Antimicrobial potential of synthesized zinc oxide nanoparticles against gram positive and gram negative bacteria

2013 ◽  
Vol 52 (25-27) ◽  
pp. 4969-4976 ◽  
Author(s):  
Edris Hoseinzadeh ◽  
Mohammad-Yosef Alikhani ◽  
Mohammad-Reza Samarghandi ◽  
Mehdi Shirzad-Siboni
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Antimicrobial Potential

scholarly journals Biosynthesized Zinc Oxide Nanoparticles Disrupt Established Biofilms of Pathogenic Bacteria

2022 ◽  
Vol 12 (2) ◽  
pp. 710
Author(s):  
Fohad Mabood Husain ◽  
Faizan Abul Qais ◽  
Iqbal Ahmad ◽  
Mohammed Jamal Hakeem ◽  
Mohammad Hassan Baig ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Pathogenic Bacteria ◽  
Oxide Nanoparticles ◽  
Antibiofilm Activity ◽  
Gram Negative Bacteria ◽  
Zno Nps ◽  
Gram Positive ◽  
Gram Negative ◽  
E Coli

Global emergence and persistence of the multidrug-resistant microbes have created a new problem for management of diseases associated with infections. The development of antimicrobial resistance is mainly due to the sub-judicious and unprescribed used of antimicrobials both in healthcare and the environment. Biofilms are important due to their role in microbial infections and hence are considered a novel target in discovery of new antibacterial or antibiofilm agents. In this article, zinc oxide nanoparticles (ZnO-NPs) were prepared using extract of Plumbago zeylanica. ZnO-NPs were characterized and then their antibiofilm activity was tested against Gram-positive and Gram-negative bacteria. The ZnO-NPs were polydispersed, and the average size was obtained as 24.62 nm. The presence of many functional groups indicated that phytocompounds of P. zeylanica were responsible for the synthesis, capping, and stabilization of ZnO-NPs. Synthesized NPs inhibited the biofilm formation of E. coli, S. aureus, and P. aeruginosa by 62.80%, 71.57%, and 77.69%, respectively. Likewise, concentration-dependent inhibition of the EPS production was recorded in all test bacteria. Microscopic examination of the biofilms revealed that ZnO-NPs reduced the bacterial colonization on solid support and altered the architecture of the biofilms. ZnO-NPs also remarkably eradicated the preformed biofilms of the test bacteria up to 52.69%, 59.79%, and 67.22% recorded for E. coli, S. aureus, P. aeruginosa, respectively. The findings reveal the ability of green synthesized zinc oxide nanoparticles to inhibit, as well as eradicate, the biofilms of Gram-positive and Gram-negative bacteria.

scholarly journals A Mini Review of Antibacterial Properties of ZnO Nanoparticles

2021 ◽  
Vol 9 ◽  
Author(s):  
Sergey V. Gudkov ◽  
Dmitriy E. Burmistrov ◽  
Dmitriy A. Serov ◽  
Maxim B. Rebezov ◽  
Anastasia A. Semenova ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Antibacterial Effect ◽  
Antibacterial Properties ◽  
World Health ◽  
Oxide Nanoparticles ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
E Coli ◽  
Antibacterial Potential

The development of antibiotic resistance of bacteria is one of the most pressing problems in world health care. One of the promising ways to overcome microbial resistance to antibiotics is the use of metal nanoparticles and their oxides. In particular, numerous studies have shown the high antibacterial potential of zinc oxide nanoparticles (ZnO-NP) in relation to gram-positive and gram-negative bacteria. This mini-review includes an analysis of the results of studies in recent years aimed at studying the antibacterial activity of nanoparticles based on zinc oxide. The dependence of the antibacterial effect on the size of the applied nanoparticles in relation to E. coli and S. aureus is given. The influence of various ways of synthesis of zinc oxide nanoparticles and the main types of modifications of NP-ZnO to increase the antibacterial efficiency are also considered.

scholarly journals Zinc Oxide Nanoparticles for Water Purification

Materials ◽  
2021 ◽  
Vol 14 (16) ◽  
pp. 4747
Author(s):  
Angela Spoială ◽  
Cornelia-Ioana Ilie ◽  
Roxana-Doina Trușcă ◽  
Ovidiu-Cristian Oprea ◽  
Vasile-Adrian Surdu ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Zinc Oxide ◽  
Photocatalytic Activity ◽  
Zno Nanoparticles ◽  
Zinc Oxide Nanoparticles ◽  
Precipitation Method ◽  
Oxide Nanoparticles ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria

In this study, zinc oxide nanoparticles were synthesized through a simple co-precipitation method starting from zinc acetate dihydrate and sodium hydroxide as reactants. The as-obtained ZnO nanoparticles were morphologically and structurally characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), photocatalytic activity, and by determining the antimicrobial activity against Gram-negative and Gram-positive bacteria. The XRD pattern of the zinc oxide nanoparticles showed the wurtzite hexagonal structure, and its purity highlighted that the crystallinity correlated with the presence of a single product, zinc oxide. The ZnO nanoparticles have an average crystallite size of 19 ± 11 nm, which is in accordance with the microscopic data. ZnO nanoparticles were tested against methyl orange, used as a model pollutant, and it was found that they exhibit strong photocatalytic activity against this dye. The antibacterial activity of ZnO nanoparticles was tested against Gram-negative and Gram-positive strains (Escherichia coli, Staphylococcus aureus, and Candida albicans). The strongest activity was found against Gram-positive bacteria (S. aureus).

Biologically synthesized zinc oxide nanoparticles as nanoantibiotics against ESBLs producing gram negative bacteria

2018 ◽  
Vol 121 ◽  
pp. 224-231 ◽  
Author(s):  
Muthuchamy Maruthupandy ◽  
Govindan Rajivgandhi ◽  
Thillaichidambaram Muneeswaran ◽  
Ji-Ming Song ◽  
Natesan Manoharan
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Gram Negative Bacteria ◽  
Gram Negative

Antibacterial activity of magnesium oxide nanoparticles prepared by Calcination method

2019 ◽  
Vol 10 (03) ◽  
Author(s):  
Elaf Ayad Kadhem ◽  
Miaad Hamzah Zghair ◽  
Sarah , Hussam H. Tizkam, Shoeb Alahmad Salih Mahdi ◽  
Hussam H. Tizkam ◽  
Shoeb Alahmad
Keyword(s):  
Antibacterial Activity ◽  
Magnesium Oxide ◽  
Diffusion Method ◽  
Oxide Nanoparticles ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Gram Positive Bacteria ◽  
Magnesium Oxide Nanoparticles ◽  
Agar Disc

magnesium oxide nanoparticles (MgO NPs) were prepared by simple wet chemical method using different calcination temperatures. The prepared NPs were characterized by Electrostatic Discharge (ESD), Scanning Electron Microscope (SEM) and X-ray Diffraction (XRD). It demonstrates sharp intensive peak with the increase of crystallinty and increase of the size with varying morphologies with respect to increase of calcination temperature. Antibacterial studies were done on gram negative bacteria (E.coli) and gram positive bacteria (S.aureus) by agar disc diffusion method. The zones of inhibitions were found larger for gram positive bacteria than gram negative bacteria, this mean, antibacterial MgO NPs activity more active on gram positive bacteria than gram negative bacteria because of the structural differences. It was found that antibacterial activity of MgO NPs was found it has directly proportional with their concentration.

scholarly journals Antibacterial Activity of The Iron-Zinc Oxide Nanoparticles Synthesized Via Electric Discharge Method

2021 ◽  
Author(s):  
Fereshteh Shahbazi ◽  
Reza Ahmadi ◽  
Mohammad Noghani ◽  
Gholamreza Karimi
Keyword(s):  
Zinc Oxide ◽  
Electrical Discharge ◽  
Zinc Oxide Nanoparticles ◽  
Viral Infections ◽  
Antibacterial Properties ◽  
Oxide Nanoparticles ◽  
Gram Negative Bacteria ◽  
Discharge Method ◽  
Electric Discharge Method ◽  
Novel Antibiotics

Abstract With the increase in diseases caused by bacterial and viral infections, the need for antibiotics has increased. On the other hand, by creating drug resistance to organicmoietiesbased antibiotics, novel antibiotics have attracted the attention of researchers.Nano-scale metal oxides are increasingly being considered for medical applications, especially as antibacterial agents.In this study, iron oxide nanoparticles (IONPs) and zinc oxide nanoparticles (ZONPs) were prepared via electrical discharge method in liquid medium by changing parameters such as wire diameter and electric current intensity. Synthesized NPs were evaluated by XRD, UV_Visible, FE_SEM, EDS, HR_TEM and TEM analyzes. Also, the antibacterial properties of these nanoparticles were evaluated in different ways against gram-positive and gram-negative bacteria.

scholarly journals Evaluation of Antimicrobial Potential of the Marine Cyanobacterium, Rivularia mesenterica

2019 ◽  
pp. 1-11 ◽  
Author(s):  
Mirjana Skočibušić ◽  
Sandra Lacić ◽  
Zorica Rašić
Keyword(s):  
Antimicrobial Activity ◽  
Resistant Bacteria ◽  
Gram Negative Bacteria ◽  
Marine Cyanobacterium ◽  
Gram Positive ◽  
Promising Alternative ◽  
Gram Negative ◽  
Antimicrobial Potential ◽  
Ethanol Extracts ◽  
Promising Source

Background: Antibiotic resistance is becoming a pivotal concern for public health accelerating the search for new antimicrobial molecules from nature. The prevention and treatment of infectious diseases by applying products from marine organisms, especially Cyanobacteria as a potential and promising source of antimicrobial agents appears as a possible alternative. Aims: To evaluate the in vitro antimicrobial potential of different extracts derived from marine cyanobacterium Rivularia mesenterica against Gram-positive and Gram-negative bacteria, including multidrug resistant bacteria, by comparison with clinically relevant antibiotics.   Methodology: The secondary metabolites were extracted from fresh and dried cyanobacterial biomass in water and different organic solvents. Antimicrobial efficacy of different extracts was evaluated by the disc diffusion assay. Additionally, the minimum inhibitory concentrations (MIC) of the ethanol extracts obtained from fresh and dried biomass was also determined. Results: The ethanol extracts obtained from fresh and dried biomass of R. mesenterica showed significant antimicrobial activity against five Gram-positive and five antibiotic resistant Gram-negative bacteria and four fungal strains in comparison with the clinically relevant antibiotics. The inhibitory effect of the ethanol extracts was observed, with MIC values in the range 0.06 to 32.00 μg/ml against tested strains. Furthermore, the water extract was inactive against of the tested bacteria and fungi. Conclusion: These results suggest that the ethanol extracts of R. mesenterica possess potent broad spectrum of antimicrobial activity, which can serve as an interesting source for antimicrobial compounds and promising alternative to synthetic antimicrobial drugs discovery.

scholarly journals Antimicrobial Potential of Camellia sinensis against Skin Associated Microbial Pathogens

2019 ◽  
pp. 413-419
Author(s):  
Lovey Sharma ◽  
Ram Kumar Pundir
Keyword(s):  
Antimicrobial Activity ◽  
Candida Albicans ◽  
Petroleum Ether ◽  
Camellia Sinensis ◽  
Methanolic Extract ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
Propionibacterium Acne ◽  
Antimicrobial Potential

The present study was undertaken to assess the antimicrobial potential of leaves’ extract of Green tea (Camellia sinensis) against skin associated microorganisms. The antimicrobial activity was studied through agar well diffusion method against Gram positive, Gram negative bacteria and fungus included Propionibacterium acne, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans in five different solvents viz. Methanol, Ethanol, Distilled water, Chloroform and Petroleum ether. The methanolic extract of Camellia sinensis showed maximum zone of inhibition against Propionibacterium acne (27 mm) and S. aureus (26 mm); ethanolic extract was most effective against Candida albicans (22 mm) and petroleum ether extract was most effective against S. aureus (20 mm). The antimicrobial analyses showed that the extracts were more effective against Gram positive bacteria than Gram negative bacteria and fungus. Comparative study of antimicrobial activity of Camellia sinensis extracts with antibiotics revealed that Camellia sinensis methanolic extract had maximum effective antimicrobial activity against all the tested microorganisms. MIC (Minimum Inhibitory Concentration) and MBC (Minimum Bactericidal Concentration) of methanolic extract of Camellia sinensis against the microbial agents under study ranged between 0.125 to 0.015625 mg/ml. The synergistic interaction of Camellia sinensis with antibiotics revealed much better results as compared to antibiotics susceptibility pattern alone. Phytochemicals analyses of Camellia sinensis included alkaloids, saponins, glycosides, proteins, phenols, tannins and phytosterols. The compounds identified by GC-MS analysis of methanolic extract of Camellia sinensis were reported to be used as water treatment, antifungals, antimicrobials and enzymatic inhibitors, improve mental alertness, antifungal, anti-HIV, anticancer, anti-inflammatory, analgesic and comonomer (e.g. for lubricating oil additives). Therefore, it may be concluded that Camellia sinensis leaves possess antibacterial and antifungal properties, which may be used as alternate drug of choice due to its lower side-effects to human skin as compared to presently used therapeutic agents.

Sign in / Sign up

Export Citation Format

Share Document