Antibacterial activities of the chemical constituents of Schizophyllum commune MST7-3 collected from coal area

: Cissus aralioides is a medicinal plant used in sub-Saharan Africa for treatment of infectious diseases; however the chemical constituents of the plant have not been investigated. Thus, in this study, attempt was made at identifying predominant phytochemical constituents of the plant through chromatographic purification and silylation of the plant extract, and subsequent characterization using spectroscopic and GC-MS techniques. The minimum inhibitory concentration (MICs) for the antibacterial activities of the plant extract, chromatographic fractions and isolated compounds were also examined. Chromatographic purification of the ethyl acetate fraction from the whole plant afforded three compounds: β-sitosterol (1), stigmasterol (2) and friedelin (3). The phytosterols (1 and 2) were obtained together as a mixture. The GC-MS analysis of silylated extract indicated alcohols, fatty acids and sugars as predominant classes, with composition of 24.62, 36.90 and 26.52% respectively. Results of MICs indicated that friedelin and other chromatographic fractions had values (0.0626-1.0 mg/mL) comparable with the standard antibiotics used. Characterization of natural products from C. aralioides is being reported for the first time in this study.

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Glutathione S-Transferase, Acetylcholinesterase Inhibitory and Antibacterial Activities of Chemical Constituents of Barleria prionitis.

ChemInform ◽

10.1002/chin.200731179 ◽

2007 ◽

Vol 38 (31) ◽

Author(s):

Kalhari S. Kosmulalage ◽

Shamsulhaq Zahid ◽

Chibuike C. Udenigwe ◽

Sarfraz Akhtar ◽

Athar Ata ◽

...

Keyword(s):

Chemical Constituents ◽

Antibacterial Activities ◽

Glutathione S Transferase

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Glutathione S-Transferase, Acetylcholinesterase Inhibitory and Antibacterial Activities of Chemical Constituents of Barleria prionitis

Zeitschrift für Naturforschung B ◽

10.1515/znb-2007-0417 ◽

2007 ◽

Vol 62 (4) ◽

pp. 580-586 ◽

Cited By ~ 11

Author(s):

Kalhari S. Kosmulalage ◽

Shamsulhaq Zahid ◽

Chibuike C. Udenigwe ◽

Sarfraz Akhtar ◽

Athar Ata ◽

...

Keyword(s):

Inhibitory Activity ◽

Chemical Constituents ◽

Ethanolic Extract ◽

Antibacterial Activities ◽

Spectroscopic Studies ◽

Sri Lankan ◽

Glutathione S Transferase ◽

Ache Inhibitory Activity ◽

Phytochemical Studies ◽

Derivatives Of

Phytochemical studies on the ethanolic extract of Barleria prionitis of Sri Lankan origin have resulted in the isolation of a new compound, balarenone (1), along with three known compounds, pipataline (2), lupeol (3) and 13,14-seco-stigmasta-5,14-diene-3-α-ol (4). The structures of 1 - 4 were elucidated with the aid of extensive NMR spectroscopic studies. Compounds 1 - 4 showed moderate inhibitory activity against glutathione S-transferase (GST) and acetylcholinesterase (AChE). Compounds 1, 2 and 4 also exhibited antibacterial activity against Bacillus cereus and Pseudomonas aeruginosa (25 μg/disk). Three different derivatives of compound (2), 7,8-epoxypipataline (5), 8- amino-7-hydroxypipataline (6) and 7,8-dibromopipataline (7) were synthesized to evaluate them for GST and AChE inhibitory activities. Household microwave radiations were used to synthesize compound (6). Among all tested compounds, 8-amino-7-hydroxypipataline (6) exhibited a significant AChE inhibitory activity with an IC50 value of 36.8 μM.

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In Vitro Pharmacological Activities and GC-MS Analysis of Different Solvent Extracts ofLantana camaraLeaves Collected from Tropical Region of Malaysia

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2015/506413 ◽

2015 ◽

Vol 2015 ◽

pp. 1-9 ◽

Cited By ~ 27

Author(s):

Mallappa Kumara Swamy ◽

Uma Rani Sinniah ◽

Mohd. Sayeed Akhtar

Keyword(s):

Ethyl Acetate ◽

Chemical Constituents ◽

Radical Scavenging ◽

Acid Methyl Ester ◽

Antibacterial Activities ◽

Tropical Region ◽

E Coli ◽

Gram Positive Bacteria ◽

Ms Analysis

We investigated the effect of different solvents (ethyl acetate, methanol, acetone, and chloroform) on the extraction of phytoconstituents fromLantana camaraleaves and their antioxidant and antibacterial activities. Further, GC-MS analysis was carried out to identify the bioactive chemical constituents occurring in the active extract. The results revealed the presence of various phytocompounds in the extracts. The methanol solvent recovered higher extractable compounds (14.4% of yield) and contained the highest phenolic (92.8 mg GAE/g) and flavonoid (26.5 mg RE/g) content. DPPH radical scavenging assay showed the IC50value of 165, 200, 245, and 440 μg/mL for methanol, ethyl acetate, acetone, and chloroform extracts, respectively. The hydroxyl scavenging activity test showed the IC50value of 110, 240, 300, and 510 μg/mL for methanol, ethyl acetate, acetone, and chloroform extracts, respectively. Gram negative bacterial pathogens (E. coliandK. pneumoniae) were more susceptible to all extracts compared to Gram positive bacteria (M. luteus,B. subtilis, andS. aureus). Methanol extract had the highest inhibition activity against all the tested microbes. Moreover, methanolic extract ofL. camaracontained 32 bioactive components as revealed by GC-MS study. The identified major compounds included hexadecanoic acid (5.197%), phytol (4.528%), caryophyllene oxide (4.605%), and 9,12,15-octadecatrienoic acid, methyl ester, (Z,Z,Z)- (3.751%).

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Essential oils extracted from Phoebe hui Cheng ex Yang: Chemical constituents, antitumor and antibacterial activities, and potential use as a species identifier

Journal of Wood Chemistry and Technology ◽

10.1080/02773813.2016.1271435 ◽

2017 ◽

Vol 37 (3) ◽

pp. 201-210 ◽

Cited By ~ 6

Author(s):

Wen Ding ◽

Liping Ning ◽

Yan Xiong ◽

Hao Shi ◽

Tianshi Wang ◽

...

Keyword(s):

Essential Oils ◽

Chemical Constituents ◽

Antibacterial Activities ◽

Potential Use

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Chemical constituents from the roots of Ampelopsis delavayana and their antibacterial activities

Natural Product Research ◽

10.1080/14786419.2016.1224875 ◽

2016 ◽

Vol 31 (2) ◽

pp. 190-195 ◽

Cited By ~ 3

Author(s):

Shuang-Xi Mei ◽

Xu-Hong Li ◽

Li-Guo Yang ◽

Xiao-Hui Li ◽

Jia-Ying Xie ◽

...

Keyword(s):

Chemical Constituents ◽

Antibacterial Activities

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Chemical Composition and Biological Activities from Croton delpyi Croton decalvatus and Croton caudatus

The Natural Products Journal ◽

10.2174/2210315510999200704143606 ◽

2020 ◽

Vol 10 ◽

Author(s):

Sakchai Chaibun ◽

Wilart Pompimon ◽

Chanika Tidchai ◽

Noraset Chalaemwongwan ◽

Jutarut Wongping ◽

...

Keyword(s):

Chemical Composition ◽

Biological Activities ◽

Chemical Constituents ◽

Antibacterial Activities ◽

Cytotoxic Activities ◽

Separation And Purification ◽

Pure Compounds ◽

Cytotoxicity Activities ◽

Anti Hiv ◽

Hiv 1

Background: C. delpyi, C. decalvatus and C. caudatus are in the Euphorbiaceae family. The aerial parts; twigs, leaves and barks of these plants were used as traditional medicine such as anti-inflammatory, cytotoxicity, and antifungal properties. Objectives: The aims of this work were 1) to study the chemical composition of C. delpyi, C. decalvatus, and C. caudatus 2) to test their antibacterial, anti-HIV-1 RT, and cytotoxicity activities of crude extracts and pure compounds from these plants. Methods: Extraction, separation and purification of three plants were performed under chromatographic method. The biological activities including antibacterial, anti-HIV-1 RT and cytotoxicity assay of three plants were evaluated by the standard methods. Results: Phytochemical investigation of C. delpyi was founded a new clerodanes diterpenoids; crotondelpyitin A (1). The five known compounds, such as acetyl aleuritolic acid (2), 5-hydroxy-7,4- dimethoxyflavone (3), and pilloin (4) were founded in C. decalvatus and 3α-benzoyloxy-D:A-friedo-oleanan-27,16αlactone (5), and bergenin (6) were founded in C. caudatus. The compound 3 show the most effective antibacterial activities with MIC in range <0.16 -1.25 mg/mL, and MBC in range 0.6 - >5.0 mg/mL. The six compounds were inactive with antiHIV-1 RT. In addition, compound 4 was active for cytotoxic activities on FaDu and KKU-M213 at <4 µg/mL. Conclusion: The present study reveals that the Croton species are sources of diterpenoid-type compounds and significant guide for further research of the chemical constituents from these plants as potential medicines.

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Chemical Composition and Bioactivity of Essential Oil of Ten Labiatae Species

Molecules ◽

10.3390/molecules25204862 ◽

2020 ◽

Vol 25 (20) ◽

pp. 4862

Author(s):

Mengting Liu ◽

Feiya Luo ◽

Zhixing Qing ◽

Huichao Yang ◽

Xiubin Liu ◽

...

Keyword(s):

Antioxidant Activities ◽

Chemical Constituents ◽

Radical Scavenging ◽

Inhibition Zone ◽

Antibacterial Activities ◽

Feed Additives ◽

Gas Chromatography Mass Spectrometry ◽

Dilution Method ◽

Antioxidant Power ◽

Minimal Inhibitory Concentrations

Using antibiotics as feed additives have been successively banned worldwide from 1986; therefore, it is an urgent task to finding safe and effective alternatives. As natural products of plant origin, essential oils (EOs) are an outstanding option due to their reported bioactivity. In this research, ten EOs of Labiatae species were extracted by steam distillation and its chemical constituents were identified by gas chromatography-mass spectrometry (GC-MS). A total of 123 chemical compounds, including alkenes, phenols, aldehydes and ketones, were identified. The results of antioxidant activity carried out through DPPH free radical scavenging (DPPH) and ferric reducing antioxidant power (FRAP), showing that EOs of Ocimum basilicum Linn. (ObEO), Thymus mongolicus Ronn. (TmEO), Origanum vulgare Linn. (OvEO) and Mosla chinensis Maxim. (McEO) have strong antioxidant activities. Their 50%-inhibitory concentration (IC50) value was <1.00, 1.42, 1.47 and 1.92 μg/mL, respectively; and their FRAP value was 1536.67 ± 24.22, 271.84 ± 4.93, 633.71 ± 13.14 and 480.66 ± 29.90, respectively. The results of filter paper diffusion showing that McEO, OvEO and TmEO inhibition zone diameter (IZD) are all over 30 mm. The results of two-fold dilution method showed that McEO, OvEO and TmEO have strong antibacterial activities against Staphylococcus aureus (S. aureus) and their minimal inhibitory concentrations (MIC) value was 1 μL/mL, 2 μL/mL, and 2 μL/mL, respectively. In conclusion, the results in this work demonstrate the possibility for development and application of EOs as potential feed additives.

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