Evaluation of Fetal Serum Thiol/Disulfide Homeostasis and Ischemia-Modified Albumin Levels in Fetal Distress

According to recent studies, in the vitamin D deficiency state (VDD), pregnancy can be complicated and the optimal level of VD in the blood is one of the conditions for the realization of reproductive potential. The objective: the possibility to preventing calcitriol-associated pregnancy complications by the correcting VD deficiency at the preconception period. Materials and methods. 57 women with VDD were examined. A history of all women had a pregnancy complicated by placental dysfunction (PD); 27 of them were observed from the preconception period (main group – IA) and 30 – from the 1st trimester of pregnancy (comparison group – IB). The VD status by the blood level of the 25-hydroxyvitamin D by ELISA was determined. Women of both groups, in addition to the vitamin-mineral complex (VMC) were prescribed supplementation colecalciferol at a dose of 4.000 IU per day. Pregnant women of both groups received VMCs up to 16 weeks. After optimizing the level (3–4 months), women continued to take VD at a dose of 2.000 IU per day throughout pregnancy. Results. At the initial study, the VD level was 15.72±2.59 ng/ml in ІА and 16.1±1.99 ng/ml in ІВ group (U=883; p>0.05); after treatment increased to 38.31±3.29 ng/ml and 36.13±2.99 ng/ml (U=900; p>0.05). In group IA, the course of pregnancy was characterized by a lower frequency of complications: PD was diagnosed in 22.2% in group IA and 50% in group IB (F=0.0001; p<0.01); fetal distress in 3.7% and 10% (F=0.16; p<0.05): signs of amnionitis – in 18.5% and 33.3% (F=0.035; p<0.05); placental hypertrophy or hypotrophy – in 7.4% and 36.7% (F=0.00001; p<0.01), preeclampsia in 3.7% and 6.7% of women (F=0,54; p<0.05). The frequency of cesarean section in the comparison group was significantly higher (40% VS 25.9%, F=0.034; p<0.05). Conclusions. During pregnancy, which occurred in conditions of VDD, the frequency of some pregnancy complications, including preeclampsia, the threat of miscarriage, placental dysfunction was in 2–4 times higher than in women with optimized VD status. One of the directions of the individual management plan for women with a negative obstetric history can be the determination of the level of VD in the blood and correction of the VDD at the preconception period. This approach is a pathogenetically substantiated and promising direction for the prevention of some pregnancy complications and improvement of perinatal outcomes. Keywords: pregnancy, deficiency vitamin D, placental dysfunction, preconception period.

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APPLYING VALUE UTERINE DOPPLER ASSOCIATED WITH PREECLAMPSIA

Journal of Medicine and Pharmacy ◽

10.34071/jmp.2016.1.7 ◽

2016 ◽

pp. 57-64

Author(s):

Thi Linh Giang Truong ◽

Vu Quoc Huy Nguyen ◽

Quang Vinh Truong ◽

Van Duc Vo

Keyword(s):

Cohort Study ◽

Key Words ◽

Doppler Ultrasound ◽

Prospective Cohort Study ◽

Prospective Cohort ◽

Fetal Distress ◽

Central Hospital ◽

Study Results ◽

Key Words Doppler

Background: Study on the correlation between the values of the Uterine Doppler with the type of preeclamsia and using uterine Doppler and predict fetal distress. Methods: Study on 116 patients with pre-eclampsia at Obs. & Gyn. Department - Hue Central Hospital were taken by an prospective cohort study. Results: There was correlation between morphology of uterine Doppler waves with the type of preeclamsia and fetal distress. Among 46 patients with server preeclamsia, the rate of abnormal of waves uterine Doppler is 78,2 %, and the rate of abnormal of waves uterine Doppler is 22% and fetal. This research also evaluate the relation between uterine Doppler with the fetal distress. The group patients with fetal distress also have the rate of abnormal uterine Doppler is 86,6% and the rate of nomal uterine dopple is 13,4 %. Conclusion: There was the correlation between the values of the Uterine Doppler with the type of preeclamsia and predict fetal distress. The value of uterine Doppler ultrasound can be predict the ricks happening for mother and fetal distress with preeclampsia. Key words: Doppler ultrosound, uterine Doppler, fetal distress, preeclampsia, IUGR.

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Efficacy of Thiol disulfide Homeostasis and Ischemia Modified Albumin Values in Estimating the Degree of Difficulty for Laparoscopic Cholecystectomy

Combinatorial Chemistry & High Throughput Screening ◽

10.2174/1386207323666200709165910 ◽

2020 ◽

Vol 23 ◽

Author(s):

Gökhan Akkurt ◽

Burcu Akkurt ◽

Emel Alptekın ◽

Birkan Birben ◽

Mehmet Keşkek ◽

...

Keyword(s):

Laparoscopic Cholecystectomy ◽

Hospital Stay ◽

Demographic Data ◽

Previous History ◽

Significant Negative Correlation ◽

White Blood Count ◽

Ischemia Modified Albumin ◽

Total Thiol ◽

Duration Of Surgery ◽

History Of

Aim: The aim of this study is to investigate the efficacy of thiol disulfide homeostasis and Ischemia Modified Albumin (IMA) values in predicting the technical difficulties that might be encountered during laparoscopic cholecystectomy. Materials and Methods: The study included 65 patients who underwent laparoscopic cholecystectomy due to cholelithiasis at the General Surgery Clinic of Ankara Numune Training and Research Hospital. All patients’ demographic data, previous history of cholecystitis, a history of chronic illness, preoperative white blood count (WBC), liver function tests (AST, ALT), amylase and lipase levels, intra-operative adhesion score, the ultrasonographic appearance of gallbladder, duration on hospital stay, duration of operation, thiol disulfide and IMA values were evaluated. Results: Native thiol and total thiol averages were higher in patients without a history of cholecystitis, on the other hand, disulfide, disulfide/native thiol rate, disulfide/total thiol rate, native thiol/total thiol rate and IMA averages were higher in patients with a history of cholecystitis. While there was a statistically significant negative correlation between native and total thiol values and age, duration of surgery and duration of hospital stay; IMA, disulfide, disulfide/Total thiol, Native/Total thiol and disulfide/Native thiol rates were higher in older patients with a longer duration of surgery and hospital stay. In addition, preoperative IMA, disulfide, disulfide/Total thiol, Native/Total thiol and disulfide/Native thiol were observed to increase as the degree of intraoperative pericholecystic adhesion increased. Conclusion: We believe that the evaluation of thiol disulfide homeostasis and IMA parameters prior to laparoscopic cholecystectomy can be used as an effective method for predicting intraoperative difficulties.

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Usefulness of ischemia-modified albumin in predicting oxidative stress in patients with vitiligo

Biomarkers in Medicine ◽

10.2217/bmm-2016-0259 ◽

2017 ◽

Vol 11 (6) ◽

pp. 439-449 ◽

Cited By ~ 3

Author(s):

Hatice Ataş ◽

Murat Kocabıyık ◽

Müzeyyen Gönül ◽

Yasin Öztürk ◽

Mustafa Kavutçu

Keyword(s):

Oxidative Stress ◽

Ischemia Modified Albumin

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On ε-insensitive simplification of fuzzy rules for fetal distress assessment

Expert Systems with Applications ◽

10.1016/j.eswa.2021.115052 ◽

2021 ◽

pp. 115052

Author(s):

Michal Jezewski ◽

Robert Czabanski ◽

Jacek M. Leski ◽

Adam Matonia ◽

Radana Kahankova

Keyword(s):

Fetal Distress ◽

Fuzzy Rules

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Severe Acute Respiratory Syndrome Coronavirus 2 Placental Infection and Inflammation Leading to Fetal Distress and Neonatal Multi-Organ Failure in an Asymptomatic Woman

Journal of the Pediatric Infectious Diseases Society ◽

10.1093/jpids/piaa153 ◽

2020 ◽

Author(s):

Sam Schoenmakers ◽

Pauline Snijder ◽

Robert M Verdijk ◽

Thijs Kuiken ◽

Sylvia S M Kamphuis ◽

...

Keyword(s):

Severe Acute Respiratory Syndrome ◽

Vertical Transmission ◽

Neonatal Intensive Care ◽

Quantitative Polymerase Chain Reaction ◽

Antigen Expression ◽

Fetal Distress ◽

Adverse Outcomes ◽

Placental Infection ◽

Emergency Cesarean ◽

Increased Risk

Abstract Background In general, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy is not considered to be an increased risk for severe maternal outcomes but has been associated with an increased risk for fetal distress. Maternal-fetal transmission of SARS-CoV-2 was initially deemed uncertain; however, recently a few cases of vertical transmission have been reported. The intrauterine mechanisms, besides direct vertical transmission, leading to the perinatal adverse outcomes are not well understood. Methods Multiple maternal, placental, and neonatal swabs were collected for the detection of SARS-CoV-2 using real-time quantitative polymerase chain reaction (RT-qPCR). Serology of immunoglobulins against SARS-CoV-2 was tested in maternal, umbilical cord, and neonatal blood. Placental examination included immunohistochemical investigation against SARS-CoV-2 antigen expression, with SARS-CoV-2 ribonucleic acid (RNA) in situ hybridization and transmission electron microscopy. Results RT-qPCRs of the oropharynx, maternal blood, vagina, placenta, and urine were all positive over a period of 6 days, while breast milk, feces, and all neonatal samples tested negative. Placental findings showed the presence of SARS-CoV-2 particles with generalized inflammation characterized by histiocytic intervillositis with diffuse perivillous fibrin depositions with damage to the syncytiotrophoblasts. Conclusions Placental infection by SARS-CoV-2 leads to fibrin depositions hampering fetal-maternal gas exchange with resulting fetal distress necessitating a premature emergency cesarean section. Postpartum, the neonate showed a fetal or pediatric inflammatory multisystem-like syndrome with coronary artery ectasia temporarily associated with SARS-CoV-2 for which admittance and care on the neonatal intensive care unit (NICU) were required, despite being negative for SARS-CoV-2. This highlights the need for awareness of adverse fetal and neonatal outcomes during the current coronavirus disease 2019 pandemic, especially considering that the majority of pregnant women appear asymptomatic.

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COVID-19 and pregnancy – where are we now? A review

Journal of Perinatal Medicine ◽

10.1515/jpm-2020-0132 ◽

2020 ◽

Vol 48 (5) ◽

pp. 428-434 ◽

Cited By ~ 7

Author(s):

Aleksandra Rajewska ◽

Wioletta Mikołajek-Bedner ◽

Joanna Lebdowicz-Knul ◽

Małgorzata Sokołowska ◽

Sebastian Kwiatkowski ◽

...

Keyword(s):

Case Fatality ◽

Fetal Distress ◽

Delivery Mode ◽

Test Results ◽

Rt Pcr ◽

Third Trimester ◽

The Third ◽

Laboratory Test Results ◽

Protective Antibodies ◽

Polymerase Chain

AbstractThe new acute respiratory disease severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is highly contagious. It has caused many deaths, despite a relatively low general case fatality rate (CFR). The most common early manifestations of infection are fever, cough, fatigue and myalgia. The diagnosis is based on the exposure history, clinical manifestation, laboratory test results, chest computed tomography (CT) findings and a positive reverse transcription-polymerase chain reaction (RT-PCR) result for coronavirus disease 2019 (COVID-19). The effect of SARS-CoV-2 on pregnancy is not already clear. There is no evidence that pregnant women are more susceptible than the general population. In the third trimester, COVID-19 can cause premature rupture of membranes, premature labour and fetal distress. There are no data on complications of SARS-CoV-2 infection before the third trimester. COVID-19 infection is an indication for delivery if necessary to improve maternal oxygenation. Decision on delivery mode should be individualised. Vertical transmission of coronavirus from the pregnant woman to the fetus has not been proven. As the virus is absent in breast milk, the experts encourage breastfeeding for neonatal acquisition of protective antibodies.

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Association of ischemia modified albumin with mortality in qSOFA positive sepsis patients by sepsis-3 in the emergency department

The American Journal of Emergency Medicine ◽

10.1016/j.ajem.2021.01.059 ◽

2021 ◽

Vol 44 ◽

pp. 72-77

Author(s):

Jonghak Park ◽

Sejoong Ahn ◽

Seonggeun Lee ◽

Juhyun Song ◽

Sungwoo Moon ◽

...

Keyword(s):

Emergency Department ◽

Ischemia Modified Albumin

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Clinical Features and Maternal-fetal Results of Pregnant Women in COVID-19 Times

Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics ◽

10.1055/s-0041-1729145 ◽

2021 ◽

Vol 43 (05) ◽

pp. 384-394

Author(s):

Ana Paula Nogueira Godoi ◽

Gilcelia Correia Santos Bernardes ◽

Leilismara Sousa Nogueira ◽

Patrícia Nessralla Alpoim ◽

Melina de Barros Pinheiro

Keyword(s):

Pregnant Women ◽

Vertical Transmission ◽

Postpartum Period ◽

Scientific Literature ◽

Respiratory Infections ◽

Clinical Manifestations ◽

Fetal Distress ◽

Medical Subject Headings ◽

Substantial Evidence ◽

The Subject

Abstract Objective Coronavirus disease 2019 (COVID-19) is a disease caused by a newly discovered coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which usually leads to non-specific respiratory symptoms. Although pregnant women are considered at risk for respiratory infections by other viruses, such as SARS and Middle East respiratory syndrome (MERS), little is known about their vulnerability to SARS-CoV-2. Therefore, this study aims to identify and present the main studies on the topic, including the postpartum period. Methods In this narrative review, articles were searched in various databases, organizations, and health entities using keywords compatible with medical subject headings (MeSH), such as: COVID-19, pregnancy, vertical transmission, coronavirus 2019, and SARS-CoV-2. Results The review of the scientific literature on the subject revealed that pregnant women with COVID-19 did not present clinical manifestations significantly different from those of non-pregnant women; however, there are contraindicated therapies. Regarding fetuses, studies were identified that reported that infection by SARS-CoV-2 in pregnant women can cause fetal distress, breathing difficulties and premature birth, but there is no substantial evidence of vertical transmission. Conclusion Due to the lack of adequate information and the limitations of the analyzed studies, it is necessary to provide detailed clinical data on pregnant women infected with SARS-CoV-2 and on the maternal-fetal repercussions caused by this infection. Thus, this review may contribute to expand the knowledge of professionals working in the area as well as to guide more advanced studies on the risk related to pregnant women and their newborns. Meanwhile, monitoring of confirmed or suspected pregnant women with COVID-19 is essential, including in the postpartum period.

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Massive Extra-Abdominal Umbilical Vein Varix: A Case Report

Fetal Diagnosis and Therapy ◽

10.1159/000512490 ◽

2021 ◽

pp. 1-4

Author(s):

Josef Jackson ◽

Eumenia Castro ◽

Michael A. Belfort ◽

Alireza A. Shamsirshaz ◽

Ahmed A. Nassr ◽

...

Keyword(s):

Case Report ◽

Umbilical Cord ◽

Neonatal Period ◽

Umbilical Vein ◽

Fetal Distress ◽

Fetal Anemia ◽

Pathologic Examination ◽

Fetal Demise ◽

Increased Risk ◽

Umbilical Vein Varix

Umbilical vein varices are rare umbilical cord anomalies that typically occur intra-abdominally. Extra-abdominal umbilical vein varices are exceedingly rare and usually diagnosed postnatally on gross pathologic examination. Umbilical vein varices have been associated with increased risk of fetal anemia, cardiac abnormalities, and intrauterine fetal demise. This case report discusses a patient who presented with a massive extra-abdominal umbilical vein varix, whose infant was ultimately delivered due to fetal distress and died in the neonatal period. This report also discusses associated fetal conditions and guidelines for antenatal testing and surveillance of known umbilical vein varices.

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