scholarly journals THE ACTIVATING EFFECT OF CALCIUM ON A BACTERICIDAL SUBSTANCE FOR BACILLUS SUBTILIS IN HUMAN SERUM

1950 ◽  
Vol 92 (2) ◽  
pp. 101-111 ◽  
Author(s):  
Ralph F. Jacox
Keyword(s):  
Bacillus Subtilis ◽  
Human Serum ◽  
Bactericidal Activity ◽  
Bacterial Infections ◽  
Coronary Occlusion ◽  
Bactericidal Effect ◽  
Serum Complement ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Acute Coronary Occlusion

An enhanced bactericidal activity of human serum for B. subtilis develops during many different forms of illness, e.g. carcinoma, virus and bacterial infections, and during acute coronary occlusion. This increased bactericidal effect cannot be related to leucocytosis, fever, serum complement, C-reactive protein, or a specific antibody reaction. The serum bactericidal factor becomes inactive in decalcified serum, but active again when optimal concentrations of calcium are added. Magnesium does not cause reactivation.

scholarly journals THE OCCURRENCE DURING ACUTE INFECTIONS OF A PROTEIN NOT NORMALLY PRESENT IN THE BLOOD

1941 ◽  
Vol 73 (2) ◽  
pp. 191-200 ◽  
Author(s):  
Colin M. MacLeod ◽  
Oswald T. Avery
Keyword(s):  
Human Serum ◽  
Bacterial Infections ◽  
Normal Human Serum ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Acute Infections ◽  
Immunological Specificity ◽  
Normal Human ◽  
Immunological Reactions ◽  
Acute Bacterial Infections

The C-reactive protein present in the albumin fraction of the serum of patients during certain acute bacterial infections is highly antigenic upon injection into rabbits. The antiserum thus prepared reacts specifically with this protein and does not react with the proteins of normal human serum. Immunological specificity has been demonstrated by both precipitin and complement-fixation tests. Antiserum prepared in rabbits to the C-reactive protein from human sources also reacts specifically with the similar protein in the serum of monkeys acutely ill with experimental pneumococcus infection. By means of immunological reactions it is possible to detect amounts of reactive protein which are too small to yield a visible precipitate in tests with the C polysaccharide. Certain of the properties are discussed which distinguish the C-reactive protein from the proteins of normal human serum.

scholarly journals Interactions of C-reactive protein with the complement system. III. Complement-dependent passive hemolysis initiated by CRP.

1975 ◽  
Vol 142 (5) ◽  
pp. 1065-1077 ◽  
Author(s):  
A.P. Osmand ◽  
R.F. Mortensen ◽  
Joan Siegel ◽  
H. Gewurz
Keyword(s):  
Guinea Pig ◽  
Human Serum ◽  
Complete System ◽  
Gel Filtration ◽  
C Reactive Protein ◽  
Inflammatory Reactions ◽  
Reactive Protein ◽  
Rabbit Igg ◽  
The Complement System ◽  
Pig Serum

Interactions of CRP with various substrates in the presence of human serum have been shown to result in efficient activation of C components C1-C5. We now report the ability of CRP to initiate C-dependent hemolysis. For this purpose CRP was isolated by affinity chromatography using pneumococcal CPS and gel filtration; its purity was established by several criteria. Erythrocytes were coated with CPS (E-CPS) and passively sensitized with CRP. C-dependent lysis of these cells was observed upon the addition of suitably absorbed human serum, and the efficiency of hemolysis compared favorably with that initiated by rabbit IgG anti-CPS antibody. CRP also sensitized E-CPS for lysis by guinea pig C; partial lysis was seen when C4-deficient guinea pig serum was used, suggesting that CRP also shares with antibody the ability of CRP to fully activate the C system and provide further evidence for a role for CRP similar to that of antibody in the initiation and modulation of inflammatory reactions via the complete system.

Value of measuring serum procalcitonin, C-reactive protein, and mannan antigens to distinguish fungal from bacterial infections

2005 ◽  
Vol 24 (4) ◽  
pp. 272-275 ◽  
Author(s):  
G. L. Petrikkos ◽  
S. A. Christofilopoulou ◽  
N. K. Tentolouris ◽  
E. A. Charvalos ◽  
C. J. Kosmidis ◽  
...  
Keyword(s):  
Bacterial Infections ◽  
C Reactive Protein ◽  
Reactive Protein

C-Reactive Protein as A Fungal Infection Marker in Acute Leukemia Patients

2021 ◽  
Vol 27 (2) ◽  
pp. 212
Author(s):  
Brigitte Rina Aninda Sidharta ◽  
JB. Suparyatmo ◽  
Avanti Fitri Astuti
Keyword(s):  
Acute Leukemia ◽  
Predictive Value ◽  
Bacterial Infections ◽  
Fungal Infections ◽  
Lymphoblastic Leukemia ◽  
Negative Likelihood Ratio ◽  
Receiver Operating Curve ◽  
High Morbidity ◽  
C Reactive Protein ◽  
Reactive Protein

Invasive Fungal Infections (IFIs) can cause serious problems in cancer patients and may result in high morbidity andmortality. C-reactive protein levels increase in response to injury, infection, and inflammation. C-reactive protein increasesin bacterial infections (mean of 32 mg/L) and in fungal infections (mean of 9 mg/L). This study aimed to determineC-Reactive Protein (CRP) as a marker of fungal infections in patients with acute leukemia by establishing cut-off values ofCRP. This study was an observational analytical study with a cross-sectional approach and was carried out at the Departmentof Clinical Pathology and Microbiology of Dr. Moewardi Hospital in Surakarta from May until August 2019. The inclusioncriteria were patients with acute leukemia who were willing to participate in this study, while exclusion criteria were patientswith liver disease. There were 61 samples consisting of 30 male and 31 female patients with ages ranging from 1 to 70 years.Fifty-four patients (88.5%) were diagnosed with Acute Lymphoblastic Leukemia (ALL) and 30 (49.18%) were in themaintenance phase. The risk factors found in those patients were neutropenia 50-1500 μL (23.8%), use of intravenous line(22%), and corticosteroid therapy for more than one week (20.9%). The median of CRP in the group of patients with positiveculture results was 11.20 mg/L (11.20-26.23 mg/L) and negative culture results in 0.38 mg/L (0.01-18.63 mg/L). The cut-offvalue of CRP using the Receiver Operating Curve (ROC) was 9.54 mg/L (area under curve 0.996 and p. 0.026), with a sensitivityof 100%, specificity of 93.2%, Positive Predictive Value (PPV) of 33.3%, Negative Predictive Value (PPV) of 100%, PositiveLikelihood Ratio (PLR) of 1.08, Negative Likelihood Ratio (NLR) of 0 and accuracy of 93.4%. C-reactive protein can be used asa screening marker for fungal infections in patients with acute leukemia.

scholarly journals Phosphoethanolamine-complexed C-reactive protein: A pharmacological-like macromolecule that binds to native low-density lipoprotein in human serum

2008 ◽  
Vol 394 (1-2) ◽  
pp. 94-98 ◽  
Author(s):  
Sanjay K. Singh ◽  
Madathilparambil V. Suresh ◽  
Deborah C. Prayther ◽  
Jonathan P. Moorman ◽  
Antonio E. Rusiñol ◽  
...  
Keyword(s):  
Human Serum ◽  
Low Density Lipoprotein ◽  
Protein A ◽  
Density Lipoprotein ◽  
Low Density ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Native Low Density Lipoprotein

scholarly journals CORRELATION OF TOTAL COUNT (WBC), NEUTROPHIL COUNT AND CRP TEST AMONG FEBRILE PATIENTS IN NAVIMUMBAI.

2019 ◽  
Vol 3 (9) ◽  
Author(s):  
Dr. Sarita Shrivatstva ◽  
Dr. Narayana Kamath ◽  
Mrs. Ashwini Panchmahalkar
Keyword(s):  
Neutrophil Count ◽  
Bacterial Infections ◽  
Blood Count ◽  
Complete Blood Count ◽  
Malarial Parasite ◽  
Differential Count ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Streptolysin O ◽  
Febrile Condition

150 febrile patients included children (50), adult (50) and neonates (50) from outpatient departments and inpatients of private clinics and hospitals. Patients presented with fever and chills for more than 1 day to 3 days, throat infection, ear infection and cold and fever and only fever as the principal symptoms. After clinical examination all the patients were prescribed for Complete Blood Count (CBC) with differential count(DC) and C-reactive protein(CRP) tests, and in children below 14 years anti-Streptolysin O(ASO) tests ( 75) were prescribed. Patients treated with antibiotics previously two weeks before the study period were not included. Qualitative and quantitative tests were performed on all patients’ samples included in the study depending on the need/prescription by the physician or paediatrician. CBC, neutrophil count and CRP have been very useful indicators and significant in the diagnosis and treatment as well as follow-up of the febrile condition of the patients specially in patients suffering with bacterial infections. Even in patients with Dengue and malaria it gives a fair idea if there were leucocytosis or leukopenia, neutrophilia or neutropenia, thrombocytosis or thrombocytopenia. CBC: Complete blood count, DC: Differential count; MP: malarial parasite, CRP: C-reactive protein, ASO: Anti-Streptolysin O.

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