AB0565 A review of cardiovascular risk factors in ankylosing spondylitis.

Objective. The aim of the study was to estimate the impact of whole-body cryotherapy (WBC) on cardiovascular risk factors in patients with ankylosing spondylitis (AS). Material and Methods. We investigated the effect of WBC with subsequent kinesiotherapy on markers of inflammation, oxidative stress, lipid profile, and atherosclerosis plaque in male AS patients (WBC group). To assess the disease activity, the BASDAI and BASFI were also calculated. The results from the WBC group were compared with results from the kinesiotherapy (KT) group. Results. The results showed that in the WBC group, the plasma hsCRP level decreased without change to the IL-6 level. The ICAM-1 level showed a decreasing tendency. The CER concentration, as well as the BASDAI and BASFI, decreased in both groups, but the index changes of disease activity were higher in the WBC than KT patients. Additionally, in the WBC group, we observed a decrease in oxidative stress markers, changes in the activity of some antioxidant enzymes and nonenzymatic antioxidant parameters. In both groups, the total cholesterol and LDL cholesterol, triglycerides, sCD40L, PAPP-A, and PLGF levels decreased, but the parameter changes were higher in the WBC group. Conclusion. WBC appears to be a useful method of atherosclerosis prevention in AS patients.

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Increased Levels of Oxidative Stress Markers, Soluble CD40 Ligand, and Carotid Intima-Media Thickness Reflect Acceleration of Atherosclerosis in Male Patients with Ankylosing Spondylitis in Active Phase and without the Classical Cardiovascular Risk Factors

Oxidative Medicine and Cellular Longevity ◽

10.1155/2017/9712536 ◽

2017 ◽

Vol 2017 ◽

pp. 1-8 ◽

Cited By ~ 15

Author(s):

Agata Stanek ◽

Armand Cholewka ◽

Tomasz Wielkoszyński ◽

Ewa Romuk ◽

Karolina Sieroń ◽

...

Keyword(s):

Oxidative Stress ◽

Risk Factors ◽

Cardiovascular Risk ◽

Ankylosing Spondylitis ◽

Cardiovascular Risk Factors ◽

Intima Media Thickness ◽

Active Phase ◽

Oxidative Stress Markers ◽

Soluble Cd40 Ligand ◽

Stress Markers

Objective. The primary aim of the study was to assess levels of oxidative stress markers, soluble CD40 ligand (sCD40L), serum pregnancy-associated plasma protein-A (PAPP-A), and placental growth factor (PlGF) as well as carotid intima-media thickness (IMT) in patients with ankylosing spondylitis (AS) with active phase without concomitant classical cardiovascular risk factors.Material and methods. The observational study involved 96 male subjects: 48 AS patients and 48 healthy ones, who did not differ significantly regarding age, BMI, comorbid disorders, and distribution of classical cardiovascular risk factors. In both groups, we estimated levels of oxidative stress markers, lipid profile, and inflammation parameters as well as sCD40L, serum PAPP-A, and PlGF. In addition, we estimated carotid IMT in each subject.Results. The study showed that markers of oxidative stress, lipid profile, and inflammation, as well as sCD40L, PlGF, and IMT, were significantly higher in the AS group compared to the healthy group.Conclusion. Our results demonstrate that ankylosing spondylitis may be associated with increased risk for atherosclerosis.

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Acute Myocardial Infarction in a Young Male with Ankylosing Spondylitis – Case Presentation

ARS Medica Tomitana ◽

10.2478/arsm-2020-0022 ◽

2020 ◽

Vol 26 (3) ◽

pp. 109-112

Author(s):

Ionescu Mihaela ◽

Ionescu Paris ◽

Peniu Luminița ◽

Șuța Victoria Cristina ◽

Parepa Irinel-Raluca

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Young Adults ◽

Cardiovascular Risk ◽

Ankylosing Spondylitis ◽

Cardiovascular Risk Factors ◽

Young Male ◽

Chronic Inflammatory Disease ◽

Risk Scores ◽

Drug Eluting Stent

Abstract Cardiovascular risk scores are useful in early detecting and, most important, early correcting the cardiovascular risk factors in order to prevent the cardiovascular disease, but the most commonly used charts have essential limitations when applied to young adults. We present the case of a 39-year-old man, known with HLA-B27-positive ankylosing spondylitis for 15 years, treated only with nonsteroidal antiinflamatory drugs, without any traditional cardiovascular risk factors, who was diagnosed with severe coronary artery disease, sub-occlusion in the proximal and mid-segment of the left anterior descending artery, which required emergency percutaneous coronary intervention with drug-eluting stent implantation. In this case report we aim to highlight the necessity of considering other parameters such as C-reactive protein levels or carotid plaques when estimating the risk of developing a cardiovascular disease, especially in young adults diagnosed with chronic inflammatory disease.

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Echocardiographic and Electrocardiographic Findings in Patients with Ankylosing Spondylitis without Cardiovascular Risk Factors

The Journal of Tehran University Heart Center ◽

10.18502/jthc.v15i2.4182 ◽

2020 ◽

Author(s):

Simin Almasi ◽

Behzad Farahani ◽

Niloufar Samiei ◽

Yousef Rezaei ◽

Habib Mahmoodi ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Ankylosing Spondylitis ◽

Aortic Valve ◽

Cardiovascular Risk Factors ◽

Cardiac Involvement ◽

Left Ventricular ◽

Control Group ◽

Number Of Patients ◽

Chronic Inflammatory Condition

Background: Ankylosing spondylitis (AS) is a chronic inflammatory condition associated with more cardiac manifestations than those in the normal population. In this study, we sought to determine the prevalence of cardiac involvement in patients suffering from AS without cardiovascular risk factors. Methods: The present case-control study, conducted in 2 university hospitals in Tehran from January 2016 to December 2017, recruited 67 patients with AS and 40 age- and sex-matched healthy controls. The diagnosis of AS was based on the classification criteria of the Assessment of SpondyloArthritis International Society. All the participants were examined using transthoracic echocardiography and a standard 12-lead ECG. Baseline characteristics, echocardiographic findings, and ECG features were compared between the AS and control groups using univariate analyses. Results: The median age was 33.5 (IQR25-75%: 20.5–59) years in the AS group and 35 (IQR25-75%: 26–59) years in the control group (P=0.301). The number of patients with left ventricular systolic and diastolic dysfunction was significantly higher in the patients with AS than in the controls (7.5% vs. 20.9%; P=0.067, and 22.9% vs. 5.0%; P=0.026, respectively). The number of individuals with a left-axis deviation and a left anterior fascicular block was significantly higher in the patients suffering from AS than in the control group. The number of patients with aortic valve involvement was comparable between the groups (P=0.332). Conclusion: The most common cardiac involvement in our patients with AS was left ventricular dysfunction, followed by rhythm disturbances and aortic valve insufficiency. These findings were independent of age, AS severity, and disease duration. Therefore, the implementation of cardiovascular screening can be recommended for patients with AS.

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Cardiovascular risk factors in gout, psoriatic arthritis, rheumatoid arthritis and ankylosing spondylitis: a cross-sectional survey of patients in Western Sweden

RMD Open ◽

10.1136/rmdopen-2021-001568 ◽

2021 ◽

Vol 7 (2) ◽

pp. e001568

Author(s):

Anton Jonatan Landgren ◽

Mats Dehlin ◽

Lennart Jacobsson ◽

Ulrika Bergsten ◽

Eva Klingberg

Keyword(s):

Rheumatoid Arthritis ◽

Risk Factors ◽

Cardiovascular Risk ◽

Psoriatic Arthritis ◽

Ankylosing Spondylitis ◽

Cardiovascular Risk Factors ◽

University Hospital ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Obesity Hypertension

ObjectivesWe aimed to compare traditional (trad) cardiovascular risk factors (CVRFs) among patients with gout, psoriatic arthritis (PsA), rheumatoid arthritis (RA) and ankylosing spondylitis (AS) stratified by sex.MethodsA survey was sent to patients with gout (n=1589), PsA (n=1200), RA (n=1246) and AS (n=1095). Patients were retrieved from Sahlgrenska University Hospital, the hospitals of Uddevalla and Skövde, and 12 primary care centres in Western Sweden. The prevalence of self-reported trad-CVRFs was compared between diagnoses by age standardisation with the 2018 population of Sweden as the standard population.ResultsIn total, 2896 (56.5%) of 5130 patients responded. Hypertension was the most frequently found comorbidity, reported by 65% of patients with gout, 41% with PsA, 43% with RA and 29% with AS. After age standardisation, women and men with gout had significantly more obesity (body mass index ≥30 kg/m2), hypertension, diabetes, hyperlipidaemia and multiple trad-CVRFs, compared with those with PsA, RA and AS. Obesity was significantly more common in PsA than in RA. In women, obesity, hypertension and multiple trad-CVRFs were more frequently reported in PsA than in RA and AS, whereas similar prevalence of CVRFs and coexistence of multiple trad-CVRFs were found in men with PsA, RA and AS.ConclusionsWomen and men with gout had the highest prevalence of trad-CVRFs. Differences in occurrence of CVRFs by sex were found in patients with PsA, RA and AS. In women, patients with PsA had higher occurrence of trad-CVRFs than those with RA and AS, whereas in men the distribution of CVRFs was similar in PsA, RA and AS.

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