scholarly journals The protective effect of piperine on oxidative stress and hepatic damage induced by diisononyl phthalate in rat

2021 ◽  
Vol 8 (1) ◽  
pp. 293-301
Author(s):  
Oluwatobi Adewumi Adeyemo ◽  
Ayokanmi Ore ◽  
Elizabeth Oyinkansola Ajisafe
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Hepatic Damage ◽  
Diisononyl Phthalate

scholarly journals Protective Effect ofBaccharis trimeraExtract on Acute Hepatic Injury in a Model of Inflammation Induced by Acetaminophen

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Bruno da Cruz Pádua ◽  
Joamyr Victor Rossoni Júnior ◽  
Cíntia Lopes de Brito Magalhães ◽  
Míriam Martins Chaves ◽  
Marcelo Eustáquio Silva ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Clinical Problem ◽  
Hepatic Damage ◽  
Histopathological Analysis ◽  
Potential Candidate ◽  
Apap Overdose ◽  
Candidate Drug ◽  
Antioxidant Parameters ◽  
High Doses

Background. Acetaminophen (APAP) is a commonly used analgesic and antipyretic. When administered in high doses, APAP is a clinical problem in the US and Europe, often resulting in severe liver injury and potentially acute liver failure. Studies have demonstrated that antioxidants and anti-inflammatory agents effectively protect against the acute hepatotoxicity induced by APAP overdose.Methods. The present study attempted to investigate the protective effect ofB. trimeraagainst APAP-induced hepatic damage in rats. The liver-function markers ALT and AST, biomarkers of oxidative stress, antioxidant parameters, and histopathological changes were examined.Results. The pretreatment withB. trimeraattenuated serum activities of ALT and AST that were enhanced by administration of APAP. Furthermore, pretreatment with the extract decreases the activity of the enzyme SOD and increases the activity of catalase and the concentration of total glutathione. Histopathological analysis confirmed the alleviation of liver damage and reduced lesions caused by APAP.Conclusions. The hepatoprotective action ofB. trimeraextract may rely on its effect on reducing the oxidative stress caused by APAP-induced hepatic damage in a rat model.General Significance. These results make the extract ofB. trimeraa potential candidate drug capable of protecting the liver against damage caused by APAP overdose.

scholarly journals Protective Effect ofAcacia nilotica(L.) against Acetaminophen-Induced Hepatocellular Damage in Wistar Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Narayanan Kannan ◽  
Kunnathur Murugesan Sakthivel ◽  
Chandrasekaran Guruvayoorappan
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Total Protein ◽  
Wistar Rats ◽  
Total Bilirubin ◽  
Stress Test ◽  
Hepatic Damage ◽  
Histopathological Analysis ◽  
Traditional System ◽  
Hepatocellular Damage

The potential biological functions ofA. niloticahave long been described in traditional system of medicine. However, the protective effect ofA. niloticaon acetaminophen-induced hepatotoxicity is still unknown. The present study attempted to investigate the protective effect ofA. niloticaagainst acetaminophen-induced hepatic damage in Wistar rats. The biochemical liver functional tests Alanine transaminase (ALT), Aspartate transaminase (AST), Alkaline phosphatase (ALP), total bilirubin, total protein, oxidative stress test (Lipid peroxidation), antioxidant parameter glutathione (GSH), and histopathological changes were examined. Our results show that the pretreatment withA. nilotica(250 mg/kg·bw) orally revealed attenuation of serum activities of ALT, AST, ALP, liver weight, and total bilirubin levels that were enhanced by administration of acetaminophen. Further, pretreatment with extract elevated the total protein and GSH level and decreased the level of LPO. Histopathological analysis confirmed the alleviation of liver damage and reduced lesions caused by acetaminophen. The present study undoubtedly provides a proof that hepatoprotective action ofA. niloticaextract may rely on its effect on reducing the oxidative stress in acetaminophen-induced hepatic damage in rat model.

Antioxidant Activity and Protective Effect against Oxidative Stress on Hippocampal HT22 Cells of Tea Seed Oil

2018 ◽  
Vol 24 (1) ◽  
pp. 53-59
Author(s):  
Jong Min Kim ◽  
Seon Kyeong Park ◽  
Jin Yong Kang ◽  
Seong-kyeong Bae ◽  
Ga-Hee Jeong ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Protective Effect ◽  
Seed Oil ◽  
Ht22 Cells ◽  
Tea Seed Oil

Protective effect of DJ-1 against oxidative stress: an advance

2012 ◽  
Vol 32 (1) ◽  
pp. 88-91
Author(s):  
Zhi-yong WANG ◽  
Ling-zhen TANG ◽  
Tian-wen GAO
Keyword(s):  
Oxidative Stress ◽  
Protective Effect

Protective Effect of Swertiamarin on Myocardial Injury Through Activation of Nrf2/HO-1 Pathway in Heart Failure Model of Rats

2020 ◽  
Vol 18 (3) ◽  
pp. 260-265
Author(s):  
Xu Lin ◽  
Zheng Xiaojun ◽  
Lv Heng ◽  
Mo Yipeng ◽  
Tong Hong
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Ejection Fraction ◽  
Protective Effect ◽  
Infarct Size ◽  
Rat Model ◽  
Left Ventricular ◽  
Related Factor ◽  
Nuclear Factor ◽  
Internal Dimension

The purpose of this study was to evaluate the protective effect of swertiamarin on heart failure. To this end, a rat model of heart failure was established via left coronary artery ligation. Infarct size of heart tissues was determined using triphenyl tetrazolium chloride staining. Echocardiography was performed to evaluate cardiac function by the determination of ejection fraction, left ventricular internal dimension in diastole and left ventricular internal dimension in systole. The effect of swertiamarin on oxidative stress was evaluated via enzyme-linked immunosorbent assay. The mechanism was evaluated using western blot. Administration of swertiamarin reduced the infarct size of heart tissues in rat models with heart failure. Moreover, swertiamarin treatment ameliorated the cardiac function, increased ejection fraction and fractional shortening, decreased left ventricular internal dimension in diastole and left ventricular internal dimension in systole. Swertiamarin improved oxidative stress with reduced malondialdehyde, while increased superoxide dismutase, glutathione, and GSH peroxidase. Furthermore, nuclear-factor erythroid 2-related factor 2, heme oxygenase and NAD(P)H dehydrogenase (quinone 1) were elevated by swertiamarin treatment in heart tissues of rat model with heart failure. Swertiamarin alleviated heart failure through suppression of oxidative stress response via nuclear-factor erythroid 2-related factor 2/heme oxygenase-1 pathway providing a novel therapeutic strategy for heart failure.

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