Cardiovascular risk in ankylosing spondylitis and the effect of anti-TNF drugs: a narrative review

2019 ◽  
Vol 20 (5) ◽  
pp. 517-524 ◽  
Author(s):  
Fabiola Atzeni ◽  
Valeria Nucera ◽  
James Galloway ◽  
Szekanecz Zoltán ◽  
Mike Nurmohamed
Keyword(s):  
Cardiovascular Risk ◽  
Ankylosing Spondylitis ◽  
Narrative Review

scholarly journals Cardiovascular, carcinogenic and reproductive effects of nicotine exposure: A narrative review of the scientific literature

F1000Research ◽  
2020 ◽  
Vol 8 ◽  
pp. 1586
Author(s):  
Leonie R. Price ◽  
Javier Martinez
Keyword(s):  
Cardiovascular Risk ◽  
Cancer Progression ◽  
Animal Studies ◽  
Scientific Literature ◽  
Human Cancer ◽  
Narrative Review ◽  
Nicotine Exposure ◽  
Health Related

The emergence of new tobacco heating products and electronic nicotine delivery systems (ENDS) is changing the way humans are exposed to nicotine. The purpose of this narrative review is to provide a broad overview of published scientific literature with respect to the effects of nicotine on three key health-related areas: 1) cardiovascular risk, 2) carcinogenesis and 3) reproductive outcomes. These areas are known to be particularly vulnerable to the effects of cigarette smoke, and in addition, nicotine has been hypothesized to play a role in disease pathogenesis. Acute toxicity will also be discussed. The literature to February 2019 suggests that there is no increased cardiovascular risk of nicotine exposure in consumers who have no underlying cardiovascular pathology. There is scientific consensus that nicotine is not a direct or complete carcinogen, however, it remains to be established whether it plays some role in human cancer propagation and metastasis. These cancer progression pathways have been proposed in models in vitro and in transgenic rodent lines in vivo but have not been demonstrated in cases of human cancer. Further studies are needed to determine whether nicotine is linked to decreased fertility in humans. The results from animal studies indicate that nicotine has the potential to act across many mechanisms during fetal development. More studies are needed to address questions regarding nicotine exposure in humans, and this may lead to additional guidance concerning new ENDS entering the market.

Pro-oxidant–antioxidant balance (PAB) as a prognostic index in assessing the cardiovascular risk factors: A narrative review

2020 ◽  
Vol 19 ◽  
pp. 100272
Author(s):  
Hamideh Ghazizadeh ◽  
Maryam Saberi-Karimian ◽  
Maliheh Aghasizadeh ◽  
Reza Sahebi ◽  
Hamed Ghazavi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Prognostic Index ◽  
Narrative Review

scholarly journals Cardiovascular risk management in patients with active Ankylosing Spondylitis: a detailed evaluation

2015 ◽  
Vol 16 (1) ◽  
Author(s):  
Sjoerd C Heslinga ◽  
Inge A Van den Oever ◽  
Alper M Van Sijl ◽  
Mike J Peters ◽  
Irene E Van der Horst-Bruinsma ◽  
...  
Keyword(s):  
Risk Management ◽  
Cardiovascular Risk ◽  
Ankylosing Spondylitis ◽  
Cardiovascular Risk Management ◽  
Detailed Evaluation

Cardiovascular risk in psoriatic arthritis, a narrative review

2020 ◽  
Vol 87 (5) ◽  
pp. 413-418 ◽  
Author(s):  
Frank Verhoeven ◽  
Clément Prati ◽  
Céline Demougeot ◽  
Daniel Wendling
Keyword(s):  
Cardiovascular Risk ◽  
Psoriatic Arthritis ◽  
Narrative Review

scholarly journals The effects and associations of whole-apple intake on diverse cardiovascular risk factors. A narrative review

2020 ◽  
Vol 60 (22) ◽  
pp. 3862-3875
Author(s):  
Berner Andrée Sandoval-Ramírez ◽  
Úrsula Catalán ◽  
Lorena Calderón-Pérez ◽  
Judit Companys ◽  
Laura Pla-Pagà ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Narrative Review

scholarly journals Whole-Body Cryotherapy Decreases the Levels of Inflammatory, Oxidative Stress, and Atherosclerosis Plaque Markers in Male Patients with Active-Phase Ankylosing Spondylitis in the Absence of Classical Cardiovascular Risk Factors

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Agata Stanek ◽  
Armand Cholewka ◽  
Tomasz Wielkoszyński ◽  
Ewa Romuk ◽  
Aleksander Sieroń
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Cardiovascular Risk ◽  
Ankylosing Spondylitis ◽  
Disease Activity ◽  
Cardiovascular Risk Factors ◽  
Whole Body ◽  
Markers Of Inflammation ◽  
Whole Body Cryotherapy ◽  
The Impact

Objective. The aim of the study was to estimate the impact of whole-body cryotherapy (WBC) on cardiovascular risk factors in patients with ankylosing spondylitis (AS). Material and Methods. We investigated the effect of WBC with subsequent kinesiotherapy on markers of inflammation, oxidative stress, lipid profile, and atherosclerosis plaque in male AS patients (WBC group). To assess the disease activity, the BASDAI and BASFI were also calculated. The results from the WBC group were compared with results from the kinesiotherapy (KT) group. Results. The results showed that in the WBC group, the plasma hsCRP level decreased without change to the IL-6 level. The ICAM-1 level showed a decreasing tendency. The CER concentration, as well as the BASDAI and BASFI, decreased in both groups, but the index changes of disease activity were higher in the WBC than KT patients. Additionally, in the WBC group, we observed a decrease in oxidative stress markers, changes in the activity of some antioxidant enzymes and nonenzymatic antioxidant parameters. In both groups, the total cholesterol and LDL cholesterol, triglycerides, sCD40L, PAPP-A, and PLGF levels decreased, but the parameter changes were higher in the WBC group. Conclusion. WBC appears to be a useful method of atherosclerosis prevention in AS patients.

scholarly journals Increased Levels of Oxidative Stress Markers, Soluble CD40 Ligand, and Carotid Intima-Media Thickness Reflect Acceleration of Atherosclerosis in Male Patients with Ankylosing Spondylitis in Active Phase and without the Classical Cardiovascular Risk Factors

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Agata Stanek ◽  
Armand Cholewka ◽  
Tomasz Wielkoszyński ◽  
Ewa Romuk ◽  
Karolina Sieroń ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Cardiovascular Risk ◽  
Ankylosing Spondylitis ◽  
Cardiovascular Risk Factors ◽  
Intima Media Thickness ◽  
Active Phase ◽  
Oxidative Stress Markers ◽  
Soluble Cd40 Ligand ◽  
Stress Markers

Objective. The primary aim of the study was to assess levels of oxidative stress markers, soluble CD40 ligand (sCD40L), serum pregnancy-associated plasma protein-A (PAPP-A), and placental growth factor (PlGF) as well as carotid intima-media thickness (IMT) in patients with ankylosing spondylitis (AS) with active phase without concomitant classical cardiovascular risk factors.Material and methods. The observational study involved 96 male subjects: 48 AS patients and 48 healthy ones, who did not differ significantly regarding age, BMI, comorbid disorders, and distribution of classical cardiovascular risk factors. In both groups, we estimated levels of oxidative stress markers, lipid profile, and inflammation parameters as well as sCD40L, serum PAPP-A, and PlGF. In addition, we estimated carotid IMT in each subject.Results. The study showed that markers of oxidative stress, lipid profile, and inflammation, as well as sCD40L, PlGF, and IMT, were significantly higher in the AS group compared to the healthy group.Conclusion. Our results demonstrate that ankylosing spondylitis may be associated with increased risk for atherosclerosis.

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