Serum uric acid (SUA) in morbidly obese patients and its relationship with metabolic syndrome

This is the first study to evaluate both the antioxidant barrier, glutathione metabolism, and oxidative damage to proteins and lipids in morbidly obese patients undergoing bariatric treatment. The study included 65 patients with class 3 obesity divided into two subgroups: morbidly obese patients without metabolic syndrome (OB) and obese patients with metabolic syndrome (OB + MS). Blood samples were collected before surgery as well as one, three, six, and twelve months after the bariatric treatment. Superoxide dismutase and reduced glutathione (GSH) were significantly decreased, whereas glutathione reductase and uric acid were enhanced in morbidly obese patients before bariatric surgery as compared to lean control. Moreover, in the OB group, we observed the increase of superoxide dismutase (SOD) and the decrease of uric acid (UA) after the bariatric treatment; however, these changes were not observed in the OB + MS group. The oxidative damage to proteins (advanced glycation end products, AGE; advanced oxidation protein products, AOPP) and lipids (8-isoprostanes, 8-isop; 4-hydroxynoneal) was higher in OB as well as OB + MS patients. We noticed that AGE and AOPP levels diminished after the bariatric treatment, whereas redox status (ratio of GSH to oxidized glutathione) was still reduced in the OB + MS group. Summarizing, morbid obesity is associated with disturbances in the antioxidant barrier and enhanced oxidative damage to proteins and lipids. Although bariatric surgery improves redox homeostasis in obese patients, those with metabolic syndrome show a continuous decrease in the antioxidant status. In patients undergoing bariatric treatment, antioxidant supplementation may be considered.

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Impact of Weight Loss on the Total Antioxidant/Oxidant Potential in Patients with Morbid Obesity—A Longitudinal Study

Antioxidants ◽

10.3390/antiox9050376 ◽

2020 ◽

Vol 9 (5) ◽

pp. 376 ◽

Cited By ~ 5

Author(s):

Barbara Choromańska ◽

Piotr Myśliwiec ◽

Magdalena Łuba ◽

Piotr Wojskowicz ◽

Hanna Myśliwiec ◽

...

Keyword(s):

Metabolic Syndrome ◽

Uric Acid ◽

Serum Insulin ◽

Diagnostic Value ◽

Morbidly Obese ◽

Obese Patients ◽

Antioxidant Power ◽

Total Antioxidant ◽

Ferric Reducing Antioxidant Power ◽

Oxidant Status

The assessment of total antioxidant activity seems to have a higher diagnostic value than the evaluation of individual antioxidants separately. Therefore, this is the first study to assess the total antioxidant/oxidant status in morbidly obese patients undergoing bariatric surgery. The study involved 60 patients with Class 3 obesity (BMI > 40 kg/m2) divided into two equal subgroups: morbidly obese patients without and with metabolic syndrome. The analyses were performed in plasma samples collected before surgery as well as 1, 3, 6, and 12 months after a laparoscopic sleeve gastrectomy. Total antioxidant capacity (TAC), ferric-reducing antioxidant power (FRAP), DPPH (2,2′-diphenyl-1-picrylhydrazyl) radical assay, and total oxidant status (TOS) were significantly higher before surgery (as compared to the healthy controls, n = 60) and generally decreased after bariatric treatment. Interestingly, all assessed biomarkers correlated positively with uric acid content. However, the total antioxidant/oxidant potential did not differ between obese patients without metabolic syndrome and those with both obesity and metabolic syndrome. Only DPPH differentiated the two subgroups (p < 0.0001; AUC 0.8) with 73% sensitivity and 77% specificity. Plasma TAC correlated positively with body mass index, waist–hip ratio, serum insulin, and uric acid. Therefore, TAC seems to be the best biomarker to assess the antioxidant status of obese patients.

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Relation of uric acid with components of metabolic syndrome before and after Roux-en-Y gastric bypass in morbidly obese subjects

Arquivos Brasileiros de Endocrinologia & Metabologia ◽

10.1590/s0004-27302011000100005 ◽

2011 ◽

Vol 55 (1) ◽

pp. 38-45 ◽

Cited By ~ 11

Author(s):

Ary Serpa Neto ◽

Felipe Martin Bianco Rossi ◽

Leonardo Guedes Moreira Valle ◽

Gabriel Kushiyama Teixeira ◽

Marçal Rossi

Keyword(s):

Metabolic Syndrome ◽

Gastric Bypass ◽

Uric Acid ◽

Morbidly Obese ◽

Obese Patients ◽

Metabolic Abnormalities ◽

Blood Samples ◽

Glucose Levels ◽

Before And After ◽

Obese Subjects

OBJECTIVE: The purpose of the study was to investigate the prevalence of hyperuricemia in morbidly obese subjects before and after Roux-en-Y gastric bypass (RYGBP) and its relationship with metabolic syndrome abnormalities. SUBJECTS AND METHOD: We evaluated 420 morbidly obese patients. Pre and postoperative (8 months after RYGBP) blood samples were drawn. Obese patients underwent laparoscopic RYGBP and after eight months all the tests were repeated. RESULTS: The overall prevalence of hyperuricemia was 34.28%. Hyperuricemia was more common in men than in women (51.72 vs. 29.72%; p = 0.0002). Men with hyperuricemia were more likely to have diabetes (p = 0.034) and more elevated fasting plasma glucose levels (p = 0.027). Women with hyperuricemia were more likely to have hypertension (p = 0.003), metabolic syndrome (p = 0.001), elevated triglycerides (p = 0.001) and GGT (p = 0.009), and decreased HDL (p = 0.011). After surgery, uric acid levels decreased from 5.60 ± 1.28 to 4.23 ± 1.20 (p < 0.0001). The prevalence of hyperuricemia decreased from 33.6% to 6.4% (p < 0.0001), in men from 48.3% to 17.2% (p < 0.0001) and in women from 29.7% to 3.6% (p < 0.0001). CONCLUSION: Concentrations of uric acid were associated with the prevalence of metabolic abnormalities in this sample of morbidly obese patients. Also, weight loss after RYGBP can reduce uric acid levels and the prevalence of hyperuricemia.

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Association between serum uric acid level, metabolic syndrome and insulin resistance in obese patients – can uric acid be considered a new metabolic marker?

Revista Portuguesa de Endocrinologia Diabetes e Metabolismo ◽

10.26497/ao200049 ◽

2021 ◽

pp. 0

Author(s):

Mariana Barbosa ◽

Inês Barros ◽

Claudia Matta-Coelho ◽

Ana Margarida Monteiro ◽

Marta Alves ◽

...

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Uric Acid ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Serum Uric Acid Level ◽

Obese Patients ◽

Metabolic Marker

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Association of Serum Uric Acid and Metabolic Syndrome Among Health Personnel from a Public Hospital in Peru

Metabolism ◽

10.1016/j.metabol.2020.154669 ◽

2021 ◽

Vol 116 ◽

pp. 154669

Author(s):

Brenda Galindo Yllu ◽

Ricardo Rojas Humpire ◽

Carlos Toro Huamanchumo ◽

Rosmery Gutierrez Ajañlcriña ◽

Anderson Soriano Moreno

Keyword(s):

Metabolic Syndrome ◽

Uric Acid ◽

Serum Uric Acid ◽

Health Personnel ◽

Public Hospital

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Association Between Serum Uric Acid Level and Components of the Metabolic Syndrome

Journal of the Chinese Medical Association ◽

10.1016/s1726-4901(09)70320-x ◽

2006 ◽

Vol 69 (11) ◽

pp. 512-516 ◽

Cited By ~ 75

Author(s):

Shi-Dou Lin ◽

Dong-Hwa Tsai ◽

Shang-Ren Hsu

Keyword(s):

Metabolic Syndrome ◽

Uric Acid ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Serum Uric Acid Level ◽

The Metabolic Syndrome

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Relation between uric acid and metabolic syndrome in subjects with cardiometabolic risk

Einstein (São Paulo) ◽

10.1590/s1679-45082015ao3194 ◽

2015 ◽

Vol 13 (2) ◽

pp. 202-208 ◽

Cited By ~ 14

Author(s):

Hellen Abreu da Silva ◽

Júlia Cristina Cardoso Carraro ◽

Josefina Bressan ◽

Helen Hermana Miranda Hermsdorff

Keyword(s):

Metabolic Syndrome ◽

Uric Acid ◽

Serum Uric Acid ◽

Abdominal Obesity ◽

Health Program ◽

Cardiovascular Health ◽

Cardiometabolic Risk ◽

Cross Sectional Study ◽

Cross Sectional ◽

Potential Biomarker

Objective To identify possible relations between serum uric acid levels and metabolic syndrome and its components in a population with cardiometabolic risk. Methods This cross-sectional study included 80 subjects (46 women), with mean age of 48±16 years, seen at the Cardiovascular Health Program. Results The prevalence of hyperuricemia and metabolic syndrome was 6.3% and 47.1%, respectively. Uric acid level was significantly higher in individuals with metabolic syndrome (5.1±1.6mg/dL), as compared to those with no syndrome or with pre-syndrome (3.9±1.2 and 4.1±1.3mg/dL, respectively; p<0.05). The uric acid levels were significantly higher in men presenting abdominal obesity, and among women with abdominal obesity, lower HDL-c levels and higher blood pressure (p<0.05). Conclusion Uric acid concentrations were positively related to the occurrence of metabolic syndrome and its components, and there were differences between genders. Our results indicate serum uric acid as a potential biomarker for patients with cardiometabolic risk.

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