scholarly journals Cleavage of the vaspin N-terminus releases cell-penetrating peptides that affect early stages of adipogenesis and inhibit lipolysis in mature adipocytes

Adipocyte ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 216-231
Author(s):  
Catherine A. Tindall ◽  
Estelle Erkner ◽  
Jan Stichel ◽  
Annette G. Beck-Sickinger ◽  
Anne Hoffmann ◽  
...  
Keyword(s):  
Cell Penetrating Peptides ◽  
Early Stages ◽  
N Terminus ◽  
Cell Penetrating

Cationic cell penetrating peptide modified SNARE protein VAMP8 as free chains for gene delivery

2018 ◽  
Vol 6 (10) ◽  
pp. 2647-2655 ◽  
Author(s):  
Baizhu Chen ◽  
Chi Wu
Keyword(s):  
Escherichia Coli ◽  
Membrane Protein ◽  
Fusion Proteins ◽  
Gene Transfection ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating Peptide ◽  
Snare Protein ◽  
Cationic Polymers ◽  
N Terminus ◽  
Cell Penetrating

To mimic the effect of cationic polymers, we selected to use vesicle associated membrane protein-8 (VAMP8) and modified its N-terminus with different cationic cell penetrating peptides (CPPs). The modified fusion proteins are expressed in an Escherichia coli system and purified after extraction. These modified VAMP8 proteins are used as free chains for gene transfection, while using bPEI-25k to condense the pDNA.

Oncolytic Coxsackievirus and the Mechanisms of its Effects on Cancer: A Narrative Review

2020 ◽  
Vol 16 ◽  
Author(s):  
Ali Ahmadi ◽  
Hadi Esmaeili Gouvarchin Ghaleh ◽  
Ruhollah Dorostkar ◽  
Mahdieh Farzanehpour ◽  
Masoumeh Bolandian
Keyword(s):  
Genetic Disease ◽  
Control Cell ◽  
Gene Mutations ◽  
Therapeutic Agents ◽  
Cell Penetrating Peptides ◽  
Triggered Release ◽  
New Techniques ◽  
Viral Therapy ◽  
Cell Penetrating ◽  
Cancer Cell Targeting

Abstract:: Cancer is a genetic disease triggered by gene mutations, which control cell growth and their functionality inherited from previous generations. The targeted therapy of some tumors was not especially successful. A host of new techniques can be used to treat aptamer-mediated targeting, cancer immunotherapy, cancer stem cell (CSC) therapy, cell-penetrating peptides (CPPs), hormone therapy, intracellular cancer cell targeting, nanoparticles, and viral therapy. These include chemical-analog conjugation, gene delivery, ligand-receptor-based targeting, prodrug therapies, and triggered release strategies. Virotherapy is a biotechnological technique for turning viruses into therapeutic agents by the reprogramming of viruses to cure diseases. In several tumors, including melanoma, multiple myeloma, bladder cancer, and breast cancer, the oncolytic capacity of oncolytic Coxsackievirus has been studied. The present study aims to assess oncolytic Coxsackievirus and its mechanisms of effect on cancer cells.

Sign in / Sign up

Export Citation Format

Share Document