High-sensitivity colorimetric detection of DNA hybridization on a gold surface with high spatial resolution

A laboratory-based X-ray microprobe, composed of a high-brilliance microfocus X-ray tube, coupled with a small glass capillary, has been developed for materials applications. Because of total external reflectance of X rays from the smooth inside bore of the glass capillary, the microprobe has a high sensitivity as well as a high spatial resolution. The use of X rays to excite elemental fluorescence offers the advantages of good peak-to-background, the ability to operate in air, and minimal specimen preparation. In addition, the development of laboratory-based instrumentation has been of Interest recently because of greater accessibility when compared with synchrotron X-ray microprobes.

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High spatial resolution at very high sensitivity using synchrotron radiation excited XPS

Review of Scientific Instruments ◽

10.1063/1.1140813 ◽

1989 ◽

Vol 60 (7) ◽

pp. 2172-2175 ◽

Cited By ~ 6

Author(s):

M. Schaible ◽

H. Petersen ◽

W. Braun ◽

E.‐E. Koch

Keyword(s):

Synchrotron Radiation ◽

Spatial Resolution ◽

High Spatial Resolution ◽

High Sensitivity ◽

Very High

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99mTc-labeled and gadolinium-chelated transferrin enhances the sensitivity and specificity of dual-modality SPECT/MR imaging of breast cancer

RSC Advances ◽

10.1039/c5ra22934k ◽

2016 ◽

Vol 6 (25) ◽

pp. 20532-20541 ◽

Cited By ~ 5

Author(s):

Bingxin Gu ◽

Jiali Cai ◽

Jianping Zhang ◽

Xiaoping Xu ◽

Jianming Luo ◽

...

Keyword(s):

Breast Cancer ◽

Mr Imaging ◽

Sensitivity And Specificity ◽

Spatial Resolution ◽

Breast Tumor ◽

High Spatial Resolution ◽

High Sensitivity ◽

Dual Modality

A dual-modal probe 99mTc–Tf–DTPA–Gd could provide high spatial resolution and high sensitivity images of breast tumor.

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NanoSIMS imaging: an approach for visualizing and quantifying lipids in cells and tissues

Journal of Investigative Medicine ◽

10.1136/jim-2016-000239 ◽

2016 ◽

Vol 65 (3) ◽

pp. 669-672 ◽

Cited By ~ 16

Author(s):

Cuiwen He ◽

Loren G Fong ◽

Stephen G Young ◽

Haibo Jiang

Keyword(s):

Mass Spectrometry ◽

Spatial Resolution ◽

Mass Spectrometry Imaging ◽

Secondary Ion Mass Spectrometry ◽

High Spatial Resolution ◽

High Sensitivity ◽

New Approach ◽

The Past ◽

Secondary Ion ◽

In Cells

Over the past few decades, several approaches have been used to image lipids in cells and tissues, but most have limited spatial resolution and sensitivity. Here, we discuss a relatively new approach, nanoscale secondary ion mass spectrometry imaging, that makes it possible to visualize lipids in cells and tissues in a quantitative fashion and with high spatial resolution and high sensitivity.

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Kelvin Probe Force Microscope Measurement Uncertainty

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.222.114 ◽

2011 ◽

Vol 222 ◽

pp. 114-117

Author(s):

Maciej Ligowski ◽

Michiharu Tabe ◽

Ryszard Jabłoński

Keyword(s):

Measurement Uncertainty ◽

Spatial Resolution ◽

Surface Potential ◽

High Spatial Resolution ◽

High Sensitivity ◽

Kelvin Probe ◽

Force Microscopy ◽

Calibration Methods ◽

Standard Calibration ◽

Nanoscale Measurements

Kelvin Probe Force Microscopy is an attractive technique for characterizing the surface potential of various samples. The main advantage of this technique is its high spatial resolution together with high sensitivity. However as in any nanoscale measurements also in case of KFM it is extremly difficult to describe the uncertainty of the measurement. Moreover, a wide variety of measuring conditions, together with the complicated operation principle cause situation, where no standard calibration methods are available. In the paper we propose the model of the KFM microscope and analyze the uncertainty of the KFM measurement.

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Wide Swath and High Resolution Airborne HyperSpectral Imaging System and Flight Validation

Sensors ◽

10.3390/s19071667 ◽

2019 ◽

Vol 19 (7) ◽

pp. 1667 ◽

Cited By ~ 2

Author(s):

Dong Zhang ◽

Liyin Yuan ◽

Shengwei Wang ◽

Hongxuan Yu ◽

Changxing Zhang ◽

...

Keyword(s):

High Resolution ◽

Spatial Resolution ◽

Spectral Resolution ◽

High Efficiency ◽

High Spatial Resolution ◽

Imaging System ◽

High Sensitivity ◽

Field Of View ◽

High Spectral Resolution ◽

Wide Swath

Wide Swath and High Resolution Airborne Pushbroom Hyperspectral Imager (WiSHiRaPHI) is the new-generation airborne hyperspectral imager instrument of China, aimed at acquiring accurate spectral curve of target on the ground with both high spatial resolution and high spectral resolution. The spectral sampling interval of WiSHiRaPHI is 2.4 nm and the spectral resolution is 3.5 nm (FWHM), integrating 256 channels coving from 400 nm to 1000 nm. The instrument has a 40-degree field of view (FOV), 0.125 mrad instantaneous field of view (IFOV) and can work in high spectral resolution mode, high spatial resolution mode and high sensitivity mode for different applications, which can adapt to the Velocity to Height Ratio (VHR) lower than 0.04. The integration has been finished, and several airborne flight validation experiments have been conducted. The results showed the system’s excellent performance and high efficiency.

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