Reverse expression pattern of sirtuin-1 and histone deacetylase-9 in coronary artery disease

2020 ◽  
pp. 1-8
Author(s):  
Laleh Heidari ◽  
Sayyed Mohammad Hossein Ghaderian ◽  
Milad Bastami ◽  
Shadi Hosseini ◽  
Saeed Alipour Parsa ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Histone Deacetylase ◽  
Expression Pattern ◽  
Sirtuin 1 ◽  
Histone Deacetylase 9 ◽  
Artery Disease

Expression pattern in human macrophages dependent on 9p21.3 coronary artery disease risk locus

2013 ◽  
Vol 227 (2) ◽  
pp. 244-249 ◽  
Author(s):  
Christa Zollbrecht ◽  
Martina Grassl ◽  
Sabine Fenk ◽  
Regina Höcherl ◽  
Ute Hubauer ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Expression Pattern ◽  
Disease Risk ◽  
Coronary Artery Disease Risk ◽  
Human Macrophages ◽  
Risk Locus ◽  
Artery Disease

scholarly journals Prospective, case-controlled study evaluating serum concentration of sirtuin-1 and mannose-binding lectin in patients with and without periodontal and coronary artery disease

2020 ◽  
Vol 11 ◽  
pp. 204062232091962
Author(s):  
Pérola Michelle Vasconcelos Caribé ◽  
Cristina Cunha Villar ◽  
Guiseppe Alexandre Romito ◽  
Júlio Yoshio Takada ◽  
Ana Paula Pacanaro ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Concentration ◽  
Mannose Binding Lectin ◽  
Sirtuin 1 ◽  
Controlled Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Mannose Binding ◽  
Artery Disease ◽  
Binding Lectin

Background: Atherosclerosis and periodontal disease (PD) are inflammatory diseases that have been shown in studies to have a direct association. Mannose-binding lectin (MBL) is an immune system protein that binds to periodontal pathogens favoring phagocytosis. Conversely, increased serum sirtuin-1 (SIRT1) concentration reduces the inflammatory process. Methods: This was a prospective, case-controlled study that analyzed serum concentration of biomarkers in patients with or without coronary artery disease (CAD) and PD. A total of 78 patients were evaluated: 20 healthy individuals, 18 patients with CAD, 20 patients with PD, and 20 patients with both PD and CAD. Clinical and laboratory characteristics were analyzed before and after nonsurgical treatment of PD and also at two equivalent times in patients without PD. Serum MBL and SIRT1 concentration were analyzed by enzyme-linked immunosorbent assay. Results: A negative correlation was observed between changes in serum concentration of MBL and SIRT1 ( r = −0.30; p = 0.006). Comparison between pre- and post-treatment of PD showed a reduction in MBL levels (886.27 ± 906.72 versus 689.94 ± 808.36; p = 0.002) and an increase in SIRT1 values (0.80 ± 1.01 versus 1.49 ± 1.55; p = 0.005) in patients with PD and without CAD. The same result was observed in patients with PD and CAD for MBL and SIRT1, respectively, of 1312.43 ± 898.21 versus 1032.90 ± 602.52 ( p = 0.010) and 1.32 ± 1.0 versus 1.82 ± 1.75 ( p = 0.044). Conclusion: PD treatment reduced MBL serum concentration and increased SIRT1 serum concentration in patients with and without CAD.

Sirtuin-1 and MMP-2 levels in patients with advanced coronary artery disease: A combined index for incidence of myocardial infarction

2017 ◽  
Vol 263 ◽  
pp. e53
Author(s):  
Ilias Doulamis ◽  
Aspasia Tzani ◽  
Panagiotis Konstantopoulos ◽  
Anastasios Gkogkos ◽  
George Samanidis ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Sirtuin 1 ◽  
Artery Disease ◽  
Advanced Coronary Artery Disease

A sirtuin 1/MMP2 prognostic index for myocardial infarction in patients with advanced coronary artery disease

2017 ◽  
Vol 230 ◽  
pp. 447-453 ◽  
Author(s):  
Ilias P. Doulamis ◽  
Aspasia I. Tzani ◽  
Panagiotis S. Konstantopoulos ◽  
George Samanidis ◽  
Georgios Georgiopoulos ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Prognostic Index ◽  
Sirtuin 1 ◽  
Artery Disease ◽  
Advanced Coronary Artery Disease

scholarly journals Sirtuin 1 rs1467568 and rs7895833 in South African Indians with early-onset coronary artery disease

2016 ◽  
Vol 27 (4) ◽  
pp. 213-217 ◽  
Author(s):  
P Ramkaran ◽  
A Phulukdaree ◽  
S Khan ◽  
D Moodley ◽  
AA Chuturgoon
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
South African ◽  
Early Onset ◽  
Sirtuin 1 ◽  
Artery Disease

scholarly journals Sirtuin-1 mediates the obesity induced risk of common degenerative diseases: Alzheimer’s disease, coronary artery disease and type 2 diabetes

Health ◽  
2012 ◽  
Vol 04 (12) ◽  
pp. 1448-1456 ◽  
Author(s):  
Ian James Martins ◽  
Andrea. C. Wilson ◽  
Wei Ling Florence Lim ◽  
Simon. M. Laws ◽  
Stephanie. J. Fuller ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Type 2 Diabetes ◽  
Coronary Artery Disease ◽  
Alzheimer's Disease ◽  
Coronary Artery ◽  
Sirtuin 1 ◽  
Degenerative Diseases ◽  
Artery Disease

scholarly journals Sirtuin-1 in Egyptian patients with coronary artery disease

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
AL-Shabrawy M. Abdelnabi ◽  
Imam M. Esmayel ◽  
Samia Hussein ◽  
Reham M. Ali ◽  
Alhoussein Alsayed AbdelAal
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Plasma Level ◽  
Sirtuin 1 ◽  
Control Group ◽  
Coronary Syndrome ◽  
Wide Range ◽  
Egyptian Patients ◽  
Silent Information Regulator 1 ◽  
Artery Disease

Abstract Background Coronary artery disease (CAD) represents the leading cause of death worldwide. Animal and human studies have demonstrated that silent information regulator 1 (SIRT1) is involved in a wide range of physiological and pathological processes. This study aimed to measure the plasma level of SIRT1 in patients with CAD and explore its correlation with cardiovascular risk factors. Results Plasma SIRT1 was significantly lower in patients with chronic coronary syndrome (CCS) than in those in the control group and was significantly lower in patients with both acute myocardial infarction and unstable angina than in those in the control group and with CCS. Moreover, plasma SIRT1 was positively correlated with platelet count and negatively correlated with cholesterol and triglyceride levels. Conclusions The plasma level of SIRT1 is lower in patients with CAD compared to control and it could be a possible marker for this disease. Multi-center studies with follow-up measurements are recommended for further investigation.

Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease

2019 ◽  
Vol 133 (22) ◽  
pp. 2283-2299
Author(s):  
Apabrita Ayan Das ◽  
Devasmita Chakravarty ◽  
Debmalya Bhunia ◽  
Surajit Ghosh ◽  
Prakash C. Mandal ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Chronic Inflammation ◽  
Ex Vivo ◽  
Human Subjects ◽  
Critical Role ◽  
Atherosclerotic Cardiovascular Disease ◽  
Tnf Α ◽  
Artery Disease

Abstract The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated with chronic inflammation. Yet, no information is available about the involvement of sTLT1 in atherosclerotic cardiovascular disease. Present study was undertaken to determine the pathophysiological significance of sTLT1 in atherosclerosis by employing an observational study on human subjects (n=117) followed by experiments in human macrophages and atherosclerotic apolipoprotein E (apoE)−/− mice. Plasma level of sTLT1 was found to be significantly (P<0.05) higher in clinical (2342 ± 184 pg/ml) and subclinical cases (1773 ± 118 pg/ml) than healthy controls (461 ± 57 pg/ml). Moreover, statistical analyses further indicated that sTLT1 was not only associated with common risk factors for Coronary Artery Disease (CAD) in both clinical and subclinical groups but also strongly correlated with disease severity. Ex vivo studies on macrophages showed that sTLT1 interacts with Fcɣ receptor I (FcɣRI) to activate spleen tyrosine kinase (SYK)-mediated downstream MAP kinase signalling cascade to activate nuclear factor-κ B (NF-kB). Activation of NF-kB induces secretion of tumour necrosis factor-α (TNF-α) from macrophage cells that plays pivotal role in governing the persistence of chronic inflammation. Atherosclerotic apoE−/− mice also showed high levels of sTLT1 and TNF-α in nearly occluded aortic stage indicating the contribution of sTLT1 in inflammation. Our results clearly demonstrate that sTLT1 is clinically related to the risk factors of CAD. We also showed that binding of sTLT1 with macrophage membrane receptor, FcɣR1 initiates inflammatory signals in macrophages suggesting its critical role in thrombus development and atherosclerosis.

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