scholarly journals A pharmacokinetics–pharmacodynamics study of single-dose total glucosides of paeony capsule on reducing serum total bile acid in hepatic injury rats

2021 ◽  
Vol 59 (1) ◽  
pp. 769-777
Author(s):  
Ninghua Jiang ◽  
Bohong Zheng ◽  
Yihan Feng ◽  
Lei Yin ◽  
Yuanrong Liu ◽  
...  
Keyword(s):  
Single Dose ◽  
Bile Acid ◽  
Hepatic Injury ◽  
Total Bile Acid ◽  
Total Glucosides Of Paeony

scholarly journals Continuous association of total bile acid levels with the risk of small for gestational age infants

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Li Li ◽  
Wei Chen ◽  
Li Ma ◽  
Zhi Bing Liu ◽  
Xue Lu ◽  
...  
Keyword(s):  
Bile Acid ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Total Bile Acid

scholarly journals A nomogram based on pretreatment levels of serum bilirubin and total bile acid levels predicts survival in colorectal cancer patients

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yinghao Cao ◽  
Shenghe Deng ◽  
Lizhao Yan ◽  
Junnan Gu ◽  
Jia Yang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Prognostic Factors ◽  
Bile Acid ◽  
Bile Acids ◽  
Cancer Patients ◽  
Serum Bilirubin ◽  
Cox Regression ◽  
Total Bile Acid ◽  
Cox Regression Analysis ◽  
Colorectal Cancer Patients

Abstract Background Serum bilirubin and total bile acid (TBA) levels have been reported to be strongly associated with the risk and prognosis of certain cancers. Here, we aimed to investigate the effects of pretreatment levels of serum bilirubin and bile acids on the prognosis of patients with colorectal cancer (CRC). Methods A retrospective cohort of 1474 patients with CRC who underwent surgical resection between January 2015 and December 2017 was included in the study. Survival analysis was used to evaluate the predictive value of pretreatment levels of bilirubin and bile acids. X-Tile software was used to identify optimal cut-off values for total bilirubin (TBIL), direct bilirubin (DBIL) and TBA in terms of overall survival (OS) and disease-free survival (DFS). Results DBIL, TBIL, and TBA were validated as significant prognostic factors by univariate Cox regression analysis for both 3-year OS and DFS. Multivariate Cox regression analyses confirmed that high DBIL, TBIL and TBA levels were independent prognostic factors for both OS (HR: 0.435, 95% CI: 0.299–0.637, P < 0.001; HR: 0.436, 95% CI: 0.329–0.578, P < 0.001; HR: 0.206, 95% CI: 0.124–0.341, P < 0.001, respectively) and DFS (HR: 0.583, 95% CI: 0.391–0.871, P = 0.008; HR:0.437,95% CI: 0.292–0.655, P <0.001; HR: 0.634, 95% CI: 0.465–0.865, P = 0.004, respectively). In addition, nomograms for OS and DFS were established according to all significant factors, and the c-indexes were 0.819 (95% CI: 0.806–0.832) and 0.835 (95% CI: 0.822–0.849), respectively. Conclusions TBIL, DBIL and TBA levels are independent prognostic factors in colorectal cancer patients. The nomograms based on OS and DFS can be used as a practical model for evaluating the prognosis of CRC patients.

scholarly journals Single-Dose Metformin Enhances Bile Acid–Induced Glucagon-Like Peptide-1 Secretion in Patients With Type 2 Diabetes

2017 ◽  
Vol 102 (11) ◽  
pp. 4153-4162 ◽  
Author(s):  
Andreas Brønden ◽  
Anders Albér ◽  
Ulrich Rohde ◽  
Jens F Rehfeld ◽  
Jens J Holst ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Single Dose ◽  
Bile Acid ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Effects of pomegranate peel polyphenols on lipid accumulation and cholesterol metabolic transformation in L-02 human hepatic cells via the PPARγ-ABCA1/CYP7A1 pathway

2016 ◽  
Vol 7 (12) ◽  
pp. 4976-4983 ◽  
Author(s):  
Ou Lv ◽  
Lifang Wang ◽  
Jianke Li ◽  
Qianqian Ma ◽  
Wei Zhao
Keyword(s):  
Bile Acid ◽  
Lipid Accumulation ◽  
Cell Model ◽  
Hepatic Cell ◽  
Total Bile Acid ◽  
Lipid Lowering ◽  
Pomegranate Peel ◽  
Hepatic Cells ◽  
Metabolic Transformation ◽  
Lipid Lowering Effect

PPPs, PC and PEA in different concentrations were found to decrease the total cholesterol (TC) content and increase the total bile acid (TBA) content of a human hepatic cell model, and so possess a lipid-lowering effect.

scholarly journals Regional Differences in the Components of Luminal Water from Rat Gastrointestinal Tract and Comparison with Other Species.

2012 ◽  
Vol 15 (4) ◽  
pp. 510 ◽  
Author(s):  
Yusuke Tanaka ◽  
Toshihiro Hara ◽  
Ryoichi Waki ◽  
Shunji Nagata
Keyword(s):  
Bile Acid ◽  
Regional Differences ◽  
Species Differences ◽  
Oral Absorption ◽  
Inorganic Ions ◽  
Total Bile Acid ◽  
Water Soluble ◽  
Residual Water ◽  
Gi Tract ◽  
Water Soluble Drug

Purpose. The bile acids, phospholipids, inorganic ions, and pH in luminal fluid are very important factors for the dissolution and oral absorption of solid drugs. In this study, we evaluated the regional differences in these factors in the rat GI tract. The solubility of griseofulvin, a poorly water-soluble drug, in the luminal fluid in each segment was also measured. In addition, the data from rats were compared with those from other species published previously to evaluate the species differences in the composition of luminal fluid. Methods. Rat abdomen was opened and residual water was sampled from each region of GI tract to measure the various components concentrations. Results. The total bile acid and phospholipid concentrations were much higher in the lower jejunum and upper jejunum, respectively, than in the other regions. The solubilities of griseofulvin in the lower jejunal fluid (153-260 g/mL) were about 1.5-2 times higher than those in the upper jejunal fluid (99-146 g/mL). The regional differences in inorganic ions and pH were also observed. As for species differences, the total bile acid and phospholipid concentration in rats GI tract were much higher than those of dogs and humans. Conclusion. These informations about the regional differences and species differences of the components in the GI fluid should be very useful to consider dissolution and oral absorption of solid drugs.

scholarly journals The comparison of total bile acid concentration and alcohol dehydrogenase activity as markers of intrahepatic cholestasis of pregnancy

2021 ◽  
Author(s):  
Wojciech Jelski ◽  
Joanna Piechota ◽  
Karolina Orywal ◽  
Barbara Mroczko
Keyword(s):  
Bile Acid ◽  
Alcohol Dehydrogenase ◽  
Bile Acids ◽  
Intrahepatic Cholestasis ◽  
Total Bile Acid ◽  
Intrahepatic Cholestasis Of Pregnancy ◽  
Third Trimester ◽  
Total Bile Acids ◽  
Adh Activity ◽  
Cholestasis Of Pregnancy

Introduction: Intrahepatic cholestasis of pregnancy (ICP) is the liver disorder in the second or early third trimester of pregnancy. It is characterized by pruritus with increased serum bile acids concentration and other liver function tests. ICP  is connected with increased risk of fetal mortality, but is unfortunately detected quite late. Therefore, it is important to recognize the disease in its early stages. We aimed to investigate the serum alcohol dehydrogenase (ADH) activity and compare it with the concentration of total bile acid (TBA) in women with ICP. Methods: Serum samples were taken for routine investigation from 80 pregnancies with ICP in the second or third trimester of pregnancy and from 80 healthy pregnant women in the same time of pregnancy. For measurement of class I activity we used the spectrofluorometric methods. The total ADH activitiy was measured by the photometric method. Results: The analysis of results shows a statistically significant increase in the activity of ADH I and ADH total (about 60% and 41.3%, respectively). Activity of ADH I well correlated with aminotransferases (alanine ALT and aspartate AST) and total bile acids (TBA) concentration. The total ADH activity was also positively correlated with ALT, AST and total bile acids. Conclusion: We can state that the activity of class I alcohol dehydrogenase isoenzyme in the sera of patients with ICP is increased and seems to be a good indicator of liver cell destruction during this disease and is comparable with the value of other markers.

INFLUENCE OF Aspergillus oryzae FERMENTED SOYBEAN MEAL ON PLASMA CHOLESTEROL AND BILE ACID LEVELS IN HYBRID TILAPIA AND POMPANO FISH

2020 ◽  
Vol 65 (10) ◽  
pp. 154-163
Author(s):  
Hung Nguyen Phuc ◽  
Anh Nguyen Phuong
Keyword(s):  
Body Weight ◽  
Bile Acid ◽  
Aspergillus Oryzae ◽  
Fish Species ◽  
Soybean Meal ◽  
Plasma Cholesterol ◽  
Total Cholesterol Level ◽  
Reduction Rate ◽  
Total Bile Acid ◽  
Initial Body Weight

Fermentation has been suggested as an economical and effective method to eliminate anti-nutritional factors and improve the nutritional value of Defatted soybean meal (SBM). The present study aimed to examine the effects of Aspergillus oryzae fermented SBM (FSBM) on plasma cholesterol and bile acid levels in hybrid tilapia and pompano. Two isonitrogenous and isoenergetic experimental diets for each fish species were formulated with SBM and FSBM as main ingredients. The diets were denoted as SBMD (SBM-based diet) and FSBMD (FSBM-based diet). Thirty juvenile hybrid tilapia (initial body weight 55 g) and eighteen juvenile pompanos (initial body weight 61 g) were allocated to each of the 4 concrete tanks (1500-L holding capacity) and each of the 4 circular polyvinyl chloride tanks (500-L holding capacity), respectively, resulting in two replicate tanks per dietary treatment for each fish species. For 4 weeks, the fish were handfed the experimental diets to apparent satiation twice daily. The results showed that feeding FSBMD tended to increase plasma total cholesterol level, gallbladdersomatic index, anterior intestinal total bile acid level, and posterior\anterior intestinal total bile acid reduction rate compared to SBMD in both hybrid tilapia and pompano. The differences in these parameters between FSBMD and SBMD dietary groups were significant in hybrid tilapia (P < 0.05), while no significant differences were found between pompano fed FSBMD and SBMD. These results indicated that fermentation of SBM with A. oryzae could effectively improve physiological conditions of hybrid tilapia fed soybean proteinbased diet and suggested that inclusion of A. oryzae FSBM might enhance growth and feed performances of the fish.

Determination of Bile Acid Concentration in Human Amniotic Fluid for Prenatal Diagnosis of Intestinal Obstruction

PEDIATRICS ◽  
1977 ◽  
Vol 59 (5) ◽  
pp. 647-650
Author(s):  
Guy Délèze ◽  
Dimitri Sidiropoulos ◽  
Gustav Paumgartner
Keyword(s):  
Bile Acid ◽  
Prenatal Diagnosis ◽  
Intestinal Obstruction ◽  
Amniotic Fluid ◽  
Acid Concentration ◽  
Total Bile Acid ◽  
Papilla Of Vater ◽  
Human Amniotic Fluid ◽  
Bile Acid Concentration

Bile acid concentration was measured in amniotic fluid obtained for standard indications from 11 healthy pregnant women without polyhydramnios (28 to 42 weeks of gestation) and from 9 patients with polyhydramnios (28 to 38 weeks of gestation). Two of the latter women delivered infants with intestinal obstruction distal to the papilla of Vater, a condition that causes regurgitation of bile into the amniotic fluid. In the women without polyhydramnios, the total bile acid concentration ranged from 1.4 to 2.4 µmol/liter. In the seven patients with polyhydramnios not associated with fetal intestinal obstruction, the bile acid concentration in amniotic fluid was not significantly different (0.9 to 1.9 µmol/liter). By contrast, the bile acid concentration in amniotic fluid specimens from the two patients with polyhydramnios who gave birth to children with intestinal obstruction was considerably elevated (30.3 and 83.1 µmol/liter). These findings suggest that determination of bile acid concentration in amniotic fluid permits prenatal diagnosis of intestinal obstruction distal to the papilla of Vater.

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