protein and infarct size were significantly reduced in the intervention groups (p≤0.05), and cardiac function increased in response to these interventions. Conclusion. The treatments exert their effect, likely, by reducing caspase-3 protein and increasing the expression of angiogenesis-promoting factors, concomitant with a reduction in inhibitors of the process.

scholarly journals Comparison of the Effectiveness of High-Intensity Interval Training in Hypoxia and Normoxia in Healthy Male Volunteers: A Pilot Study

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Aleksandra Żebrowska ◽  
Dariusz Jastrzębski ◽  
Ewa Sadowska-Krępa ◽  
Marcin Sikora ◽  
Camillo Di Giulio
Keyword(s):  
Nitric Oxide ◽  
Growth Factor ◽  
High Intensity ◽  
Hypoxia Inducible Factor ◽  
Interval Training ◽  
Vascular Endothelial ◽  
High Intensity Interval Training ◽  
Hypoxia Inducible Factor 1 ◽  
High Intensity Interval ◽  
Endothelial Growth Factor

Aims. The study investigated the effect of high-intensity interval training in hypoxia and normoxia on serum concentrations of proangiogenic factors, nitric oxide, and inflammatory responses in healthy male volunteers. Methods. Twelve physically active male subjects completed a high-intensity interval training (HIIT) in normoxia (NorTr) and in normobaric hypoxia (HypTr) (FiO2 = 15.2%). The effects of HIIT in hypoxia and normoxia on maximal oxygen uptake, hypoxia-inducible factor-1-alpha, vascular endothelial growth factor, nitric oxide, and cytokines were analyzed. Results. HIIT in hypoxia significantly increases maximal oxygen uptake (p=0.01) levels compared to pretraining levels. Serum hypoxia-inducible factor-1 (p=0.01) and nitric oxide levels (p=0.05), vascular endothelial growth factor (p=0.04), and transforming growth factor-β (p=0.01) levels were increased in response to exercise test after hypoxic training. There was no effect of training conditions for serum baseline angiogenic factors and cytokines (p>0.05) with higher HIF-1α and NO levels after hypoxic training compared to normoxic training (F = 9.1; p<0.01 and F = 5.7; p<0.05, respectively). Conclusions. High-intensity interval training in hypoxia seems to induce beneficial adaptations to exercise mediated via a significant increase in the serum concentrations of proangiogenic factors and serum nitric oxide levels compared to the same training regimen in normoxia.

scholarly journals HIIT produces increases in muscle power and free testosterone in male masters athletes

2017 ◽  
Vol 6 (7) ◽  
pp. 430-436 ◽  
Author(s):  
P Herbert ◽  
LD Hayes ◽  
NF Sculthorpe ◽  
FM Grace
Keyword(s):  
Muscle Power ◽  
Interval Training ◽  
Free Testosterone ◽  
Peak Power Output ◽  
Total Testosterone ◽  
High Intensity Interval Training ◽  
Active Recovery ◽  
Aging Men ◽  
Masters Athletes ◽  
High Intensity Interval

High-intensity interval training (HIIT) improves peak power output (PPO) in sedentary aging men but has not been examined in masters endurance athletes. Therefore, we investigated whether a six-week program of low-volume HIIT would (i) improve PPO in masters athletes and (ii) whether any change in PPO would be associated with steroid hormone perturbations. Seventeen male masters athletes (60 ± 5 years) completed the intervention, which comprised nine HIIT sessions over six weeks. HIIT sessions involved six 30-s sprints at 40% PPO, interspersed with 3 min active recovery. Absolute PPO (799 ± 205 W and 865 ± 211 W) and relative PPO (10.2 ± 2.0 W/kg and 11.0 ± 2.2 W/kg) increased from pre- to post-HIIT respectively (P < 0.001, Cohen’s d = 0.32−0.38). No significant change was observed for total testosterone (15.2 ± 4.2 nmol/L to 16.4 ± 3.3 nmol/L (P = 0.061, Cohen’s d = 0.32)), while a small increase in free testosterone occurred following HIIT (7.0 ± 1.2 ng/dL to 7.5 ± 1.1 ng/dL pre- to post-HIIT (P = 0.050, Cohen’s d = 0.40)). Six weeks’ HIIT improves PPO in masters athletes and increases free testosterone. Taken together, these data indicate there is a place for carefully timed HIIT epochs in regimes of masters athletes.

scholarly journals Effect of High-intensity Interval Training on Serum Levels of Fibroblast Growth Factor 21 and Insulin Resistance in Overweight Young Men

2021 ◽  
pp. 34-42
Keyword(s):  
Insulin Resistance ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
High Intensity ◽  
Young Men ◽  
Interval Training ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
High Intensity Interval Training ◽  
High Intensity Interval

Background: The fibroblast growth factor 21 is a protein that is involved in regulating glucose and fat metabolism. The present study aimed to investigate the effect of eight weeks of high-intensity interval training on serum levels of fibroblast growth factor 21 and insulin resistance in overweight young men. Materials and Methods: In this semi-experimental study, 30 overweight young men (BMI<25 kg /m2) were purposefully selected and randomly divided to control (n=15) and experimental (n=15) groups. The experimental group performed ten repetitions of one-minute aerobic exercise (treadmill, elliptical trainer, or stationary bike) with an intensity of 80-75% of the target heart rate with one-minute active intermittent rest periods with an intensity of 35-40% of the heart rate for 8 weeks, 4 sessions per week. Fibroblast growth factor 21 and insulin resistance were measured 24 hours before starting the program and 48 hours after the last training session. Intragroup and Intergroup changes were analyzed using dependent and independent t-test, respectively. Results: Serum levels of fibroblast growth factor 21 indicated a significant increase (t=6.94, P= 0.031) compared to that of the control group after 8 weeks of high-intensity interval training, but insulin resistance significantly decreased (t=5.81, P=0.008). Conclusion: High-intensity interval training for 8 weeks can be prescribed as an optimal exercise protocol to increase serum fibroblast growth factor 21 and reduce insulin resistance in overweight young men.

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