Streblus asper attenuates alloxan-induced diabetes in rats and demonstrates antioxidant and cytotoxic effects

Nicolau syndrome (NS) is a rare complication characterized by tissue necrosis that occurs after parenteral injection of drugs. The exact pathogenesis is uncertain, but there are several hypotheses, including direct damage to the end artery, acute vasospasm and cytotoxic effects of the drug. Severe pain in the immediate post injection period and purplish discoloration of the skin with reticulate pigmentary pattern is characteristic of this syndrome. Diagnosis is mainly clinical and there is no standard treatment for the disease. Herein, we present a rare case of NS due to Diclofenac Sodium (Voltaren®) injection in an 80-year-old female suffering from Lower Respiratory Tract Infection (LRTI) who was managed conservatively. Keywords: Nicolau Syndrome, Embolia cutis medicamentosa, Voltaren, Diclofenac sodium

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Antibacterial and Cytotoxic Effects of Silver Nanoparticles on Staphylococcus aureus and Normal Vero Cells

10.36295/asro.2019.221025 ◽

2019 ◽

Vol 22 (10) ◽

pp. 184-190

Author(s):

Rasha Hadi Saleh ◽

Entisar J. Al-Mukhtar ◽

Zaytoon A. Al-Khafaji ◽

Mohammed H. Al Hasnawy ◽

Huda H. Al-Hasnawy

Keyword(s):

Staphylococcus Aureus ◽

Silver Nanoparticles ◽

Vero Cells ◽

Cytotoxic Effects

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CITOTOXICITY OF INDIUM-111-LABELED AUTOLOGOUS WBC

Токсикологический вестник ◽

10.36946/0869-7922-2019-1-18-22 ◽

2019 ◽

pp. 18-22

Author(s):

K. A. Luneva ◽

K. E. Ternovskaya ◽

O. E. Klement’eva ◽

A. S. Lunev

Keyword(s):

Cytotoxic Effect ◽

Single Photon ◽

Photon Emission ◽

Emission Computed Tomography ◽

Blood Leukocytes ◽

Cytotoxic Effects ◽

Indium 111 ◽

Single Photon Emission Computed ◽

Photon Emission Computed Tomography ◽

Subsequent Introduction

The radiopharmaceutical precursor «Oxind, 111In» is a complex compound for labeling autologous leukocytes of human blood and their subsequent introduction for non-specific visualization and localization of inflammation foci of different nature by single-photon emission computed tomography (SPECT). The cytotoxic effect of lyophilisate for preparation of radiopharmaceutical preparation «Oxind, 111In» and its radiopharmaceutical precursor on rabbit blood leukocytes has been investigated. In the course of studies of the cytotoxicity of the lyophilisate for the preparation of a radiopharmaceutical precursor with successively increasing concentrations of the main substance, 8-hydroxyquinoline, the permissible concentrations have been determined and the absolutely cytotoxic concentration was achieved.In the study of the cytotoxic effect of the precursor of radiopharmaceutical on two dosages that differ by 10 times in volume activities (MBq / ml), the absence of cytotoxic effects has been confirmed.

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Indicators of the antioxidant system in the long-term period after acute mercury nitrate poisoning in the experiment

Токсикологический вестник ◽

10.36946/0869-7922-2020-2-35-40 ◽

2020 ◽

pp. 36-41

Author(s):

E. G. Batotsyrenova ◽

O. A. Vakunenkova ◽

E. A. Zolotoverkhaya ◽

V. A. Kashuro ◽

T. A. Kostrova ◽

...

Keyword(s):

Antioxidant System ◽

Antioxidant Defense ◽

Reduced Glutathione ◽

Antioxidant Defense System ◽

Mercury Content ◽

The State ◽

Cytotoxic Effects ◽

Entire Study ◽

Mercury Nitrate

The article presents experimental data on the state of the antioxidant system in red blood cells of white outbred rats 1 and 3 months after acute mercury nitrate poisoning with a semilethal dose. It has been established that this form of intoxication is accompanied by pronounced changes in the state of the antioxidant defense system in erythrocytes of poisoned animals (a decrease in the concentration of reduced glutathione, a decrease in the activity of superoxide dismutase and glutathione peroxidase, and an increase in the concentration of lipid peroxidation products).It has been shown that the mercury content in the blood of experimental animals remains elevated during the entire study period.The results obtained indicate the importance of impaired functioning of the antioxidant system in the implementation of long-term consequences of acute mercury poisoning. The reasons for the occurrence of these biochemical shifts and their role in the development of the long-term cytotoxic effects of mercury nitrate are discussed.

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