Feasibility of a Wearable Biosensor Device to Characterize Exercise and Sleep in Neurology Residents

We develop here tools for speeding up binding in a biosensor device through augmenting diffusive transport, applicable to immunoassays as well as DNA hybridization, and to a variety of formats, from microfluidic to microarray. AC electric fields generate the fluid motion through the well documented but unexploited phenomenon, Electrothermal Flow, where the circulating flow redirects or stirs the fluid, providing more binding opportunities between suspended and wall-immobilized molecules. Numerical simulations predict a factor of up to 8 increase in binding rate for an immunoassay under reasonable conditions. Preliminary experiments show qualitatively higher binding after 15 minutes. In certain applications, dielectrophoretic capture of passing molecules, when combined with electrothermal flow, can increase local analyte concentration and further enhance binding.

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Study on the Physical Properties of a SiNW Biosensor to the Sensitivity of DNA Detection

Materials ◽

10.3390/ma14195716 ◽

2021 ◽

Vol 14 (19) ◽

pp. 5716

Author(s):

Siti Noorhaniah Yusoh ◽

Khatijah Aisha Yaacob

Keyword(s):

Surface Roughness ◽

Physical Properties ◽

Limit Of Detection ◽

Silicon Nanowire ◽

Volume Ratio ◽

Silicon Nanowire Arrays ◽

Atomic Force ◽

Local Anodic Oxidation ◽

Wet Chemical ◽

Biosensor Device

SiNW (silicon nanowire) arrays consisting of 5- and 10-wires were fabricated by using an atomic force microscope—the local anodic oxidation (AFM-LAO) technique followed by wet chemical etching. Tetramethylammonium hydroxide (TMAH) and isopropyl alcohol (IPA) at various concentrations were used to etch SiNWs. The SiNWs produced were differed in dimension and surface roughness. The SiNWs were functionalized and used for the detection of deoxyribonucleic acid (DNA) dengue (DEN-1). SiNW-based biosensors show sensitive detection of dengue DNA due to certain factors. The physical properties of SiNWs, such as the number of wires, the dimensions of wires, and surface roughness, were found to influence the sensitivity of the biosensor device. The SiNW biosensor device with 10 wires, a larger surface-to-volume ratio, and a rough surface is the most sensitive device, with a 1.93 fM limit of detection (LOD).

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Special Feature — Medical Device

Asia-Pacific Biotech News ◽

10.1142/s0219030305000534 ◽

2005 ◽

Vol 09 (21) ◽

pp. 1120-1146

Keyword(s):

Cell Separation ◽

State Of The Art ◽

Blood Pressure Monitoring ◽

Microfluidic Devices ◽

Molecular Diagnostic ◽

Pressure Monitoring ◽

Contract Manufacturing ◽

Separation Technology ◽

Biomedical Device ◽

Biosensor Device

AmpliChip CYP450 Test—An Important Step Forward in Making Personalized Medicine a Reality.Automating and Miniaturizing Molecular Diagnostic on a BioChip.Blood Pressure Monitoring: State-Of-the-Art: BPro.Nanobiotechnologies to Provide a Portable Genetic Biosensor Device.Inzign–A Singapore-based Company with Biomedical Device Contract Manufacturing Ambitions.Technical Paper on Microfluidic Devices—Cell Separation Technology.

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High performance microbial 3-D bionanocomposite as a bioanode for a mediated biosensor device

Electrochemistry Communications ◽

10.1016/j.elecom.2011.06.013 ◽

2011 ◽

Vol 13 (9) ◽

pp. 966-968 ◽

Cited By ~ 12

Author(s):

Jana Šefčovičová ◽

Jaroslav Filip ◽

Peter Gemeiner ◽

Alica Vikartovská ◽

Vladimír Pätoprstý ◽

...

Keyword(s):

High Performance ◽

Biosensor Device

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Nanoplasmonic biosensor device for the monitoring of acenocoumarol therapeutic drug in plasma

Biosensors and Bioelectronics ◽

10.1016/j.bios.2018.08.011 ◽

2018 ◽

Vol 119 ◽

pp. 149-155 ◽

Cited By ~ 6

Author(s):

E. Cristina Peláez ◽

M.-Carmen Estevez ◽

Alejandro Portela ◽

J.-Pablo Salvador ◽

M.-Pilar Marco ◽

...

Keyword(s):

Therapeutic Drug ◽

Biosensor Device

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Amplified microgravimetric quartz-crystal-microbalance analyses of oligonucleotide complexes: a route to a Tay–Sachs biosensor device

Chemical Communications ◽

10.1039/a800215k ◽

1998 ◽

pp. 839-840 ◽

Cited By ~ 53

Author(s):

Amos Bardea ◽

Arie Dagan ◽

Iddo Ben-Dov ◽

Itamar Willner ◽

Amos Bardea ◽

...

Keyword(s):

Quartz Crystal Microbalance ◽

Quartz Crystal ◽

Biosensor Device

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Quantifying Fraction of Total Power Vs Wavelength of Ultra-Nanoscale Plasmonic Biosensor Device using Metal-Insulator-Metal-Metal Stack, Nano wells and Biotin Layer.

International Journal of Recent Technology and Engineering - 2 ◽

10.35940/ijrte.b1464.07821 ◽

2019 ◽

Vol 8 (2) ◽

pp. 339-343

Keyword(s):

Power Loss ◽

Wave Length ◽

Three Dimensional ◽

Total Power ◽

Metal Insulator ◽

Functional Behavior ◽

Metal Metal ◽

Metal Insulator Metal ◽

The Cost ◽

Biosensor Device

An ultra-thin three-dimensional nanostructured biosensor device based on the Plasmonic principle is custom designed and analyzed for the Plasmonic properties. Here the FDTD (Finite Difference Time Domain) method is adopted as mathematical model using MEEP (MIT Electromagnetic Equation Propagation) open-source simulation tool. The four models are investigated and analyzed in the following order for respective Plasmonic properties of fraction of total power with respect to the wavelength for model-I MIMM layers (Metal-Insulator-Metal-Metal) with no nanostructure (AlAl2O3-Cr-Au), model-II MIMM layers with no nanostructure (Al- Al2O3-Cr-Au) and Biotin layer, model-III MIMM layers (AlAl2O3-Cr-Au) with 11 x 11 Nano well structures and model-IV MIMM layers with Nano well structures and Biotin layer (AlAl2O3-Cr-Au-Biotin). Here the structural and functional behavior of model I Vs Model II Vs Model III vs Model IV is simulated and the fraction of power is measured across the biosensor stack layer of MIMM for the wave length range quantified. In model II there is an approximate 5% power loss at all layers when compared to model I due to addition of the Biotin layer. In model IV there is an approximate 50 % power loss when compared to model III at Au layer, 60% power loss when compared to model III at Al layer and 67% of power loss at Cr + Al2O3 due to Biotin layer. These quantifications can be used to understand the model and the behavior of the biosensor under various conditions well before the fabrication, thereby reducing the cost and to comprehend the behavior of each material in terms of power dissipation so different material can be experimented.

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Validation of a wearable biosensor device for vital sign monitoring in septic emergency department patients in Rwanda

Digital Health ◽

10.1177/2055207619879349 ◽

2019 ◽

Vol 5 ◽

pp. 205520761987934

Author(s):

Stephanie C Garbern ◽

Gabin Mbanjumucyo ◽

Christian Umuhoza ◽

Vinay K Sharma ◽

James Mackey ◽

...

Keyword(s):

Heart Rate ◽

Respiratory Rate ◽

Vital Sign ◽

Vital Signs ◽

University Teaching ◽

Suspected Sepsis ◽

Middle Income ◽

Radiologic Study ◽

Emergency Department Patients ◽

Biosensor Device

Objective Critical care capabilities needed for the management of septic patients, such as continuous vital sign monitoring, are largely unavailable in most emergency departments (EDs) in low- and middle-income country (LMIC) settings. This study aimed to assess the feasibility and accuracy of using a wireless wearable biosensor device for continuous vital sign monitoring in ED patients with suspected sepsis in an LMIC setting. Methods This was a prospective observational study of pediatric (≥2 mon) and adult patients with suspected sepsis at the Kigali University Teaching Hospital ED. Heart rate, respiratory rate and temperature measurements were continuously recorded using a wearable biosensor device for the duration of the patients’ ED course and compared to intermittent manually collected vital signs. Results A total of 42 patients had sufficient data for analysis. Mean duration of monitoring was 32.8 h per patient. Biosensor measurements were strongly correlated with manual measurements for heart rate (r = 0.87, p < 0.001) and respiratory rate (r = 0.75, p < 0.001), although were less strong for temperature (r = 0.61, p < 0.001). Mean (SD) differences between biosensor and manual measurements were 1.2 (11.4) beats/min, 2.5 (5.5) breaths/min and 1.4 (1.0)°C. Technical or practical feasibility issues occurred in 12 patients (28.6%) although were minor and included biosensor detachment, connectivity problems, removal for a radiologic study or exam, and patient/parent desire to remove the device. Conclusions Wearable biosensor devices can be feasibly implemented and provide accurate continuous heart rate and respiratory rate monitoring in acutely ill pediatric and adult ED patients with sepsis in an LMIC setting.

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