Decreased serum calcium levels and negative correlation with degree of nicotine dependence in heavy smokers

Background: Normal cerebral membrane integration is important to maintain the cellular calcium homeostasis. Recent studies have suggested that elevated serum calcium levels at presentation correlates well with the infarct size and severity of stroke.Methods: A total of 73 patients with acute ischemic stroke satisfying inclusion and exclusion criteria were included in the study from November 1st 2017 to April 30th 2019 at a tertiary care centre in Kolar, Karnataka. Serum calcium (total, ionized and albumin corrected calcium) levels were measured at the time of presentation and compared with the infarct size and severity of stroke using NIHSS score (National Institute of Health Stroke Scale).Results: The levels of total calcium, albumin-corrected calcium, and ionized calcium were 9.13±0.89 mg/dL (range: 8.24-10.02), 9.56±0.82 mg/dL (range: 8.74-10.38), and 4.79±0.47 mg/dL (range: 4.3-5.2), respectively. Mean stroke size as measured on the CT scan was 47.38±17.7 cm (range: 21-88). Analysis revealed significant negative correlation between calcium levels (total, corrected, and ionized) and infarct size and severity of stroke.Conclusions: In this study, it was found that there was a statistically significant negative correlation between total, ionized and corrected calcium with the infarct size in patients with ischemic stroke and also the total calcium at presentation and severity of stroke calculated using NIHSS score.

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Bone Density, Osteocalcin and Deoxypyridinoline for Early Detection of Osteoporosis in Obese Children

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2015.092 ◽

2015 ◽

Vol 3 (3) ◽

pp. 413-419 ◽

Cited By ~ 3

Author(s):

Ghada El-Dorry ◽

Hala Ashry ◽

Tarek Ibrahim ◽

Tahany Elias ◽

Fatma Alzaree

Keyword(s):

Alkaline Phosphatase ◽

Bone Density ◽

Serum Calcium ◽

Negative Correlation ◽

Total Mass ◽

Serum Alkaline Phosphatase ◽

Significant Negative Correlation ◽

Whole Body ◽

Serum Osteocalcin ◽

Obese Children

AIM: This study aimed at comparing between bone density using DEXA, serum osteocalcin and urinary DPD in obese and non obese prepubertal children. METHODS: After taking the consent of eighty children they were subjected to: full examination, anthropometric measurements, blood samples were withdrawn to determine serum osteocalcin, Ca, Ph, alkaline phosphatase, and urinary DPD. Bone densities, body composition of the whole body were examined using DEXA. Data were analyzed using SPSS.RESULTS: All anthropometric variables showed significant increase in obese children except for height in comparison to control group. Total mass, lean + BMC, lean, fat, area, BMC, BMD and Z score of the whole body were significantly increased in obese children. Serum calcium showed significant increase while alkaline phosphatase was significantly decreased in obese children. DPD showed no significant difference between obese and non obese children. Significant negative correlation was found between ca, lean, lean + BMC and total mass. Serum alkaline phosphatase showed also a significant negative correlation with (lean + BMC and total mass). Serum osteocalcin showed negative significant correlation with area, BMC, BMD, lean and Z score.CONCLUSION: Obese children showed significant increase in anthropometric and DEXA parameters, increase in serum calcium and significant decrease in serum alkaline phosphatase. Osteocalcin was negatively correlated with most of DEXA results.

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Correlation of serum calcium levels with infarct size and severity of stroke using NIHSS score in patients with acute ischemic stroke

International Journal of Research in Medical Sciences ◽

10.18203//2320-6012.ijrms20195613 ◽

2019 ◽

Author(s):

Prabhakar K. ◽

Pujitha S. N. ◽

Phaneesh Bharadwaj B. S.

Keyword(s):

Ischemic Stroke ◽

Infarct Size ◽

Acute Ischemic Stroke ◽

Serum Calcium ◽

Negative Correlation ◽

Tertiary Care ◽

Elevated Serum ◽

Significant Negative Correlation ◽

Total Calcium ◽

Nihss Score

Background: Normal cerebral membrane integration is important to maintain the cellular calcium homeostasis. Recent studies have suggested that elevated serum calcium levels at presentation correlates well with the infarct size and severity of stroke.Methods: A total of 73 patients with acute ischemic stroke satisfying inclusion and exclusion criteria were included in the study from November 1st 2017 to April 30th 2019 at a tertiary care centre in Kolar, Karnataka. Serum calcium (total, ionized and albumin corrected calcium) levels were measured at the time of presentation and compared with the infarct size and severity of stroke using NIHSS score (National Institute of Health Stroke Scale).Results: The levels of total calcium, albumin-corrected calcium, and ionized calcium were 9.13±0.89 mg/dL (range: 8.24-10.02), 9.56±0.82 mg/dL (range: 8.74-10.38), and 4.79±0.47 mg/dL (range: 4.3-5.2), respectively. Mean stroke size as measured on the CT scan was 47.38±17.7 cm (range: 21-88). Analysis revealed significant negative correlation between calcium levels (total, corrected, and ionized) and infarct size and severity of stroke.Conclusions: In this study, it was found that there was a statistically significant negative correlation between total, ionized and corrected calcium with the infarct size in patients with ischemic stroke and also the total calcium at presentation and severity of stroke calculated using NIHSS score.

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ALTERATIONS OF SERUM CALCIUM, PHOSPHORUS, MAGNESIUM, AND COPPER IN HYPERTHYROIDISM PATIENTS: A CASE–CONTROL STUDY

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2020.v13i12.39611 ◽

2020 ◽

pp. 95-98

Author(s):

DIANA ATHOKPHAM ◽

SHRABANI MOHANTY ◽

VENKATA BHARATKUMAR PINNELLI

Keyword(s):

Serum Calcium ◽

Negative Correlation ◽

Significant Positive Correlation ◽

Guanidine Hydrochloride ◽

Serum Copper ◽

Serum Phosphorus ◽

Positive Correlation ◽

Study Results ◽

Serum T3 ◽

Calcium Phosphorus

Objective: The objective of the study was to estimate the levels of serum calcium, phosphorus, magnesium, and copper in hyperthyroid cases and to correlate each of the parameter with serum T3, T4, TSH, FT3, and FT4, respectively. Methods: The study was conducted on 60 newly confirmed hyperthyroid cases based on the thyroid profile and 60 euthyroid cases were recruited as controls. Blood samples were collected from all these subjects and estimation of serum T3, T4, TSH, FT3, FT4, calcium, phosphorus, and magnesium was done by autoanalyzer method. Serum copper was measured by modified spectrophotometric micro-method using guanidine hydrochloride and bathocuproine disulfonate disodium salt. The statistical analysis was done by paired test and Pearson’s correlation. Results: Study results in hyperthyroid cases show mean serum calcium and copper levels were significantly (p<0.001) increased, serum phosphorus levels were significantly (p<0.001) decreased when compared to euthyroid. However, there was no significant change in magnesium when compared with euthyroid controls (p=0.556). We also found a significant positive correlation among serum Ca versus T3, T4, FT3, and FT4. A negative correlation with serum Ca versus TSH as observed. We also found significant positive correlation between serum phosphorus with TSH and significant negative correlation of phosphorus with T3, T4, FT3, and FT4. No suggestive significant correlation was found between serum Mg with T3, T4, TSH, FT3, and FT4 and serum copper with serum T3, T4, TSH, FT3, and FT4. Conclusion: The present study has shown that metabolism of minerals is altered in hyperthyroid cases. Impaired metabolism of calcium, phosphorus, magnesium, and copper can lead to various metabolic disorders. Estimation of serum calcium, phosphorus, magnesium, and copper may be helpful in better management to prevent further complication and can be used as diagnostic or prognostic aid in patients with hyperthyroidism along with other biochemical parameters.

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An unusual case of nicotine dependence

Psychological Medicine ◽

10.1017/s0033291700026015 ◽

1987 ◽

Vol 17 (3) ◽

pp. 779-781 ◽

Cited By ~ 5

Author(s):

J. Guy Edwards

Keyword(s):

Nicotine Dependence ◽

Unusual Case ◽

Cultural Aspects ◽

Plasma Nicotine ◽

Heavy Smokers

SynopsisThe case of a 49-year-old woman who has been brushing her teeth for 12 years with large amounts of snuff is described. She was dependent on the habit and had plasma nicotine and cotinine levels similar to those found in heavy smokers. Historical and cultural aspects of the use of snuff are discussed.

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A comparative study of serum calcium and magnesium levels in women with pre-eclampsia and normotensive women

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20212186 ◽

2021 ◽

Vol 10 (6) ◽

pp. 2420

Author(s):

Saloni Sethi ◽

Ankita Chaudhary ◽

Priya Sonkhya ◽

Premlata Mital ◽

Aditi Arora ◽

...

Keyword(s):

Pregnant Women ◽

Serum Calcium ◽

Negative Correlation ◽

Calcium Concentration ◽

Serum Magnesium ◽

Measured Data ◽

Magnesium Concentration ◽

Multisystem Disorder ◽

Ionic Calcium ◽

Calcium And Magnesium

Background: Pre-eclampsia is transient but potentially dangerous complication of pregnancy. Despite of pre-eclampsia's prevalence and severity, the pathophysiology of this multisystem disorder is still poorly understood and its aetiology has not yet been fully elucidated. Recently, nutritional deficiency especially micronutrients deficiency is gaining prominence in the pathogenesis of pre-eclampsia. Hypocalcaemia and hypomagnesaemia have been implicated in the pathogenesis of pre-eclampsia. This study has been done to compare serum calcium and magnesium levels in women with pre-eclampsia and normotensive women and their association with severity of pre-eclampsia.Methods: 50 women with pre-eclampsia and 50 normotensive women were included in the study and serum calcium and magnesium levels were measured. Data were analyzed.Results: The serum ionic calcium concentration was significantly lower in the pre-eclamptic cases compared to the normotensive controls (3.34±1.35 versus 4.37±0.74, p=0.0000) similarly serum magnesium concentration was significantly lower in the pre-eclamptic cases compared to the normotensive controls (1.68±0.41 versus 1.94±0.42, p-0.002). Mean serum ionic Ca levels in severe pre-eclampsia group was significantly lower than normotensive pregnant women (p=0.0000) as well as mild pre-eclampsia group (p=0.001). Mean serum Mg in severe pre-eclampsia was significantly lower than normotensive pregnant women (p=0.0008) as well as mild pre-eclampsia group (p=0.03). Serum ionic Ca and Mg had a negative correlation with systolic and diastolic blood pressure.Conclusions: Based on this study, measurements of serum ionic calcium and magnesium among women at risk of for pre-eclampsia may be used to predict the onset and severity of pre-eclampsia.

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Status of Serum Calcium, Phosphorus, Magnesium and Copper in Hypothyroid Patients- A Case Control Study

JOURNAL FOR CLINICAL AND DIAGNOSTIC RESEARCH ◽

10.7860/jcdr/2020/44711.14094 ◽

2020 ◽

Author(s):

Diana Athokpham ◽

Shrabani Mohanty ◽

Venkata BharatKumar Pinnelli

Keyword(s):

Serum Calcium ◽

Negative Correlation ◽

Significant Positive Correlation ◽

Significant Negative Correlation ◽

Serum Copper ◽

Serum Phosphorus ◽

Thyroid Disorders ◽

Positive Correlation ◽

Serum T3 ◽

Calcium Phosphorus

Introduction: Thyroid disorders are the most common endocrine abnormality in the world secondary to diabetes mellitus. Thyroid hormones are essential for growth, neuronal development, reproduction and regulation of energy metabolism. It influences the metabolism of all substrates including minerals. Many studies have shown that mineral metabolism is frequently disturbed in thyroid disorders. Aim: To estimate the levels of serum calcium, phosphorus, magnesium and copper in hypothyroid cases and to correlate each of the parameter with serum Triiodothyronine (T3), Thyroxine (T4), Free T3 (FT3), Free T4 (FT4) and Thyroid-Stimulating Hormone (TSH), respectively. Materials and Methods: The study was conducted on sixty newly confirmed hypothyroid cases based on the thyroid profile and sixty euthyroid cases were recruited as controls. Blood samples were collected from all the patients for the estimation of serum T3, T4, FT3, FT4, TSH, calcium, phosphorus and magnesium by autoanalyser method. Modified spectrophotometric micro-method was used to measure Serum copper using Bathocuprine Disulphonate Disodium Salt (BCDS) and Guanidine hydrochloride salt. The Statistical software namely SPSS 18.0, and R environment ver.3.2.2 were used for the analysis of the data. Results: Study results shows that mean serum calcium, magnesium and copper levels were significantly (p<0.001) decreased while serum phosphorus levels were increased significantly (p<0.001) in hypothyroid cases as compared to euthyroid cases. A significant positive correlation was found between serum Ca vs T3, serum Ca vs T4, negative correlation with serum Ca vs TSH, serum Ca has no significant correlation with serum FT3 and FT4. Significant positive correlation was found between serum phosphorus and TSH while significant negative correlation of phosphorus in comparison with T3 and T4. No significant correlation was found between serum phosphorus with FT3 and FT4. Suggestive significant positive correlation was found between serum Mg with T3, T4 and significant negative correlation with serum TSH, Mg has no significant correlation with FT3 and FT4, there was no significant correlation of serum copper with serum T3, T4, TSH and FT4 but significant positive correlation with serum Cu with FT3 were observed. Conclusion: The present study has shown that metabolism of minerals are altered in thyroid dysfunction cases. This study concluded that impaired metabolism of minerals like calcium, phosphorus, magnesium and copper can lead to various metabolic disorders. Preventive measures like supplementation of minerals or hormone replacement therapy can be initiated early to control these secondary disorders.

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Urinary 3',5'-cyclic adenosine monophosphate in relation to serum and urinary calcium in acromegaly and primary hyperparathyroidism

Acta Endocrinologica ◽

10.1530/acta.0.0940468 ◽

1980 ◽

Vol 94 (4) ◽

pp. 468-474 ◽

Cited By ~ 1

Author(s):

Johan Halse

Keyword(s):

Primary Hyperparathyroidism ◽

Serum Calcium ◽

Negative Correlation ◽

Calcium Metabolism ◽

Active Form ◽

Negative Relationship ◽

Adenosine Monophosphate ◽

Urinary Calcium ◽

Calcium Excretion ◽

Positive Correlation

Abstract. A comparison of the interrelations between serum and urinary calcium values and the urinary excretion of cAMP in acromegaly (No. of subjects: 26), patients with primary hyperparathyroidism (n = 18) and control subjects (n = 42) is presented. The cAMP excretion was greatest in primary hyperparathyroidism, but acromegalics also exhibited higher values for this parameter than controls. A positive correlation was found between serum calcium values and cAMP in primary hyperparathyroidism, while acromegalics showed no correlation between these parameters. In controls there was a negative correlation between serum calcium and cAMP. Serum calcium levels corrected for variations in total protein concentrations were elevated both in acromegaly and primary hyperparathyroidism, mostly in the latter. Acromegalics and patients with primary hyperparathyroidism exhibited an increase in 24 h calcium excretion. While there was a negative relationship between urinary calcium excretion and cAMP in acromegaly, a positive correlation between these parameters was found in primary hyperparathyroidism. Controls showed a negative correlation between urinary calcium values and cAMP. It is concluded that the role of the parathyroids in the regulation of calcium metabolism in acromegaly is different from that of both normal controls and primary hyperparathyroidism. It is postulated that an active form of Vitamin D plays a major role in the regulation of calcium metabolism in acromegaly.

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Association of Serum Calcium Levels with Infarct Size in Acute Ischemic Stroke: Observations from Northeast India

Journal of Neurosciences in Rural Practice ◽

10.4103/0976-3147.196461 ◽

2016 ◽

Vol 07 (S 01) ◽

pp. S041-S045 ◽

Cited By ~ 2

Author(s):

Meghna Borah ◽

Sriparna Dhar ◽

Dipankar Mall Gogoi ◽

Alice Abraham Ruram

Keyword(s):

Ischemic Stroke ◽

Infarct Size ◽

Acute Ischemic Stroke ◽

Serum Calcium ◽

Negative Correlation ◽

Tertiary Care ◽

Elevated Serum ◽

Significant Negative Correlation ◽

Northeast India ◽

Ionized Calcium

ABSTRACT Background: Calcium is known to be major mediator in ischemic neuronal cell death. Recent studies have shown that elevated serum calcium levels at admission in patients with stroke have been associated with less severe clinical deficits and with better outcomes. Aim: The aim of this to determine the correlation between serum calcium (total, corrected, and ionized) and infarct size (IS) in patients with acute ischemic stroke. Materials and Methods: Data were collected from 61 patients presenting with acute ischemic stroke from May 2015 to April 2016 at a tertiary care institute in Northeast India. Only patients aged ≥40 years and diagnosed as having acute ischemic cerebrovascular stroke with clinical examination and confirmed by a computed tomography scan were included in the study. Serum calcium levels (total, albumin corrected, and ionized) were collapsed into quartiles, and these quartile versions were used for calculating correlation. Pearson’s correlation coefficient was used for comparing calcium levels with IS. Results: Total calcium, albumin-corrected calcium, and ionized calcium had a statistically significant negative correlation with IS with r = −0.578, −0.5396, and −0.5335, respectively. Total and ionized calcium showed a significant negative correlation with IS across all four quartiles. Albumin-corrected calcium levels showed a significant negative correlation with IS only across the lowest and highest quartiles. Conclusion: The findings in our study suggest that serum calcium can be used as a prognostic indicator in ischemic stroke as its levels directly correlates with the IS.

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Evaluation of Vitamin D (25OHD), Bone Alkaline Phosphatase (BALP), Serum Calcium, Serum Phosphorus, Ionized Calcium in Patients with Mandibular Third Molar Impaction. An Observational Study

Nutrients ◽

10.3390/nu13061938 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1938

Author(s):

Vito Crincoli ◽

Angela Pia Cazzolla ◽

Mariasevera Di Comite ◽

Lorenzo Lo Muzio ◽

Domenico Ciavarella ◽

...

Keyword(s):

Vitamin D ◽

Alkaline Phosphatase ◽

Serum Calcium ◽

Negative Correlation ◽

Third Molar ◽

Bone Alkaline Phosphatase ◽

Serum Phosphorus ◽

Bone Biomarkers ◽

Whitney Test ◽

Mandibular Third Molar

The aim of this study was to evaluate the levels of vitamin D (25OHD) and other bone biomarkers in patients with third molar impaction (TMI). Thirty males and 30 females with unilateral or bilateral impacted mandibular third molar, and 15 males and 15 females as a control group (CG) were recruited. Rx-OPT was used to evaluate dental position and Pederson index to measure the difficulty of the intervention. Bone biomarkers were measured through blood venous sample in TMI group and CG. Mann-Whitney test, Pearson’s correlation coefficient, linear regression model were used to compare the different parameters in the two groups. 25OHD showed lower values in TMI group than in CG (p < 0.05) with values significantly lower in bilateral impaction (p < 0.05). Pearson’s coefficient for 25OHD presented a negative correlation with the Pederson index (ρ = −0.75). Bone alkaline phosphatase (BALP) showed significantly lower dosage in TMI group than CG (p = 0.02), Pearson’s coefficient for BALP presented a negative correlation with the Pederson index. Serum calcium, serum phosphorus, ionized calcium levels in TMI and CG groups were similar and Mann-Whitney test did not significantly differ between TMI and CG. TMI could be a sign of vitamin D deficiency and of low BALP levels that should be investigated.

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