ALTERATIONS OF SERUM CALCIUM, PHOSPHORUS, MAGNESIUM, AND COPPER IN HYPERTHYROIDISM PATIENTS: A CASE–CONTROL STUDY

2020 ◽  
pp. 95-98
Author(s):  
DIANA ATHOKPHAM ◽  
SHRABANI MOHANTY ◽  
VENKATA BHARATKUMAR PINNELLI
Keyword(s):  
Serum Calcium ◽  
Negative Correlation ◽  
Significant Positive Correlation ◽  
Guanidine Hydrochloride ◽  
Serum Copper ◽  
Serum Phosphorus ◽  
Positive Correlation ◽  
Study Results ◽  
Serum T3 ◽  
Calcium Phosphorus

Objective: The objective of the study was to estimate the levels of serum calcium, phosphorus, magnesium, and copper in hyperthyroid cases and to correlate each of the parameter with serum T3, T4, TSH, FT3, and FT4, respectively. Methods: The study was conducted on 60 newly confirmed hyperthyroid cases based on the thyroid profile and 60 euthyroid cases were recruited as controls. Blood samples were collected from all these subjects and estimation of serum T3, T4, TSH, FT3, FT4, calcium, phosphorus, and magnesium was done by autoanalyzer method. Serum copper was measured by modified spectrophotometric micro-method using guanidine hydrochloride and bathocuproine disulfonate disodium salt. The statistical analysis was done by paired test and Pearson’s correlation. Results: Study results in hyperthyroid cases show mean serum calcium and copper levels were significantly (p<0.001) increased, serum phosphorus levels were significantly (p<0.001) decreased when compared to euthyroid. However, there was no significant change in magnesium when compared with euthyroid controls (p=0.556). We also found a significant positive correlation among serum Ca versus T3, T4, FT3, and FT4. A negative correlation with serum Ca versus TSH as observed. We also found significant positive correlation between serum phosphorus with TSH and significant negative correlation of phosphorus with T3, T4, FT3, and FT4. No suggestive significant correlation was found between serum Mg with T3, T4, TSH, FT3, and FT4 and serum copper with serum T3, T4, TSH, FT3, and FT4. Conclusion: The present study has shown that metabolism of minerals is altered in hyperthyroid cases. Impaired metabolism of calcium, phosphorus, magnesium, and copper can lead to various metabolic disorders. Estimation of serum calcium, phosphorus, magnesium, and copper may be helpful in better management to prevent further complication and can be used as diagnostic or prognostic aid in patients with hyperthyroidism along with other biochemical parameters.

scholarly journals Status of Serum Calcium, Phosphorus, Magnesium and Copper in Hypothyroid Patients- A Case Control Study

2020 ◽  
Author(s):  
Diana Athokpham ◽  
Shrabani Mohanty ◽  
Venkata BharatKumar Pinnelli
Keyword(s):  
Serum Calcium ◽  
Negative Correlation ◽  
Significant Positive Correlation ◽  
Significant Negative Correlation ◽  
Serum Copper ◽  
Serum Phosphorus ◽  
Thyroid Disorders ◽  
Positive Correlation ◽  
Serum T3 ◽  
Calcium Phosphorus

Introduction: Thyroid disorders are the most common endocrine abnormality in the world secondary to diabetes mellitus. Thyroid hormones are essential for growth, neuronal development, reproduction and regulation of energy metabolism. It influences the metabolism of all substrates including minerals. Many studies have shown that mineral metabolism is frequently disturbed in thyroid disorders. Aim: To estimate the levels of serum calcium, phosphorus, magnesium and copper in hypothyroid cases and to correlate each of the parameter with serum Triiodothyronine (T3), Thyroxine (T4), Free T3 (FT3), Free T4 (FT4) and Thyroid-Stimulating Hormone (TSH), respectively. Materials and Methods: The study was conducted on sixty newly confirmed hypothyroid cases based on the thyroid profile and sixty euthyroid cases were recruited as controls. Blood samples were collected from all the patients for the estimation of serum T3, T4, FT3, FT4, TSH, calcium, phosphorus and magnesium by autoanalyser method. Modified spectrophotometric micro-method was used to measure Serum copper using Bathocuprine Disulphonate Disodium Salt (BCDS) and Guanidine hydrochloride salt. The Statistical software namely SPSS 18.0, and R environment ver.3.2.2 were used for the analysis of the data. Results: Study results shows that mean serum calcium, magnesium and copper levels were significantly (p<0.001) decreased while serum phosphorus levels were increased significantly (p<0.001) in hypothyroid cases as compared to euthyroid cases. A significant positive correlation was found between serum Ca vs T3, serum Ca vs T4, negative correlation with serum Ca vs TSH, serum Ca has no significant correlation with serum FT3 and FT4. Significant positive correlation was found between serum phosphorus and TSH while significant negative correlation of phosphorus in comparison with T3 and T4. No significant correlation was found between serum phosphorus with FT3 and FT4. Suggestive significant positive correlation was found between serum Mg with T3, T4 and significant negative correlation with serum TSH, Mg has no significant correlation with FT3 and FT4, there was no significant correlation of serum copper with serum T3, T4, TSH and FT4 but significant positive correlation with serum Cu with FT3 were observed. Conclusion: The present study has shown that metabolism of minerals are altered in thyroid dysfunction cases. This study concluded that impaired metabolism of minerals like calcium, phosphorus, magnesium and copper can lead to various metabolic disorders. Preventive measures like supplementation of minerals or hormone replacement therapy can be initiated early to control these secondary disorders.

scholarly journals Correlates of SARS-CoV-2 Variants on Deaths, Case Incidence and Case Fatality Ratio among the Continents for the Period of 1 December 2020 to 15 March 2021

Genes ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 1061
Author(s):  
Wajdy J. Al-Awaida ◽  
Baker Jawabrah Al Hourani ◽  
Samer Swedan ◽  
Refat Nimer ◽  
Foad Alzoughool ◽  
...  
Keyword(s):  
Negative Correlation ◽  
Significant Positive Correlation ◽  
Vaccine Development ◽  
Case Fatality ◽  
Significant Negative Correlation ◽  
Reference Sequence ◽  
Genome Sequences ◽  
Positive Correlation ◽  
Case Fatality Ratio ◽  
Epidemiological Surveys

The outbreak of coronavirus disease 2019 (COVID-19), by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has quickly developed into a worldwide pandemic. Mutations in the SARS-CoV-2 genome may affect various aspects of the disease including fatality ratio. In this study, 553,518 SARS-CoV-2 genome sequences isolated from patients from continents for the period 1 December 2020 to 15 March 2021 were comprehensively analyzed and a total of 82 mutations were identified concerning the reference sequence. In addition, associations between the mutations and the case fatality ratio (CFR), cases per million and deaths per million, were examined. The mutations having the highest frequencies among different continents were Spike_D614G and NSP12_P323L. Among the identified mutations, NSP2_T153M, NSP14_I42V and Spike_L18F mutations showed a positive correlation to CFR. While the NSP13_Y541C, NSP3_T73I and NSP3_Q180H mutations demonstrated a negative correlation to CFR. The Spike_D614G and NSP12_P323L mutations showed a positive correlation to deaths per million. The NSP3_T1198K, NS8_L84S and NSP12_A97V mutations showed a significant negative correlation to deaths per million. The NSP12_P323L and Spike_D614G mutations showed a positive correlation to the number of cases per million. In contrast, NS8_L84S and NSP12_A97V mutations showed a negative correlation to the number of cases per million. In addition, among the identified clades, none showed a significant correlation to CFR. The G, GR, GV, S clades showed a significant positive correlation to deaths per million. The GR and S clades showed a positive correlation to number of cases per million. The clades having the highest frequencies among continents were G, followed by GH and GR. These findings should be taken into consideration during epidemiological surveys of the virus and vaccine development.

scholarly journals Evaluation of serum adropin and irisin levels and its association with anthropometric obesity indices and biochemical parameters in Type 2 diabetic patients

2021 ◽  
pp. 1-8
Author(s):  
Foad Alzoughool ◽  
Huda Al Hourani ◽  
Manar Atoum ◽  
Sajedah Bateineh ◽  
Hanan Alsheikh ◽  
...  
Keyword(s):  
Negative Correlation ◽  
Biochemical Parameters ◽  
Significant Positive Correlation ◽  
Glycosylated Hemoglobin ◽  
Significant Negative Correlation ◽  
Diabetic Patients ◽  
Positive Correlation ◽  
Obesity Indices ◽  
Group Serum

BACKGROUND/AIM: The newly described proteins adropin and irisin are a highly conserved polypeptide that plays essential roles in metabolic and energy homeostasis, insulin resistance, and fat browning. The aim of this study is to evaluate the circulating levels of serum adropin and irisin in type 2 diabetes mellitus (T2DM) patients and also to elucidate possible relationships between serum adropin and irisin levels with anthropometric obesity indices and biochemical parameters. SUBJECTS AND METHODS: Single-center prospective observational study included 90 T2DM patients referred to the diabetes outpatient clinic. Height, weight, and waist circumference (WC) were measured. Body mass index (BMI) and waist to height ratio (WHtR) were calculated. Fasting blood glucose, glycosylated hemoglobin, serum lipids, creatinine, urea, and blood urea nitrogen were evaluated. Estimated glomerular filtration rate (GFR) was calculated, serum adropin and irisin were evaluated. RESULTS: The results showed a significant positive correlation between adropin and irisin in females but not in males (r = 0.311; P = 0.042). In males’ group, serum adropin levels showed significant negative correlation with serum glucose (–0.423, P = <  0.05), HbA1C (–0.364, P = <  0.05), and GFR (–0.355, P = <  0.05). In contrast, creatinine was showed a significant positive correlation with adropin in males (0.381, P = <  0.05). In females’ group, adropin showed a significant negative correlation with weight (–0.371, P = <  0.05), BMI (–0.349, P = <  0.05), WC (–0.402, P = <  0.01), and WHtR (–0.398, P = <  0.01). Contrary, in males’ group, serum irisin levels showed significant positive correlation with weight (0.338, P = <  0.05), BMI (0.332, P = <  0.05), WC (0.409, P = <  0.01), and WHtR (0.432, P = <  0.01). CONCLUSION: This study demonstrated that, in T2DM patients, circulating serum adrpoin correlated negatively with anthropometric obesity indices of obesity in females, while serum irisin was positively correlated with anthropometric obesity indices of obesity in males.

Increased plasma kynurenine and its relationship to neopterin and tryptophan in Tourette's syndrome

1996 ◽  
Vol 26 (4) ◽  
pp. 857-862 ◽  
Author(s):  
H. Rickards ◽  
S. M. Dursun ◽  
G. Farrar ◽  
T. Betts ◽  
J. A. Corbett ◽  
...  
Keyword(s):  
Tourette Syndrome ◽  
Negative Correlation ◽  
Plasma Levels ◽  
Significant Positive Correlation ◽  
Significant Negative Correlation ◽  
Healthy Controls ◽  
Positive Correlation ◽  
Control Value ◽  
Cellular Immune ◽  
Patient Value

SynopsisFasting plasma levels of tryptophan, kynurenine and the pteridines, neopterin and tetrahydrobiopterin were measured in seven patients with Gilles de la Tourette syndrome (GTS) and 10 healthy controls. Plasma kynurenine was significantly elevated in the GTS patients. The lowest patient value was higher than the highest control value. Values for tryptophan, neopterin and tetrahydrobiopterin were similar in TS patients and controls. However, in TS patients only, there was a significant negative correlation between tryptophan and neopterin and a significant positive correlation between kynurenine and neopterin when controlling for tryptophan. This finding indicates that activation of cellular immune processes is a possible explanation for the rise in plasma kynurenine.

Morpho-Biochemical Characteristics of Brinjal Germplasms Affect the Abundance And Infestation of Jassid

2021 ◽  
Vol 19 (1) ◽  
pp. 81-91
Author(s):  
F Yasmin ◽  
MR Amin ◽  
M Afroz ◽  
MAH Swapon ◽  
MM Hossain
Keyword(s):  
Protein Content ◽  
Chlorophyll Content ◽  
Negative Correlation ◽  
Significant Positive Correlation ◽  
Significant Negative Correlation ◽  
Reducing Sugar ◽  
Total Sugar ◽  
The Other ◽  
Biochemical Characteristics ◽  
Positive Correlation

The tropical vegetable, brinjal is cultivated throughout the year in Bangladesh but the crop is infested by a number of insects including jassid. This study investigated the effects of different biophysical and biochemical characteristics of twelve brinjal germplasms on the abundance and infestation of jassid. The experiment was conducted during September 2018 to March 2019 in Gazipur, Bangladesh with twelve brinjal germplasms namely BD-7320, BD-7328, BD-9952, BD-10154, BD-10158, BARI Begun-1, BARI Begun-4, BARI Begun-5, BARI Begun- 6, BARI Begun-7, BARI Begun-8 and BARI Begun-9. The incidence of jassid was recorded from 3rd December to 26th March, and the lowest population was found on BARI Begun- 6. Among the biophysical traits, plant height, number of branch and leaf per plant, and leaf area exerted significant positive correlation; whereas trichome on lower and upper surfaces of leaf, spine per stem and leaf showed significant negative correlation with the abundance of jassid. On the other hand, moisture, reducing sugar, total sugar and protein content of the leaves and fruits, chlorophyll content of the leaves exerts significant positive correlation but ash and pH contents of the leaves and fruits were negatively correlated with the abundance of jassid. Jassids showed the lowest level of leaf infestation on BARI Begun-6, which could be for further analysis to develop jassid resistant brinjal. SAARC J. Agric., 19(1): 81-91 (2021)

scholarly journals Reproductive performance of spiralling whitefly on guava and impact of weather parameters on its immature stages

2018 ◽  
Vol 15 (2) ◽  
pp. 207-214
Author(s):  
I Hossain ◽  
MMH Khan ◽  
SMH Jahan
Keyword(s):  
Relative Humidity ◽  
Negative Correlation ◽  
Reproductive Performance ◽  
Significant Positive Correlation ◽  
Instar Nymph ◽  
Maximum Temperature ◽  
Immature Stages ◽  
Positive Correlation ◽  
Aleurodicus Dispersus ◽  
Weather Parameters

The study was conducted to know the reproductive performance of spiralling whitefly on guava. Number of colony, eggs, 1st instar, 2nd instar, 3rd instar and 4th instar nymphs per five leaves ranged from 6 to 15, 8 to 32, 0 to 44, 0 to 22, 0 to 45 and 0 to 28, respectively. Maximum number of adults and nymphs were found in the month of January. Highest longevity of Aleurodicus dispersus (21.5 days) was recorded in adult while the lowest was in 2nd instar nymph (6.4 days). The number of colony/leaf and number of 3rd and 4th instar nymphs of A. dispersus had significant positive correlation with minimum and maximum temperature while non-significant positive correlation is observed between the number of egg/colony, the number 1st and 2nd instar nymphs with minimum and maximum temperature. A. dispersus showed nonsignificant positive correlation with minimum and maximum relative humidity regarding number of colony/leaf, 2nd instar nymph while nonsignificant negative correlation with 4th instar nymph.SAARC J. Agri., 15(2): 207-214 (2017)

scholarly journals THE CORRELATION OF MOBILITY TREND AND SITUATION OF COVID-19 BY COUNTRY, TERRITORY, AND AREA

2021 ◽  
Vol 8 (3) ◽  
pp. 153-164
Author(s):  
Adrina Esther Liaw ◽  
Jihan Natra Shafira ◽  
Muhammad Aziz ◽  
Iche Andriyani Liberty
Keyword(s):  
Negative Correlation ◽  
Government Policy ◽  
Significant Positive Correlation ◽  
Significant Negative Correlation ◽  
Research Paper ◽  
Analytic Study ◽  
Cross Sectional ◽  
Positive Correlation ◽  
The World ◽  
The Government

Each country around the world has taken several approaches in order to stop the spreading of the virus. This study was conducted to correlate the mobility trend and the situation of COVID-19 by country, territory, and area. This research paper adopts an observational analytic study with a cross-sectional approach for 115 countries from February 17th to August 27th, 2020. Tajikistan (r=0,956) and Italy (r=0,931) has the highest positive correlation for retail and recreations. For grocery,the highest degree of positive correlation is Mongolia (r=0,945) and Tajikistan (r=0,933). Bostwana and Italy showed highest significant positive correlation among countries (r=0,985 and r=0,902, respectively) for transit stations and residential  (r=0,994 and r=0,984). Bostwana also has the highest significant positive correlation for the park (r=0.980). Meanwhile, for the workplace, Mauritius (r=0,863) and Dominica (r=0,785) are countries with the highest degree of positive correlation with a cumulative case of COVID-19. Society's behavior plays an important role by following the government policy in order to slow down the spread of the virus. Retail and recreations, groceries and pharmacy stores, transit stations, parks, and workplaces found to have a significant positive correlation while residential have a significant negative correlation with cumulative cases of COVID-19 in most countries.  

scholarly journals Analysis of the Correlation between Commodity Grade and Quality ofAngelica sinensisby Determination of Active Compounds Using Ultraperformance Liquid Chromatography Coupled with Chemometrics

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Zenghui Wang ◽  
Dongmei Wang ◽  
Linfang Huang
Keyword(s):  
Ferulic Acid ◽  
Bioactive Compounds ◽  
Negative Correlation ◽  
Significant Positive Correlation ◽  
Principal Component ◽  
Significant Negative Correlation ◽  
Average Weight ◽  
Positive Correlation ◽  
Grade Classification ◽  
The Difference

The contents of ferulic acid, senkyunolide A, butylidenephthalide, ligustilide, and n-butylphthalide were determined by UPLC analytical method; the correlation among the grade, average weight, and content was explored by correlation analysis and analysis of variance (ANOVA); the different commercial grades with average weight and content were revealed by principal component analysis (PCA) and then rationality analysis grade classification ofA. sinensis. The results showed that various commercial grades can be distinguished by PCA analysis. And there was significant negative correlation between the commodity grades and average weight, commodity, and the content of bioactive compounds, while the content of senkyunolide A had significant negative correlation with commodity grades (P<0.01). Average weight had no correlation with chemicals compounds. Additionally, there was significant positive correlation among the bioactive compounds (content of ferulic acid and phthalides) of different grades ofA. sinensis. The content of senkyunolide A, butylidenephthalide, and ligustilide had significant positive correlation with the content of ferulic acid. The content of ligustilide and butylidenephthalide had significant positive correlation with the content of senkyunolide A. The content of ligustilide had significant positive correlation with the content of butylidenephthalide. The basis of grades classification is related with the difference levels of the bioactive compounds.

Renal osteodystrophy

2013 ◽  
pp. 1274-1282
Author(s):  
Thomas Bardin ◽  
Tilman Drüeke
Keyword(s):  
Vitamin D ◽  
Bone Turnover ◽  
Serum Calcium ◽  
Renal Osteodystrophy ◽  
Serum Phosphorus ◽  
Osteitis Fibrosa ◽  
Alkaline Phosphatases ◽  
Calcium Phosphorus ◽  
Turnover Markers ◽  
25 Oh Vitamin D

Renal osteodystrophy (ROD) is a term that encompasses the various consequences of chronic kidney disease (CKD) for the bone. It has been divided into several entities based on bone histomorphometry observations. ROD is accompanied by several abnormalities of mineral metabolism: abnormal levels of serum calcium, phosphorus, parathyroid hormone (PTH), vitamin D metabolites, alkaline phosphatases, fibroblast growth factor-23 (FGF-23) and klotho, which all have been identified as cardiovascular risk factors in patients with CKD. ROD can presently be schematically divided into three main types by histology: (1) osteitis fibrosa as the bony expression of secondary hyperparathyroidism (sHP), which is a high bone turnover disease developing early in CKD; (2) adynamic bone disease (ABD), the most frequent type of ROD in dialysis patients, which is at present most often observed in the absence of aluminium intoxication and develops mainly as a result of excessive PTH suppression; and (3) mixed ROD, a combination of osteitis fibrosa and osteomalacia whose prevalence has decreased in the last decade. Laboratory features include increased serum levels of PTH and bone turnover markers such as total and bone alkaline phosphatases, osteocalcin, and several products of type I collagen metabolism products. Serum phosphorus is increased only in CKD stages 4-5. Serum calcium levels are variable. They may be low initially, but hypercalcaemia develops in case of severe sHP. Serum 25-OH-vitamin D (25OHD) levels are generally below 30 ng/mL, indicating vitamin D insufficiency or deficiency. The international KDIGO guideline recommends serum PTH levels to be maintained in the range of approximately 2-9 times the upper normal normal limit of the assay and to intervene only in case of significant changes in PTH levels. It is generally recommended that calcium intake should be up to 2 g per day including intake with food and administration of calcium supplements or calcium-containing phosphate binders. Reduction of serum phosphorus towards the normal range in patients with endstage kidney failure is a major objective. Once sHP has developed, active vitamin D derivatives such as alfacalcidol or calcitriol are indicated in order to halt its progression.

The Hla System and the Clinical Response to Treatment with Chlorpromazine

1976 ◽  
Vol 129 (5) ◽  
pp. 486-489 ◽  
Author(s):  
E. Smeraldi ◽  
L. Bellodi ◽  
E. Sacchetti ◽  
C. L. Cazzullo
Keyword(s):  
Clinical Response ◽  
Negative Correlation ◽  
Significant Positive Correlation ◽  
Significant Negative Correlation ◽  
Response To Treatment ◽  
Positive Correlation ◽  
Hla System ◽  
Schizophrenic Patients ◽  
Clinical Responses ◽  
Pre Treatment

SummaryA group of 33 schizophrenic patients were typed for HLA-SD antigens and their qualitative clinical responses to chlorpromazine therapy determined. A highly significant positive correlation was found between response to chlorpromazine and HLA-A1 positive, while HLA-A2 positive subjects showed a significant negative correlation to chlorpromazine treatment.In a second group of 17 patients the clinical responses to chlorpromazine were evaluated quantitatively, by WPRS, in HLA-A1 positive and HLA-A1 negative patients. There were no pre-treatment differences in the scores. After treatment the scores of positive patients were significantly lower, indicating that they responded to a greater degree.Since the frequency of HLA-A1 in hebephrenic patients is higher than that in other schizophrenics this may explain our earlier finding that hebephrenics, as a group, respond better to chlorpromazine than do other schizophrenics.

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